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Search results 4201 to 4300 out of 8321 for Src

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Type Details Score
Publication
17579091 | J:149404
First Author: Vepachedu R
Year: 2007
Journal: J Immunol
Title: Unc119 regulates myofibroblast differentiation through the activation of Fyn and the p38 MAPK pathway.
Volume: 179
Issue: 1
Pages: 682-90
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Publication
11741956 | J:230372
First Author: Hawash IY
Year: 2002
Journal: J Biol Chem
Title: The Lck SH3 domain negatively regulates localization to lipid rafts through an interaction with c-Cbl.
Volume: 277
Issue: 7
Pages: 5683-91
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Publication
10713090 | J:61068
First Author: Reilly JF
Year: 2000
Journal: J Biol Chem
Title: Association of fibroblast growth factor receptor 1 with the adaptor protein Grb14. Characterization of a new receptor binding partner.
Volume: 275
Issue: 11
Pages: 7771-8
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Publication
32565338 | J:329574
 
First Author: Saminathan H
Year: 2020
Journal: Eur J Pharmacol
Title: Fyn kinase mediates pro-inflammatory response in a mouse model of endotoxemia: Relevance to translational research.
Volume: 881
Pages: 173259
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Publication
17210649 | J:118860
First Author: Davidson D
Year: 2007
Journal: Mol Cell Biol
Title: PAG-associated FynT regulates calcium signaling and promotes anergy in T lymphocytes.
Volume: 27
Issue: 5
Pages: 1960-73
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Publication
26512138 | J:239190
First Author: Reginald K
Year: 2015
Journal: J Immunol
Title: Revisiting the Timing of Action of the PAG Adaptor Using Quantitative Proteomics Analysis of Primary T Cells.
Volume: 195
Issue: 11
Pages: 5472-81
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Publication
16400024 | J:104361
First Author: Jiang ST
Year: 2006
Journal: Am J Pathol
Title: Defining a link with autosomal-dominant polycystic kidney disease in mice with congenitally low expression of Pkd1.
Volume: 168
Issue: 1
Pages: 205-20
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Publication
11356033 | J:69637
First Author: Alavizadeh A
Year: 2001
Journal: Dev Biol
Title: The Wheels mutation in the mouse causes vascular, hindbrain, and inner ear defects.
Volume: 234
Issue: 1
Pages: 244-60
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Publication
8982254 | J:51736
First Author: Angiolillo A
Year: 1996
Journal: Biochim Biophys Acta
Title: Molecular cloning of a cDNA encoding an antigen which is salt-stably attached to centrosomes.
Volume: 1309
Issue: 3
Pages: 194-6
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Publication
8048169 | J:19272
First Author: Myers MG Jr
Year: 1994
Journal: Trends Biochem Sci
Title: The IRS-1 signaling system.
Volume: 19
Issue: 7
Pages: 289-93
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Publication
10612399 | J:59044
First Author: Senzaki K
Year: 1999
Journal: Cell
Title: Proteins of the CNR family are multiple receptors for Reelin.
Volume: 99
Issue: 6
Pages: 635-47
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Publication
26449489 | J:227130
First Author: Peckham H
Year: 2016
Journal: Glia
Title: Fyn is an intermediate kinase that BDNF utilizes to promote oligodendrocyte myelination.
Volume: 64
Issue: 2
Pages: 255-69
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Publication
26552706 | J:229022
First Author: Zhang Z
Year: 2015
Journal: J Exp Med
Title: DNAM-1 controls NK cell activation via an ITT-like motif.
Volume: 212
Issue: 12
Pages: 2165-82
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Publication
18832694 | J:140767
First Author: Mamchak AA
Year: 2008
Journal: J Immunol
Title: Normal development and activation but altered cytokine production of Fyn-deficient CD4+ T cells.
Volume: 181
Issue: 8
Pages: 5374-85
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Publication
28818835 | J:263523
First Author: Zhang L
Year: 2017
Journal: EMBO Mol Med
Title: Src-dependent phosphorylation of μ-opioid receptor at Tyr336 modulates opiate withdrawal.
Volume: 9
Issue: 11
Pages: 1521-1536
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Publication
27616741 | J:315916
First Author: Seo HY
Year: 2016
Journal: Kidney Int
Title: Fyn deficiency attenuates renal fibrosis by inhibition of phospho-STAT3.
Volume: 90
Issue: 6
Pages: 1285-1297
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Publication
21427288 | J:173265
First Author: Chen K
Year: 2011
Journal: Blood
Title: Vav guanine nucleotide exchange factors link hyperlipidemia and a prothrombotic state.
