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Search results 4001 to 4100 out of 8321 for Src

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Type Details Score
Protein Domain
Type: Family
Description: This entry represents receptor tyrosine-protein phosphatase (PTP) alpha (). PTP catalyses the dephosphorylation of protein tyrosine phosphate to protein tyrosine, and appear to play a pivotal role in insulin receptor signalling. It can exist as a single-pass membrane protein or in the cytoplasm. PTP-alpha is as a positive regulator of Src and Src family kinases, acting to dephosphorylate and activate Src. As such, PTP-alpha affects transformation and tumourigenesis, inhibition of proliferation and cell cycle arrest, mitotic activation of Src, integrin signalling, neuronal differentiation and outgrowth, and ion channel activity [].
Protein Domain
Type: Domain
Description: This entry represents the SH2 domain found in SLAP/SLAP2.Src-like adapter proteins (SLAP and SLAP2) are involved in the regulation of immune cell surface expression and signaling. They negatively regulate T cell receptor signaling []and act as critical inhibitors of platelet (hem)ITAM signaling in the setting of arterial thrombosis and ischemic stroke []. They contain adjacent Src homology 3 (SH3) and Src homology 2 (SH2) domains. SLAP has been shown to regulate receptor tyrosine kinase (RTK) signaling []. It also binds to the receptor tyrosine kinase Flt3 and plays a role in signal transduction downstream of Flt3 []. SLAP2 acts as a negative regulator of FLT3 signaling [].
Protein Domain
Type: Domain
Description: This entry represents the SH3 domain of SLAP. Src-like adapter proteins (SLAP and SLAP2) are involved in the regulation of immune cell surface expression and signaling. They negatively regulate T cell receptor signaling []and act as critical inhibitors of platelet (hem)ITAM signaling in the setting of arterial thrombosis and ischemic stroke []. They contain adjacent Src homology 3 (SH3) and Src homology 2 (SH2) domains. SLAP has been shown to regulate receptor tyrosine kinase (RTK) signaling []. It also binds to the receptor tyrosine kinase Flt3 and plays a role in signal transduction downstream of Flt3 []. SLAP2 acts as a negative regulator of FLT3 signaling [].
Protein Domain
Type: Family
Description: This entry represents Src-like-adapter 2 (SLAP2).Src-like adapter proteins (SLAP and SLAP2) are involved in the regulation of immune cell surface expression and signaling. They negatively regulate T cell receptor signaling []and act as critical inhibitors of platelet (hem)ITAM signaling in the setting of arterial thrombosis and ischemic stroke []. They contain adjacent Src homology 3 (SH3) and Src homology 2 (SH2) domains. SLAP has been shown to regulate receptor tyrosine kinase (RTK) signaling []. It also binds to the receptor tyrosine kinase Flt3 and plays a role in signal transduction downstream of Flt3 []. SLAP2 acts as a negative regulator of FLT3 signaling [].
Protein Domain
Type: Family
Description: This entry represents SLAP.Src-like adapter proteins (SLAP and SLAP2) are involved in the regulation of immune cell surface expression and signaling. They negatively regulate T cell receptor signaling []and act as critical inhibitors of platelet (hem)ITAM signaling in the setting of arterial thrombosis and ischemic stroke []. They contain adjacent Src homology 3 (SH3) and Src homology 2 (SH2) domains. SLAP has been shown to regulate receptor tyrosine kinase (RTK) signaling []. It also binds to the receptor tyrosine kinase Flt3 and plays a role in signal transduction downstream of Flt3 []. SLAP2 acts as a negative regulator of FLT3 signaling [].
Publication
First Author: Avraham KB
Year: 1993
Journal: Genomics
Title: Murine chromosomal location of four class III POU transcription factors.
Volume: 18
Issue: 1
Pages: 131-3
Publication
First Author: Pathak BG
Year: 1996
Journal: Genomics
Title: Mouse chromosomal location of four Na/H exchanger isoform genes.
