| Type |
Details |
Score |
| Protein Domain |
| Type: |
Family |
| Description: |
This entry represents receptor tyrosine-protein phosphatase (PTP) alpha (). PTP catalyses the dephosphorylation of protein tyrosine phosphate to protein tyrosine, and appear to play a pivotal role in insulin receptor signalling. It can exist as a single-pass membrane protein or in the cytoplasm. PTP-alpha is as a positive regulator of Src and Src family kinases, acting to dephosphorylate and activate Src. As such, PTP-alpha affects transformation and tumourigenesis, inhibition of proliferation and cell cycle arrest, mitotic activation of Src, integrin signalling, neuronal differentiation and outgrowth, and ion channel activity []. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
This entry represents the SH2 domain found in SLAP/SLAP2.Src-like adapter proteins (SLAP and SLAP2) are involved in the regulation of immune cell surface expression and signaling. They negatively regulate T cell receptor signaling []and act as critical inhibitors of platelet (hem)ITAM signaling in the setting of arterial thrombosis and ischemic stroke []. They contain adjacent Src homology 3 (SH3) and Src homology 2 (SH2) domains. SLAP has been shown to regulate receptor tyrosine kinase (RTK) signaling []. It also binds to the receptor tyrosine kinase Flt3 and plays a role in signal transduction downstream of Flt3 []. SLAP2 acts as a negative regulator of FLT3 signaling []. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
This entry represents the SH3 domain of SLAP. Src-like adapter proteins (SLAP and SLAP2) are involved in the regulation of immune cell surface expression and signaling. They negatively regulate T cell receptor signaling []and act as critical inhibitors of platelet (hem)ITAM signaling in the setting of arterial thrombosis and ischemic stroke []. They contain adjacent Src homology 3 (SH3) and Src homology 2 (SH2) domains. SLAP has been shown to regulate receptor tyrosine kinase (RTK) signaling []. It also binds to the receptor tyrosine kinase Flt3 and plays a role in signal transduction downstream of Flt3 []. SLAP2 acts as a negative regulator of FLT3 signaling []. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This entry represents Src-like-adapter 2 (SLAP2).Src-like adapter proteins (SLAP and SLAP2) are involved in the regulation of immune cell surface expression and signaling. They negatively regulate T cell receptor signaling []and act as critical inhibitors of platelet (hem)ITAM signaling in the setting of arterial thrombosis and ischemic stroke []. They contain adjacent Src homology 3 (SH3) and Src homology 2 (SH2) domains. SLAP has been shown to regulate receptor tyrosine kinase (RTK) signaling []. It also binds to the receptor tyrosine kinase Flt3 and plays a role in signal transduction downstream of Flt3 []. SLAP2 acts as a negative regulator of FLT3 signaling []. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This entry represents SLAP.Src-like adapter proteins (SLAP and SLAP2) are involved in the regulation of immune cell surface expression and signaling. They negatively regulate T cell receptor signaling []and act as critical inhibitors of platelet (hem)ITAM signaling in the setting of arterial thrombosis and ischemic stroke []. They contain adjacent Src homology 3 (SH3) and Src homology 2 (SH2) domains. SLAP has been shown to regulate receptor tyrosine kinase (RTK) signaling []. It also binds to the receptor tyrosine kinase Flt3 and plays a role in signal transduction downstream of Flt3 []. SLAP2 acts as a negative regulator of FLT3 signaling []. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Avraham KB |
| Year: |
1993 |
| Journal: |
Genomics |
| Title: |
Murine chromosomal location of four class III POU transcription factors. |
| Volume: |
18 |
| Issue: |
1 |
| Pages: |
131-3 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pathak BG |
| Year: |
1996 |
| Journal: |
Genomics |
| Title: |
Mouse chromosomal location of four Na/H exchanger isoform genes. |
| Volume: |
31 |
| Issue: |
2 |
| Pages: |
261-3 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Potter AS |
| Year: |
2019 |
| Journal: |
PLoS One |
| Title: |
A bigenic mouse model of FSGS reveals perturbed pathways in podocytes, mesangial cells and endothelial cells. |
| Volume: |
14 |
| Issue: |
8 |
| Pages: |
e0216261 |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Lyn/Lyn<+> Ptpn6/Ptpn6<+> Tg(IghelMD4)4Ccg/? |
| Background: |
involves: 129P2/OlaHsd * C57BL/6 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Cd22/Cd22<+> Lyn/Lyn<+> Ptpn6/Ptpn6<+> Tg(IghelMD4)4Ccg/? |
| Background: |
involves: 129P2/OlaHsd * C57BL/6 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Shc2/Shc2<+> Shc3/Shc3<+> |
| Background: |
involves: 129 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Engen JR |
| Year: |
2008 |
| Journal: |
Cell Mol Life Sci |
| Title: |
