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Search results 4301 to 4400 out of 8321 for Src

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Type Details Score
Publication
First Author: Liao Z
Year: 2015
Journal: Blood
Title: Interaction of kindlin-2 with integrin β3 promotes outside-in signaling responses by the αVβ3 vitronectin receptor.
Volume: 125
Issue: 12
Pages: 1995-2004
Strain
Attribute String: congenic, mutant strain, transgenic, major histocompatibility congenic
Publication
First Author: Li Y
Year: 1995
Journal: J Leukoc Biol
Title: Differential regulation of fyn-associated protein tyrosine kinase activity by macrophage colony-stimulating factor (M-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF).
Volume: 57
Issue: 3
Pages: 484-90
Publication
First Author: Huang T
Year: 2014
Journal: Dev Biol
Title: BDNF and NT4 play interchangeable roles in gustatory development.
Volume: 386
Issue: 2
Pages: 308-20
Publication
First Author: Castro DS
Year: 2011
Journal: Genes Dev
Title: A novel function of the proneural factor Ascl1 in progenitor proliferation identified by genome-wide characterization of its targets.
Volume: 25
Issue: 9
Pages: 930-45
Publication
First Author: Lickert H
Year: 2005
Journal: Development
Title: Dissecting Wnt/beta-catenin signaling during gastrulation using RNA interference in mouse embryos.
Volume: 132
Issue: 11
Pages: 2599-609
Publication  
First Author: Li H
Year: 2019
Journal: Development
Title: The molecular anatomy of mammalian upper lip and primary palate fusion at single cell resolution.
Volume: 146
Issue: 12
Publication
First Author: Tripathi P
Year: 2012
Journal: J Am Soc Nephrol
Title: Absence of canonical Smad signaling in ureteral and bladder mesenchyme causes ureteropelvic junction obstruction.
Volume: 23
Issue: 4
Pages: 618-28
Publication
First Author: Galazo MJ
Year: 2023
Journal: Cell Rep
Title: Tle4 controls both developmental acquisition and early post-natal maturation of corticothalamic projection neuron identity.
Volume: 42
Issue: 8
Pages: 112957
Publication
First Author: Fujimoto M
Year: 2008
Journal: J Biol Chem
Title: Analysis of HSF4 binding regions reveals its necessity for gene regulation during development and heat shock response in mouse lenses.
Volume: 283
Issue: 44
Pages: 29961-70
Publication
First Author: Takase H
Year: 2012
Journal: Blood
Title: Genome-wide identification of endothelial cell-enriched genes in the mouse embryo.
Volume: 120
Issue: 4
Pages: 914-23
Publication
First Author: Rendtorff ND
Year: 2001
Journal: Genomics
Title: Identification and characterization of an inner ear-expressed human melanoma inhibitory activity (MIA)-like gene (MIAL) with a frequent polymorphism that abolishes translation.
Volume: 71
Issue: 1
Pages: 40-52
Publication
First Author: Lu B
Year: 2010
Journal: Neuron
Title: Extracellular calcium controls background current and neuronal excitability via an UNC79-UNC80-NALCN cation channel complex.
Volume: 68
Issue: 3
Pages: 488-99
Publication
First Author: Geyer M
Year: 1999
Journal: J Mol Biol
Title: Structure of the anchor-domain of myristoylated and non-myristoylated HIV-1 Nef protein.
Volume: 289
Issue: 1
Pages: 123-38
Publication
First Author: Freund J
Year: 1994
Journal: Eur J Biochem
Title: Stability and proteolytic domains of Nef protein from human immunodeficiency virus (HIV) type 1.
Volume: 221
Issue: 2
Pages: 811-9
Publication
First Author: Wendt MK
Year: 2009
Journal: J Biol Chem
Title: p130Cas is required for mammary tumor growth and transforming growth factor-beta-mediated metastasis through regulation of Smad2/3 activity.
Volume: 284
Issue: 49
Pages: 34145-56
Publication
First Author: Marcotte DJ
Year: 2010
Journal: Protein Sci
Title: Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases.
