| Type |
Details |
Score |
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chen R |
| Year: |
2024 |
| Journal: |
Cell Stem Cell |
| Title: |
Analyzing embryo dormancy at single-cell resolution reveals dynamic transcriptional responses and activation of integrin-Yap/Taz prosurvival signaling. |
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•
•
•
•
|
| Publication |
| First Author: |
Nishioka N |
| Year: |
2008 |
| Journal: |
Mech Dev |
| Title: |
Tead4 is required for specification of trophectoderm in pre-implantation mouse embryos. |
| Volume: |
125 |
| Issue: |
3-4 |
| Pages: |
270-83 |
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•
•
•
•
•
|
| Publication |
| First Author: |
Wu Q |
| Year: |
2015 |
| Journal: |
Development |
| Title: |
SMAD2 and p38 signaling pathways act in concert to determine XY primordial germ cell fate in mice. |
| Volume: |
142 |
| Issue: |
3 |
| Pages: |
575-86 |
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•
•
•
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| Publication |
| First Author: |
Rugg-Gunn PJ |
| Year: |
2012 |
| Journal: |
Dev Cell |
| Title: |
Cell-surface proteomics identifies lineage-specific markers of embryo-derived stem cells. |
| Volume: |
22 |
| Issue: |
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| Pages: |
887-901 |
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•
•
•
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| Publication |
| First Author: |
Amadei G |
| Year: |
2022 |
| Journal: |
Nature |
| Title: |
Embryo model completes gastrulation to neurulation and organogenesis. |
| Volume: |
610 |
| Issue: |
7930 |
| Pages: |
143-153 |
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•
•
•
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| Publication |
| First Author: |
Ye B |
| Year: |
2018 |
| Journal: |
Nat Commun |
| Title: |
Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
1261 |
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•
•
•
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| Publication |
| First Author: |
Yu C |
| Year: |
2016 |
| Journal: |
Nat Struct Mol Biol |
| Title: |
BTG4 is a meiotic cell cycle-coupled maternal-zygotic-transition licensing factor in oocytes. |
| Volume: |
23 |
| Issue: |
5 |
| Pages: |
387-94 |
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•
•
•
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| Publication |
| First Author: |
Lighthouse JK |
| Year: |
2011 |
| Journal: |
Dev Dyn |
| Title: |
MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm. |
| Volume: |
240 |
| Issue: |
3 |
| Pages: |
577-88 |
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•
•
•
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| Publication |
| First Author: |
Cook MS |
| Year: |
2011 |
| Journal: |
Development |
| Title: |
Regulation of male germ cell cycle arrest and differentiation by DND1 is modulated by genetic background. |
| Volume: |
138 |
| Issue: |
1 |
| Pages: |
23-32 |
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| First Author: |
Rong Y |
| Year: |
2022 |
| Journal: |
Nucleic Acids Res |
| Title: |
USP16-mediated histone H2A lysine-119 deubiquitination during oocyte maturation is a prerequisite for zygotic genome activation. |
| Volume: |
50 |
| Issue: |
10 |
| Pages: |
5599-5616 |
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| First Author: |
Gordeeva O |
| Year: |
2019 |
| Journal: |
Oncotarget |
| Title: |
Expression dynamics of Mage family genes during self-renewal and differentiation of mouse pluripotent stem and teratocarcinoma cells. |
| Volume: |
10 |
| Issue: |
35 |
| Pages: |
3248-3266 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
305
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Spiller CM |
| Year: |
2012 |
| Journal: |
Development |
| Title: |
Endogenous Nodal signaling regulates germ cell potency during mammalian testis development. |
| Volume: |
139 |
| Issue: |
22 |
| Pages: |
4123-32 |
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| Publication |
| First Author: |
Senft AD |
| Year: |
2019 |
| Journal: |
Nat Commun |
| Title: |
Genetic dissection of Nodal and Bmp signalling requirements during primordial germ cell development in mouse. |
| Volume: |
10 |
| Issue: |
1 |
| Pages: |
1089 |
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•
•
•
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| Publication |
| First Author: |
Talchai C |
| Year: |
2012 |
| Journal: |
Cell |
| Title: |
Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure. |
| Volume: |
150 |
| Issue: |
6 |
| Pages: |
1223-34 |
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•
•
•
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| Publication |
| First Author: |
Tao H |
| Year: |
2012 |
| Journal: |
Dev Biol |
| Title: |
Nuclear localization of Prickle2 is required to establish cell polarity during early mouse embryogenesis. |
| Volume: |
364 |
| Issue: |
2 |
| Pages: |
138-48 |
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•
•
•
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| Publication |
| First Author: |
Nowotschin S |
| Year: |
2013 |
| Journal: |
Genes Dev |
| Title: |
The T-box transcription factor Eomesodermin is essential for AVE induction in the mouse embryo. |
| Volume: |
27 |
| Issue: |
9 |
| Pages: |
997-1002 |
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•
•
•
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| Publication |
| First Author: |
Di-Gregorio A |