Volume: 117
Issue: 21
Pages: 5744-50
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Publication
20850416 | J:165846
First Author: García-Román J
Year: 2010
Journal: Biochem Biophys Res Commun
Title: VEGF secretion during hypoxia depends on free radicals-induced Fyn kinase activity in mast cells.
Volume: 401
Issue: 2
Pages: 262-7
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Publication
20233604 | J:164138
First Author: Jurd R
Year: 2010
Journal: Mol Cell Neurosci
Title: Fyn kinase contributes to tyrosine phosphorylation of the GABA(A) receptor gamma2 subunit.
Volume: 44
Issue: 2
Pages: 129-34
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Publication
27913425 | J:238785
First Author: Suresh K
Year: 2017
Journal: Am J Physiol Lung Cell Mol Physiol
Title: CD36 mediates H2O2-induced calcium influx in lung microvascular endothelial cells.
Volume: 312
Issue: 1
Pages: L143-L153
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Publication
18482989 | J:138665
First Author: Zhong MC
Year: 2008
Journal: J Biol Chem
Title: Control of T lymphocyte signaling by Ly108, a signaling lymphocytic activation molecule family receptor implicated in autoimmunity.
Volume: 283
Issue: 28
Pages: 19255-64
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Publication
24045941 | J:303004
First Author: Zhong MC
Year: 2013
Journal: J Biol Chem
Title: The adaptor molecule signaling lymphocytic activation molecule (SLAM)-associated protein (SAP) is essential in mechanisms involving the Fyn tyrosine kinase for induction and progression of collagen-induced arthritis.
Volume: 288
Issue: 44
Pages: 31423-36
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Publication
25492967 | J:260191
First Author: Granum S
Year: 2014
Journal: Sci Signal
Title: The kinase Itk and the adaptor TSAd change the specificity of the kinase Lck in T cells by promoting the phosphorylation of Tyr192.
Volume: 7
Issue: 355
Pages: ra118
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Publication
32016283 | J:289379
First Author: Nagy Z
Year: 2020
Journal: Blood
Title: Interplay between the tyrosine kinases Chk and Csk and phosphatase PTPRJ is critical for regulating platelets in mice.
Volume: 135
Issue: 18
Pages: 1574-1587
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Publication
7664803 | J:115170
First Author: Campbell KS
Year: 1995
Journal: Eur J Immunol
Title: Interactions between the amino-terminal domain of p56lck and cytoplasmic domains of CD4 and CD8 alpha in yeast.
Volume: 25
Issue: 8
Pages: 2408-12
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Publication
12921535 | J:113608
First Author: Sanguinetti AR
Year: 2003
Journal: Biochem J
Title: Fyn is required for oxidative- and hyperosmotic-stress-induced tyrosine phosphorylation of caveolin-1.
Volume: 376
Issue: Pt 1
Pages: 159-68
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Publication
16339530 | J:122244
First Author: Maksumova L
Year: 2005
Journal: J Immunol
Title: Protein tyrosine phosphatase alpha regulates Fyn activity and Cbp/PAG phosphorylation in thymocyte lipid rafts.
Volume: 175
Issue: 12
Pages: 7947-56
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Publication
19380812 | J:147711
First Author: Dale BM
Year: 2009
Journal: J Immunol
Title: Phagocytosis in macrophages lacking Cbl reveals an unsuspected role for Fc gamma receptor signaling and actin assembly in target binding.
Volume: 182
Issue: 9
Pages: 5654-62
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Publication
11468287 | J:120418
First Author: Derkinderen P
Year: 2001
Journal: J Biol Chem
Title: Dual role of Fyn in the regulation of FAK+6,7 by cannabinoids in hippocampus.
Volume: 276
Issue: 41
Pages: 38289-96
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Publication
20417561 | J:160621
First Author: Lefebvre DC
Year: 2010
Journal: Mol Immunol
Title: CD44 interacts directly with Lck in a zinc-dependent manner.
Volume: 47
Issue: 10
Pages: 1882-9
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Publication
29197620 | J:302789
 
First Author: Sharma S
Year: 2018
Journal: Neurobiol Dis
Title: Role of the Fyn-PKCδ signaling in SE-induced neuroinflammation and epileptogenesis in experimental models of temporal lobe epilepsy.
Volume: 110
Pages: 102-121
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Publication
17114649 | J:187362
First Author: Munton RP
Year: 2007
Journal: Mol Cell Proteomics
Title: Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.
Volume: 6
Issue: 2
Pages: 283-93
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Publication
17383541 | -
 
First Author: Felices M
Year: 2007
Journal: Adv Immunol
Title: Tec kinases in T cell and mast cell signaling.