Volume: 19
Issue: 3
Pages: 429-39
Publication
First Author: Mesci L
Year: 2006
Journal: Turk J Pediatr
Title: A novel mutation leading to a deletion in the SH3 domain of Bruton's tyrosine kinase.
Volume: 48
Issue: 4
Pages: 362-4
Publication  
First Author: Vihinen M
Year: 2000
Journal: Front Biosci
Title: Bruton tyrosine kinase (BTK) in X-linked agammaglobulinemia (XLA).
Volume: 5
Pages: D917-28
Publication
First Author: Brunner C
Year: 2005
Journal: Histol Histopathol
Title: Bruton's Tyrosine Kinase is involved in innate and adaptive immunity.
Volume: 20
Issue: 3
Pages: 945-55
Publication
First Author: Kang SW
Year: 2001
Journal: EMBO J
Title: PKCbeta modulates antigen receptor signaling via regulation of Btk membrane localization.
Volume: 20
Issue: 20
Pages: 5692-702
Publication  
First Author: Cochet-Bissuel M
Year: 2014
Journal: Front Cell Neurosci
Title: The sodium leak channel, NALCN, in health and disease.
Volume: 8
Pages: 132
Publication
First Author: Zhou C
Year: 2020
Journal: G3 (Bethesda)
Title: The NALCN Channel Regulator UNC-80 Functions in a Subset of Interneurons To Regulate Caenorhabditis elegans Reversal Behavior.
Volume: 10
Issue: 1
Pages: 199-210
Protein Domain
Type: Domain
Description: Lck is a member of the Src non-receptor type tyrosine kinase family of proteins. CD4 and CD8 directly couple with Lck, and cross-linking of these receptors leads to Lck activation [, ]. The N-terminal tail of Lck is myristoylated and palmitoylated and it tethers the protein to the plasma membrane of the cell. Lck also contains an SH3 domain, an SH2 domain, and a C-terminal tyrosine kinase domain. Lck has 2 phosphorylation sites, the first an autophosphorylation site that is linked to activation of the protein and the second which is phosphorylated by Csk, which inhibits it. Lck is also inhibited by SHP-1 dephosphorylation and by Cbl ubiquitin ligase, which is part of the ubiquitin-mediated pathway []. This entry represents the SH2 domain of Lck.The Src non-receptor type tyrosine kinase (SFK) family members have an unique N-terminal domain, an SH3 domain, an SH2 domain, a kinase domain and a regulatory tail. The SH2 domain of SFKs is involved in kinase autoinhibition and T-cell receptor signaling. The binding SH2 domains to phosphotyrosine (pY) sites is critical for the autoinhibition and substrate recognition of the SFKs [].
Protein Domain
Type: Domain
Description: Btk (Bruton tyrosine kinase) is a member of the Tec family, which is a group of nonreceptor tyrosine kinases containing Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. Btk also contains an N-terminal pleckstrin homology (PH) domain, which binds the products of PI3K and allows membrane recruitment and activation, and the Tec homology (TH) domain with proline-rich and zinc-binding regions [].Btk is expressed in B-cells, and a variety of myeloid cells including mast cells, platelets, neutrophils, and dendrictic cells [, ]. It interacts with a variety of partners, from cytosolic proteins to nuclear transcription factors, suggesting a diversity of functions. Stimulation of a diverse array of cell surface receptors, including antigen engagement of the B-cell receptor (BCR), leads to PH-mediated membrane translocation of Btk and subsequent phosphorylation by Src kinase and activation []. Btk plays an important role in the life cycle of B-cells including their development, differentiation, proliferation, survival, and apoptosis []. Mutations in Btk cause the primary immunodeficiency disease, X-linked agammaglobulinaemia (XLA) in humans [, ]. This entry represents the SH3 domain of Btk.
Publication
First Author: Trost M
Year: 2009
Journal: Immunity
Title: The phagosomal proteome in interferon-gamma-activated macrophages.
Volume: 30
Issue: 1
Pages: 143-54
Protein
Organism: Mus musculus/domesticus
Length: 334  
Fragment?: false
Publication
First Author: Blouw B
Year: 2008
Journal: Eur J Cell Biol
Title: A role for the podosome/invadopodia scaffold protein Tks5 in tumor growth in vivo.
Volume: 87
Issue: 8-9
Pages: 555-67
Publication
First Author: Schaeffer EM
Year: 1999
Journal: Science
Title: Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity.
Volume: 284
Issue: 5414
Pages: 638-41
Publication  
First Author: Dowler S
Year: 1999
Journal: Biochem J
Title: DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides.
Volume: 342 ( Pt 1)
Pages: 7-12
Publication
First Author: Wu J
Year: 1999
Journal: Science
Title: An activating immunoreceptor complex formed by NKG2D and DAP10.
Volume: 285
Issue: 5428
Pages: 730-2
Publication
First Author: Carlyle JR
Year: 1999
Journal: J Immunol
Title: Mouse NKR-P1B, a novel NK1.1 antigen with inhibitory function.
Volume: 162
Issue: 10
Pages: 5917-23
Publication
First Author: Krendel M
Year: 2009
Journal: J Am Soc Nephrol
Title: Disruption of Myosin 1e promotes podocyte injury.
Volume: 20
Issue: 1
Pages: 86-94
Publication
First Author: Yuan M
Year: 2005
Journal: FEBS Lett
Title: Fyn binding protein, Fyb, interacts with mammalian actin binding protein, mAbp1.
Volume: 579
Issue: 11
Pages: 2339-47
Publication
First Author: Carretero J
Year: 2010
Journal: Cancer Cell
Title: Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors.
Volume: 17
Issue: 6
Pages: 547-59
Publication
First Author: Dickerson MT
Year: 2022
Journal: Nat Commun
Title: G(i/o) protein-coupled receptor inhibition of beta-cell electrical excitability and insulin secretion depends on Na(+)/K(+) ATPase activation.
Volume: 13
Issue: 1
Pages: 6461
Publication
First Author: Xie J
Year: 2008
Journal: FEBS Lett
Title: SHIP2 associates with intersectin and recruits it to the plasma membrane in response to EGF.
Volume: 582
Issue: 20
Pages: 3011-7
Publication
First Author: Stallings RL
Year: 1985
Journal: Chromosoma
Title: Oncogenes and linkage groups: conservation during mammalian chromosome evolution.
Volume: 92
Issue: 2
Pages: 156-63
Publication
First Author: Löffler C
Year: 1991
Journal: Hum Genet
Title: Mapping of the ribophorin II (RPN II) gene to human chromosome 20q12-q13.1 by in-situ hybridization.
Volume: 87
Issue: 2
Pages: 221-2
Publication
First Author: Darnell JE Jr
Year: 1997
Journal: Science
Title: STATs and gene regulation.
Volume: 277
Issue: 5332
Pages: 1630-5
Publication
First Author: Takemoto Y
Year: 1998
Journal: J Immunol
Title: Growth factor receptor-bound protein 2 (Grb2) association with hemopoietic specific protein 1: linkage between Lck and Grb2.
Volume: 161
Issue: 2
Pages: 625-30
Publication
First Author: Yamauchi J
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Neurotrophins regulate Schwann cell migration by activating divergent signaling pathways dependent on Rho GTPases.
Volume: 101
Issue: 23
Pages: 8774-9
Publication
First Author: Liu G
Year: 2007
Journal: J Neurosci
Title: p130CAS is required for netrin signaling and commissural axon guidance.
Volume: 27
Issue: 4
Pages: 957-68
Publication
First Author: Bovée JV
Year: 2010
Journal: Nat Rev Cancer
Title: Cartilage tumours and bone development: molecular pathology and possible therapeutic targets.
Volume: 10
Issue: 7
Pages: 481-8
Publication
First Author: Petersen W
Year: 2014
Journal: Cancer Lett
Title: Dasatinib suppression of medulloblastoma survival and migration is markedly enhanced by combining treatment with the aurora kinase inhibitor AT9283.
Volume: 354
Issue: 1
Pages: 68-76
Publication
First Author: Ko R
Year: 2019
Journal: J Immunol
Title: Glycogen Synthase Kinase 3β Regulates Antiviral Responses of TLR3 via TRAF2-Src Axis.
Volume: 203
Issue: 11
Pages: 2990-2999
Publication
First Author: Brdicková N
Year: 2003
Journal: J Exp Med
Title: LIME: a new membrane Raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling.
Volume: 198
Issue: 10
Pages: 1453-62
Publication
First Author: Liu J
Year: 2020
Journal: Sci Rep
Title: Transcriptional analysis of cleft palate in TGFβ3 mutant mice.
Volume: 10
Issue: 1
Pages: 14940
Publication
First Author: Purohit AA
Year: 2012
Journal: J Biol Chem
Title: Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse.
Volume: 287
Issue: 32
Pages: 27126-38
Publication
First Author: Dutta M
Year: 2012
Journal: J Immunol
Title: Characterization of Ly108 in the thymus: evidence for distinct properties of a novel form of Ly108.
Volume: 188
Issue: 7
Pages: 3031-41
Publication
First Author: Rajasekharan S
Year: 2009
Journal: Development
Title: Netrin 1 and Dcc regulate oligodendrocyte process branching and membrane extension via Fyn and RhoA.
Volume: 136
Issue: 3
Pages: 415-26
Publication
First Author: Morita A
Year: 2006
Journal: J Neurosci
Title: Regulation of dendritic branching and spine maturation by semaphorin3A-Fyn signaling.
Volume: 26
Issue: 11
Pages: 2971-80
Publication
First Author: Li J
Year: 2008
Journal: J Biol Chem
Title: Leukocyte antigen-related protein tyrosine phosphatase negatively regulates hydrogen peroxide-induced vascular smooth muscle cell apoptosis.
Volume: 283
Issue: 49
Pages: 34260-72
Publication
First Author: Baumeister U
Year: 2005
Journal: EMBO J
Title: Association of Csk to VE-cadherin and inhibition of cell proliferation.
Volume: 24
Issue: 9
Pages: 1686-95
Publication
First Author: Sulimenko V
Year: 2006
Journal: J Immunol
Title: Regulation of microtubule formation in activated mast cells by complexes of gamma-tubulin with Fyn and Syk kinases.
Volume: 176
Issue: 12
Pages: 7243-53
Publication
First Author: Reddy KB
Year: 2008
Journal: J Cell Sci
Title: Analysis of Fyn function in hemostasis and alphaIIbbeta3-integrin signaling.
Volume: 121
Issue: Pt 10
Pages: 1641-8
Publication  
First Author: Putra M
Year: 2020
Journal: Front Cell Neurosci
Title: Fyn-tau Ablation Modifies PTZ-Induced Seizures and Post-seizure Hallmarks of Early Epileptogenesis.
Volume: 14
Pages: 592374
Publication
First Author: Johnson SA
Year: 1995
Journal: J Immunol
Title: Phosphorylated immunoreceptor signaling motifs (ITAMs) exhibit unique abilities to bind and activate Lyn and Syk tyrosine kinases.
Volume: 155
Issue: 10
Pages: 4596-603
Publication
First Author: Stoll R
Year: 2008
Journal: Curr Protein Pept Sci
Title: Extracellular SH3 domain containing proteins--features of a new protein family.
Volume: 9
Issue: 3
Pages: 221-6
Publication
First Author: Stoll R
Year: 2003
Journal: Protein Sci
Title: Backbone dynamics of the human MIA protein studied by (15)N NMR relaxation: implications for extended interactions of SH3 domains.
Volume: 12
Issue: 3
Pages: 510-9
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Gross JA
Year: 1995
Journal: J Exp Med
Title: Control of lymphopoiesis by p50csk, a regulatory protein tyrosine kinase.