Structure and dynamic regulation of Src-family kinases. |
| Volume: |
65 |
| Issue: |
19 |
| Pages: |
3058-73 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zikherman J |
| Year: |
2010 |
| Journal: |
Immunity |
| Title: |
CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development. |
| Volume: |
32 |
| Issue: |
3 |
| Pages: |
342-54 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Samayawardhena LA |
| Year: |
2007 |
| Journal: |
Blood |
| Title: |
Involvement of Fyn kinase in Kit and integrin-mediated Rac activation, cytoskeletal reorganization, and chemotaxis of mast cells. |
| Volume: |
109 |
| Issue: |
9 |
| Pages: |
3679-86 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Eberl G |
| Year: |
1999 |
| Journal: |
J Immunol |
| Title: |
Cutting edge: NKT cell development is selectively impaired in Fyn- deficient mice. |
| Volume: |
163 |
| Issue: |
8 |
| Pages: |
4091-4 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Watson AR |
| Year: |
2012 |
| Journal: |
Cell Immunol |
| Title: |
Superantigen-induced CD4 memory T cell anergy. I. Staphylococcal enterotoxin B induces Fyn-mediated negative signaling. |
| Volume: |
276 |
| Issue: |
1-2 |
| Pages: |
16-25 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Filby A |
| Year: |
2007 |
| Journal: |
J Immunol |
| Title: |
Fyn regulates the duration of TCR engagement needed for commitment to effector function. |
| Volume: |
179 |
| Issue: |
7 |
| Pages: |
4635-44 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yagi T |
| Year: |
1993 |
| Journal: |
Nature |
| Title: |
A role for Fyn tyrosine kinase in the suckling behaviour of neonatal mice. |
| Volume: |
366 |
| Issue: |
6457 |
| Pages: |
742-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shima T |
| Year: |
2000 |
| Journal: |
Brain Res |
| Title: |
Changes in circadian period and morphology of the hypothalamic suprachiasmatic nucleus in fyn kinase-deficient mice. |
| Volume: |
870 |
| Issue: |
1-2 |
| Pages: |
36-43 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kumar L |
| Year: |
2005 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
A 10-aa-long sequence in SLP-76 upstream of the Gads binding site is essential for T cell development and function. |
| Volume: |
102 |
| Issue: |
52 |
| Pages: |
19063-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kawakami T |
| Year: |
1986 |
| Journal: |
Mol Cell Biol |
| Title: |
Isolation and oncogenic potential of a novel human src-like gene. |
| Volume: |
6 |
| Issue: |
12 |
| Pages: |
4195-201 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ilić D |
| Year: |
1997 |
| Journal: |
Carcinogenesis |
| Title: |
Skin abnormality in aged fyn-/- fak+/- mice. |
| Volume: |
18 |
| Issue: |
8 |
| Pages: |
1473-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
An L |
| Year: |
2014 |
| Journal: |
Exp Cell Res |
| Title: |
The aspartic acid of Fyn at 390 is critical for neuronal migration during corticogenesis. |
| Volume: |
328 |
| Issue: |
2 |
| Pages: |
419-28 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Huang Y |
| Year: |
2017 |
| Journal: |
Neuroscience |
| Title: |
Fyn regulates multipolar-bipolar transition and neurite morphogenesis of migrating neurons in the developing neocortex. |
| Volume: |
352 |
|
| Pages: |
39-51 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lu X |
| Year: |
2015 |
| Journal: |
BMB Rep |
| Title: |
The SH2 domain is crucial for function of Fyn in neuronal migration and cortical lamination. |
| Volume: |
48 |
| Issue: |
2 |
| Pages: |
97-102 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ochi H |
| Year: |
2000 |
| Journal: |
Int Immunol |
| Title: |
Negative regulation of B cell receptor-mediated signaling in B-1 cells through CD5 and Ly49 co-receptors via Lyn kinase activity. |
| Volume: |
12 |
| Issue: |
10 |
| Pages: |
1417-23 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Greene TA |
| Year: |
2003 |
| Journal: |
J Biol Chem |
| Title: |
Cloning and characterization of ALX, an adaptor downstream of CD28. |
| Volume: |
278 |
| Issue: |
46 |
| Pages: |
45128-34 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
429
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
113
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
429
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kyogoku C |
| Year: |
2004 |
| Journal: |
Am J Hum Genet |
| Title: |
Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE. |
| Volume: |
75 |
| Issue: |
3 |
| Pages: |
504-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Brdicková N |
| Year: |
2001 |
| Journal: |
FEBS Lett |
| Title: |
Interaction between two adapter proteins, PAG and EBP50: a possible link between membrane rafts and actin cytoskeleton. |
| Volume: |
507 |
| Issue: |
2 |
| Pages: |
133-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kalland ME |
| Year: |
2012 |
| Journal: |
Exp Cell Res |
| Title: |
