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Search results 4401 to 4500 out of 9662 for Egf

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Type Details Score
Allele  
Name: delta like canonical Notch ligand 1; targeted mutation 14.1, Achim Gossler
Allele Type: Targeted
Allele  
Name: delta like canonical Notch ligand 1; targeted mutation 15.1, Achim Gossler
Allele Type: Targeted
Allele  
Name: delta like canonical Notch ligand 1; targeted mutation 8.1, Achim Gossler
Allele Type: Targeted
Allele  
Name: delta like canonical Notch ligand 1; targeted mutation 9.1, Achim Gossler
Allele Type: Targeted
Allele  
Name: delta like canonical Notch ligand 1; targeted mutation 10.1, Achim Gossler
Allele Type: Targeted
Allele  
Name: delta like canonical Notch ligand 1; targeted mutation 11.1, Achim Gossler
Allele Type: Targeted
Allele  
Name: delta like canonical Notch ligand 1; targeted mutation 12.1, Achim Gossler
Allele Type: Targeted
Allele  
Name: delta like canonical Notch ligand 1; targeted mutation 13.1, Achim Gossler
Allele Type: Targeted
Publication
First Author: Bongers G
Year: 2012
Journal: Gastroenterology
Title: A role for the epidermal growth factor receptor signaling in development of intestinal serrated polyps in mice and humans.
Volume: 143
Issue: 3
Pages: 730-740
Publication
First Author: Bongers G
Year: 2014
Journal: J Exp Med
Title: Interplay of host microbiota, genetic perturbations, and inflammation promotes local development of intestinal neoplasms in mice.
Volume: 211
Issue: 3
Pages: 457-72
Publication
First Author: He Z
Year: 2019
Journal: Gastroenterology
Title: Interleukin 1 beta and Matrix Metallopeptidase 3 Contribute to Development of Epidermal Growth Factor Receptor-Dependent Serrated Polyps in Mouse Cecum.
Volume: 157
Issue: 6
Pages: 1572-1583.e8
Genotype
Symbol: Tle5/Tle5 Notch1/Notch1<+>
Background: involves: 129S1/Sv * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Erbb2/Erbb2<+> Erbb3/Erbb3<+> Nrg1/Nrg1<+>
Background: involves: 129P2/OlaHsd
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Nrg1/Nrg1 Isl1/Isl1<+>
Background: involves: 129P2/OlaHsd * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Notch2/Notch2
Background: involves: 129S1/Sv * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Dll1/Dll1<+> Jag2/Jag2<+>
Background: involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Mib1/Mib1<+> Notch1/Notch1<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Mib1/Mib1<+> Notch1/Notch1<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Notch2/Notch2<+>
Background: involves: 129S1/Sv * C57BL/6J
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Nos3/Nos3 Notch1/Notch1<+>
Background: involves: 129 * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Notch1/Notch1
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: ht
Has Mutant Allele: true
Publication
First Author: Shima Y
Year: 2002
Journal: Dev Dyn
Title: Differential expression of the seven-pass transmembrane cadherin genes Celsr1-3 and distribution of the Celsr2 protein during mouse development.
Volume: 223
Issue: 3
Pages: 321-32
Publication
First Author: Shirakata Y
Year: 2005
Journal: J Cell Sci
Title: Heparin-binding EGF-like growth factor accelerates keratinocyte migration and skin wound healing.
Volume: 118
Issue: Pt 11
Pages: 2363-70
Publication
First Author: Iwamoto R
Year: 2010
Journal: Development
Title: HB-EGF function in cardiac valve development requires interaction with heparan sulfate proteoglycans.
Volume: 137
Issue: 13
Pages: 2205-14
Publication
First Author: Oyagi A
Year: 2009
Journal: PLoS One
Title: Generation and characterization of conditional heparin-binding EGF-like growth factor knockout mice.
Volume: 4
Issue: 10
Pages: e7461
Publication
First Author: Raab G
Year: 1997
Journal: Biochim Biophys Acta
Title: Heparin-binding EGF-like growth factor.
Volume: 1333
Issue: 3
Pages: F179-99
Publication
First Author: Haworth K
Year: 2007
Journal: Gene Expr Patterns
Title: Expression of the Scube3 epidermal growth factor-related gene during early embryonic development in the mouse.