Volume: 181
Issue: 2
Pages: 463-73
Publication
First Author: Kohara Y
Year: 2001
Journal: Immunogenetics
Title: A major determinant quantitative-trait locus responsible for atopic dermatitis-like skin lesions in NC/Nga mice is located on Chromosome 9.
Volume: 53
Issue: 1
Pages: 15-21
Publication
First Author: Gao P
Year: 2020
Journal: Biochem Biophys Res Commun
Title: CSK promotes innate immune response to DNA virus by phosphorylating MITA.
Volume: 526
Issue: 1
Pages: 199-205
Publication
First Author: Lowry WE
Year: 2002
Journal: Dev Cell
Title: Csk, a critical link of g protein signals to actin cytoskeletal reorganization.
Volume: 2
Issue: 6
Pages: 733-44
GXD Expression    
Probe: MGI:2673141
Assay Type: Northern blot
Annotation Date: 2003-09-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876824
Stage: TS24
Assay Id: MGI:2673145
Age: embryonic day 16.0
Image: 3
Specimen Label: None
Detected: true
Specimen Num: 9
GXD Expression    
Probe: MGI:2673141
Assay Type: Northern blot
Annotation Date: 2003-09-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:2673145
Age: postnatal adult
Image: 3
Specimen Label: None
Detected: true
Specimen Num: 10
GXD Expression      
Probe: MGI:2673141
Assay Type: Northern blot
Annotation Date: 2003-09-10
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2673145
Age: postnatal adult
Image: 3
Specimen Label: None
Specimen Num: 11
GXD Expression    
Probe: MGI:5614228
Assay Type: RT-PCR
Annotation Date: 2015-02-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:5614232
Age: embryonic day 12.0
Image: 1
Specimen Label: E12
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5614228
Assay Type: RT-PCR
Annotation Date: 2015-02-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:5614232
Age: postnatal day 1
Image: 1
Specimen Label: P1
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:5614228
Assay Type: RT-PCR
Annotation Date: 2015-02-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:5614232
Age: postnatal day 42
Image: 1
Specimen Label: P42
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:5614228
Assay Type: RT-PCR
Annotation Date: 2015-02-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:5614232
Age: postnatal day 60
Image: 1
Specimen Label: P60
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:5614228
Assay Type: RT-PCR
Annotation Date: 2015-02-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:5614232
Age: embryonic day 12.0
Image: 1
Specimen Label: E12
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5614228
Assay Type: RT-PCR
Annotation Date: 2015-02-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185820
Stage: TS20
Assay Id: MGI:5614232
Age: embryonic day 12.0
Image: 1
Specimen Label: E12
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:5614228
Assay Type: RT-PCR
Annotation Date: 2015-02-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:5614232
Age: postnatal day 1
Image: 1
Specimen Label: P1
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:5614228
Assay Type: RT-PCR
Annotation Date: 2015-02-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:5614232
Age: postnatal day 42
Image: 1
Specimen Label: P42
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:5614228
Assay Type: RT-PCR
Annotation Date: 2015-02-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:5614232
Age: postnatal day 60
Image: 1
Specimen Label: P60
Detected: true
Specimen Num: 9
GXD Expression    
Probe: MGI:5614242
Assay Type: Western blot
Annotation Date: 2015-02-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:5614248
Age: postnatal day 1
Image: 1
Specimen Label: P1
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5614242
Assay Type: Western blot
Annotation Date: 2015-02-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:5614248
Age: postnatal week 6
Image: 1
Specimen Label: 6 w
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5614242
Assay Type: Western blot
Annotation Date: 2015-02-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:5614248
Age: postnatal month 3
Image: 1
Specimen Label: 3 m
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:5913870
Assay Type: Western blot
Annotation Date: 2017-11-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:5913875
Age: embryonic day 8.5
Specimen Label: E8.5 +/+
Detected: true
Specimen Num: 1