|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 4101 to 4200 out of 8321 for Src

<< First    < Previous  |  Next >    Last >>
0.021s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Publication
23788624 | J:199467
First Author: Do DV
Year: 2013
Journal: Genes Dev
Title: A genetic and developmental pathway from STAT3 to the OCT4-NANOG circuit is essential for maintenance of ICM lineages in vivo.
Volume: 27
Issue: 12
Pages: 1378-90
•
•
•
•
•
Publication
19013146 | J:143539
First Author: Bredemeyer AJ
Year: 2009
Journal: Dev Biol
Title: The gastric epithelial progenitor cell niche and differentiation of the zymogenic (chief) cell lineage.
Volume: 325
Issue: 1
Pages: 211-24
•
•
•
•
•
Publication
20440272 | J:162024
First Author: Osborne LC
Year: 2010
Journal: Oncogene
Title: Selective ablation of the YxxM motif of IL-7Ralpha suppresses lymphomagenesis but maintains lymphocyte development.
Volume: 29
Issue: 26
Pages: 3854-64
•
•
•
•
•
Publication
23696567 | J:201185
First Author: Singireddy AV
Year: 2013
Journal: Endocrinology
Title: Neither signal transducer and activator of transcription 3 (STAT3) or STAT5 signaling pathways are required for leptin's effects on fertility in mice.
Volume: 154
Issue: 7
Pages: 2434-45
•
•
•
•
•
Publication
27335373 | J:280974
First Author: Raij L
Year: 2016
Journal: Am J Physiol Renal Physiol
Title: Podocyte injury: the role of proteinuria, urinary plasminogen, and oxidative stress.
Volume: 311
Issue: 6
Pages: F1308-F1317
•
•
•
•
•
Publication
26901816 | J:232418
First Author: Yu H
Year: 2016
Journal: J Clin Invest
Title: A role for genetic susceptibility in sporadic focal segmental glomerulosclerosis.
Volume: 126
Issue: 3
Pages: 1067-78
•
•
•
•
•
Genotype
Genotype
Symbol: Stat3/Stat3 Tg(Tek-cre)12Flv/?
Background: involves: 129 * C3H * C57BL/6
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Lrp5/Lrp5<+> Stat3/Stat3 Tg(Prrx1-cre)1Cjt/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL/J
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
Publication
28399411 | J:242492
First Author: Poh AR
Year: 2017
Journal: Cancer Cell
Title: Inhibition of Hematopoietic Cell Kinase Activity Suppresses Myeloid Cell-Mediated Colon Cancer Progression.
Volume: 31
Issue: 4
Pages: 563-575.e5
•
•
•
•
•
Publication
16166631 | J:101365
First Author: Xu S
Year: 2005
Journal: Mol Cell Biol
Title: Cbp deficiency alters Csk localization in lipid rafts but does not affect T-cell development.
Volume: 25
Issue: 19
Pages: 8486-95
•
•
•
•
•
Publication
8197166 | J:18624
First Author: Chow LM
Year: 1994
Journal: Proc Natl Acad Sci U S A
Title: Ntk: a Csk-related protein-tyrosine kinase expressed in brain and T lymphocytes.
Volume: 91
Issue: 11
Pages: 4975-9
•
•
•
•
•
Publication
8806656 | J:35262
First Author: Ishii T
Year: 1996
Journal: Biochem Biophys Res Commun
Title: Murine peritoneal macrophages induce a novel 60-kDa protein with structural similarity to a tyrosine kinase p56lck-associated protein in response to oxidative stress.
Volume: 226
Issue: 2
Pages: 456-60
•
•
•
•
•
Publication
15738056 | J:96625
First Author: Pasquier B
Year: 2005
Journal: J Exp Med
Title: Defective NKT cell development in mice and humans lacking the adapter SAP, the X-linked lymphoproliferative syndrome gene product.
Volume: 201
Issue: 5
Pages: 695-701
•
•
•
•
•
Publication
31237563 | J:277736
   
First Author: Padmanabhan P
Year: 2019
Journal: Elife
Title: Frontotemporal dementia mutant Tau promotes aberrant Fyn nanoclustering in hippocampal dendritic spines.
Volume: 8
•
•
•
•
•
Publication
20655099 | J:164597
First Author: Ittner LM
Year: 2010
Journal: Cell
Title: Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models.