Volume: 93
Pages: 145-84
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Publication
27926878 | J:241670
First Author: Davidson D
Year: 2016
Journal: Cell Rep
Title: The Csk-Associated Adaptor PAG Inhibits Effector T Cell Activation in Cooperation with Phosphatase PTPN22 and Dok Adaptors.
Volume: 17
Issue: 10
Pages: 2776-2788
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Publication
2110361 | -
First Author: Kanner SB
Year: 1990
Journal: Proc Natl Acad Sci U S A
Title: Monoclonal antibodies to individual tyrosine-phosphorylated protein substrates of oncogene-encoded tyrosine kinases.
Volume: 87
Issue: 9
Pages: 3328-32
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Protein
Q3URY3
Organism: Mus musculus/domesticus
Length: 213  
Fragment?: false
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Protein
D3YZD3
Organism: Mus musculus/domesticus
Length: 134  
Fragment?: true
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Protein
Q3TLZ9
Organism: Mus musculus/domesticus
Length: 113  
Fragment?: false
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Publication
21852110 | -
First Author: Reinartz S
Year: 2012
Journal: Eur J Cancer
Title: CA125 (MUC16) gene silencing suppresses growth properties of ovarian and breast cancer cells.
Volume: 48
Issue: 10
Pages: 1558-69
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Publication
22542127 | -
First Author: Streppel MM
Year: 2012
Journal: Hum Pathol
Title: Mucin 16 (cancer antigen 125) expression in human tissues and cell lines and correlation with clinical outcome in adenocarcinomas of the pancreas, esophagus, stomach, and colon.
Volume: 43
Issue: 10
Pages: 1755-63
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Publication
8808684 | -
First Author: Nakamura T
Year: 1996
Journal: Oncogene
Title: N-Shc: a neural-specific adapter molecule that mediates signaling from neurotrophin/Trk to Ras/MAPK pathway.
Volume: 13
Issue: 6
Pages: 1111-21
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Publication
16931156 | -
First Author: Kosaka Y
Year: 2006
Journal: Trends Immunol
Title: Itk and Th2 responses: action but no reaction.
Volume: 27
Issue: 10
Pages: 453-60
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Publication
10066823 | -
First Author: Brunati AM
Year: 1999
Journal: J Biol Chem
Title: Molecular features underlying the sequential phosphorylation of HS1 protein and its association with c-Fgr protein-tyrosine kinase.
Volume: 274
Issue: 11
Pages: 7557-64
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Publication
15572145 | -
First Author: Tsai WB
Year: 2005
Journal: Dev Biol
Title: Role of Yes kinase during early zebrafish development.
Volume: 277
Issue: 1
Pages: 129-41
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Publication
12456296 | -
 
First Author: Summy JM
Year: 2003
Journal: Front Biosci
Title: Specificity in signaling by c-Yes.
Volume: 8
Pages: s185-205
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Protein Domain
IPR028521 | PACSIN2
Type: Family
Description: PACSIN2 (protein kinase C and casein kinase substrate in neurons protein 2, also known as Syndapin-2) belongs to the PACSIN family that contains a N-terminal F-BAR (FCH-BAR) domain and a C-terminal SH3 domain []. They are cytoplasmic phosphoproteins that play a role in vesicle formation andtransport []. PACSIN2 interacts with several proteins such as Rac1, dynamin, Neuronal Wiskott-Aldrich Syndrome Protein (N-WASP), and synaptojanin via its C-terminal Src homology 3 (SH3) domain []. PACSIN2 negatively regulates the EGF (epidermal growth factor) receptor activation and signaling [, ]. It plays an important role in caveolae membrane sculpting [].
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Protein Domain
IPR028850 | MUC16
Type: Family
Description: Mucin-16 (also known as CA125) belongs to the mucin family. They are high molecular weight proteins that are components of mucus and are synthesised and secreted by specialised cells of the epithelium (goblet cells, cells of mucous glands) or non mucin-secreting cells []. Mucin-16 is over-expressed in human epithelial tumors including ovarian, breast and digestive tract carcinomas [, ]. Its expression is an independent predictor of poor outcome in pancreatic ductal adenocarcinomas and probably in esophageal adenocarcinomas and gastric adenocarcinomas, being proposed to be used as a prognostic marker and a therapeutic target []. It interacts with Src family kinases (SFKs) and this may affect cell-cell adhesion of epithelial cancer cells [].