| Year: |
2007 |
| Journal: |
Development |
| Title: |
BMP signalling inhibits premature neural differentiation in the mouse embryo. |
| Volume: |
134 |
| Issue: |
18 |
| Pages: |
3359-69 |
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| Publication |
| First Author: |
Kim J |
| Year: |
2022 |
| Journal: |
PLoS Genet |
| Title: |
The RNA helicase DDX6 controls early mouse embryogenesis by repressing aberrant inhibition of BMP signaling through miRNA-mediated gene silencing. |
| Volume: |
18 |
| Issue: |
10 |
| Pages: |
e1009967 |
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| First Author: |
Fulcoli FG |
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2016 |
| Journal: |
Nat Commun |
| Title: |
Rebalancing gene haploinsufficiency in vivo by targeting chromatin. |
| Volume: |
7 |
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11688 |
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| Publication |
| First Author: |
Krentz AD |
| Year: |
2013 |
| Journal: |
Dev Biol |
| Title: |
Interaction between DMRT1 function and genetic background modulates signaling and pluripotency to control tumor susceptibility in the fetal germ line. |
| Volume: |
377 |
| Issue: |
1 |
| Pages: |
67-78 |
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•
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| Publication |
| First Author: |
Krawchuk D |
| Year: |
2015 |
| Journal: |
J Cell Sci |
| Title: |
Loss of LKB1 leads to impaired epithelial integrity and cell extrusion in the early mouse embryo. |
| Volume: |
128 |
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5 |
| Pages: |
1011-22 |
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| First Author: |
Kaji K |
| Year: |
2007 |
| Journal: |
Development |
| Title: |
Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells. |
| Volume: |
134 |
| Issue: |
6 |
| Pages: |
1123-32 |
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•
•
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| Publication |
| First Author: |
St-Jean G |
| Year: |
2019 |
| Journal: |
Development |
| Title: |
Lats1 and Lats2 are required for the maintenance of multipotency in the Müllerian duct mesenchyme. |
| Volume: |
146 |
| Issue: |
20 |
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•
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| First Author: |
Torres-Cano A |
| Year: |
2022 |
| Journal: |
PLoS Genet |
| Title: |
Deletion of Wt1 during early gonadogenesis leads to differences of sex development in male and female adult mice. |
| Volume: |
18 |
| Issue: |
6 |
| Pages: |
e1010240 |
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| Publication |
| First Author: |
Huang X |
| Year: |
2017 |
| Journal: |
Elife |
| Title: |
Zfp281 is essential for mouse epiblast maturation through transcriptional and epigenetic control of Nodal signaling. |
| Volume: |
6 |
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•
•
•
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| First Author: |
Kagey MH |
| Year: |
2010 |
| Journal: |
Nature |
| Title: |
Mediator and cohesin connect gene expression and chromatin architecture. |
| Volume: |
467 |
| Issue: |
7314 |
| Pages: |
430-5 |
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Mitiku N |
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2007 |
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Dev Cell |
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Genomic analysis of gastrulation and organogenesis in the mouse. |
| Volume: |
13 |
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6 |
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| First Author: |
Tomaz RA |
| Year: |
2017 |
| Journal: |
Development |
| Title: |
Jmjd2c facilitates the assembly of essential enhancer-protein complexes at the onset of embryonic stem cell differentiation. |
| Volume: |
144 |
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4 |
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567-579 |
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Fiorenzano A |
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2016 |
| Journal: |
Nat Commun |
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Cripto is essential to capture mouse epiblast stem cell and human embryonic stem cell pluripotency. |
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Weberling A |
| Year: |
2025 |
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iScience |
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Primitive to visceral endoderm maturation is essential for mouse epiblast survival beyond implantation. |
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28 |
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1 |
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Krentz AD |
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2009 |
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Proc Natl Acad Sci U S A |
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The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency. |
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22323-8 |
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Iwafuchi-Doi M |
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Development |
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Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells. |
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Nakajima R |
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2016 |
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PLoS One |