Volume: 31
Issue: 2
Pages: 261-3
Publication
First Author: Potter AS
Year: 2019
Journal: PLoS One
Title: A bigenic mouse model of FSGS reveals perturbed pathways in podocytes, mesangial cells and endothelial cells.
Volume: 14
Issue: 8
Pages: e0216261
Genotype
Symbol: Lyn/Lyn<+> Ptpn6/Ptpn6<+> Tg(IghelMD4)4Ccg/?
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Cd22/Cd22<+> Lyn/Lyn<+> Ptpn6/Ptpn6<+> Tg(IghelMD4)4Ccg/?
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Shc2/Shc2<+> Shc3/Shc3<+>
Background: involves: 129
Zygosity: cx
Has Mutant Allele: true
Publication
First Author: Engen JR
Year: 2008
Journal: Cell Mol Life Sci
Title: Structure and dynamic regulation of Src-family kinases.
Volume: 65
Issue: 19
Pages: 3058-73
Publication
First Author: Zikherman J
Year: 2010
Journal: Immunity
Title: CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development.
Volume: 32
Issue: 3
Pages: 342-54
Publication
First Author: Samayawardhena LA
Year: 2007
Journal: Blood
Title: Involvement of Fyn kinase in Kit and integrin-mediated Rac activation, cytoskeletal reorganization, and chemotaxis of mast cells.
Volume: 109
Issue: 9
Pages: 3679-86
Publication
First Author: Eberl G
Year: 1999
Journal: J Immunol
Title: Cutting edge: NKT cell development is selectively impaired in Fyn- deficient mice.
Volume: 163
Issue: 8
Pages: 4091-4
Publication
First Author: Watson AR
Year: 2012
Journal: Cell Immunol
Title: Superantigen-induced CD4 memory T cell anergy. I. Staphylococcal enterotoxin B induces Fyn-mediated negative signaling.
Volume: 276
Issue: 1-2
Pages: 16-25
Publication
First Author: Filby A
Year: 2007
Journal: J Immunol
Title: Fyn regulates the duration of TCR engagement needed for commitment to effector function.
Volume: 179
Issue: 7
Pages: 4635-44
Publication
First Author: Yagi T
Year: 1993
Journal: Nature
Title: A role for Fyn tyrosine kinase in the suckling behaviour of neonatal mice.
Volume: 366
Issue: 6457
Pages: 742-5
Publication
First Author: Shima T
Year: 2000
Journal: Brain Res
Title: Changes in circadian period and morphology of the hypothalamic suprachiasmatic nucleus in fyn kinase-deficient mice.
Volume: 870
Issue: 1-2
Pages: 36-43
Publication
First Author: Kumar L
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: A 10-aa-long sequence in SLP-76 upstream of the Gads binding site is essential for T cell development and function.
Volume: 102
Issue: 52
Pages: 19063-8
Publication
First Author: Kawakami T
Year: 1986
Journal: Mol Cell Biol
Title: Isolation and oncogenic potential of a novel human src-like gene.
Volume: 6
Issue: 12
Pages: 4195-201
Publication
First Author: Ilić D
Year: 1997
Journal: Carcinogenesis
Title: Skin abnormality in aged fyn-/- fak+/- mice.
Volume: 18
Issue: 8
Pages: 1473-6
Publication
First Author: An L
Year: 2014
Journal: Exp Cell Res
Title: The aspartic acid of Fyn at 390 is critical for neuronal migration during corticogenesis.
Volume: 328
Issue: 2
Pages: 419-28
Publication  
First Author: Huang Y
Year: 2017
Journal: Neuroscience
Title: Fyn regulates multipolar-bipolar transition and neurite morphogenesis of migrating neurons in the developing neocortex.
Volume: 352
Pages: 39-51
Publication
First Author: Lu X
Year: 2015
Journal: BMB Rep
Title: The SH2 domain is crucial for function of Fyn in neuronal migration and cortical lamination.
Volume: 48
Issue: 2
Pages: 97-102
Publication
First Author: Ochi H
Year: 2000
Journal: Int Immunol
Title: Negative regulation of B cell receptor-mediated signaling in B-1 cells through CD5 and Ly49 co-receptors via Lyn kinase activity.