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Protein Domain
IPR028848 | BCAR1
Type: Family
Description: Breast cancer anti-estrogen resistance protein 1 (BCAR1, also known as p130Cas) is a member of the Cas (Crk-associated substrate) family of adaptor proteins, which function as key signalling nodes with important regulatory roles in normal and pathological cells [, ]. BCAR1 plays a central coordinating role for tyrosine kinase-based signalling through focal adhesion kinase (FAK) []. It is readily phosphorylated by FAK and Src []. Overexpression of BCAR1 confers anti-estrogen resistance on breast cancer cells []. It regulates the tumour suppressor function of TGF-beta during breast cancer progression through regulation of Smad2/3 activity [].
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Protein Domain
IPR035875 | BMX_SH2
Type: Domain
Description: Cytoplasmic tyrosine-protein kinase BMX (bone marrow tyrosine kinase gene on chromosome X, also known as ETK) is a non-receptor tyrosine kinase (). It plays central but diverse modulator roles in various signalling processes involved in the regulation of actin reorganisation, cell migration, cell proliferation and survival, cell adhesion, and apoptosis [, , ]. It has a role in inflammation, cardiovascular disease, and cancer []. It is activated downstream of phosphatidylinositol-3 kinase (PI3K) and the kinase Src [].This entry represents the SH2 domain of BMX.
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Protein Domain
IPR035693 | Fgr_SH2
Type: Domain
Description: Tyrosine-protein kinase Fgr belongs to the SRC family of the Tyr protein kinases. It is a non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration [, , ]. It contains a protein kinase domain, an SH2 domain and an SH3 domain. Fgr interacts with tyrosine phosphorylated SYK, FLT3 and HCLS1 via its SH2 domain [].This entry represents the SH2 domain of Fgr.
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Protein Domain
IPR046460 | UNC80_C
Type: Domain
Description: This entry represents the C-terminal domain of protein UNC80 from eukaryotes, a component of the NALCN sodium channel complex. NALC is a cation voltage-independent channel activated by substance P, neurotensin, acetylcholine and noradrenaline that controls neuronal excitability. UNC80 forms a complex with UNC79 and both are key regulators of the channel and required for the proper expression and axonal localisation of NALCN. UNC80 is required for NALCN control by GPCRs and essential for its sensitivity to extracellular calcium. This protein acts as a scaffold for Src family of tyrosine kinases (SFK) and UNC-79 to mediate interaction with NALCN [, , ].
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Protein Domain
IPR029593 | Shc3/ShcC/N-Shc
Type: Family
Description: The SH2-containing Shc adapter proteins are targets of activated tyrosine kinases and are implicated in the transmission of activation signals to the Ras/mitogen-activated protein kinase (MAPK) pathway []. Three Shc genes were originally identified in mammals that encode proteins characterised by an amino-terminal phosphotyrosine binding (PTB) domain and a carboxy-terminal Src homology 2 domain. Shc1 (ShcA) is ubiquitously expressed, whereas expression of Shc2 (ShcB) and Shc3 (ShcC) appears to be limited to neuronal cells [].Shc3 (also known as NShc from neuronal Shc) mediates neurotrophin and other neuronal signallings in the central nervous system [, ].
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Protein Domain
IPR042801 | OTOR
Type: Family
Description: Otoraplin, also known as MIAL (MIA-like), is specifically expressed in the cochlea and the vestibule of the inner ear and may contribute to inner ear dysfunction in humans []. It is a member of the MIA family. MIA (melanoma inhibitory activity) family members include MIA, MIAL, MIA2, and MIA3 (also called TANGO). MIA was found to be strongly expressed and secreted by malignant melanomas. It contains a domain that adopts a Src Homology 3 (SH3) domain-like fold; however, it contains an additional antiparallel beta sheet and two disulfide bonds compared to classical SH3 domains. Unlike classical SH3 domains, MIA does not bind proline-rich ligands [, ].
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Protein Domain
IPR027481 | HIV-1_Nef_core_sf
Type: Homologous_superfamily
Description: Human immunodeficiency virus 1 (HIV-1) negative factor (Nef protein) accelerates virulent progression of acquired immunodeficiency syndrome (AIDS) by its interaction with specific cellular proteins involved in signal transduction and host cell activation. Nef has been shown to bind specifically to a subset of the Src family of kinases [].Negative factor (Nef) has a two-domain structure consisting of an N-terminal anchor domain and a core domain separated by a specific cleavage site of the HIV proteases. The N-terminal domain is not compactly folded and constitutes a mobile membrane anchor and a linker to the core domain [, ].
