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Search results 4101 to 4200 out of 8814 for Clock

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Type Details Score
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1754428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692639
Age: postnatal adult
Image: MRC Harwell_633885
Specimen Label: MRC Harwell_633885
Detected: true
Specimen Num: 1
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1754428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692639
Age: postnatal adult
Image: MRC Harwell_633889
Specimen Label: MRC Harwell_633889
Detected: true
Specimen Num: 3
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1754428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692639
Age: postnatal adult
Image: MRC Harwell_633895
Specimen Label: MRC Harwell_633895
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1752322
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3267222
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1672822
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1691022
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3284522
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3284528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692639
Age: postnatal adult
Image: MRC Harwell_633885
Specimen Label: MRC Harwell_633885
Detected: true
Specimen Num: 1
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3284528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692639
Age: postnatal adult
Image: MRC Harwell_633889
Specimen Label: MRC Harwell_633889
Detected: true
Specimen Num: 3
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3284528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692639
Age: postnatal adult
Image: MRC Harwell_633895
Specimen Label: MRC Harwell_633895
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1853522
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1666822
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689622
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610522
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1647022
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1842622
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3274322
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3277822
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3090122
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1685322
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684622
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3272922
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Note: Expression was not detected in the skeleton (limbs, shoulder, hip).
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1752422
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3267322
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1718522
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3283722
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1842522
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Note: Expression was not detected in the endocrine system.
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1781522
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1759722
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1672722
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1750322
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1775122
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692639
Age: postnatal adult
Image: MRC Harwell_633901
Specimen Label: MRC Harwell_633901
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3274122
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3287422
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3266022
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1624622
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Note: Expression was not detected in the digestive system.
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1721422
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1646922
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1736222
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1683322
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1700022
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1832122
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876522
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Note: Expression was not detected in the immune system.
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1741222
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754022
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3599822
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3599828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692639
Age: postnatal adult
Image: MRC Harwell_633893
Specimen Label: MRC Harwell_633893
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3280922
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1833322
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3287022
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1752522
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1821522
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3557722
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1702122
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1702128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692639
Age: postnatal adult
Image: MRC Harwell_633887
Specimen Label: MRC Harwell_633887
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1756322
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1668822
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1757722
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1757728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692639
Age: postnatal adult
Image: MRC Harwell_633891
Specimen Label: MRC Harwell_633891
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1757522
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1738322
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1802422
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692639
Age: postnatal adult
Image: MRC Harwell_633885
Specimen Label: MRC Harwell_633885
Detected: true
Specimen Num: 1
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692639
Age: postnatal adult
Image: MRC Harwell_633889
Specimen Label: MRC Harwell_633889
Detected: true
Specimen Num: 3
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692639
Age: postnatal adult
Image: MRC Harwell_633895
Specimen Label: MRC Harwell_633895
Detected: true
Specimen Num: 6
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692639
Age: postnatal adult
Image: MRC Harwell_633897
Specimen Label: MRC Harwell_633897
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1768022
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Note: Expression was not detected in the skull (base and vault).
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5310204
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2672022
Stage: TS22
Assay Id: MGI:5423528
Age: embryonic day 14.5
Note: Expression was not detected in whisker follicle.
Specimen Label: EB281; Specimen B244
Detected: false
Specimen Num: 1
Protein
Organism: Mus musculus/domesticus
Length: 637  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 146  
Fragment?: false
Publication
First Author: Komatsu M
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration.
Volume: 104
Issue: 36
Pages: 14489-94
Publication
First Author: Zhang Y
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis.
Volume: 106
Issue: 47
Pages: 19860-5
Publication
First Author: Mortensen M
Year: 2011
Journal: J Exp Med
Title: The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance.
Volume: 208
Issue: 3
Pages: 455-67
Protein
Organism: Mus musculus/domesticus
Length: 221  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 88  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 60  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 637  
Fragment?: false
Publication
First Author: Ng WO
Year: 2000
Journal: Arch Microbiol
Title: PhrA, the major photoreactivating factor in the cyanobacterium Synechocystis sp. strain PCC 6803 codes for a cyclobutane-pyrimidine-dimer-specific DNA photolyase.
Volume: 173
Issue: 5-6
Pages: 412-7
Publication
First Author: Ng WO
Year: 2001
Journal: Mol Gen Genet
Title: DNA photolyase homologs are the major UV resistance factors in the cyanobacterium Synechocystis sp. PCC 6803.
Volume: 264
Issue: 6
Pages: 924-30
Publication
First Author: Rajagopal A
Year: 2008
Journal: Nature
Title: Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins.
Volume: 453
Issue: 7198
Pages: 1127-31
Publication
First Author: Fukumoto Y
Year: 2008
Journal: Mol Cell Biol
Title: Schizosaccharomyces pombe Ddb1 recruits substrate-specific adaptor proteins through a novel protein motif, the DDB-box.