Volume: 12
Issue: 10
Pages: 1417-23
Publication
First Author: Greene TA
Year: 2003
Journal: J Biol Chem
Title: Cloning and characterization of ALX, an adaptor downstream of CD28.
Volume: 278
Issue: 46
Pages: 45128-34
Protein
Organism: Mus musculus/domesticus
Length: 429  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 113  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 429  
Fragment?: false
Publication
First Author: Kyogoku C
Year: 2004
Journal: Am J Hum Genet
Title: Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE.
Volume: 75
Issue: 3
Pages: 504-7
Publication
First Author: Brdicková N
Year: 2001
Journal: FEBS Lett
Title: Interaction between two adapter proteins, PAG and EBP50: a possible link between membrane rafts and actin cytoskeleton.
Volume: 507
Issue: 2
Pages: 133-6
Publication
First Author: Kalland ME
Year: 2012
Journal: Exp Cell Res
Title: Modulation of proximal signaling in normal and transformed B cells by transmembrane adapter Cbp/PAG.
Volume: 318
Issue: 14
Pages: 1611-9
Publication
First Author: Romir J
Year: 2007
Journal: J Mol Biol
Title: Crystal structure analysis and solution studies of human Lck-SH3; zinc-induced homodimerization competes with the binding of proline-rich motifs.
Volume: 365
Issue: 5
Pages: 1417-28
Publication
First Author: Li M
Year: 2008
Journal: Mol Cell Biol
Title: The SH3 domain of Lck modulates T-cell receptor-dependent activation of extracellular signal-regulated kinase through activation of Raf-1.
Volume: 28
Issue: 2
Pages: 630-41
Publication
First Author: Fukushima A
Year: 2006
Journal: Cell Signal
Title: Lck couples Shc to TCR signaling.
Volume: 18
Issue: 8
Pages: 1182-9
Publication
First Author: Patrussi L
Year: 2012
Journal: Apoptosis
Title: p66Shc-dependent apoptosis requires Lck and CamKII activity.
Volume: 17
Issue: 2
Pages: 174-86
Publication
First Author: Craven RJ
Year: 1995
Journal: Cancer Res
Title: The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb.
Volume: 55
Issue: 18
Pages: 3969-72
Publication
First Author: Brauer PM
Year: 2009
Journal: Cell Cycle
Title: RAKing in AKT: a tumor suppressor function for the intracellular tyrosine kinase FRK.
Volume: 8
Issue: 17
Pages: 2728-32
Publication
First Author: Cance WG
Year: 1994
Journal: Cell Growth Differ
Title: Rak, a novel nuclear tyrosine kinase expressed in epithelial cells.
Volume: 5
Issue: 12
Pages: 1347-55
Publication
First Author: Annerén C
Year: 2003
Journal: Curr Mol Med
Title: The FRK/RAK-SHB signaling cascade: a versatile signal-transduction pathway that regulates cell survival, differentiation and proliferation.
Volume: 3
Issue: 4
Pages: 313-24
Protein Domain
Type: Family
Description: Tyrosine-protein phosphatase non-receptor type 22 (PTPN22) acts as negative regulator of T-cell receptor (TCR) signalling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signalling molecules [].Variations of the PTPN22 gene affects the susceptibility of systemic lupus erythematosus (SLE) [].
Protein Domain
Type: Family
Description: TOM1-like protein 1 (TOM1L1) is an adapter protein involved in signaling pathways. It interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. TOM1L1 promotes activation of Src family tyrosine kinase Fyn, possibly by disrupting intramolecular SH3-dependent interactions [].