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Protein Domain
IPR027480 | HIV-1_Nef_anchor_sf
Type: Homologous_superfamily
Description: Human immunodeficiency virus 1 (HIV-1) negative factor (Nef protein) accelerates virulent progression of acquired immunodeficiency syndrome (AIDS) by its interaction with specific cellular proteins involved in signal transduction and host cell activation. Nef has been shown to bind specifically to a subset of the Src family of kinases [].Negative factor (Nef) has a two-domain structure consisting of an N-terminal anchor domain and a core domain separated by a specific cleavage site of the HIV proteases. The N-terminal domain is not compactly folded and constitutes a mobile membrane anchor and a linker to the core domain [, ].
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Protein Domain
IPR027331 | CORO7
Type: Family
Description: Coronins belong to the WD40-repeat family, which contains the WD40 motifs that act as the protein-protein interaction sites. There are several isoforms of Coronin in mammalian cells []. This entry represents Coronin 7. Unlike most of the Coronin isoforms, Coronin 7 has not been shown to interact with actin []. Instead, Coronin 7 binds to the outer side of Golgi complex membranes and acts as a mediator of cargo vesicle formation at the trans-Golgi network []. It physically interacts with both the AP-1 adaptor protein complex and the Src kinase [].
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Protein Domain
IPR027654 | Formin_DIAPH3
Type: Family
Description: Protein diaphanous homologue 3 (DIAPH3) belongs to the formin homology family, Diaphanous subfamily (also known as the Diaphanous-related formins, Drfs). In addition to the FH1 and FH2 domains, Drfs contain an N-terminal GTPase-binding domain (mDiaN) and a C-terminal Diaphanous-autoregulatory domain (DAD).DIAPH3 (also known as mDia2, which can be confusing) acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerisation. It is required for cytokinesis, stress fibre formation, and transcriptional activation of the serum response factor []. It couples Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics [].
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Protein Domain
IPR035449 | SH3PXD2A_SH3_3
Type: Domain
Description: This entry represents the third SH3 domain of SH3PXD2A. Tks5, also called SH3 and PX domain-containing protein 2A (SH3PXD2A) or Five SH (FISH), is a scaffolding protein and Src substrate that is localized in podosomes, which are electron-dense structures found in Src-transformed fibroblasts, osteoclasts, macrophages, and some invasive cancer cells [, ]. It binds and regulates some members of the ADAMs family of transmembrane metalloproteases, which function as sheddases and mediators of cell and matrix interactions. It is required for podosome formation, degradation of the extracellular matrix, and cancer cell invasion []. Tks5 contains an N-terminal Phox homology (PX) domain and five SH3 domains.
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Protein Domain
IPR035450 | SH3PXD2A_SH3_1
Type: Domain
Description: This entry represents the first SH3 domain of SH3PXD2A. Tks5, also called SH3 and PX domain-containing protein 2A (SH3PXD2A) or Five SH (FISH), is a scaffolding protein and Src substrate that is localized in podosomes, which are electron-dense structures found in Src-transformed fibroblasts, osteoclasts, macrophages, and some invasive cancer cells [, ]. It binds and regulates some members of the ADAMs family of transmembrane metalloproteases, which function as sheddases and mediators of cell and matrix interactions. It is required for podosome formation, degradation of the extracellular matrix, and cancer cell invasion []. Tks5 contains an N-terminal Phox homology (PX) domain and five SH3 domains.
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Protein Domain
IPR035452 | SH3PXD2A_SH3_2
Type: Domain
Description: This entry represents the second SH3 domain of SH3PXD2A. Tks5, also called SH3 and PX domain-containing protein 2A (SH3PXD2A) or Five SH (FISH), is a scaffolding protein and Src substrate that is localized in podosomes, which are electron-dense structures found in Src-transformed fibroblasts, osteoclasts, macrophages, and some invasive cancer cells [, ]. It binds and regulates some members of the ADAMs family of transmembrane metalloproteases, which function as sheddases and mediators of cell and matrix interactions. It is required for podosome formation, degradation of the extracellular matrix, and cancer cell invasion []. Tks5 contains an N-terminal Phox homology (PX) domain and five SH3 domains.
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Protein Domain
IPR035453 | SH3PXD2A_SH3_4
Type: Domain
Description: This entry represents the fourth SH3 domain of SH3PXD2A. Tks5, also called SH3 and PX domain-containing protein 2A (SH3PXD2A) or Five SH (FISH), is a scaffolding protein and Src substrate that is localized in podosomes, which are electron-dense structures found in Src-transformed fibroblasts, osteoclasts, macrophages, and some invasive cancer cells [, ]. It binds and regulates some members of the ADAMs family of transmembrane metalloproteases, which function as sheddases and mediators of cell and matrix interactions. It is required for podosome formation, degradation of the extracellular matrix, and cancer cell invasion []. Tks5 contains an N-terminal Phox homology (PX) domain and five SH3 domains.