Volume: 7
Issue: 5
Pages: 630-4
Protein Domain
Type: Domain
Description: A sequence of about thirty to forty amino-acid residues long found in the sequence of epidermal growth factor (EGF)has been shown [, , , ]to be present, in a moreor less conserved form, in a large number of other, mostly animal proteins. The list of proteins currently known tocontain one or more copiesof an EGF-like pattern is large and varied. The functional significance of EGF domains inwhat appear to be unrelated proteins is not yet clear. However, a common feature is that these repeats are found inthe extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandinG/H synthase). The EGF domain includes six cysteine residues which have been shown (in EGF) to be involved in disulphidebonds. The main structure is a two-stranded β-sheet followed by a loop to a C-terminal short two-stranded sheet.Subdomains between the conserved cysteines vary in length.This entry contains EGF domains found in a variety of extracellular and membrane proteins
Publication
First Author: Chaboub LS
Year: 2016
Journal: J Neurosci
Title: Temporal Profiling of Astrocyte Precursors Reveals Parallel Roles for Asef during Development and after Injury.
Volume: 36
Issue: 47
Pages: 11904-11917
Publication
First Author: Wang L
Year: 2004
Journal: Biochem Biophys Res Commun
Title: Identification of potential nuclear reprogramming and differentiation factors by a novel selection method for cloning chromatin-binding proteins.
Volume: 325
Issue: 1
Pages: 302-7
Publication
First Author: Konishi H
Year: 2006
Journal: J Biol Chem
Title: CFBP is a novel tyrosine-phosphorylated protein that might function as a regulator of CIN85/CD2AP.
Volume: 281
Issue: 39
Pages: 28919-31
Publication
First Author: Ghimire SR
Year: 2019
Journal: J Neurosci
Title: Frizzled3 and Frizzled6 Cooperate with Vangl2 to Direct Cochlear Innervation by Type II Spiral Ganglion Neurons.
Volume: 39
Issue: 41
Pages: 8013-8023
Publication
First Author: Tissir F
Year: 2006
Journal: Eur J Neurosci
Title: Expression of planar cell polarity genes during development of the mouse CNS.
Volume: 23
Issue: 3
Pages: 597-607
HT Experiment
Series Id: E-GEOD-49346
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: GEO
Publication
First Author: Dawe CE
Year: 2011
Journal: Dev Dyn
Title: Role of chromatin remodeling gene Cecr2 in neurulation and inner ear development.
Volume: 240
Issue: 2
Pages: 372-83
Publication
First Author: Gur-Cohen S
Year: 2019
Journal: Science
Title: Stem cell-driven lymphatic remodeling coordinates tissue regeneration.
Volume: 366
Issue: 6470
Pages: 1218-1225
Publication
First Author: Vladar EK
Year: 2012
Journal: Curr Biol
Title: Microtubules enable the planar cell polarity of airway cilia.
Volume: 22
Issue: 23
Pages: 2203-12
Publication
First Author: Mahaffey JP
Year: 2013
Journal: Development
Title: Cofilin and Vangl2 cooperate in the initiation of planar cell polarity in the mouse embryo.
Volume: 140
Issue: 6
Pages: 1262-71
Publication
First Author: Bellchambers HM
Year: 2021
Journal: Hum Mol Genet
Title: Loss of Zic3 impairs planar cell polarity leading to abnormal left-right signaling, heart defects and neural tube defects.
Volume: 30
Issue: 24
Pages: 2402-2415
Publication
First Author: Wang Y
Year: 2016
Journal: Development
Title: Syndecan 4 controls lymphatic vasculature remodeling during mouse embryonic development.
Volume: 143
Issue: 23
Pages: 4441-4451
Publication
First Author: Kimura-Yoshida C
Year: 2018
Journal: Nat Commun
Title: Cytoplasmic localization of GRHL3 upon epidermal differentiation triggers cell shape change for epithelial morphogenesis.
Volume: 9
Issue: 1
Pages: 4059
Publication  
First Author: Bhattarai SR
Year: 2019
Journal: Development
Title: The ciliary GTPase Arl3 maintains tissue architecture by directing planar spindle orientation during epidermal morphogenesis.
Volume: 146
Issue: 9
Publication  
First Author: Vied CM
Year: 2014
Journal: Front Neurosci
Title: A multi-resource data integration approach: identification of candidate genes regulating cell proliferation during neocortical development.