Modulation of proximal signaling in normal and transformed B cells by transmembrane adapter Cbp/PAG. |
| Volume: |
318 |
| Issue: |
14 |
| Pages: |
1611-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Romir J |
| Year: |
2007 |
| Journal: |
J Mol Biol |
| Title: |
Crystal structure analysis and solution studies of human Lck-SH3; zinc-induced homodimerization competes with the binding of proline-rich motifs. |
| Volume: |
365 |
| Issue: |
5 |
| Pages: |
1417-28 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li M |
| Year: |
2008 |
| Journal: |
Mol Cell Biol |
| Title: |
The SH3 domain of Lck modulates T-cell receptor-dependent activation of extracellular signal-regulated kinase through activation of Raf-1. |
| Volume: |
28 |
| Issue: |
2 |
| Pages: |
630-41 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fukushima A |
| Year: |
2006 |
| Journal: |
Cell Signal |
| Title: |
Lck couples Shc to TCR signaling. |
| Volume: |
18 |
| Issue: |
8 |
| Pages: |
1182-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Patrussi L |
| Year: |
2012 |
| Journal: |
Apoptosis |
| Title: |
p66Shc-dependent apoptosis requires Lck and CamKII activity. |
| Volume: |
17 |
| Issue: |
2 |
| Pages: |
174-86 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Craven RJ |
| Year: |
1995 |
| Journal: |
Cancer Res |
| Title: |
The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb. |
| Volume: |
55 |
| Issue: |
18 |
| Pages: |
3969-72 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Brauer PM |
| Year: |
2009 |
| Journal: |
Cell Cycle |
| Title: |
RAKing in AKT: a tumor suppressor function for the intracellular tyrosine kinase FRK. |
| Volume: |
8 |
| Issue: |
17 |
| Pages: |
2728-32 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cance WG |
| Year: |
1994 |
| Journal: |
Cell Growth Differ |
| Title: |
Rak, a novel nuclear tyrosine kinase expressed in epithelial cells. |
| Volume: |
5 |
| Issue: |
12 |
| Pages: |
1347-55 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Annerén C |
| Year: |
2003 |
| Journal: |
Curr Mol Med |
| Title: |
The FRK/RAK-SHB signaling cascade: a versatile signal-transduction pathway that regulates cell survival, differentiation and proliferation. |
| Volume: |
3 |
| Issue: |
4 |
| Pages: |
313-24 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Tyrosine-protein phosphatase non-receptor type 22 (PTPN22) acts as negative regulator of T-cell receptor (TCR) signalling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signalling molecules [].Variations of the PTPN22 gene affects the susceptibility of systemic lupus erythematosus (SLE) []. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
TOM1-like protein 1 (TOM1L1) is an adapter protein involved in signaling pathways. It interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. TOM1L1 promotes activation of Src family tyrosine kinase Fyn, possibly by disrupting intramolecular SH3-dependent interactions []. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
Frk (RAK) is a member of the Src non-receptor type tyrosine kinase family of proteins. The Frk subfamily is composed of Frk/Rak and Iyk/Bsk/Gst. It is expressed primarily epithelial cells. Frk is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth []. Unlike the other Src members it lacks a glycine at position 2 of SH4 which is important for addition of a myristic acid moiety that is involved in targeting Src PTKs to cellular membranes []. FRK and SHB exert similar effects when overexpressed in rat phaeochromocytoma (PC12) and beta-cells, where both induce PC12 cell differentiation and beta-cell proliferation. Under conditions that cause beta-cell degeneration these proteins augment beta-cell apoptosis. The FRK-SHB responses involve FAK and insulin receptor substrates (IRS) -1 and -2 []. Frk has been demonstrated to interact with retinoblastoma protein []. Frk regulates PTEN protein stability by phosphorylating PTEN, which in turn prevents PTEN degradation []. Frk also plays a role in regulation of embryonal pancreatic beta cell formation [].The Src non-receptor type tyrosine kinase (SFK) family members have an unique N-terminal domain, an SH3 domain, an SH2 domain, a kinase domain and a regulatory tail. The SH2 domain of SFKs is involved in kinase autoinhibition and T-cell receptor signaling. The binding SH2 domains to phosphotyrosine (pY) sites is critical for the autoinhibition and substrate recognition of the SFKs []. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
PAG, or Cbp/PAG (Csk binding protein/phospho-protein associated with glycosphingolipid-enriched microdomains) is a transmembrane protein that has a negative regulatory role in T-cell activation through being an adapter for C-terminal Src kinase, Csk. This family of proteins is found in eukaryotes [, , , ]. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