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Protein Domain
IPR035454 | SH3PXD2A_SH3_5
Type: Domain
Description: This entry represents the fifth SH3 domain of SH3PXD2A. Tks5, also called SH3 and PX domain-containing protein 2A (SH3PXD2A) or Five SH (FISH), is a scaffolding protein and Src substrate that is localized in podosomes, which are electron-dense structures found in Src-transformed fibroblasts, osteoclasts, macrophages, and some invasive cancer cells [, ]. It binds and regulates some members of the ADAMs family of transmembrane metalloproteases, which function as sheddases and mediators of cell and matrix interactions. It is required for podosome formation, degradation of the extracellular matrix, and cancer cell invasion []. Tks5 contains an N-terminal Phox homology (PX) domain and five SH3 domains.
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Protein Domain
IPR035554 | Otoraplin_SH3
Type: Domain
Description: Otoraplin, also known as MIAL (MIA-like), is specifically expressed in the cochlea and the vestibule of the inner ear and may contribute to inner ear dysfunction in humans []. It is a member of the MIA family. MIA (melanoma inhibitory activity) family members include MIA, MIAL, MIA2, and MIA3 (also called TANGO). MIA was found to be strongly expressed and secreted by malignant melanomas. It contains a domain that adopts a Src Homology 3 (SH3) domain-like fold; however, it contains an additional antiparallel beta sheet and two disulfide bonds compared to classical SH3 domains. Unlike classical SH3 domains, MIA does not bind proline-rich ligands [, ].
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Protein Domain
IPR035745 | BCAR1_SH3
Type: Domain
Description: Breast cancer anti-estrogen resistance protein 1 (BCAR1, also known as p130Cas) is a member of the Cas (Crk-associated substrate) family of adaptor proteins, which function as key signalling nodes with important regulatory roles in normal and pathological cells [, ]. BCAR1 plays a central coordinating role for tyrosine kinase-based signalling through focal adhesion kinase (FAK) []. It is readily phosphorylated by FAK and Src []. Overexpression of BCAR1 confers anti-estrogen resistance on breast cancer cells []. It regulates the tumour suppressor function of TGF-beta during breast cancer progression through regulation of Smad2/3 activity [].This entry represents the SH3 domain of BCAR1.
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Protein Domain
IPR035751 | Yes_SH3
Type: Domain
Description: Yes kinase (also known as c-Yes) is a member of the Src family of nonreceptor tyrosine kinases []. It is involved in the regulation of cell division, differentiation, survival, motility, adhesion, spreading and vesicular transport []. It plays an important role in epiboly during early development in zebrafish []. Yes kinase contains an SH4 motif responsible for membrane localization, a Unique domain, followed by SH3 and SH2 domains, the protein tyrosine kinases or SH1 domain, and a carboxy terminal regulatory region []. This entry represents the SH3 domain of Yes tyrosine kinase.
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Protein Domain
IPR035512 | CASS4
Type: Family
Description: CASS4, also known as HEPL, is a Cas family member that regulates FAK and cell spreading [].The CAS (Crk-Associated Substrate) protein family is a group of scaffolding proteins that play important modulatory roles in both normal and pathological cell growth regulation. They contain an N-terminal Src homology 3 (SH3) domain and a substrate domain (SD). The SD contains a large number of YxxP motifs, which when phosphorylated by Src-family kinases provide canonical binding sites for proteins containing SH2 domains such as Crk, Crk-L, CRKII [].
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Protein Domain
IPR045852 | UNC80_central
Type: Domain
Description: This entry represents the central region of protein UNC80 from eukaryotes, a component of the NALCN sodium channel complex. NALCN is a cation voltage-independent channel activated by substance P, neurotensin, acetylcholine and noradrenaline that controls neuronal excitability. UNC80 forms a complex with UNC79 and both are key regulators of the channel and required for the proper expression and axonal localisation of NALCN. UNC80 is required for NALCN control by GPCRs and essential for its sensitivity to extracellular calcium. This protein acts as a scaffold for Src family of tyrosine kinases (SFK) and UNC-79 to mediate interaction with NALCN [, , ]. Proteins containing this domain also include some uncharacterised proteins from fungi.
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Publication
16870172 | J:112887
First Author: Mori AD
Year: 2006
Journal: Dev Biol
Title: Tbx5-dependent rheostatic control of cardiac gene expression and morphogenesis.