Volume: 8
Pages: 257
Publication
First Author: Yuzwa SA
Year: 2017
Journal: Cell Rep
Title: Developmental Emergence of Adult Neural Stem Cells as Revealed by Single-Cell Transcriptional Profiling.
Volume: 21
Issue: 13
Pages: 3970-3986
Publication
First Author: Yoshioka R
Year: 2010
Journal: Invest Ophthalmol Vis Sci
Title: Corneal epithelial wound healing impaired in keratinocyte-specific HB-EGF-deficient mice in vivo and in vitro.
Volume: 51
Issue: 11
Pages: 5630-9
Publication
First Author: Zeng F
Year: 2016
Journal: Am J Physiol Renal Physiol
Title: Specific endothelial heparin-binding EGF-like growth factor deletion ameliorates renal injury induced by chronic angiotensin II infusion.
Volume: 311
Issue: 4
Pages: F695-F707
Publication
First Author: Chalothorn D
Year: 2005
Journal: Arterioscler Thromb Vasc Biol
Title: Heparin-binding epidermal growth factor-like growth factor, collateral vessel development, and angiogenesis in skeletal muscle ischemia.
Volume: 25
Issue: 9
Pages: 1884-90
Publication
First Author: Mulder GM
Year: 2010
Journal: J Pathol
Title: Heparin binding epidermal growth factor in renal ischaemia/reperfusion injury.
Volume: 221
Issue: 2
Pages: 183-92
Publication
First Author: Liu Z
Year: 2004
Journal: Exp Cell Res
Title: Lysophosphatidic acid regulates murine blastocyst development by transactivation of receptors for heparin-binding EGF-like growth factor.
Volume: 296
Issue: 2
Pages: 317-26
Publication
First Author: Farahnak S
Year: 2019
Journal: J Immunol
Title: HB-EGF Synthesized by CD4 T Cells Modulates Allergic Airway Eosinophilia by Regulating IL-5 Synthesis.
Volume: 203
Issue: 1
Pages: 39-47
Publication
First Author: Zhang N
Year: 2002
Journal: Genesis
Title: Segmentation defects of Notch pathway mutants and absence of a synergistic phenotype in lunatic fringe/radical fringe double mutant mice.
Volume: 33
Issue: 1
Pages: 21-8
Publication
First Author: Richardson RJ
Year: 2009
Journal: Hum Mol Genet
Title: Integration of IRF6 and Jagged2 signalling is essential for controlling palatal adhesion and fusion competence.
Volume: 18
Issue: 14
Pages: 2632-42
Publication
First Author: Fisher RE
Year: 2012
Journal: Anat Rec (Hoboken)
Title: Mutations in the Notch pathway alter the patterning of multifidus.
Volume: 295
Issue: 1
Pages: 32-9
Publication
First Author: Meyer-Bahlburg A
Year: 2008
Journal: J Exp Med
Title: Characterization of a late transitional B cell population highly sensitive to BAFF-mediated homeostatic proliferation.
Volume: 205
Issue: 1
Pages: 155-68
Publication
First Author: Hadland BK
Year: 2004
Journal: Blood
Title: A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development.
Volume: 104
Issue: 10
Pages: 3097-105
Publication
First Author: Robert-Moreno A
Year: 2008
Journal: EMBO J
Title: Impaired embryonic haematopoiesis yet normal arterial development in the absence of the Notch ligand Jagged1.
Volume: 27
Issue: 13
Pages: 1886-95
Publication
First Author: Outtz HH
Year: 2011
Journal: Blood
Title: Notch1 controls macrophage recruitment and Notch signaling is activated at sites of endothelial cell anastomosis during retinal angiogenesis in mice.
Volume: 118
Issue: 12
Pages: 3436-9
Publication
First Author: Li Y
Year: 2011
Journal: Circulation
Title: Notch1 in bone marrow-derived cells mediates cardiac repair after myocardial infarction.
Volume: 123
Issue: 8
Pages: 866-76
Publication
First Author: Jin JZ
Year: 2010
Journal: Dev Dyn
Title: Mesenchymal cell remodeling during mouse secondary palate reorientation.
Volume: 239
Issue: 7
Pages: 2110-7
Publication
First Author: Alappat SR
Year: 2005
Journal: Dev Biol
Title: The cellular and molecular etiology of the cleft secondary palate in Fgf10 mutant mice.
Volume: 277
Issue: 1
Pages: 102-13
Publication  
First Author: Kumar P
Year: 2017
Journal: Sci Rep
Title: Soluble OX40L and JAG1 Induce Selective Proliferation of Functional Regulatory T-Cells Independent of canonical TCR signaling.
Volume: 7
Pages: 39751
Publication
First Author: Erickson SL
Year: 1997
Journal: Development
Title: ErbB3 is required for normal cerebellar and cardiac development: a comparison with ErbB2-and heregulin-deficient mice.
Volume: 124
Issue: 24
Pages: 4999-5011
Publication
First Author: Gerlai R
Year: 2000
Journal: Behav Brain Res
Title: Heregulin, but not ErbB2 or ErbB3, heterozygous mutant mice exhibit hyperactivity in multiple behavioral tasks.
Volume: 109
Issue: 2
Pages: 219-27
Publication
First Author: O'Shea S
Year: 2001
Journal: Am J Pathol
Title: Effects of in vivo heregulin beta1 treatment in wild-type and ErbB gene-targeted mice depend on receptor levels and pregnancy.
Volume: 158
Issue: 5
Pages: 1871-80
Publication
First Author: Britsch S
Year: 1998
Journal: Genes Dev
Title: The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system.
Volume: 12
Issue: 12
Pages: 1825-36
Publication
First Author: Baeten JT
Year: 2015
Journal: Genesis
Title: Loss of Notch2 and Notch3 in vascular smooth muscle causes patent ductus arteriosus.
Volume: 53
Issue: 12
Pages: 738-48
Publication
First Author: Baeten JT
Year: 2015
Journal: J Biol Chem
Title: Differential Regulation of NOTCH2 and NOTCH3 Contribute to Their Unique Functions in Vascular Smooth Muscle Cells.
Volume: 290
Issue: 26
Pages: 16226-37
Strain
Attribute String: mutant stock, targeted mutation
Strain
Attribute String: targeted mutation, mutant stock
Strain
Attribute String: mutant stock, targeted mutation
Strain
Attribute String: targeted mutation, mutant stock
Strain
Attribute String: mutant stock, targeted mutation
Strain
Attribute String: targeted mutation, mutant stock
Strain
Attribute String: mutant stock, targeted mutation
Strain
Attribute String: targeted mutation, mutant stock
Genotype
Symbol: Notch1/Notch1 Notch2/Notch2
Background: involves: 129S1/Sv * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Notch2/Notch2<+> Dll1/Dll1<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Notch1/Notch1 Foxg1/Foxg1<+>
Background: involves: 129 * C57BL/6J * Swiss Webster
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Dll1/Dll1 Jag2/Jag2
Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Foxg1/Foxg1<+> Nrg1/Nrg1
Background: involves: 129P2/OlaHsd
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Yates LL
Year: 2013
Journal: Dev Biol
Title: Scribble is required for normal epithelial cell-cell contacts and lumen morphogenesis in the mammalian lung.
Volume: 373
Issue: 2
Pages: 267-80
Publication
First Author: Margolis RU
Year: 1997
Journal: Cell Tissue Res
Title: Chondroitin sulfate proteoglycans as mediators of axon growth and pathfinding.
Volume: 290
Issue: 2
Pages: 343-8
Publication
First Author: Sen M
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Leukocyte integrin αLβ2 headpiece structures: The αI domain, the pocket for the internal ligand, and concerted movements of its loops.
Volume: 113
Issue: 11
Pages: 2940-5
Publication  
First Author: Luo BH
Year: 2007
Journal: Annu Rev Immunol
Title: Structural basis of integrin regulation and signaling.
Volume: 25
Pages: 619-47
Publication
First Author: Thio GL
Year: 2000
Journal: Dev Biol
Title: Localization of gurken RNA in Drosophila oogenesis requires elements in the 5' and 3' regions of the transcript.
Volume: 221
Issue: 2
Pages: 435-46
Publication
First Author: Touchard A
Year: 2020
Journal: J Proteome Res
Title: Venom Peptide Repertoire of the European Myrmicine Ant Manica rubida: Identification of Insecticidal Toxins.