Volume: 142
Issue: 3
Pages: 387-97
•
•
•
•
•
Publication
8631859 | J:33665
First Author: Sun XJ
Year: 1996
Journal: J Biol Chem
Title: The Fyn tyrosine kinase binds Irs-1 and forms a distinct signaling complex during insulin stimulation.
Volume: 271
Issue: 18
Pages: 10583-7
•
•
•
•
•
Publication
18086565 | J:130803
First Author: Saito K
Year: 2008
Journal: Biochem Biophys Res Commun
Title: Proteomic identification of ZO-1/2 as a novel scaffold for Src/Csk regulatory circuit.
Volume: 366
Issue: 4
Pages: 969-75
•
•
•
•
•
Publication
7898936 | J:23799
First Author: Kaneko Y
Year: 1995
Journal: Oncogene
Title: Presence of alternative 5' untranslated sequences and identification of cells expressing ctk transcripts in the brain and testis.
Volume: 10
Issue: 5
Pages: 945-52
•
•
•
•
•
Publication
10553045 | J:58458
First Author: Choi YB
Year: 1999
Journal: J Immunol
Title: Lad, an adapter protein interacting with the SH2 domain of p56lck, is required for T cell activation.
Volume: 163
Issue: 10
Pages: 5242-9
•
•
•
•
•
Publication
12471123 | J:118421
First Author: Donlin LT
Year: 2002
Journal: J Immunol
Title: Defective thymocyte maturation by transgenic expression of a truncated form of the T lymphocyte adapter molecule and Fyn substrate, Sin.
Volume: 169
Issue: 12
Pages: 6900-9
•
•
•
•
•
Publication
28586109 | J:247110
First Author: Ramírez-Valadez KA
Year: 2017
Journal: Eur J Immunol
Title: Fyn kinase mediates cortical actin ring depolymerization required for mast cell migration in response to TGF-β in mice.
Volume: 47
Issue: 8
Pages: 1305-1316
•
•
•
•
•
Publication
17845201 | J:149050
First Author: De Fazio SR
Year: 2007
Journal: Am J Reprod Immunol
Title: Activation of T cells by cross-linking Qa-2, the ped gene product, requires Fyn.
Volume: 58
Issue: 4
Pages: 315-24
•
•
•
•
•
Publication
19118543 | J:145987
First Author: McGinnis LK
Year: 2009
Journal: Dev Biol
Title: Functions of Fyn kinase in the completion of meiosis in mouse oocytes.
Volume: 327
Issue: 2
Pages: 280-7
•
•
•
•
•
Publication
23593269 | J:200582
First Author: Chaimowitz NS
Year: 2013
Journal: PLoS One
Title: Fyn kinase is required for optimal humoral responses.
Volume: 8
Issue: 4
Pages: e60640
•
•
•
•
•
Publication
7544314 | J:28276
First Author: Grant SG
Year: 1995
Journal: Genes Dev
Title: Focal adhesion kinase in the brain: novel subcellular localization and specific regulation by Fyn tyrosine kinase in mutant mice.
Volume: 9
Issue: 15
Pages: 1909-21
•
•
•
•
•
Publication
11751285 | J:74017
First Author: Maekawa M
Year: 2002
Journal: Biol Reprod
Title: Fyn tyrosine kinase in Sertoli cells is involved in mouse spermatogenesis.
Volume: 66
Issue: 1
Pages: 211-21
•
•
•
•
•
Publication
7509042 | J:16847
First Author: Umemori H
Year: 1994
Journal: Nature
Title: Initial events of myelination involve Fyn tyrosine kinase signalling.
Volume: 367
Issue: 6463
Pages: 572-6
•
•
•
•
•
Publication
8058305 | J:19921
First Author: Yagi T
Year: 1994
Journal: Oncogene
Title: Fyn expression during early neurogenesis in mouse embryos.
Volume: 9
Issue: 9
Pages: 2433-40
•
•
•
•
•
Publication
11160194 | J:67104
First Author: Utting O
Year: 2001
Journal: J Immunol
Title: p59fyn (Fyn) promotes the survival of anergic CD4-CD8- alpha beta TCR+ cells but negatively regulates their proliferative response to antigen stimulation.