Protein Domain
Type: Domain
Description: Frk (RAK) is a member of the Src non-receptor type tyrosine kinase family of proteins. The Frk subfamily is composed of Frk/Rak and Iyk/Bsk/Gst. It is expressed primarily epithelial cells. Frk is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth []. Unlike the other Src members it lacks a glycine at position 2 of SH4 which is important for addition of a myristic acid moiety that is involved in targeting Src PTKs to cellular membranes []. FRK and SHB exert similar effects when overexpressed in rat phaeochromocytoma (PC12) and beta-cells, where both induce PC12 cell differentiation and beta-cell proliferation. Under conditions that cause beta-cell degeneration these proteins augment beta-cell apoptosis. The FRK-SHB responses involve FAK and insulin receptor substrates (IRS) -1 and -2 []. Frk has been demonstrated to interact with retinoblastoma protein []. Frk regulates PTEN protein stability by phosphorylating PTEN, which in turn prevents PTEN degradation []. Frk also plays a role in regulation of embryonal pancreatic beta cell formation [].The Src non-receptor type tyrosine kinase (SFK) family members have an unique N-terminal domain, an SH3 domain, an SH2 domain, a kinase domain and a regulatory tail. The SH2 domain of SFKs is involved in kinase autoinhibition and T-cell receptor signaling. The binding SH2 domains to phosphotyrosine (pY) sites is critical for the autoinhibition and substrate recognition of the SFKs [].
Protein Domain
Type: Family
Description: PAG, or Cbp/PAG (Csk binding protein/phospho-protein associated with glycosphingolipid-enriched microdomains) is a transmembrane protein that has a negative regulatory role in T-cell activation through being an adapter for C-terminal Src kinase, Csk. This family of proteins is found in eukaryotes [, , , ].
Protein Domain
Type: Domain
Description: TXK is a member of the Tec family, which is a group of nonreceptor tyrosine kinases containing Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. It also contains an N-terminal cysteine-rich region. TXK forms a complex with EF-1alpha and PARP1 that regulates interferon-gamma gene transcription in Th1 cells []. This entry represents the SH3 domain of TXK.
Protein Domain
Type: Domain
Description: Lyn is a member of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Lyn is expressed in B lymphocytes and myeloid cells. It exhibits both positive and negative regulatory roles in B cell receptor (BCR) signaling. Lyn, as well as Fyn and Blk, promotes B cell activation by phosphorylating ITAMs (immunoreceptor tyr activation motifs) in CD19 and in Ig components of BCR []. It negatively regulates signaling by its unique ability to phosphorylate ITIMs (immunoreceptor tyr inhibition motifs) in cell surface receptors like CD22 and CD5 []. Lyn also plays an important role in G-CSF receptor signaling by phosphorylating a variety of adaptor molecules []. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The SH3 domain of Src kinases contributes to substrate recruitment by binding adaptor proteins/substrates, and regulation of kinase activity through an intramolecular interaction [, ].
Protein Domain
Type: Domain
Description: Lck is a member of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Lck is expressed in T-cellsand natural killer cells. It plays a critical role in T-cell maturation, activation, and T-cell receptor (TCR) signaling [, ]. Lck phosphorylates ITAM (immunoreceptor tyr activation motif) sequences on several subunits of TCRs, leading to the activation of different second messenger cascades. Phosphorylated ITAMs serve as binding sites for other signaling factor such as Syk and ZAP-70, leading to their activation and propagation of downstream events []. In addition, Lck regulates drug-induced apoptosis by interfering with the mitochondrial death pathway. The apototic role of Lck is independent of its primary function in T-cell signaling []. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The SH3 domain of Src kinases contributes to substrate recruitment by binding adaptor proteins/substrates, and regulation of kinase activity through an intramolecular interaction [, ].
Protein Domain
Type: Family
Description: HSH2D (hematopoietic SH2 domain-containing protein, also known as ALX) is an adapter protein involved in tyrosine kinase and CD28 signaling []. It is expressed exclusively in hematopoietic cells. It contains an Src homology 2 (SH2) domain, four PXXP polyproline sequences, and two likely sites of tyrosine phosphorylation. The SH2 domain plays a critical role in ALX function downstream of CD28 [].
Protein Domain
Type: Family
Description: Human immunodeficiency virus 1 (HIV-1) negative factor (Nef protein) accelerates virulent progression of acquired immunodeficiency syndrome (AIDS) by its interaction with specific cellular proteins involved in signal transduction and host cell activation. Nef has been shown to bind specifically to a subset of the Src family of kinases [].