Volume: 19
Issue: 4
Pages: 1800-1811
Protein Domain
Type: Family
Description: This entry represents a group of invertebrate proteins, including Gurken/Spitz from Drosophila melanogaster. They are TGFalpha-like protein that interacts with EGF (epidermal growth factor) receptor. Gurken plays an important role in defining the egg anterior-posterior and dorsal-ventral axes []. Spitz is required for photoreceptor determination in the Drosophila eye []. This entry also includes a myrmicitoxin from Manica rubida (European giant red ant) [].
Protein Domain
Type: Family
Description: MVB12A (also known as CFBP) and MVB12B are subunits of the ESCRT-I complex, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle [, ]. MVB12A plays a key role in the ligand-mediated internalization and down-regulation of the EGF receptor [].
Protein Domain
Type: Family
Description: MVB12A (also known as CFBP) and MVB12B are subunits of the ESCRT-I complex, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle [, ]. MVB12A plays a key role in the ligand-mediated internalization and down-regulation of the EGF receptor [].
Protein Domain
Type: Homologous_superfamily
Description: This entry represents a short domain found the matrilin (cartilage matrix) proteins. It forms a coiled coil structure and contains a single cysteine residue at its start which is likely to form a di-sulphide bridge with a corresponding cysteine in an upstream EGF domain, thereby spanning the VWA domain of the protein ().This domain is likely to be responsible for protein trimerisation [, ].
Protein Domain
Type: Domain
Description: This entry represents the C-terminal cytoplasmic domain of vertebrate neural chondroitin sulphate proteoglycans that contain EGF modules. Evidence has been accumulated to support the idea that neural proteoglycans are involved in various cellular events including mitogenesis, differentiation, axonal outgrowth and synaptogenesis []. This domain contains a number of potential sites of phosphorylation by protein kinase C [].
Protein Domain
Type: Domain
Description: This entry represents a short domain found the matrilin (cartilage matrix) proteins. It forms a coiled coil structure and contains a single cysteine residue at its start which is likely to form a di-sulphide bridge with a corresponding cysteine in an upstream EGF domain, thereby spanning the VWA domain of the protein ().This domain is likely to be responsible for protein trimerisation [, ].
Protein Domain
Type: Domain
Description: This is the I-EGF domain 1 found in several integrin beta subunits. Structural analysis revealed the presence of four integrin epidermal growth factor-like (I-EGF) domains in integrin beta []. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains; this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end [].
Protein Domain
Type: Domain
Description: SNX16 contains a central PX domain followed by a coiled-coil region. SNX16 is localized in early and recycling endosomes through the binding of its PX domain to phosphatidylinositol-3-phosphate (PI3P). It plays a role in epidermal growth factor (EGF) signaling by regulating EGF receptor membrane trafficking []. This entry represents the PX domain of SNX16.
Publication
First Author: Fong KS
Year: 2016
Journal: Dis Model Mech
Title: A mutation in the tuft mouse disrupts TET1 activity and alters the expression of genes that are crucial for neural tube closure.
Volume: 9
Issue: 5
Pages: 585-96
Publication
First Author: Aikawa S
Year: 2017
Journal: EMBO J
Title: Autotaxin-lysophosphatidic acid-LPA3 signaling at the embryo-epithelial boundary controls decidualization pathways.
Volume: 36
Issue: 14
Pages: 2146-2160
Publication
First Author: Takeshita T
Year: 1996
Journal: Biochem Biophys Res Commun
Title: Cloning of a novel signal-transducing adaptor molecule containing an SH3 domain and ITAM.
Volume: 225
Issue: 3
Pages: 1035-9
Publication
First Author: Schechter AL
Year: 1984
Journal: Nature
Title: The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen.
Volume: 312
Issue: 5994
Pages: 513-6
Publication
First Author: Arnush M
Year: 1996
Journal: Lab Invest
Title: Growth factors in the regenerating pancreas of gamma-interferon transgenic mice.
Volume: 74
Issue: 6
Pages: 985-90
Publication
First Author: Rezvani K
Year: 2009
Journal: J Neurosci
Title: UBXD4, a UBX-containing protein, regulates the cell surface number and stability of alpha3-containing nicotinic acetylcholine receptors.
Volume: 29
Issue: 21
Pages: 6883-96