Volume: 166
Issue: 3
Pages: 1540-6
•
•
•
•
•
Publication
30277607 | J:268262
First Author: Lim SL
Year: 2018
Journal: Glia
Title: Inhibition of hematopoietic cell kinase dysregulates microglial function and accelerates early stage Alzheimer's disease-like neuropathology.
Volume: 66
Issue: 12
Pages: 2700-2718
•
•
•
•
•
Publication
21242978 | J:173715
First Author: Shields DJ
Year: 2011
Journal: Oncogene
Title: Oncogenic Ras/Src cooperativity in pancreatic neoplasia.
Volume: 30
Issue: 18
Pages: 2123-34
•
•
•
•
•
Publication
23127881 | J:197490
 
First Author: Knox R
Year: 2013
Journal: Neurobiol Dis
Title: Enhanced NMDA receptor tyrosine phosphorylation and increased brain injury following neonatal hypoxia-ischemia in mice with neuronal Fyn overexpression.
Volume: 51
Pages: 113-9
•
•
•
•
•
Publication
29301754 | J:261556
First Author: Mori J
Year: 2018
Journal: Blood
Title: Maintenance of murine platelet homeostasis by the kinase Csk and phosphatase CD148.
Volume: 131
Issue: 10
Pages: 1122-1144
•
•
•
•
•
Publication
9535845 | J:200348
First Author: Bhandari V
Year: 1998
Journal: J Biol Chem
Title: Physical and functional interactions between receptor-like protein-tyrosine phosphatase alpha and p59fyn.
Volume: 273
Issue: 15
Pages: 8691-8
•
•
•
•
•
Publication
7557381 | J:28918
First Author: Calautti E
Year: 1995
Journal: Genes Dev
Title: fyn tyrosine kinase is involved in keratinocyte differentiation control.
Volume: 9
Issue: 18
Pages: 2279-91
•
•
•
•
•
Publication
18006633 | J:131128
First Author: Aga-Mizrachi S
Year: 2008
Journal: Endocrinology
Title: Cytosolic protein tyrosine phosphatase-epsilon is a negative regulator of insulin signaling in skeletal muscle.
Volume: 149
Issue: 2
Pages: 605-14
•
•
•
•
•
Publication
16325581 | -
First Author: Tosoni D
Year: 2005
Journal: Cell
Title: TTP specifically regulates the internalization of the transferrin receptor.
Volume: 123
Issue: 5
Pages: 875-88
•
•
•
•
•
Protein
A0A2I3BRP5
Organism: Mus musculus/domesticus
Length: 467  
Fragment?: false
•
•
•
•
•
Publication
15738637 | -
First Author: Nakagawa Y
Year: 2005
Journal: Zoolog Sci
Title: Receptor-type protein tyrosine phosphatase epsilon (PTPepsilonM) is a negative regulator of insulin signaling in primary hepatocytes and liver.
Volume: 22
Issue: 2
Pages: 169-75
•
•
•
•
•
Publication
9520419 | -
First Author: Qiu Y
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3'-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cells.
Volume: 95
Issue: 7
Pages: 3644-9
•
•
•
•
•
Publication
23716717 | J:306757
First Author: Chen S
Year: 2013
Journal: Sci Signal
Title: Tyrosine kinase BMX phosphorylates phosphotyrosine-primed motif mediating the activation of multiple receptor tyrosine kinases.
Volume: 6
Issue: 277
Pages: ra40
•
•
•
•
•
Publication
15355990 | -
First Author: Jiang T
Year: 2004
Journal: J Biol Chem
Title: Bi-directional regulation between tyrosine kinase Etk/BMX and tumor suppressor p53 in response to DNA damage.
Volume: 279
Issue: 48
Pages: 50181-9
•
•
•
•
•
Publication
22449076 | -
First Author: Cenni B
Year: 2012
Journal: Int Rev Immunol
Title: BMX and its role in inflammation, cardiovascular disease, and cancer.
Volume: 31
Issue: 2
Pages: 166-73
•
•
•
•
•
Publication
22575674 | -
First Author: Kim YM
Year: 2012
Journal: Mol Cell
Title: SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling.
Volume: 46
Issue: 6
Pages: 833-46
•
•
•
•
•
Publication
10748115 | -
First Author: Gaul BS
Year: 2000
Journal: J Biol Chem
Title: Substrate recognition by the Lyn protein-tyrosine kinase. NMR structure of the immunoreceptor tyrosine-based activation motif signaling region of the B cell antigen receptor.