Protein Domain
Type: Family
Description: SH3BP4 binds to the inactive Rag GTPase complex through its Src homology 3 (SH3) domain and acts as a negative regulator of amino acid-Rag GTPase-mTORC1 signaling []. It has been shown to act as an endocytic accessory protein that interacts with endocytic proteins including clathrin and dynamin, and regulates the internalization of the transferrin receptor (TfR) [].
Protein Domain
Type: Family
Description: This entry represents eukaryotic proteins that are typically between 144 and 156 amino acids in length. The entry is found in association with , . There is a conserved LGKK sequence motif. SAM/SH3 domain-containing proteins contain a Src homology 3 domain and a sterile alpha motif, suggesting that they may function as a signaling adaptor protein in lymphocytes [].
Publication
First Author: Voronova AF
Year: 1987
Journal: Mol Cell Biol
Title: Two lck transcripts containing different 5' untranslated regions are present in T cells.
Volume: 7
Issue: 12
Pages: 4407-13
Publication
First Author: Oberg-Welsh C
Year: 1995
Journal: Gene
Title: Cloning of BSK, a murine FRK homologue with a specific pattern of tissue distribution.
Volume: 152
Issue: 2
Pages: 239-42
Publication
First Author: Dymecki SM
Year: 1992
Journal: J Biol Chem
Title: Structure and developmental regulation of the B-lymphoid tyrosine kinase gene blk.
Volume: 267
Issue: 7
Pages: 4815-23
Publication
First Author: De Cunto G
Year: 2016
Journal: Am J Pathol
Title: Severe Reduction in Number and Function of Peripheral T Cells Does Not Afford Protection toward Emphysema and Bronchial Remodeling Induced in Mice by Cigarette Smoke.
Volume: 186
Issue: 7
Pages: 1814-24
Publication
First Author: Kemp KL
Year: 2010
Journal: J Immunol
Title: Lck mediates Th2 differentiation through effects on T-bet and GATA-3.
Volume: 184
Issue: 8
Pages: 4178-84
Publication
First Author: Omri B
Year: 1998
Journal: Oncogene
Title: Retinal dysplasia in mice lacking p56lck.
Volume: 16
Issue: 18
Pages: 2351-6
Publication
First Author: Vérollet C
Year: 2013
Journal: FASEB J
Title: Hck contributes to bone homeostasis by controlling the recruitment of osteoclast precursors.
Volume: 27
Issue: 9
Pages: 3608-18
Publication
First Author: Lim SL
Year: 2020
Journal: Mol Neurobiol
Title: Genetic Ablation of Hematopoietic Cell Kinase Accelerates Alzheimer's Disease-Like Neuropathology in Tg2576 Mice.
Volume: 57
Issue: 5
Pages: 2447-2460
Publication
First Author: Macdonald A
Year: 2005
Journal: J Gen Virol
Title: Further studies on hepatitis C virus NS5A-SH3 domain interactions: identification of residues critical for binding and implications for viral RNA replication and modulation of cell signalling.
Volume: 86
Issue: Pt 4
Pages: 1035-44
Publication
First Author: Choi KS
Year: 2001
Journal: J Virol
Title: Role of Hck in the pathogenesis of encephalomyocarditis virus-induced diabetes in mice.
Volume: 75
Issue: 4
Pages: 1949-57
Publication
First Author: Marth JD
Year: 1988
Journal: Mol Cell Biol
Title: Neoplastic transformation induced by an activated lymphocyte-specific protein tyrosine kinase (pp56lck).
Volume: 8
Issue: 2
Pages: 540-50
Publication
First Author: Rozdzial MM
Year: 1998
Journal: J Immunol
Title: pp56Lck mediates TCR zeta-chain binding to the microfilament cytoskeleton.
Volume: 161
Issue: 10
Pages: 5491-9
Publication
First Author: Bae ON
Year: 2012
Journal: J Neurosci
Title: Lymphocyte cell kinase activation mediates neuroprotection during ischemic preconditioning.