TXK is a member of the Tec family, which is a group of nonreceptor tyrosine kinases containing Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. It also contains an N-terminal cysteine-rich region. TXK forms a complex with EF-1alpha and PARP1 that regulates interferon-gamma gene transcription in Th1 cells []. This entry represents the SH3 domain of TXK. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
Lyn is a member of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Lyn is expressed in B lymphocytes and myeloid cells. It exhibits both positive and negative regulatory roles in B cell receptor (BCR) signaling. Lyn, as well as Fyn and Blk, promotes B cell activation by phosphorylating ITAMs (immunoreceptor tyr activation motifs) in CD19 and in Ig components of BCR []. It negatively regulates signaling by its unique ability to phosphorylate ITIMs (immunoreceptor tyr inhibition motifs) in cell surface receptors like CD22 and CD5 []. Lyn also plays an important role in G-CSF receptor signaling by phosphorylating a variety of adaptor molecules []. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The SH3 domain of Src kinases contributes to substrate recruitment by binding adaptor proteins/substrates, and regulation of kinase activity through an intramolecular interaction [, ]. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
Lck is a member of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Lck is expressed in T-cellsand natural killer cells. It plays a critical role in T-cell maturation, activation, and T-cell receptor (TCR) signaling [, ]. Lck phosphorylates ITAM (immunoreceptor tyr activation motif) sequences on several subunits of TCRs, leading to the activation of different second messenger cascades. Phosphorylated ITAMs serve as binding sites for other signaling factor such as Syk and ZAP-70, leading to their activation and propagation of downstream events []. In addition, Lck regulates drug-induced apoptosis by interfering with the mitochondrial death pathway. The apototic role of Lck is independent of its primary function in T-cell signaling []. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The SH3 domain of Src kinases contributes to substrate recruitment by binding adaptor proteins/substrates, and regulation of kinase activity through an intramolecular interaction [, ]. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
HSH2D (hematopoietic SH2 domain-containing protein, also known as ALX) is an adapter protein involved in tyrosine kinase and CD28 signaling []. It is expressed exclusively in hematopoietic cells. It contains an Src homology 2 (SH2) domain, four PXXP polyproline sequences, and two likely sites of tyrosine phosphorylation. The SH2 domain plays a critical role in ALX function downstream of CD28 []. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Human immunodeficiency virus 1 (HIV-1) negative factor (Nef protein) accelerates virulent progression of acquired immunodeficiency syndrome (AIDS) by its interaction with specific cellular proteins involved in signal transduction and host cell activation. Nef has been shown to bind specifically to a subset of the Src family of kinases []. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
SH3BP4 binds to the inactive Rag GTPase complex through its Src homology 3 (SH3) domain and acts as a negative regulator of amino acid-Rag GTPase-mTORC1 signaling []. It has been shown to act as an endocytic accessory protein that interacts with endocytic proteins including clathrin and dynamin, and regulates the internalization of the transferrin receptor (TfR) []. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This entry represents eukaryotic proteins that are typically between 144 and 156 amino acids in length. The entry is found in association with , . There is a conserved LGKK sequence motif. SAM/SH3 domain-containing proteins contain a Src homology 3 domain and a sterile alpha motif, suggesting that they may function as a signaling adaptor protein in lymphocytes []. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Voronova AF |
| Year: |
1987 |
| Journal: |
Mol Cell Biol |
| Title: |
Two lck transcripts containing different 5' untranslated regions are present in T cells. |
| Volume: |
7 |
| Issue: |
12 |
| Pages: |
4407-13 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Oberg-Welsh C |
| Year: |
1995 |
| Journal: |
Gene |
| Title: |
Cloning of BSK, a murine FRK homologue with a specific pattern of tissue distribution. |
| Volume: |
152 |
| Issue: |
2 |
| Pages: |
239-42 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dymecki SM |
| Year: |
1992 |
| Journal: |
J Biol Chem |
| Title: |
Structure and developmental regulation of the B-lymphoid tyrosine kinase gene blk. |
| Volume: |
267 |
| Issue: |
7 |
| Pages: |
4815-23 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
De Cunto G |
| Year: |
2016 |
| Journal: |
Am J Pathol |
| Title: |
Severe Reduction in Number and Function of Peripheral T Cells Does Not Afford Protection toward Emphysema and Bronchial Remodeling Induced in Mice by Cigarette Smoke. |