Volume: 275
Issue: 21
Pages: 16174-82
•
•
•
•
•
Publication
7687428 | -
First Author: Roifman CM
Year: 1993
Journal: Biochem Biophys Res Commun
Title: CD19 is a substrate of the antigen receptor-associated protein tyrosine kinase in human B cells.
Volume: 194
Issue: 1
Pages: 222-5
•
•
•
•
•
Publication
15795233 | -
First Author: Brunati AM
Year: 2005
Journal: J Biol Chem
Title: Thrombin-induced tyrosine phosphorylation of HS1 in human platelets is sequentially catalyzed by Syk and Lyn tyrosine kinases and associated with the cellular migration of the protein.
Volume: 280
Issue: 22
Pages: 21029-35
•
•
•
•
•
Protein Domain
IPR016336 | Tyr_Pase_rcpt_a/e-type
Type: Family
Description: This entry represents receptor tyrosine-protein phosphatases (PTP) (), including both alpha type and epsilon type. PTP catalyses the dephosphorylation of protein tyrosine phosphate to protein tyrosine, and appear to play a pivotal role in insulin receptor signalling. It can exist as a single-pass membrane protein or in the cytoplasm. PTP-alpha is as a positive regulator of Src and Src family kinases, acting to dephosphorylate and activate Src. As such, PTP-alpha affects transformation and tumourigenesis, inhibition of proliferation and cell cycle arrest, mitotic activation of Src, integrin signalling, neuronal differentiation and outgrowth, and ion channel activity []. PTP-epsilon is a negative regulator of insulin signalling, where the cytosolic form has been shown to act in skeletal muscle []and the receptor-type enzyme has been shown to act in primary hepatocytes and liver [].
•
•
•
•
•
Protein Domain
IPR035852 | Lyn_SH2
Type: Domain
Description: Lyn is a member of the Src non-receptor type tyrosine kinase family. It plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance [, ]. It also mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils [, , ]. Lyn plays an essential role in the transmission of signals through phosphorylation of tyrosine residues within the immunoreceptor tyrosine-based inhibitory motifs (ITIM) in regulatory proteins [, ].This entry represents the SH2 domain of Lyn.The Src non-receptor type tyrosine kinase (SFK) family members have an unique N-terminal domain, an SH3 domain, an SH2 domain, a kinase domain and a regulatory tail. The SH2 domain of SFKs is involved in kinase autoinhibition and T-cell receptor signaling. The binding SH2 domains to phosphotyrosine (pY) sites is critical for the autoinhibition and substrate recognition of the SFKs [].
•
•
•
•
•
Protein Domain
IPR015503 | Cortactin
Type: Family
Description: Cortactin is a key regulator of actin polymerisation in response to tyrosine kinase signalling []. It was first identified as a tyrosine-phosphorylated protein in v-Src infected fibroblasts []. It contains several domains: an N-terminal acidic (NTA) domain, a central repeat region and a C-terminal Src homology 3 (SH3) domain. The central repeat region binds to actin filaments, the NTA domain binds to the Arp2/3 complex and the SH3 domain interacts with N-WASp, Arg and WIP []. When activated, cortactin can recruit Arp2/3 complex to existing actin filaments to nucleate a new actin filament. Cortactin is involved in the regulation of cell migration, lamellipodia formation, invadopodia formation and endocytosis []. Cortactin can be phosphorylated by Src at several sites, and also binds directly to the SH2 domain of SRC. The non-receptor kinases, such as Fyn, Syk and Fer may also play a role in cortactin tyrosine phosphorylation. The structure of cortactin has been solved [].
•
•
•
•
•
Publication
29962266 | J:288021
First Author: Mei J
Year: 2018
Journal: Autophagy
Title: Suppression of autophagy and HCK signaling promotes PTGS2high FCGR3- NK cell differentiation triggered by ectopic endometrial stromal cells.
Volume: 14
Issue: 8
Pages: 1376-1397
•
•
•
•
•
Publication
19060924 | -
First Author: Lodyga M
Year: 2009
Journal: Oncogene
Title: XB130, a tissue-specific adaptor protein that couples the RET/PTC oncogenic kinase to PI 3-kinase pathway.