Volume: 32
Issue: 21
Pages: 7278-86
Publication
First Author: Harr MW
Year: 2010
Journal: Cell Death Differ
Title: Inhibition of Lck enhances glucocorticoid sensitivity and apoptosis in lymphoid cell lines and in chronic lymphocytic leukemia.
Volume: 17
Issue: 9
Pages: 1381-91
Publication
First Author: Gorska MM
Year: 2004
Journal: J Exp Med
Title: Unc119, a novel activator of Lck/Fyn, is essential for T cell activation.
Volume: 199
Issue: 3
Pages: 369-79
Publication
First Author: Lovatt M
Year: 2006
Journal: Mol Cell Biol
Title: Lck regulates the threshold of activation in primary T cells, while both Lck and Fyn contribute to the magnitude of the extracellular signal-related kinase response.
Volume: 26
Issue: 22
Pages: 8655-65
Protein
Organism: Mus musculus/domesticus
Length: 3326  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 3258  
Fragment?: false
Publication
First Author: Matsui A
Year: 2007
Journal: Circulation
Title: Central role of calcium-dependent tyrosine kinase PYK2 in endothelial nitric oxide synthase-mediated angiogenic response and vascular function.
Volume: 116
Issue: 9
Pages: 1041-51
Publication
First Author: Jones N
Year: 2007
Journal: Mol Cell Biol
Title: Analysis of a Shc family adaptor protein, ShcD/Shc4, that associates with muscle-specific kinase.
Volume: 27
Issue: 13
Pages: 4759-73
Publication
First Author: Groves T
Year: 1996
Journal: Immunity
Title: Fyn can partially substitute for Lck in T lymphocyte development.
Volume: 5
Issue: 5
Pages: 417-28
Publication
First Author: Fiore VF
Year: 2015
Journal: J Cell Biol
Title: Conformational coupling of integrin and Thy-1 regulates Fyn priming and fibroblast mechanotransduction.
Volume: 211
Issue: 1
Pages: 173-90
Publication
First Author: Courtney AH
Year: 2017
Journal: Mol Cell
Title: A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45.
Volume: 67
Issue: 3
Pages: 498-511.e6
Publication
First Author: Fernandes R
Year: 2012
Journal: Biol Reprod
Title: NLRP5 mediates mitochondrial function in mouse oocytes and embryos.
Volume: 86
Issue: 5
Pages: 138, 1-10
Publication
First Author: Mitchem KL
Year: 2002
Journal: Hum Mol Genet
Title: Mutation of the novel gene Tmie results in sensory cell defects in the inner ear of spinner, a mouse model of human hearing loss DFNB6.
Volume: 11
Issue: 16
Pages: 1887-98
Publication  
First Author: Campbell DP
Year: 2016
Journal: Sci Rep
Title: Canonical Notch signaling plays an instructive role in auditory supporting cell development.
Volume: 6
Pages: 19484
Publication
First Author: Findlay GM
Year: 2013
Journal: Cell
Title: Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate.
Volume: 152
Issue: 5
Pages: 1008-20
Publication
First Author: Titz B
Year: 2010
Journal: Oncogene
Title: The proximal signaling network of the BCR-ABL1 oncogene shows a modular organization.
Volume: 29
Issue: 44
Pages: 5895-910
Publication
First Author: Hryciw T
Year: 2010
Journal: J Neurochem
Title: The fibroblast growth factor receptor substrate 3 adapter is a developmentally regulated microtubule-associated protein expressed in migrating and differentiated neurons.
Volume: 112
Issue: 4
Pages: 924-39
Publication
First Author: Romand R
Year: 2015
Journal: PLoS One
Title: Integrated annotation and analysis of in situ hybridization images using the ImAnno system: application to the ear and sensory organs of the fetal mouse.
Volume: 10
Issue: 2
Pages: e0118024
Publication
First Author: Yamada H
Year: 1997
Journal: Immunology
Title: p56lck is not essential for the T-cell response to allo-MHC antigens.