Volume: 28
Issue: 22
Pages: 6746-56
Protein Domain
Type: Family
Description: This entry describes a narrow clade of cyanobacterial deoxyribodipyrimidine photolyase (or DNA photolyase). This group, in contrast to several closely related proteins, uses a chromophore that, in other lineages is modified further to become coenzyme F420. This chromophore is called 8-HDF in most articles on the DNA photolyase and FO in most literature on coenzyme F420. This entry includes PhrA from Synechocystis sp. strain PCC 6803. PhrA is a DNA photolyase responsible for the majority of the observed UV resistance in Synechocystis 6803 [, ]. The cryptochrome and photolyase families consist of structurally related flavin adenine dinucleotide (FAD) proteins that use the absorption of blue light to accomplish different tasks. The photolyasess use the blue light for light-driven electron transfer to repair UV-damaged DNA, while the cryptochromes are blue-light photoreceptors involved in the circadian clock for plants and animals [, ]. On the basis of the primary structure, the cryptochrome/DNA photolyase family can be grouped into two classes []. The first class contains cryptochromes and DNA photolyases from eubacteria, archaea, fungi, animals and plants. The second class contains DNA photolyases from prokaryotes, plants and animals.
Protein Domain
Type: Family
Description: Haems are metalloporphyrins that serve as prosthetic groups for a variety of biological processes, including respiration, gas sensing, xenobiotic detoxification, cell differentiation, circadian clock control, metabolic reprogramming and microRNA processing. Haem is usually synthesised by a multistep biosynthetic pathway. The cellular pathways and molecules that mediate intracellular haem trafficking are still largely unknown [].Caenorhabditis elegans and related helminths are natural haem auxotrophs that acquire environmental haem for incorporation into haemoproteins. In C.elegans, it has been shown that HRG-1 proteins are essential for haem homeostasis. In worms, depletion of hrg-1, or its paralogue hrg-4, results in the disruption of organismal haem sensing, and an abnormal response to haem analogues [].HRG-1 and HRG-4 are transmembrane (TM) proteins that reside in distinct intracellular compartments. Transient knockdown of hrg-1 in zebrafish leads to hydrocephalus, yolk tube malformations and profound defects in erythropoiesis-phenotypes that are fully rescued by worm HRG-1. Human and worm proteins have been shown to co-localise, and bind and transport haem, thus establishing an evolutionarily conserved function for HRG-1 [].Sequence analysis of HRG-1 has identified 4 predicted TM domains, and a conserved tyrosine and acidic-di-leucine-based sorting signal in the cytoplasmic C terminus. In addition, residues that could potentially either directly bind haem (H90 in TM2) or interact with the haem side chains (FARKY) are situated in the C-terminal tail [].
Protein Domain
Type: Homologous_superfamily
Description: This entry represents a multi-helical domain, composed of two alpha subdomains, found in the C terminus of the cryptochrome proteins and DNA photolyases. It acts as a FAD-binding domain [].The cryptochrome and photolyase families consist of structurally related flavin adenine dinucleotide (FAD) proteins that use the absorption of blue light to accomplish different tasks. The photolyasess use the blue light for light-driven electron transfer to repair UV-damaged DNA, while the cryptochromes are blue-light photoreceptors involved in the circadian clock for plants and animals [, ]. DNA photolyases are DNA repair enzymes that repair mismatched pyrimidine dimers induced by exposure to ultra-violet light. They bind to UV-damaged DNA containing pyrimidine dimers and, upon absorbing a near-UV photon (300 to 500 nm), they catalyse dimer splitting, breaking the cyclobutane ring joining the two pyrimidines of the dimer so as to split them into the constituent monomers; this process is called photoreactivation. DNA photolyases require two choromophore-cofactors for their activity. All monomers contain a reduced FAD moiety, and, in addition, either a reduced pterin or 8-hydroxy-5-diazaflavin as a second chromophore. Either chromophore may act as the primary photon acceptor, peak absorptions occurring in the blue region of the spectrum and in the UV-B region, at a wavelength around 290nm [, ].
Protein Domain
Type: Domain
Description: The PAS (Per, Arnt, Sim) domain [, ]is an approximately 300 amino-acid segment of sequence similarity which is conserved between the Drosophila protein period clock (PER), the Ah receptor nuclear translocator (ARNT) and the Drosophila single-minded (SIM). It is composed of two or more imperfect repeats (PAS-1, PAS-2). In addition, some proteins have another similar region of 40-45 amino acids situated carboxy-terminal to any PAS repeat and which contributes to the PAS structural domain: the PAC motif. The PAS family can be divided in two groups; the proteins that have the PAS motif followed by a PAC motif, and those that do not. It appears that these domains are directly linked, and that together they form the conserved 3D PAS fold. The division between the PAS and PAC domains is caused by major differences in sequences in the region connecting these two motifs []. Within the bHLH/PAS proteins, the PAS domain is involved in protein dimerization with another protein of the family. It has also been associated with light reception, light regulation and circadian rhythm regulators (clock).In bacteria, the PAS domain is usually associated with the input domain of a histidine kinase, or a sensor protein that regulates a histidine kinase.
