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Details |
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| First Author: |
Xue X |
| Year: |
2018 |
| Journal: |
J Biol Chem |
| Title: |
Protein kinase C? drives fibroblast activation and kidney fibrosis by stimulating autophagic flux. |
| Volume: |
293 |
| Issue: |
28 |
| Pages: |
11119-11130 |
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| First Author: |
Ng SY |
| Year: |
2018 |
| Journal: |
Blood |
| Title: |
RhoA G17V is sufficient to induce autoimmunity and promotes T-cell lymphomagenesis in mice. |
| Volume: |
132 |
| Issue: |
9 |
| Pages: |
935-947 |
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•
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| Publication |
| First Author: |
Krishnamoorthy GP |
| Year: |
2019 |
| Journal: |
Cancer Discov |
| Title: |
EIF1AX and RAS Mutations Cooperate to Drive Thyroid Tumorigenesis through ATF4 and c-MYC. |
| Volume: |
9 |
| Issue: |
2 |
| Pages: |
264-281 |
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| First Author: |
Zeng H |
| Year: |
2018 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
mTORC1 signaling suppresses Wnt/?-catenin signaling through DVL-dependent regulation of Wnt receptor FZD level. |
| Volume: |
115 |
| Issue: |
44 |
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E10362-E10369 |
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| First Author: |
Duszka K |
| Year: |
2018 |
| Journal: |
Sci Rep |
| Title: |
Complementary intestinal mucosa and microbiota responses to caloric restriction. |
| Volume: |
8 |
| Issue: |
1 |
| Pages: |
11338 |
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•
•
•
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| First Author: |
Saito N |
| Year: |
2019 |
| Journal: |
J Immunol |
| Title: |
Involvement of Lamin B1 Reduction in Accelerated Cellular Senescence during Chronic Obstructive Pulmonary Disease Pathogenesis. |
| Volume: |
202 |
| Issue: |
5 |
| Pages: |
1428-1440 |
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•
•
•
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| Publication |
| First Author: |
Chaplot K |
| Year: |
2019 |
| Journal: |
Dis Model Mech |
| Title: |
SOD1 activity threshold and TOR signalling modulate VAP(P58S) aggregation via reactive oxygen species-induced proteasomal degradation in a Drosophila model of amyotrophic lateral sclerosis. |
| Volume: |
12 |
| Issue: |
2 |
|
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•
•
•
•
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| Publication |
| First Author: |
Brooks DL |
| Year: |
2019 |
| Journal: |
Endocrinology |
| Title: |
Aldosterone Modulates the Mechanistic Target of Rapamycin Signaling in Male Mice. |
| Volume: |
160 |
| Issue: |
4 |
| Pages: |
716-728 |
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| First Author: |
Stout MB |
| Year: |
2017 |
| Journal: |
J Gerontol A Biol Sci Med Sci |
| Title: |
17?-Estradiol Alleviates Age-related Metabolic and Inflammatory Dysfunction in Male Mice Without Inducing Feminization. |
| Volume: |
72 |
| Issue: |
1 |
| Pages: |
3-15 |
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•
•
•
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| First Author: |
Kikani CK |
| Year: |
2019 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Activation of PASK by mTORC1 is required for the onset of the terminal differentiation program. |
| Volume: |
116 |
| Issue: |
21 |
| Pages: |
10382-10391 |
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| First Author: |
Zhang HM |
| Year: |
2017 |
| Journal: |
Sci Rep |
| Title: |
Moderate lifelong overexpression of tuberous sclerosis complex 1 (TSC1) improves health and survival in mice. |
| Volume: |
7 |
| Issue: |
1 |
| Pages: |
834 |
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•
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| First Author: |
Kitakaze T |
| Year: |
2020 |
| Journal: |
Biochim Biophys Acta Mol Cell Res |
| Title: |
Extracellular transglutaminase 2 induces myotube hypertrophy through G protein-coupled receptor 56. |
| Volume: |
1867 |
| Issue: |
2 |
| Pages: |
118563 |
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| First Author: |
Zhou J |
| Year: |
2019 |
| Journal: |
Hum Mol Genet |
| Title: |
Titin truncations lead to impaired cardiomyocyte autophagy and mitochondrial function in vivo. |
| Volume: |
28 |
| Issue: |
12 |
| Pages: |
1971-1981 |
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| First Author: |
Reid JJ |
| Year: |
2020 |
| Journal: |
J Gerontol A Biol Sci Med Sci |
| Title: |
Brain Protein Synthesis Rates in the UM-HET3 Mouse Following Treatment With Rapamycin or Rapamycin With Metformin. |
| Volume: |
75 |
| Issue: |
1 |
| Pages: |
40-49 |
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•
•
•
•
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| Publication |
| First Author: |
Wang XS |
| Year: |
2020 |
| Journal: |
Glia |
| Title: |
Activation of G protein-coupled receptor 30 protects neurons by regulating autophagy in astrocytes. |
| Volume: |
68 |
| Issue: |
1 |
| Pages: |
27-43 |
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•
•
•
•
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| First Author: |
Granados-Aparici S |
| Year: |
2019 |
| Journal: |
Sci Rep |
| Title: |
SMAD3 directly regulates cell cycle genes to maintain arrest in granulosa cells of mouse primordial follicles. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
6513 |
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•
•
•
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| First Author: |
Raman A |
| Year: |
2018 |
| Journal: |
Am J Physiol Renal Physiol |
| Title: |
Periostin overexpression in collecting ducts accelerates renal cyst growth and fibrosis in polycystic kidney disease. |
| Volume: |
315 |
| Issue: |
6 |
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F1695-F1707 |
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| First Author: |
Son K |
| Year: |
2019 |
| Journal: |
J Clin Invest |
| Title: |
Nontranslational function of leucyl-tRNA synthetase regulates myogenic differentiation and skeletal muscle regeneration. |
| Volume: |
129 |
| Issue: |
5 |
| Pages: |
2088-2093 |
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| First Author: |
Ravi V |
| Year: |
2019 |
| Journal: |
Nucleic Acids Res |
| Title: |
SIRT6 transcriptionally regulates global protein synthesis through transcription factor Sp1 independent of its deacetylase activity. |
| Volume: |
47 |
| Issue: |
17 |
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9115-9131 |
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| First Author: |
Shum M |
| Year: |
2019 |
| Journal: |
J Biol Chem |
| Title: |
Inhibition of mitochondrial complex 1 by the S6K1 inhibitor PF-4708671 partly contributes to its glucose metabolic effects in muscle and liver cells. |
| Volume: |
294 |
| Issue: |
32 |
| Pages: |
12250-12260 |
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| First Author: |
Murugina NE |
| Year: |
2020 |
| Journal: |
J Biol Chem |
| Title: |
Glycolytic reprogramming of macrophages activated by NOD1 and TLR4 agonists: No association with proinflammatory cytokine production in normoxia. |
| Volume: |
295 |
| Issue: |
10 |
| Pages: |
3099-3114 |
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| First Author: |
Endo M |
| Year: |
2020 |
| Journal: |
J Biol Chem |
| Title: |
The two splice variant forms of Cdc42 exert distinct and essential functions in neurogenesis. |
| Volume: |
295 |
| Issue: |
14 |
| Pages: |
4498-4512 |
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| First Author: |
Zhang L |
| Year: |
2020 |
| Journal: |
Sci Transl Med |
| Title: |
Filamin A inhibition reduces seizure activity in a mouse model of focal cortical malformations. |
| Volume: |
12 |
| Issue: |
531 |
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| First Author: |
Li H |
| Year: |
2019 |
| Journal: |
Stem Cells |
| Title: |
Melatonin Enhances Proliferation and Modulates Differentiation of Neural Stem Cells Via Autophagy in Hyperglycemia. |
| Volume: |
37 |
| Issue: |
4 |
| Pages: |
504-515 |
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| First Author: |
Wang X |
| Year: |
2019 |
| Journal: |
Haematologica |
| Title: |
Rheb1 loss leads to increased hematopoietic stem cell proliferation and myeloid-biased differentiation in vivo. |
| Volume: |
104 |
| Issue: |
2 |
| Pages: |
245-255 |
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| First Author: |
Zhao X |
| Year: |
2019 |
| Journal: |
Aging Cell |
| Title: |
SLC1A5 glutamine transporter is a target of MYC and mediates reduced mTORC1 signaling and increased fatty acid oxidation in long-lived Myc hypomorphic mice. |
| Volume: |
18 |
| Issue: |
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e12947 |
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Baek MO |
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2019 |
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Sci Rep |
| Title: |
Simulated microgravity inhibits C2C12 myogenesis via phospholipase D2-induced Akt/FOXO1 regulation. |
| Volume: |
9 |
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14910 |
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Villegas-Mendez A |
| Year: |
2020 |
| Journal: |
J Immunol |
| Title: |
Exhausted CD4(+) T Cells during Malaria Exhibit Reduced mTORc1 Activity Correlated with Loss of T-bet Expression. |
| Volume: |
205 |
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6 |
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1608-1619 |
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Diwakar L |
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2021 |
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Endothelin-1 mediated vasoconstriction leads to memory impairment and synaptic dysfunction. |
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11 |
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Cancer Prev Res (Phila) |
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Dietary resveratrol prevents development of high-grade prostatic intraepithelial neoplastic lesions: involvement of SIRT1/S6K axis. |
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6 |
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Breda CNS |
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2021 |
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J Immunol |
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Loss of mTORC2 Activity in Neutrophils Impairs Fusion of Granules and Affects Cellular Metabolism Favoring Increased Bacterial Burden in Sepsis. |
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JCI Insight |
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IMPDH inhibitors for antitumor therapy in tuberous sclerosis complex. |
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Int J Biol Sci |
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Fenofibrate Suppresses Oral Tumorigenesis via Reprogramming Metabolic Processes: Potential Drug Repurposing for Oral Cancer. |
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AMPK directly activates mTORC2 to promote cell survival during acute energetic stress. |
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Resistin inhibits neuronal autophagy through Toll-like receptor 4. |
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The Tumor Suppressor PTEN as Molecular Switch Node Regulating Cell Metabolism and Autophagy: Implications in Immune System and Tumor Microenvironment. |
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Mol Neurobiol |
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Novel roles of mTORC2 in regulation of insulin secretion by actin filament remodeling. |
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Age-related changes to adipose tissue and peripheral neuropathy in genetically diverse HET3 mice differ by sex and are not mitigated by rapamycin longevity treatment. |
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Fibronectin leucine-rich transmembrane protein 2 drives monocyte differentiation into macrophages via the UNC5B-Akt/mTOR axis. |
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Immunity against Non-Melanoma Skin Cancer and the Effect of Immunosuppressive Medication on Non-Melanoma Skin Cancer Risk in Solid Organ Transplant Recipients. |
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Tripartite motif?containing 14 may aggravate cardiac hypertrophy via the AKT signalling pathway in neonatal rat cardiomyocytes and transgenic mice. |
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Functional characterization of cooperating MGA mutations in RUNX1::RUNX1T1 acute myeloid leukemia. |
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2024 |
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Gastroenterology |
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WNT Oncogenic Transcription Requires MYC Suppression of Lysosomal Activity and EPCAM Stabilization in Gastric Tumors. |
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167 |
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2024 |
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Sci Immunol |
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TGF? prevents IgE-mediated allergic disease by restraining T follicular helper 2 differentiation. |
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| Publication |
| First Author: |
Arsham AM |
| Year: |
2002 |
| Journal: |
J Biol Chem |
| Title: |
Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1 alpha nor sufficient for HIF-1-dependent target gene transcription. |
| Volume: |
277 |
| Issue: |
17 |
| Pages: |
15162-70 |
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•
•
•
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| Publication |
| First Author: |
Giegerich AK |
| Year: |
2014 |
| Journal: |
Autophagy |
| Title: |
Autophagy-dependent PELI3 degradation inhibits proinflammatory IL1B expression. |
| Volume: |
10 |
| Issue: |
11 |
| Pages: |
1937-52 |
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•
•
•
•
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| Publication |
| First Author: |
Thapa D |
| Year: |
2026 |
| Journal: |
Cancers (Basel) |
| Title: |
MDM4 at the Crossroads: Beyond p53 and MDM2. |
| Volume: |
18 |
| Issue: |
7 |
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•
•
•
•
•
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| Publication |
| First Author: |
Castillo SD |
| Year: |
2025 |
| Journal: |
Cancer Discov |
| Title: |
Somatic Uniparental Disomy of PTEN in Endothelial Cells Causes Vascular Malformations in Patients with PTEN Hamartoma Tumor Syndrome. |
| Volume: |
15 |
| Issue: |
7 |
| Pages: |
1350-1362 |
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•
•
•
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| Publication |
| First Author: |
Javary J |
| Year: |
2018 |
| Journal: |
Gut |
| Title: |
Liver Reptin/RUVBL2 controls glucose and lipid metabolism with opposite actions on mTORC1 and mTORC2 signalling. |
| Volume: |
67 |
| Issue: |
12 |
| Pages: |
2192-2203 |
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•
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| Publication |
| First Author: |
Marderosian M |
| Year: |
2006 |
| Journal: |
Oncogene |
| Title: |
Tristetraprolin regulates Cyclin D1 and c-Myc mRNA stability in response to rapamycin in an Akt-dependent manner via p38 MAPK signaling. |
| Volume: |
25 |
| Issue: |
47 |
| Pages: |
6277-90 |
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•
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| Publication |
| First Author: |
Housden BE |
| Year: |
2015 |
| Journal: |
Sci Signal |
| Title: |
Identification of potential drug targets for tuberous sclerosis complex by synthetic screens combining CRISPR-based knockouts with RNAi. |
| Volume: |
8 |
| Issue: |
393 |
| Pages: |
rs9 |
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•
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| Publication |
| First Author: |
Liu Z |
| Year: |
2014 |
| Journal: |
J Biol Chem |
| Title: |
PDK4 protein promotes tumorigenesis through activation of cAMP-response element-binding protein (CREB)-Ras homolog enriched in brain (RHEB)-mTORC1 signaling cascade. |
| Volume: |
289 |
| Issue: |
43 |
| Pages: |
29739-49 |
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•
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| Publication |
| First Author: |
Zhang X |
| Year: |
2026 |
| Journal: |
Glia |
| Title: |
Suppression of Astrocytic PirB Alleviates A??-Induced Excitotoxicity and Cognitive Deficits via EAAT Expression. |
| Volume: |
74 |
| Issue: |
2 |
| Pages: |
e70130 |
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•
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| Publication |
| First Author: |
Wang B |
| Year: |
2023 |
| Journal: |
bioRxiv |
| Title: |
TFEB-vacuolar ATPase signaling regulates lysosomal function and microglial activation in tauopathy. |
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•
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| Publication |
| First Author: |
Chang S |
| Year: |
2026 |
| Journal: |
Exp Mol Med |
| Title: |
Targeting the SIRT6-TDO2/KYNA-mTOR axis rescues synaptic and cognitive deficits in fetal growth restriction offspring. |
| Volume: |
58 |
| Issue: |
6 |
| Pages: |
1987-2006 |
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•
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| Publication |
| First Author: |
Yang H |
| Year: |
2026 |
| Journal: |
J Clin Invest |
| Title: |
SLC15A3-mediated dipeptide metabolism confers antimetabolite resistance in lymphoma via mTORC1 activation. |
| Volume: |
136 |
| Issue: |
14 |
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| Publication |
| First Author: |
Yamada O |
| Year: |
2012 |
| Journal: |
Mol Cancer Ther |
| Title: |
JAK-STAT and JAK-PI3K-mTORC1 pathways regulate telomerase transcriptionally and posttranslationally in ATL cells. |
| Volume: |
11 |
| Issue: |
5 |
| Pages: |
1112-21 |
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| Publication |
| First Author: |
Ziegler ME |
| Year: |
2016 |
| Journal: |
Angiogenesis |
| Title: |
mTORC2 mediates CXCL12-induced angiogenesis. |
| Volume: |
19 |
| Issue: |
3 |
| Pages: |
359-71 |
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•
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| Publication |
| First Author: |
Hu X |
| Year: |
2020 |
| Journal: |
Lab Invest |
| Title: |
PI3K-Akt-mTOR/PFKFB3 pathway mediated lung fibroblast aerobic glycolysis and collagen synthesis in lipopolysaccharide-induced pulmonary fibrosis. |
| Volume: |
100 |
| Issue: |
6 |
| Pages: |
801-811 |
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•
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| Publication |
| First Author: |
Cho SH |
| Year: |
2019 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Hypoxia-inducible factors in CD4(+) T cells promote metabolism, switch cytokine secretion, and T cell help in humoral immunity. |
| Volume: |
116 |
| Issue: |
18 |
| Pages: |
8975-8984 |
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•
•
•
•
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| Publication |
| First Author: |
Chimin P |
| Year: |
2017 |
| Journal: |
J Lipid Res |
| Title: |
Adipocyte mTORC1 deficiency promotes adipose tissue inflammation and NLRP3 inflammasome activation via oxidative stress and de novo ceramide synthesis. |
| Volume: |
58 |
| Issue: |
9 |
| Pages: |
1797-1807 |
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•
•
•
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| Publication |
| First Author: |
Yang C |
| Year: |
2018 |
| Journal: |
Elife |
| Title: |
mTORC1 and mTORC2 differentially promote natural killer cell development. |
| Volume: |
7 |
|
|
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1165
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1108
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
677
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
888
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1138
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
631
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
171
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
373
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lee AS |
| Year: |
2015 |
| Journal: |
Nature |
| Title: |
eIF3 targets cell-proliferation messenger RNAs for translational activation or repression. |
| Volume: |
522 |
| Issue: |
7554 |
| Pages: |
111-4 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lee AS |
| Year: |
2016 |
| Journal: |
Nature |
| Title: |
eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation. |
| Volume: |
536 |
| Issue: |
7614 |
| Pages: |
96-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lawrence RE |
| Year: |
2019 |
| Journal: |
Science |
| Title: |
Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex. |
| Volume: |
366 |
| Issue: |
6468 |
| Pages: |
971-977 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus caroli |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|