Volume: 28
Issue: 7
Pages: 937-49
•
•
•
•
•
Publication
22928011 | -
First Author: Shiozaki A
Year: 2012
Journal: PLoS One
Title: XB130 mediates cancer cell proliferation and survival through multiple signaling events downstream of Akt.
Volume: 7
Issue: 8
Pages: e43646
•
•
•
•
•
Publication
17412687 | -
First Author: Xu J
Year: 2007
Journal: J Biol Chem
Title: XB130, a novel adaptor protein for signal transduction.
Volume: 282
Issue: 22
Pages: 16401-12
•
•
•
•
•
Publication
24995146 | -
 
First Author: Bai XH
Year: 2014
Journal: Scientifica (Cairo)
Title: XB130-A Novel Adaptor Protein: Gene, Function, and Roles in Tumorigenesis.
Volume: 2014
Pages: 903014
•
•
•
•
•
Protein Domain
IPR028840 | BMX
Type: Family
Description: Cytoplasmic tyrosine-protein kinase BMX (bone marrow tyrosine kinase gene on chromosome X, also known as ETK) is a non-receptor tyrosine kinase (). It plays central but diverse modulator roles in various signalling processes involved in the regulation of actin reorganisation, cell migration, cell proliferation and survival, cell adhesion, and apoptosis [, , ]. It has a role in inflammation, cardiovascular disease, and cancer []. It is activated downstream of phosphatidylinositol-3 kinase (PI3K) andthe kinase Src [].
•
•
•
•
•
Protein Domain
IPR037362 | CAS_fam
Type: Family
Description: The CAS (Crk-Associated Substrate) protein family is a group of scaffolding proteins that play important modulatory roles in both normal and pathological cell growth regulation. They contain an N-terminal Src homology 3 (SH3) domain and a substrate domain (SD). The SD contains a large number of YxxP motifs, which when phosphorylated by Src-family kinases provide canonical binding sites for proteins containing SH2 domains such as Crk, Crk-L, CRKII [].
•
•
•
•
•
Protein Domain
IPR030115 | AFAP1L2
Type: Family
Description: Actin filament-associated protein 1-like 2 (AFAP1L, also known as XB130) belongs to the actin-filament associated protein (AFAP) family of adaptor proteins (including AFAP1, AFAP1L1, and AFAP1L2/XB130). XB130 is an adaptor protein for signal transduction predominantly localised in the cytoplasm, and regulates cell proliferation, survival, and gene expression []. It is a Src kinase substrate []and couples the RET/PTC oncogenic kinase to the PI 3-kinase pathway []. It is involved in growth and survival of different cancer cells [].
•
•
•
•
•
Protein Domain
IPR029591 | SHC2
Type: Family
Description: The SH2-containing Shc adapter proteins are targets of activated tyrosine kinases and are implicated in the transmission of activation signals to the Ras/mitogen-activated protein kinase (MAPK) pathway []. Three Shc genes were originally identified in mammals that encode proteins characterised by an amino-terminal phosphotyrosine binding (PTB) domain and a carboxy-terminal Src homology 2 domain. Shc1 (ShcA) is ubiquitously expressed, whereas expression of Shc2 (ShcB) and Shc3 (ShcC) appears to be limited to neuronal cells [].This entry represents Shc2.
•
•
•
•
•
Protein Domain
IPR035456 | SH3BP4_SH3
Type: Domain
Description: This entry represents the SH3 domain of SH3BP4 (SH3 domain-binding protein 4). SH3BP4 binds to the inactive Rag GTPase complex through its Src homology 3 (SH3) domain and acts as a negative regulator of amino acid-Rag GTPase-mTORC1 signaling []. It has been shown to act as an endocytic accessory protein that interacts with endocytic proteins including clathrin and dynamin, and regulates the internalization of the transferrin receptor (TfR) [].
•
•
•
•
•
Protein Domain
IPR035822 | SH3RF2_SH3_3
Type: Domain
Description: Plenty of SH3 domains protein 2 (POSH2 also known as SH3 domain-containing RING finger protein 3 or putative E3 ubiquitin-protein ligase SH3RF2) contains the Src homology 3 (SH3) domains and a RING finger domain which confers E3 ligase activity to the protein. It belongs to the POSH family, which includes POSH1, POSH2 and POSH3 []. POSH2 interacts with GTP-loaded Rac1, which is a small signaling G protein [].This entry represents the third SH3 domain of SH3RF2.