Volume: 297
Issue: 2
Pages: 566-86
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Publication
8636124 | J:32101
First Author: Malek SN
Year: 1996
Journal: J Biol Chem
Title: p150TSP, a conserved nuclear phosphoprotein that contains multiple tetratricopeptide repeats and binds specifically to SH2 domains.
Volume: 271
Issue: 12
Pages: 6952-62
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Publication
20398064 | J:169648
First Author: Murata Y
Year: 2010
Journal: Genes Cells
Title: Tyrosine phosphorylation of R3 subtype receptor-type protein tyrosine phosphatases and their complex formations with Grb2 or Fyn.
Volume: 15
Issue: 5
Pages: 513-24
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Publication
11477403 | J:227397
First Author: Latour S
Year: 2001
Journal: Nat Immunol
Title: Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product.
Volume: 2
Issue: 8
Pages: 681-90
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Publication
12545173 | J:109313
First Author: Latour S
Year: 2003
Journal: Nat Cell Biol
Title: Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulation.
Volume: 5
Issue: 2
Pages: 149-54
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Publication
16777849 | J:116509
First Author: Liu H
Year: 2006
Journal: J Biol Chem
Title: Physical and functional interaction of Fyn tyrosine kinase with a brain-enriched Rho GTPase-activating protein TCGAP.
Volume: 281
Issue: 33
Pages: 23611-9
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Publication
17623670 | J:124948
First Author: Stuart LM
Year: 2007
Journal: J Biol Chem
Title: CD36 signals to the actin cytoskeleton and regulates microglial migration via a p130Cas complex.
Volume: 282
Issue: 37
Pages: 27392-401
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Publication
23602477 | J:199730
First Author: Cioni JM
Year: 2013
Journal: Curr Biol
Title: SEMA3A signaling controls layer-specific interneuron branching in the cerebellum.
Volume: 23
Issue: 10
Pages: 850-61
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Publication
18089558 | J:134018
First Author: Hoe HS
Year: 2008
Journal: J Biol Chem
Title: Fyn modulation of Dab1 effects on amyloid precursor protein and ApoE receptor 2 processing.
Volume: 283
Issue: 10
Pages: 6288-99
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Publication
31452242 | J:285891
First Author: Liu G
Year: 2019
Journal: J Neurosci Res
Title: Loss of tau and Fyn reduces compensatory effects of MAP2 for tau and reveals a Fyn-independent effect of tau on calcium.
Volume: 97
Issue: 11
Pages: 1393-1413
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Publication
20685990 | J:162849
First Author: Ohnishi H
Year: 2010
Journal: J Neurosci
Title: Stress-evoked tyrosine phosphorylation of signal regulatory protein α regulates behavioral immobility in the forced swim test.
Volume: 30
Issue: 31
Pages: 10472-83
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Publication
15240808 | J:97273
First Author: Li C
Year: 2004
Journal: J Neurosci
Title: Correlation between semaphorin3A-induced facilitation of axonal transport and local activation of a translation initiation factor eukaryotic translation initiation factor 4E.
Volume: 24
Issue: 27
Pages: 6161-70
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Publication
25157091 | J:249495
First Author: Samovski D
Year: 2015
Journal: Diabetes
Title: Regulation of AMPK activation by CD36 links fatty acid uptake to β-oxidation.
Volume: 64
Issue: 2
Pages: 353-9
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Publication
22539787 | J:188741
First Author: Ueda A
Year: 2012
Journal: J Immunol
Title: Fyn promotes Th17 differentiation by regulating the kinetics of RORγt and Foxp3 expression.
Volume: 188
Issue: 11
Pages: 5247-56
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Publication
16339032 | J:103750
First Author: Macdonald DS
Year: 2005
Journal: J Neurosci
Title: Modulation of NMDA receptors by pituitary adenylate cyclase activating peptide in CA1 neurons requires G alpha q, protein kinase C, and activation of Src.
Volume: 25
Issue: 49
Pages: 11374-84
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Publication
16880206 | J:116928
First Author: Tan AH
Year: 2006
Journal: J Biol Chem
Title: Regulation of mouse inducible costimulator (ICOS) expression by Fyn-NFATc2 and ERK signaling in T cells.
Volume: 281
Issue: 39
Pages: 28666-78
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Publication
18981123 | J:140940
First Author: Wong NK
Year: 2008
Journal: J Immunol
Title: CD45 down-regulates Lck-mediated CD44 signaling and modulates actin rearrangement in T cells.