| Volume: |
186 |
| Issue: |
7 |
| Pages: |
1814-24 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kemp KL |
| Year: |
2010 |
| Journal: |
J Immunol |
| Title: |
Lck mediates Th2 differentiation through effects on T-bet and GATA-3. |
| Volume: |
184 |
| Issue: |
8 |
| Pages: |
4178-84 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Omri B |
| Year: |
1998 |
| Journal: |
Oncogene |
| Title: |
Retinal dysplasia in mice lacking p56lck. |
| Volume: |
16 |
| Issue: |
18 |
| Pages: |
2351-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Vérollet C |
| Year: |
2013 |
| Journal: |
FASEB J |
| Title: |
Hck contributes to bone homeostasis by controlling the recruitment of osteoclast precursors. |
| Volume: |
27 |
| Issue: |
9 |
| Pages: |
3608-18 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lim SL |
| Year: |
2020 |
| Journal: |
Mol Neurobiol |
| Title: |
Genetic Ablation of Hematopoietic Cell Kinase Accelerates Alzheimer's Disease-Like Neuropathology in Tg2576 Mice. |
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57 |
| Issue: |
5 |
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2447-2460 |
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2005 |
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J Gen Virol |
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Further studies on hepatitis C virus NS5A-SH3 domain interactions: identification of residues critical for binding and implications for viral RNA replication and modulation of cell signalling. |
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86 |
| Issue: |
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2001 |
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J Virol |
| Title: |
Role of Hck in the pathogenesis of encephalomyocarditis virus-induced diabetes in mice. |
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J Immunol |
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J Neurosci |
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Cell Death Differ |
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Inhibition of Lck enhances glucocorticoid sensitivity and apoptosis in lymphoid cell lines and in chronic lymphocytic leukemia. |
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17 |
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9 |
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Gorska MM |
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2004 |
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J Exp Med |
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Unc119, a novel activator of Lck/Fyn, is essential for T cell activation. |
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199 |
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3 |
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2006 |
| Journal: |
Mol Cell Biol |
| Title: |
Lck regulates the threshold of activation in primary T cells, while both Lck and Fyn contribute to the magnitude of the extracellular signal-related kinase response. |
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26 |
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22 |
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
3326
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| Fragment?: |
false |
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
3258
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| Fragment?: |
false |
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| First Author: |
Matsui A |
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2007 |
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Circulation |
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Central role of calcium-dependent tyrosine kinase PYK2 in endothelial nitric oxide synthase-mediated angiogenic response and vascular function. |
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116 |
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9 |
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2007 |
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Mol Cell Biol |
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Analysis of a Shc family adaptor protein, ShcD/Shc4, that associates with muscle-specific kinase. |
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27 |
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13 |
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Immunity |
| Title: |
Fyn can partially substitute for Lck in T lymphocyte development. |
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5 |
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5 |
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2015 |
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J Cell Biol |
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Conformational coupling of integrin and Thy-1 regulates Fyn priming and fibroblast mechanotransduction. |