•
•
•
•
•
Protein Domain
IPR021901 | CAS_C
Type: Domain
Description: This domain is found in the C terminus of the CAS family members.The CAS (Crk-Associated Substrate) protein family is a group of scaffolding proteins that play important modulatory roles in both normal and pathological cell growth regulation. They contain an N-terminal Src homology 3 (SH3) domain and a substrate domain (SD). The SD contains a large number of YxxP motifs, which when phosphorylated by Src-family kinases provide canonical binding sites for proteins containing SH2 domains such as Crk, Crk-L, CRKII [].
•
•
•
•
•
Publication
9351809 | -
First Author: Arold S
Year: 1997
Journal: Structure
Title: The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling.
Volume: 5
Issue: 10
Pages: 1361-72
•
•
•
•
•
Publication
15489916 | -
First Author: Palacios EH
Year: 2004
Journal: Oncogene
Title: Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation.
Volume: 23
Issue: 48
Pages: 7990-8000
•
•
•
•
•
Publication
28033507 | -
 
First Author: Zahratka JA
Year: 2017
Journal: Neurobiol Aging
Title: Regulatory region genetic variation is associated with FYN expression in Alzheimer's disease.
Volume: 51
Pages: 43-53
•
•
•
•
•
Publication
10716632 | -
First Author: Martins-Green M
Year: 2000
Journal: Int J Biochem Cell Biol
Title: Tissue specific expression of Yrk kinase: implications for differentiation and inflammation.
Volume: 32
Issue: 3
Pages: 351-64
•
•
•
•
•
Publication
14766749 | -
First Author: Brown K
Year: 2004
Journal: J Biol Chem
Title: Crystal structures of interleukin-2 tyrosine kinase and their implications for the design of selective inhibitors.
Volume: 279
Issue: 18
Pages: 18727-32
•
•
•
•
•
Publication
17060314 | -
First Author: Qi Q
Year: 2006
Journal: J Biol Chem
Title: Tec kinase Itk forms membrane clusters specifically in the vicinity of recruiting receptors.
Volume: 281
Issue: 50
Pages: 38529-34
•
•
•
•
•
Publication
16802597 | -
 
First Author: Tsoukas CD
Year: 2006
Journal: Adv Exp Med Biol
Title: Inducible T cell tyrosine kinase (ITK): structural requirements and actin polymerization.
Volume: 584
Pages: 29-41
•
•
•
•
•
Publication
20545945 | -
First Author: Kutach AK
Year: 2010
Journal: Chem Biol Drug Des
Title: Crystal structures of IL-2-inducible T cell kinase complexed with inhibitors: insights into rational drug design and activity regulation.
Volume: 76
Issue: 2
Pages: 154-63
•
•
•
•
•
Protein Domain
IPR042785 | ITK_PTKc
Type: Domain
Description: PTKs catalyse the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Itk, also known as Tsk or Emt, is a member of the Tec-like subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs with similarity to Src kinases in that they contain Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. Unlike Src kinases, most Tec subfamily members except Rlk also contain an N-terminal pleckstrin homology (PH) domain, which binds the products of PI3K and allows membrane recruitment and activation. In addition, Itk contains the Tec homology (TH) domain containing one proline-rich region and a zinc-binding region [, ].Itk is expressed in T-cells and mast cells, and is important in their development and differentiation []. Of the three Tec kinases expressed in T-cells, Itk plays the predominant role in T-cell receptor (TCR) signalling. It is activated by phosphorylation upon TCR crosslinking and is involved in the pathway resulting in phospholipase C-gamma1 activation and actin polymerization []. It also plays a role in the downstream signalling of the T-cell costimulatory receptor CD28, the T-cell surface receptor CD2, and the chemokine receptor CXCR4 [, ]. In addition, Itk is crucial for the development of T-helper(Th)2 effector responses [].
•
•
•
•
•
Protein Domain
IPR035750 | Fyn/Yrk_SH3
Type: Domain
Description: Fyn and Yrk (Yes-related kinase) are members of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Fyn, together with Lck, plays a critical role in T-cell signal transduction by phosphorylating ITAM (immunoreceptor tyr activation motif) sequences on T-cell receptors, ultimately leading to the proliferation and differentiation of T-cells []. In addition, Fyn is involved in the myelination of neurons, and is implicated in Alzheimer's []and Parkinson's diseases []. Yrk has been detected only in chickens. It is primarily found in neuronal and epithelial cells and in macrophages. It may play a role in inflammation and in response to injury [].Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The SH3 domain of Src kinases contributes to substrate recruitment by binding adaptor proteins/substrates, and regulation of kinase activity through an intramolecular interaction [, ].