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JMJD1C Exhibits Multiple Functions in Epigenetic Regulation during Spermatogenesis. |
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2021 |
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PLoS One |
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Distinct expression of select and transcriptome-wide isolated 3'UTRs suggests critical roles in development and transition states. |
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Landry J |
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PLoS Genet |
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Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cells. |
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Lin T |
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Nat Cell Biol |
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p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression. |
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
280
 |
| Fragment?: |
false |
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•
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| First Author: |
Zhao L |
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2017 |
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Dev Biol |
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SOX4 regulates gonad morphogenesis and promotes male germ cell differentiation in mice. |
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423 |
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Yu C |
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2016 |
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Cell Res |
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Oocyte-expressed yes-associated protein is a key activator of the early zygotic genome in mouse. |
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Singh AP |
| Year: |
2014 |
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Nucleic Acids Res |
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Analysis of the SWI/SNF chromatin-remodeling complex during early heart development and BAF250a repression cardiac gene transcription during P19 cell differentiation. |
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Cell Rep |
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Single-cell profiling of epigenetic modifiers identifies PRDM14 as an inducer of cell fate in the mammalian embryo. |
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Yu C |
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Science |
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CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins. |
| Volume: |
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| Issue: |
6165 |
| Pages: |
1518-21 |
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| Year: |
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| Journal: |
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Prostaglandin D2 acts through the Dp2 receptor to influence male germ cell differentiation in the foetal mouse testis. |
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141 |
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18 |
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•
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Dali O |
| Year: |
2024 |
| Journal: |
Life Sci Alliance |
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Transgenerational epigenetic effects imposed by neonicotinoid thiacloprid exposure. |
| Volume: |
7 |
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2 |
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•
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Nishiyama A |
| Year: |
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Cell Stem Cell |
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Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. |
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4 |
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420-33 |
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| First Author: |
Yoshikawa T |
| Year: |
2006 |
| Journal: |
Gene Expr Patterns |
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High-throughput screen for genes predominantly expressed in the ICM of mouse blastocysts by whole mount in situ hybridization. |
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6 |
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2 |
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Boroviak T |
| Year: |
2014 |
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Nat Cell Biol |
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The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification. |
| Volume: |
16 |
| Issue: |
6 |
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516-28 |
|
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•
•
•
•
|
| Allele |
| Name: |
Nanog homeobox; targeted mutation 1.1, Antonio Simeone |
| Allele Type: |
Targeted |
| Attribute String: |
Not Specified |
|
•
•
•
•
•
|
| Publication |
| First Author: |
European Mouse Mutant Archive |
| Year: |
2003 |
| Journal: |
Unpublished |
| Title: |
Information obtained from the European Mouse Mutant Archive (EMMA) |
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| Publication |
| First Author: |
Mager J |
| Year: |
2019 |
| Journal: |
MGI Direct Data Submission |
| Title: |
A Catalog of Early Lethal KOMP Phenotypes |
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