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211 |
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Mol Cell |
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A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45. |
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67 |
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3 |
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Biol Reprod |
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NLRP5 mediates mitochondrial function in mouse oocytes and embryos. |
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86 |
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5 |
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2002 |
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Hum Mol Genet |
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Mutation of the novel gene Tmie results in sensory cell defects in the inner ear of spinner, a mouse model of human hearing loss DFNB6. |
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11 |
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16 |
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Sci Rep |
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Canonical Notch signaling plays an instructive role in auditory supporting cell development. |
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Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate. |
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2010 |
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Oncogene |
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The proximal signaling network of the BCR-ABL1 oncogene shows a modular organization. |
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29 |
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2010 |
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J Neurochem |
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The fibroblast growth factor receptor substrate 3 adapter is a developmentally regulated microtubule-associated protein expressed in migrating and differentiated neurons. |
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112 |
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4 |
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PLoS One |
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J Am Soc Nephrol |
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Gastroenterology |
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Cell type-dependent pro- and anti-inflammatory role of signal transducer and activator of transcription 3 in alcoholic liver injury. |
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134 |
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4 |
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2007 |
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J Mol Cell Cardiol |
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STAT3 mediates bone marrow mesenchymal stem cell VEGF production. |
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42 |
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6 |
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Proc Natl Acad Sci U S A |
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STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity. |
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2007 |
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Am J Physiol Endocrinol Metab |
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Sex differences in endothelial STAT3 mediate sex differences in myocardial inflammation. |
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Blood |
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Mouse hematopoietic cell-targeted STAT3 deletion: stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging-like phenotype. |
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Immunity |
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STAT3 is required for Flt3L-dependent dendritic cell differentiation. |
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19 |
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2014 |
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Hepatology |
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Aldehyde dehydrogenase 2 deficiency ameliorates alcoholic fatty liver but worsens liver inflammation and fibrosis in mice. |
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60 |
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2014 |
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Dev Cell |
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Integrin αvβ3 drives slug activation and stemness in the pregnant and neoplastic mammary gland. |
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30 |
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3 |
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295-308 |
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