•
•
•
•
•
Publication
7893599 | J:22208
First Author: Ruiz JC
Year: 1994
Journal: Mech Dev
Title: Identification of novel protein kinases expressed in the myocardium of the developing mouse heart.
Volume: 48
Issue: 3
Pages: 153-64
•
•
•
•
•
Publication
31803974 | J:283878
First Author: Wiede F
Year: 2020
Journal: EMBO J
Title: PTPN2 phosphatase deletion in T cells promotes anti-tumour immunity and CAR T-cell efficacy in solid tumours.
Volume: 39
Issue: 2
Pages: e103637
•
•
•
•
•
Publication
10742150 | J:119597
First Author: Liu P
Year: 2000
Journal: Nat Med
Title: The tyrosine kinase p56lck is essential in coxsackievirus B3-mediated heart disease.
Volume: 6
Issue: 4
Pages: 429-34
•
•
•
•
•
Publication
28798028 | J:244288
First Author: Wiede F
Year: 2017
Journal: J Exp Med
Title: PTPN2 regulates T cell lineage commitment and αβ versus γδ specification.
Volume: 214
Issue: 9
Pages: 2733-2758
•
•
•
•
•
Publication
9548458 | J:44275
First Author: Yu CL
Year: 1997
Journal: J Immunol
Title: Constitutive activation of the Janus kinase-STAT pathway in T lymphoma overexpressing the Lck protein tyrosine kinase.
Volume: 159
Issue: 11
Pages: 5206-10
•
•
•
•
•
Publication
12077322 | J:126523
First Author: Huang J
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: CD28 plays a critical role in the segregation of PKC theta within the immunologic synapse.
Volume: 99
Issue: 14
Pages: 9369-73
•
•
•
•
•
Publication
10453000 | J:57092
First Author: Chu DH
Year: 1999
Journal: J Immunol
Title: Pre-T cell receptor signals are responsible for the down-regulation of Syk protein tyrosine kinase expression.
Volume: 163
Issue: 5
Pages: 2610-20
•
•
•
•
•
Publication
16709819 | J:131771
First Author: Mason LH
Year: 2006
Journal: J Immunol
Title: Regulation of Ly49D/DAP12 signal transduction by Src-family kinases and CD45.
Volume: 176
Issue: 11
Pages: 6615-23
•
•
•
•
•
Publication
19937461 | -
First Author: Tikhmyanova N
Year: 2010
Journal: Cell Mol Life Sci
Title: CAS proteins in normal and pathological cell growth control.
Volume: 67
Issue: 7
Pages: 1025-48
•
•
•
•
•
Publication
15814704 | J:98147
First Author: Ljutic B
Year: 2005
Journal: J Immunol
Title: Functional requirements for signaling through the stimulatory and inhibitory mouse NKR-P1 (CD161) NK cell receptors.
Volume: 174
Issue: 8
Pages: 4789-96
•
•
•
•
•
Publication
14761972 | J:89507
First Author: Hisatsune C
Year: 2004
Journal: J Biol Chem
Title: Regulation of TRPC6 channel activity by tyrosine phosphorylation.
Volume: 279
Issue: 18
Pages: 18887-94
•
•
•
•
•
Publication
19776266 | J:153045
First Author: Relucio J
Year: 2009
Journal: J Neurosci
Title: Laminin alters fyn regulatory mechanisms and promotes oligodendrocyte development.
Volume: 29
Issue: 38
Pages: 11794-806
•
•
•
•
•
Publication
27460989 | J:260551
First Author: Dobbins J
Year: 2016
Journal: Sci Signal
Title: Binding of the cytoplasmic domain of CD28 to the plasma membrane inhibits Lck recruitment and signaling.
Volume: 9
Issue: 438
Pages: ra75
•
•
•
•
•
Publication
28096359 | J:240605
First Author: Kang SS
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: α-Synuclein binds and sequesters PIKE-L into Lewy bodies, triggering dopaminergic cell death via AMPK hyperactivation.