Volume: 181
Issue: 10
Pages: 7033-43
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Publication
9079653 | J:152668
First Author: Beggs HE
Year: 1997
Journal: J Biol Chem
Title: NCAM140 interacts with the focal adhesion kinase p125(fak) and the SRC-related tyrosine kinase p59(fyn).
Volume: 272
Issue: 13
Pages: 8310-9
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Publication
18025162 | J:133009
First Author: El Kasmi KC
Year: 2007
Journal: J Immunol
Title: Cutting edge: A transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway.
Volume: 179
Issue: 11
Pages: 7215-9
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Publication
20576809 | J:185927
First Author: Wu F
Year: 2010
Journal: J Am Soc Nephrol
Title: Anion exchanger 1 interacts with nephrin in podocytes.
Volume: 21
Issue: 9
Pages: 1456-67
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Publication
25143441 | J:267164
First Author: Patton DT
Year: 2014
Journal: J Immunol
Title: The survival and differentiation of pro-B and pre-B cells in the bone marrow is dependent on IL-7Rα Tyr449.
Volume: 193
Issue: 7
Pages: 3446-55
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Publication
21435447 | J:169853
First Author: Yin S
Year: 2011
Journal: Am J Pathol
Title: Enhanced liver regeneration in IL-10-deficient mice after partial hepatectomy via stimulating inflammatory response and activating hepatocyte STAT3.
Volume: 178
Issue: 4
Pages: 1614-21
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Publication
23189186 | J:195005
First Author: Plumb AW
Year: 2012
Journal: PLoS One
Title: Interleukin-7, but not thymic stromal lymphopoietin, plays a key role in the T cell response to influenza A virus.
Volume: 7
Issue: 11
Pages: e50199
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Publication
25063867 | J:317747
First Author: Feng D
Year: 2014
Journal: J Immunol
Title: Acute and chronic effects of IL-22 on acetaminophen-induced liver injury.
Volume: 193
Issue: 5
Pages: 2512-8
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Publication
39796680 | J:361323
 
First Author: Slusny B
Year: 2024
Journal: Cancers (Basel)
Title: Optimized Spheroid Model of Pancreatic Cancer Demonstrates Influence of Macrophage-T Cell Interaction for Intratumoral T Cell Motility.
Volume: 17
Issue: 1
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Publication
18577706 | J:138893
First Author: Cohen PA
Year: 2008
Journal: Blood
Title: STAT3- and STAT5-dependent pathways competitively regulate the pan-differentiation of CD34pos cells into tumor-competent dendritic cells.
Volume: 112
Issue: 5
Pages: 1832-43
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Publication
19509418 | J:153461
First Author: Zhang W
Year: 2009
Journal: J Biol Chem
Title: Negative regulation of Stat3 by activating PTPN11 mutants contributes to the pathogenesis of Noonan syndrome and juvenile myelomonocytic leukemia.
Volume: 284
Issue: 33
Pages: 22353-63
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Publication
25962121 | J:228459
First Author: Schiffer M
Year: 2015
Journal: Nat Med
Title: Pharmacological targeting of actin-dependent dynamin oligomerization ameliorates chronic kidney disease in diverse animal models.
Volume: 21
Issue: 6
Pages: 601-9
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Publication
28652396 | J:251506
First Author: Ye J
Year: 2017
Journal: J Immunol
Title: TLR7 Signaling Regulates Th17 Cells and Autoimmunity: Novel Potential for Autoimmune Therapy.
Volume: 199
Issue: 3
Pages: 941-954
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Publication
26673325 | J:269853
First Author: Alejandro EU
Year: 2015
Journal: Cell Rep
Title: Disruption of O-linked N-Acetylglucosamine Signaling Induces ER Stress and β Cell Failure.
Volume: 13
Issue: 11
Pages: 2527-2538
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Publication
25887956 | J:323141
 
First Author: Liao F
Year: 2015
Journal: Mol Neurodegener
Title: Effects of CD2-associated protein deficiency on amyloid-β in neuroblastoma cells and in an APP transgenic mouse model.
Volume: 10
Pages: 12
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Publication
25968128 | J:250305
 
First Author: Brunskill EW
Year: 2015
Journal: BMC Nephrol
Title: Pathogenic pathways are activated in each major cell type of the glomerulus in the Cd2ap mutant mouse model of focal segmental glomerulosclerosis.
Volume: 16
Pages: 71
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Publication
19233194 | J:149164
First Author: Luckey SW
Year: 2009
Journal: J Mol Cell Cardiol
Title: The role of Akt/GSK-3beta signaling in familial hypertrophic cardiomyopathy.
Volume: 46
Issue: 5
Pages: 739-47
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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