Volume: 92
Issue: 1
Pages: 33-8
Publication
First Author: Adler HT
Year: 1988
Journal: J Virol
Title: Transcriptional activation of lck by retrovirus promoter insertion between two lymphoid-specific promoters.
Volume: 62
Issue: 11
Pages: 4113-22
Publication
First Author: Adler HT
Year: 1992
Journal: Oncogene
Title: Generation and characterization of transforming variants of the lck tyrosine protein kinase.
Volume: 7
Issue: 6
Pages: 1191-9
Publication
First Author: Volpi EV
Year: 1994
Journal: Cytogenet Cell Genet
Title: Subregional mapping of the human lymphocyte-specific protein tyrosine kinase gene (LCK) to 1p35-->p34.3 and its position relative to the 1p marker D1S57.
Volume: 67
Issue: 3
Pages: 187-9
Publication
First Author: Slack-Davis J
Year: 2010
Journal: Cancer Cell
Title: LKB1 and Src: antagonistic regulators of tumor growth and metastasis.
Volume: 17
Issue: 6
Pages: 527-9
Publication
First Author: Gao Q
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation.
Volume: 101
Issue: 13
Pages: 4661-6
Publication
First Author: Casalena G
Year: 2014
Journal: Am J Physiol Renal Physiol
Title: Mpv17 in mitochondria protects podocytes against mitochondrial dysfunction and apoptosis in vivo and in vitro.
Volume: 306
Issue: 11
Pages: F1372-80
Publication
First Author: Xavier S
Year: 2009
Journal: J Am Soc Nephrol
Title: TbetaRI independently activates Smad- and CD2AP-dependent pathways in podocytes.
Volume: 20
Issue: 10
Pages: 2127-37
Publication
First Author: Wang H
Year: 2011
Journal: Am J Pathol
Title: Hepatoprotective versus oncogenic functions of STAT3 in liver tumorigenesis.
Volume: 179
Issue: 2
Pages: 714-24
Publication
First Author: Wang H
Year: 2010
Journal: Hepatology
Title: Interplay of hepatic and myeloid signal transducer and activator of transcription 3 in facilitating liver regeneration via tempering innate immunity.
Volume: 51
Issue: 4
Pages: 1354-62
Publication
First Author: Horiguchi N
Year: 2008
Journal: Gastroenterology
Title: Cell type-dependent pro- and anti-inflammatory role of signal transducer and activator of transcription 3 in alcoholic liver injury.
Volume: 134
Issue: 4
Pages: 1148-58
Publication
First Author: Wang M
Year: 2007
Journal: J Mol Cell Cardiol
Title: STAT3 mediates bone marrow mesenchymal stem cell VEGF production.
Volume: 42
Issue: 6
Pages: 1009-15
Publication
First Author: Welte T
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity.
Volume: 100
Issue: 4
Pages: 1879-84
Publication
First Author: Wang M
Year: 2007
Journal: Am J Physiol Endocrinol Metab
Title: Sex differences in endothelial STAT3 mediate sex differences in myocardial inflammation.
Volume: 293
Issue: 3
Pages: E872-7
Publication
First Author: Mantel C
Year: 2012
Journal: Blood
Title: Mouse hematopoietic cell-targeted STAT3 deletion: stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging-like phenotype.
Volume: 120
Issue: 13
Pages: 2589-99
Publication
First Author: Laouar Y
Year: 2003
Journal: Immunity
Title: STAT3 is required for Flt3L-dependent dendritic cell differentiation.
Volume: 19
Issue: 6
Pages: 903-12
Publication
First Author: Kwon HJ
Year: 2014
Journal: Hepatology
Title: Aldehyde dehydrogenase 2 deficiency ameliorates alcoholic fatty liver but worsens liver inflammation and fibrosis in mice.
Volume: 60
Issue: 1
Pages: 146-57
Publication
First Author: Desgrosellier JS
Year: 2014
Journal: Dev Cell
Title: Integrin αvβ3 drives slug activation and stemness in the pregnant and neoplastic mammary gland.
Volume: 30
Issue: 3
Pages: 295-308