Protein Domain
Type: Domain
Description: This entry represents a multi-helical domain found in the C terminus of the cryptochrome proteins and DNA photolyases. It acts as a FAD-binding domain [].The cryptochrome and photolyase families consist of structurally related flavin adenine dinucleotide (FAD) proteins that use the absorption of blue light to accomplish different tasks. The photolyasess use the blue light for light-driven electron transfer to repair UV-damaged DNA, while the cryptochromes are blue-light photoreceptors involved in the circadian clock for plants and animals [, ]. DNA photolyases are DNA repair enzymes that repair mismatched pyrimidine dimers induced by exposure to ultra-violet light. They bind to UV-damaged DNA containing pyrimidine dimers and, upon absorbing a near-UV photon (300 to 500 nm), they catalyse dimer splitting, breaking the cyclobutane ring joining the two pyrimidines of the dimer so as to split them into the constituent monomers; this process is called photoreactivation. DNA photolyases require two choromophore-cofactors for their activity. All monomers contain a reduced FAD moiety, and, in addition, either a reduced pterin or 8-hydroxy-5-diazaflavin as a second chromophore. Either chromophore may act as the primary photon acceptor, peak absorptions occurring in the blue region of the spectrum and in the UV-B region, at a wavelength around 290nm [, ].
Protein Domain
Type: Family
Description: This is a family of eukaryotic proteins found in animals, plants, and yeasts that includes Atg7p (YHR171W) from Saccharomyces cerevisiae (Baker's yeast) and ATG7 from Pichia angusta. Members are about 650 to 700 residues in length and include a central domain of about 150 residues shared with the ThiF/MoeB/HesA family of proteins. A low level of similarity toubiquitin-activating enzyme E1 is described in a paper on peroxisome autophagy mediated by ATG7 [], and is the basis of the name ubiquitin activating enzyme E1-like protein. Members of the family are involved in protein lipidation events analogous to ubiquitination and required for membrane fusion events during autophagy.This protein is important for several processes. It plays a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration [], the maintenance of hematopoietic stem cells [], the formation of Paneth cell granules [[cite22291845]], as well as in adipose differentiation []. It is involved in circadian clock regulation in the liver and glucose metabolism through the autophagic degradation of CRY1 (clock repressor) in a time-dependent manner [].
Publication
First Author: Okano T
Year: 2001
Journal: Neurosci Lett
Title: Cloning of mouse BMAL2 and its daily expression profile in the suprachiasmatic nucleus: a remarkable acceleration of Bmal2 sequence divergence after Bmal gene duplication.
Volume: 300
Issue: 2
Pages: 111-4
Publication
First Author: Fraser PJ
Year: 1986
Journal: J Mol Evol
Title: Molecular evolution of the carbonic anhydrase genes: calculation of divergence time for mouse carbonic anhydrase I and II.
Volume: 23
Issue: 4
Pages: 294-9
Publication
First Author: Robles MS
Year: 2010
Journal: Science
Title: Identification of RACK1 and protein kinase Calpha as integral components of the mammalian circadian clock.
Volume: 327
Issue: 5964
Pages: 463-6
Publication
First Author: Kaasik K
Year: 2013
Journal: Cell Metab
Title: Glucose sensor O-GlcNAcylation coordinates with phosphorylation to regulate circadian clock.
Volume: 17
Issue: 2
Pages: 291-302
Publication
First Author: Krebs LT
Year: 2012
Journal: Genesis
Title: The Notch-regulated ankyrin repeat protein is required for proper anterior-posterior somite patterning in mice.
Volume: 50
Issue: 4
Pages: 366-74
Publication
First Author: Yin L
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: E3 ligases Arf-bp1 and Pam mediate lithium-stimulated degradation of the circadian heme receptor Rev-erb alpha.
Volume: 107
Issue: 25
Pages: 11614-9
Publication
First Author: Nguyen KD
Year: 2013
Journal: Science
Title: Circadian gene Bmal1 regulates diurnal oscillations of Ly6C(hi) inflammatory monocytes.
Volume: 341
Issue: 6153
Pages: 1483-8
Publication
First Author: Yoon JK
Year: 2000
Journal: Genes Dev
Title: The bHLH regulator pMesogenin1 is required for maturation and segmentation of paraxial mesoderm.
Volume: 14
Issue: 24
Pages: 3204-14
Publication
First Author: Wang N
Year: 2008
Journal: Cell Metab
Title: Vascular PPARgamma controls circadian variation in blood pressure and heart rate through Bmal1.
Volume: 8
Issue: 6
Pages: 482-91
Publication
First Author: Somanath PR
Year: 2011
Journal: J Cell Physiol
Title: Deficiency in core circadian protein Bmal1 is associated with a prothrombotic and vascular phenotype.
Volume: 226
Issue: 1
Pages: 132-40
Publication
First Author: Khapre RV
Year: 2014
Journal: Aging (Albany NY)
Title: BMAL1-dependent regulation of the mTOR signaling pathway delays aging.
Volume: 6
Issue: 1
Pages: 48-57