Volume: 114
Issue: 5
Pages: 1183-1188
•
•
•
•
•
Publication
12545174 | J:109312
First Author: Chan B
Year: 2003
Journal: Nat Cell Biol
Title: SAP couples Fyn to SLAM immune receptors.
Volume: 5
Issue: 2
Pages: 155-60
•
•
•
•
•
Publication
27859601 | J:237919
First Author: Schneble N
Year: 2017
Journal: Glia
Title: The protein-tyrosine phosphatase DEP-1 promotes migration and phagocytic activity of microglial cells in part through negative regulation of fyn tyrosine kinase.
Volume: 65
Issue: 2
Pages: 416-428
•
•
•
•
•
Publication
27525436 | J:237245
First Author: Matsushima S
Year: 2016
Journal: J Clin Invest
Title: Tyrosine kinase FYN negatively regulates NOX4 in cardiac remodeling.
Volume: 126
Issue: 9
Pages: 3403-16
•
•
•
•
•
Publication
21061443 | J:166659
First Author: Kemp KL
Year: 2010
Journal: Eur J Immunol
Title: Lck regulates IL-10 expression in memory-like Th1 cells.
Volume: 40
Issue: 11
Pages: 3210-9
•
•
•
•
•
Publication
11854322 | J:74698
First Author: Ping P
Year: 2002
Journal: J Clin Invest
Title: Formation of protein kinase C(epsilon)-Lck signaling modules confers cardioprotection.
Volume: 109
Issue: 4
Pages: 499-507
•
•
•
•
•
Publication
25829544 | J:220529
First Author: Roh KH
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: The coreceptor CD4 is expressed in distinct nanoclusters and does not colocalize with T-cell receptor and active protein tyrosine kinase p56lck.
Volume: 112
Issue: 13
Pages: E1604-13
•
•
•
•
•
Publication
17046829 | J:118155
First Author: Li W
Year: 2007
Journal: J Biol Chem
Title: Srcasm corrects Fyn-induced epidermal hyperplasia by kinase down-regulation.
Volume: 282
Issue: 2
Pages: 1161-9
•
•
•
•
•
Publication
23169819 | J:205618
First Author: Kim YJ
Year: 2012
Journal: Sci Signal
Title: GPRC5B activates obesity-associated inflammatory signaling in adipocytes.
Volume: 5
Issue: 251
Pages: ra85
•
•
•
•
•
Publication
9581568 | J:200350
 
First Author: Ng DH
Year: 1997
Journal: Biochem J
Title: CD45 and RPTPalpha display different protein tyrosine phosphatase activities in T lymphocytes.
Volume: 327 ( Pt 3)
Pages: 867-76
•
•
•
•
•
Publication
10781838 | J:62319
First Author: Ulivieri C
Year: 2000
Journal: Mol Immunol
Title: Restoration of thymic development in an Lck(-/-) thymoma overexpressing ZAP-70.
Volume: 37
Issue: 1-2
Pages: 85-90
•
•
•
•
•
Publication
8910336 | J:36499
First Author: Pathan NI
Year: 1996
Journal: J Biol Chem
Title: The protein-tyrosine kinase Lck associates with and is phosphorylated by Cdc2.
Volume: 271
Issue: 44
Pages: 27517-23
•
•
•
•
•
Publication
12570875 | J:83355
First Author: Kabouridis PS
Year: 2003
Journal: Biochem J
Title: Selective interaction of LAT (linker of activated T cells) with the open-active form of Lck in lipid rafts reveals a new mechanism for the regulation of Lck in T cells.
Volume: 371
Issue: Pt 3
Pages: 907-15
•
•
•
•
•
Publication
14980511 | J:88324
First Author: Cao H
Year: 2004
Journal: Exp Cell Res
Title: Oxidative stress activates both Src-kinases and their negative regulator Csk and induces phosphorylation of two targeting proteins for Csk: caveolin-1 and paxillin.
Volume: 294
Issue: 1
Pages: 159-71
•
•
•
•
•
Publication
16899217 | J:111977
First Author: Lee MF
Year: 2006
Journal: Biochem Biophys Res Commun
Title: Magicin associates with the Src-family kinases and is phosphorylated upon CD3 stimulation.
Volume: 348
Issue: 3
Pages: 826-31
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom