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Search results 4301 to 4400 out of 6467 for Myc

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Type Details Score
Publication
38065069 | J:344656
First Author: Luo H
Year: 2023
Journal: Cell Stem Cell
Title: SON is an essential m(6)A target for hematopoietic stem cell fate.
Volume: 30
Issue: 12
Pages: 1658-1673.e10
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Publication
34669700 | J:324060
First Author: Carroll PA
Year: 2021
Journal: PLoS Biol
Title: The glucose-sensing transcription factor MLX balances metabolism and stress to suppress apoptosis and maintain spermatogenesis.
Volume: 19
Issue: 10
Pages: e3001085
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Publication
32442396 | J:309387
First Author: Gambini A
Year: 2020
Journal: Dev Cell
Title: Developmentally Programmed Tankyrase Activity Upregulates β-Catenin and Licenses Progression of Embryonic Genome Activation.
Volume: 53
Issue: 5
Pages: 545-560.e7
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Publication
29636449 | J:261937
First Author: Mirzamohammadi F
Year: 2018
Journal: Nat Commun
Title: Distinct molecular pathways mediate Mycn and Myc-regulated miR-17-92 microRNA action in Feingold syndrome mouse models.
Volume: 9
Issue: 1
Pages: 1352
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Publication
28957681 | J:253246
First Author: Clements MP
Year: 2017
Journal: Neuron
Title: The Wound Microenvironment Reprograms Schwann Cells to Invasive Mesenchymal-like Cells to Drive Peripheral Nerve Regeneration.
Volume: 96
Issue: 1
Pages: 98-114.e7
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Publication
14966287 | J:88188
First Author: Murphy DJ
Year: 2004
Journal: Mol Cell Biol
Title: Id2 is dispensable for Myc-induced epidermal neoplasia.
Volume: 24
Issue: 5
Pages: 2083-90
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Publication
32694718 | J:301643
First Author: Ostermann AL
Year: 2019
Journal: Nat Metab
Title: Intestinal insulin/IGF1 signalling through FoxO1 regulates epithelial integrity and susceptibility to colon cancer.
Volume: 1
Issue: 3
Pages: 371-389
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Publication
17013838 | J:114516
First Author: Roh M
Year: 2006
Journal: Genesis
Title: Transgenic mice for Cre-inducible overexpression of the oncogenes c-MYC and Pim-1 in multiple tissues.
Volume: 44
Issue: 10
Pages: 447-53
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Publication
35393570 | J:349055
First Author: Fang L
Year: 2022
Journal: Cancer Gene Ther
Title: TMPRSS2-ERG promotes the initiation of prostate cancer by suppressing oncogene-induced senescence.
Volume: 29
Issue: 10
Pages: 1463-1476
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Publication
33168647 | J:300113
First Author: Farria AT
Year: 2020
Journal: Cancer Res
Title: Transcriptional Activation of MYC-Induced Genes by GCN5 Promotes B-cell Lymphomagenesis.
Volume: 80
Issue: 24
Pages: 5543-5553
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Publication
28737488 | J:258214
   
First Author: Wells AC
Year: 2017
Journal: Elife
Title: Modulation of let-7 miRNAs controls the differentiation of effector CD8 T cells.
Volume: 6
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Publication
28423341 | J:259281
First Author: Mak TW
Year: 2017
Journal: Immunity
Title: Glutathione Primes T Cell Metabolism for Inflammation.
Volume: 46
Issue: 4
Pages: 675-689
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Publication
21075312 | J:166830
First Author: Gan B
Year: 2010
Journal: Cancer Cell
Title: FoxOs enforce a progression checkpoint to constrain mTORC1-activated renal tumorigenesis.
Volume: 18
Issue: 5
Pages: 472-84
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Publication
26634297 | J:228317
 
First Author: Muthukrishnan SD
Year: 2015
Journal: Nat Commun
Title: Concurrent BMP7 and FGF9 signalling governs AP-1 function to promote self-renewal of nephron progenitor cells.
Volume: 6
Pages: 10027
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Publication
2537153 | J:79624
First Author: van Lohuizen M
Year: 1989
Journal: Cell
Title: Predisposition to lymphomagenesis in pim-1 transgenic mice: cooperation with c-myc and N-myc in murine leukemia virus-induced tumors.
Volume: 56
Issue: 4
Pages: 673-82
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Publication
25199831 | J:232462
First Author: Villa Del Campo C
Year: 2014
Journal: Cell Rep
Title: Cell competition promotes phenotypically silent cardiomyocyte replacement in the mammalian heart.
Volume: 8
Issue: 6
Pages: 1741-1751
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Publication
22206758 | J:182713
First Author: McDonel P
Year: 2012
Journal: Dev Biol
Title: Sin3a is essential for the genome integrity and viability of pluripotent cells.
Volume: 363
Issue: 1
Pages: 62-73
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Publication
34169837 | J:307679
   
First Author: Shani O
Year: 2021
Journal: Elife
Title: Evolution of fibroblasts in the lung metastatic microenvironment is driven by stage-specific transcriptional plasticity.
Volume: 10
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Publication
31797926 | J:285635
First Author: Shu Y
Year: 2019
Journal: Nat Commun
Title: Renewed proliferation in adult mouse cochlea and regeneration of hair cells.
Volume: 10
Issue: 1
Pages: 5530
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Publication
37733590 | J:341961
First Author: Zhang Y
Year: 2023
Journal: Cell Rep
Title: Hyperpolarization-activated cyclic nucleotide-gated cation channel 3 promotes HCC development in a female-biased manner.
Volume: 42
Issue: 10
Pages: 113157
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Publication
31875547 | J:292171
First Author: Apicco DJ
Year: 2019
Journal: Cell Rep
Title: Dysregulation of RNA Splicing in Tauopathies.
Volume: 29
Issue: 13
Pages: 4377-4388.e4
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Publication
23153536 | J:194098
First Author: Qing G
Year: 2012
Journal: Cancer Cell
Title: ATF4 regulates MYC-mediated neuroblastoma cell death upon glutamine deprivation.
Volume: 22
Issue: 5
Pages: 631-44
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Publication
37310381 | J:336672
 
First Author: Litzler LC
Year: 2023
Journal: J Exp Med
Title: Protein arginine methyltransferase 1 regulates B cell fate after positive selection in the germinal center in mice.
Volume: 220
Issue: 9
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Publication
30860479 | J:275991
   
First Author: Francesconi M
Year: 2019
Journal: Elife
Title: Single cell RNA-seq identifies the origins of heterogeneity in efficient cell transdifferentiation and reprogramming.
Volume: 8
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Publication
22225880 | J:182320
First Author: Le A
Year: 2012
Journal: Cell Metab
Title: Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells.
Volume: 15
Issue: 1
Pages: 110-21
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Publication
24394663 | J:208690
First Author: Roderick JE
Year: 2014
Journal: Blood
Title: c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells.
Volume: 123
Issue: 7
Pages: 1040-50
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Publication
34648327 | J:314931
First Author: Conner JM
Year: 2021
Journal: Science
Title: Modulation of tactile feedback for the execution of dexterous movement.
Volume: 374
Issue: 6565
Pages: 316-323
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Publication
21709672 | J:175910
First Author: Mduff FK
Year: 2011
Journal: Lab Invest
Title: Determining the contribution of NPM1 heterozygosity to NPM-ALK-induced lymphomagenesis.
Volume: 91
Issue: 9
Pages: 1298-303
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Publication
37863903 | J:341957
First Author: Lobón-Iglesias MJ
Year: 2023
Journal: Nat Commun
Title: Imaging and multi-omics datasets converge to define different neural progenitor origins for ATRT-SHH subgroups.
Volume: 14
Issue: 1
Pages: 6669
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Publication
31447265 | J:284132
First Author: Murakami S
Year: 2019
Journal: Dev Cell
Title: A Yap-Myc-Sox2-p53 Regulatory Network Dictates Metabolic Homeostasis and Differentiation in Kras-Driven Pancreatic Ductal Adenocarcinomas.
Volume: 51
Issue: 1
Pages: 113-128.e9
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Publication
26908355 | J:231688
First Author: Sarris ME
Year: 2016
Journal: Cancer Cell
Title: Smyd3 Is a Transcriptional Potentiator of Multiple Cancer-Promoting Genes and Required for Liver and Colon Cancer Development.
Volume: 29
Issue: 3
Pages: 354-66
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Publication
28650479 | J:246516
First Author: Zhou F
Year: 2017
Journal: Nat Cell Biol
Title: AML1-ETO requires enhanced C/D box snoRNA/RNP formation to induce self-renewal and leukaemia.
Volume: 19
Issue: 7
Pages: 844-855
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Publication
31204175 | J:301448
First Author: Hashimoto M
Year: 2019
Journal: Dev Cell
Title: Epiblast Formation by TEAD-YAP-Dependent Expression of Pluripotency Factors and Competitive Elimination of Unspecified Cells.
Volume: 50
Issue: 2
Pages: 139-154.e5
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Publication
34402854 | J:338279
 
First Author: Grenov AC
Year: 2021
Journal: J Exp Med
Title: The germinal center reaction depends on RNA methylation and divergent functions of specific methyl readers.
Volume: 218
Issue: 10
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Publication
10094394 | J:53821
First Author: Xu X
Year: 1999
Journal: Mol Cell Biochem
Title: Murine protein kinase CK2: gene and oncogene.
Volume: 191
Issue: 1-2
Pages: 65-74
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Publication
22195962 | J:196247
First Author: Hitosugi T
Year: 2011
Journal: Mol Cell
Title: Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism.
Volume: 44
Issue: 6
Pages: 864-77
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Publication
6422467 | J:7359
First Author: Wiener F
Year: 1984
Journal: Proc Natl Acad Sci U S A
Title: Hemizygous interstitial deletion of chromosome 15 (band D) in three translocation-negative murine plasmacytomas.
Volume: 81
Issue: 4
Pages: 1159-63
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Publication
6324081 | J:7393
First Author: Harris LJ
Year: 1983
Journal: Nucleic Acids Res
Title: c-myc Gene rearrangements involving gamma immunoglobulin heavy chain gene switch regions in murine plasmacytomas.
Volume: 11
Issue: 23
Pages: 8303-15
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Publication
2537150 | J:9615
First Author: Wright WE
Year: 1989
Journal: Cell
Title: Myogenin, a factor regulating myogenesis, has a domain homologous to MyoD.
Volume: 56
Issue: 4
Pages: 607-17
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Publication
2653809 | J:9745
First Author: van Lohuizen M
Year: 1989
Journal: EMBO J
Title: N-myc is frequently activated by proviral insertion in MuLV-induced T cell lymphomas.
Volume: 8
Issue: 1
Pages: 133-6
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Publication
1728975 | J:1865
First Author: Kitajima T
Year: 1992
Journal: Clin Immunol Immunopathol
Title: Histological detection of c-myb and c-myc proto-oncogene expression in infiltrating cells in cutaneous lupus erythematosus-like lesions of MRL/l mice by in situ hybridization.
Volume: 62
Issue: 1 Pt 1
Pages: 119-23
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Publication
7829091 | J:20739
First Author: Shapiro DN
Year: 1994
Journal: Genomics
Title: Assignment of the human MAD and MXI1 genes to chromosomes 2p12-p13 and 10q24-q25.
Volume: 23
Issue: 1
Pages: 282-5
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Publication
7829250 | J:24059
First Author: Greene DR
Year: 1995
Journal: Int J Cancer
Title: DNA ploidy and clonal selection in ras + myc-induced mouse prostate cancer.
Volume: 60
Issue: 3
Pages: 395-9
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Publication
8601779 | J:33354
 
First Author: Stewart M
Year: 1996
Journal: J Gen Virol
Title: til-1: a novel proviral insertion locus for Moloney murine leukaemia virus in lymphomas of CD2-myc transgenic mice.
Volume: 77 ( Pt 3)
Pages: 443-6
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Publication
9303076 | J:43883
First Author: Lumniczky K
Year: 1997
Journal: Radiat Oncol Investig
Title: Oncogenic changes in murine lymphoid tumors induced by in utero exposure to ionizing radiation.
Volume: 5
Issue: 3
Pages: 158-62
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Publication
9310239 | J:42875
First Author: Webster G
Year: 1997
Journal: Br J Cancer
Title: Skewed T-cell receptor Vbeta8.2 expression in transgenic CD2-myc induced thymic lymphoma: a role for antigen stimulation in tumour development?
Volume: 76
Issue: 6
Pages: 739-46
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Publication
9311610 | J:42799
First Author: Pumphrey JG
Year: 1997
Journal: Int J Cancer
Title: Characterization of C57BL/6 plasmacytomas lacking a c-myc translocation.
Volume: 72
Issue: 5
Pages: 892-7
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Publication
9819439 | J:51059
First Author: Voeltz GK
Year: 1998
Journal: Mol Cell Biol
Title: AUUUA sequences direct mRNA deadenylation uncoupled from decay during Xenopus early development.
Volume: 18
Issue: 12
Pages: 7537-45
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Publication
14498825 | J:86086
First Author: Pelengaris S
Year: 2003
Journal: Expert Opin Ther Targets
Title: The c-MYC oncoprotein as a treatment target in cancer and other disorders of cell growth.
Volume: 7
Issue: 5
Pages: 623-42
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Publication
15082916 | J:90196
First Author: Jamerson MH
Year: 2004
Journal: J Mammary Gland Biol Neoplasia
Title: Of mice and Myc: c-Myc and mammary tumorigenesis.
Volume: 9
Issue: 1
Pages: 27-37
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Publication
14996726 | J:88831
First Author: Prince S
Year: 2004
Journal: Cancer Res
Title: Tbx2 directly represses the expression of the p21(WAF1) cyclin-dependent kinase inhibitor.
Volume: 64
Issue: 5
Pages: 1669-74
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Publication
15927364 | J:100601
First Author: Slack A
Year: 2005
Journal: Cancer Lett
Title: MDM2 as MYCN transcriptional target: implications for neuroblastoma pathogenesis.
Volume: 228
Issue: 1-2
Pages: 21-7
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Publication
7898919 | J:101799
First Author: Lindeman GJ
Year: 1995
Journal: Oncogene
Title: Overexpressed max is not oncogenic and attenuates myc-induced lymphoproliferation and lymphomagenesis in transgenic mice.
Volume: 10
Issue: 5
Pages: 1013-7
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Publication
2657573 | J:102026
First Author: Alexander WS
Year: 1989
Journal: Oncogene
Title: Lymphomagenesis in E mu-myc transgenic mice can involve ras mutations.
Volume: 4
Issue: 5
Pages: 575-81
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Publication
11739276 | J:134940
First Author: Xiao G
Year: 2001
Journal: Circ Res
Title: Inducible activation of c-Myc in adult myocardium in vivo provokes cardiac myocyte hypertrophy and reactivation of DNA synthesis.
Volume: 89
Issue: 12
Pages: 1122-9
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Publication
19805518 | J:154987
First Author: Fernandez-Sanchez ME
Year: 2009
Journal: Mol Cell Biol
Title: S-adenosyl homocysteine hydrolase is required for Myc-induced mRNA cap methylation, protein synthesis, and cell proliferation.
Volume: 29
Issue: 23
Pages: 6182-91
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Publication
19934336 | J:155050
First Author: Ruggero D
Year: 2009
Journal: Cancer Res
Title: The role of Myc-induced protein synthesis in cancer.
Volume: 69
Issue: 23
Pages: 8839-43
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Publication
20308430 | J:158803
First Author: Herkert B
Year: 2010
Journal: J Cell Biol
Title: The Arf tumor suppressor protein inhibits Miz1 to suppress cell adhesion and induce apoptosis.
Volume: 188
Issue: 6
Pages: 905-18
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Publication
21035406 | J:166716
First Author: Rakhra K
Year: 2010
Journal: Cancer Cell
Title: CD4(+) T cells contribute to the remodeling of the microenvironment required for sustained tumor regression upon oncogene inactivation.
Volume: 18
Issue: 5
Pages: 485-98
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Publication
21997212 | J:177509
First Author: Yim HC
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: A role for c-Myc in regulating anti-mycobacterial responses.
Volume: 108
Issue: 43
Pages: 17749-54
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Publication
22431589 | J:182657
First Author: Suh SS
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: MicroRNAs/TP53 feedback circuitry in glioblastoma multiforme.
Volume: 109
Issue: 14
Pages: 5316-21
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Publication
22314321 | J:183679
First Author: Hakim O
Year: 2012
Journal: Nature
Title: DNA damage defines sites of recurrent chromosomal translocations in B lymphocytes.
Volume: 484
Issue: 7392
Pages: 69-74
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Publication
23832660 | J:199229
First Author: Sur I
Year: 2013
Journal: Cancer Res
Title: Lessons from functional analysis of genome-wide association studies.
Volume: 73
Issue: 14
Pages: 4180-4
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Publication
24361252 | J:205909
First Author: Das PP
Year: 2014
Journal: Mol Cell
Title: Distinct and combinatorial functions of Jmjd2b/Kdm4b and Jmjd2c/Kdm4c in mouse embryonic stem cell identity.
Volume: 53
Issue: 1
Pages: 32-48
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Publication
37980563 | J:353096
First Author: Ohara Y
Year: 2023
Journal: Cell Rep
Title: SERPINB3-MYC axis induces the basal-like/squamous subtype and enhances disease progression in pancreatic cancer.
Volume: 42
Issue: 12
Pages: 113434
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Publication
25561493 | J:217370
First Author: Lavagnolli T
Year: 2015
Journal: Genes Dev
Title: Initiation and maintenance of pluripotency gene expression in the absence of cohesin.
Volume: 29
Issue: 1
Pages: 23-38
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Publication
26302406 | J:227348
First Author: Kourtidis A
Year: 2015
Journal: Nat Cell Biol
Title: Distinct E-cadherin-based complexes regulate cell behaviour through miRNA processing or Src and p120 catenin activity.
Volume: 17
Issue: 9
Pages: 1145-57
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Publication
27025988 | J:236826
 
First Author: Suzuki A
Year: 2016
Journal: Nat Commun
Title: Loss of MAX results in meiotic entry in mouse embryonic and germline stem cells.
Volume: 7
Pages: 11056
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Publication
27566402 | J:238282
First Author: Anderson S
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: MYC-nick promotes cell migration by inducing fascin expression and Cdc42 activation.
Volume: 113
Issue: 37
Pages: E5481-90
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Publication
28249162 | J:255858
First Author: Hogg SJ
Year: 2017
Journal: Cell Rep
Title: BET-Bromodomain Inhibitors Engage the Host Immune System and Regulate Expression of the Immune Checkpoint Ligand PD-L1.
Volume: 18
Issue: 9
Pages: 2162-2174
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Publication
28591571 | J:254574
First Author: Percharde M
Year: 2017
Journal: Cell Rep
Title: Global Hypertranscription in the Mouse Embryonic Germline.
Volume: 19
Issue: 10
Pages: 1987-1996
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Publication
29358508 | J:257788
First Author: Rickman DS
Year: 2018
Journal: Cancer Discov
Title: The Expanding World of N-MYC-Driven Tumors.
Volume: 8
Issue: 2
Pages: 150-163
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Publication
29429824 | J:258773
First Author: Zhang S
Year: 2018
Journal: Dev Cell
Title: The Polyploid State Plays a Tumor-Suppressive Role in the Liver.
Volume: 44
Issue: 4
Pages: 447-459.e5
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Publication
29720585 | J:262915
First Author: Hyrenius-Wittsten A
Year: 2018
Journal: Nat Commun
Title: De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia.
Volume: 9
Issue: 1
Pages: 1770
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Publication
22253711 | J:264943
First Author: Manganelli G
Year: 2012
Journal: PLoS One
Title: Modulation of the pentose phosphate pathway induces endodermal differentiation in embryonic stem cells.
Volume: 7
Issue: 1
Pages: e29321
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Publication
30013107 | J:269971
First Author: Mai T
Year: 2018
Journal: Nat Cell Biol
Title: NKX3-1 is required for induced pluripotent stem cell reprogramming and can replace OCT4 in mouse and human iPSC induction.
Volume: 20
Issue: 8
Pages: 900-908
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Publication
32117244 | J:304154
 
First Author: Honjo K
Year: 2020
Journal: Front Immunol
Title: Fc Receptor-Like 6 (FCRL6) Discloses Progenitor B Cell Heterogeneity That Correlates With Pre-BCR Dependent and Independent Pathways of Natural Antibody Selection.
Volume: 11
Pages: 82
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Publication
34162555 | J:314917
 
First Author: Ballabio C
Year: 2021
Journal: Sci Adv
Title: Notch1 switches progenitor competence in inducing medulloblastoma.
Volume: 7
Issue: 26
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Publication
34788095 | J:315124
First Author: Heino S
Year: 2021
Journal: Sci Adv
Title: Lef1 restricts ectopic crypt formation and tumor cell growth in intestinal adenomas.
Volume: 7
Issue: 47
Pages: eabj0512
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Publication
34907175 | J:317485
First Author: Almeida ARM
Year: 2021
Journal: Nat Commun
Title: Interleukin-7 receptor α mutational activation can initiate precursor B-cell acute lymphoblastic leukemia.
Volume: 12
Issue: 1
Pages: 7268
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Publication
36201590 | J:330279
First Author: Yanchus C
Year: 2022
Journal: Science
Title: A noncoding single-nucleotide polymorphism at 8q24 drives IDH1-mutant glioma formation.
Volume: 378
Issue: 6615
Pages: 68-78
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Publication
36446869 | J:331703
First Author: Kameda T
Year: 2022
Journal: Commun Biol
Title: CARD11 mutation and HBZ expression induce lymphoproliferative disease and adult T-cell leukemia/lymphoma.
Volume: 5
Issue: 1
Pages: 1309
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Publication
36608116 | J:352157
First Author: Piol D
Year: 2023
Journal: Sci Adv
Title: Antagonistic effect of cyclin-dependent kinases and a calcium-dependent phosphatase on polyglutamine-expanded androgen receptor toxic gain of function.
Volume: 9
Issue: 1
Pages: eade1694
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Publication
36473869 | J:331870
First Author: Kameda-Smith MM
Year: 2022
Journal: Nat Commun
Title: Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma.
Volume: 13
Issue: 1
Pages: 7506
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Publication
37844756 | J:341958
 
First Author: Jing T
Year: 2023
Journal: Cancer Lett
Title: POH1 facilitates pancreatic carcinogenesis through MYC-driven acinar-to-ductal metaplasia and is a potential therapeutic target.
Volume: 577
Pages: 216444
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Publication
37804507 | J:358034
First Author: Yu T
Year: 2023
Journal: Cell Rep
Title: TRIM11 attenuates Treg cell differentiation by p62-selective autophagic degradation of AIM2.
Volume: 42
Issue: 10
Pages: 113231
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Publication
37673892 | J:355389
First Author: Antal CE
Year: 2023
Journal: Nat Commun
Title: A super-enhancer-regulated RNA-binding protein cascade drives pancreatic cancer.
Volume: 14
Issue: 1
Pages: 5195
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Publication
38493213 | J:346385
First Author: Ye M
Year: 2024
Journal: Nat Commun
Title: Therapeutic targeting nudix hydrolase 1 creates a MYC-driven metabolic vulnerability.
Volume: 15
Issue: 1
Pages: 2377
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Publication
39198404 | J:353581
First Author: Graham MK
Year: 2024
Journal: Nat Commun
Title: Convergent alterations in the tumor microenvironment of MYC-driven human and murine prostate cancer.
Volume: 15
Issue: 1
Pages: 7414
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Publication
37546418 | J:358411
 
First Author: Murti K
Year: 2023
Journal: Front Oncol
Title: Calcineurin-independent NFATc1 signaling is essential for survival of Burkitt lymphoma cells.
Volume: 13
Pages: 1205788
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Publication
39025963 | J:361561
First Author: Nguyen HT
Year: 2024
Journal: Nat Immunol
Title: Gα13 restricts nutrient driven proliferation in mucosal germinal centers.
Volume: 25
Issue: 9
Pages: 1718-1730
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Publication
- | J:17651
 
First Author: Beechey CV
Year: 1987
Journal: Mouse News Lett
Title: T(4;9)45H
Volume: 78
Pages: 50-1
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Protein
P28574
Organism: Mus musculus/domesticus
Length: 160  
Fragment?: false
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Protein Coding Gene
MGI:96921 | Max
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
10318877 | -
First Author: Grossberger R
Year: 1999
Journal: J Biol Chem
Title: Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex.
Volume: 274
Issue: 20
Pages: 14500-7
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Publication
11524682 | -
First Author: Wendt KS
Year: 2001
Journal: Nat Struct Biol
Title: Crystal structure of the APC10/DOC1 subunit of the human anaphase-promoting complex.
Volume: 8
Issue: 9
Pages: 784-8
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Protein Domain
IPR004939 | APC_su10/DOC_dom
Type: Domain
Description: The anaphase-promoting complex (APC) or cyclosome is a multi-subunit E3 protein ubiquitin ligase that regulates important events in mitosis, such as the initiation of anaphase and exit from telophase. The APC, in conjunction with other enzymes, assembles multi-ubiquitin chains on a variety of regulatory proteins, thereby targeting them for proteolysis by the 26S proteasome [].One of the subunits of the APC that is required for ubiquitination activity is APC10, a one-domain protein homologous to a sequence element, termed the DOC domain, found in several hypothetical proteins that may also mediate ubiquitination reactions, because they contain combinations of either RING finger (see ), cullin (see ) or HECT (see ) domains [, , ].The DOC domain consists of a β-sandwich, in which a five-stranded antiparallel β-sheet is packed on top of a three stranded antiparallel β-sheet, exhibiting a 'jellyroll' fold [, ].Proteins known to contain a DOC domain include:Eucaryotic Doc1/Apc10.Mammalian protein associated with the transcription factor Myc (PAM).Mouse runty-jerky-sterile (RJS) protein.Human HERC2, the ortholog of RJS.
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Protein
O35185
Organism: Mus musculus/domesticus
Length: 411  
Fragment?: false
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Protein
Q99PV5
Organism: Mus musculus/domesticus
Length: 410  
Fragment?: false
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Protein
Q61657
Organism: Mus musculus/domesticus
Length: 175  
Fragment?: false
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