Type |
Details |
Score |
Genotype |
Symbol: |
Tg(Actb-GFP,-Bmp4)1Csk/? Tg(CAG-cre/Esr1*)67Csk/? |
Background: |
C57BL/6-Tg(Actb-GFP,-Bmp4)1Csk Tg(CAG-cre/Esr1*)67Csk |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
447
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
426
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
426
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
433
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Ohyama Y |
Year: |
2012 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Modulation of matrix mineralization by Vwc2-like protein and its novel splicing isoforms. |
Volume: |
418 |
Issue: |
1 |
Pages: |
12-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Urist MR |
Year: |
1965 |
Journal: |
Science |
Title: |
Bone: formation by autoinduction. |
Volume: |
150 |
Issue: |
3698 |
Pages: |
893-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Reddi AH |
Year: |
2009 |
Journal: |
Cytokine Growth Factor Rev |
Title: |
Bone morphogenetic proteins (BMPs): from morphogens to metabologens. |
Volume: |
20 |
Issue: |
5-6 |
Pages: |
341-2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ohazama A |
Year: |
2010 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A role for suppressed incisor cuspal morphogenesis in the evolution of mammalian heterodont dentition. |
Volume: |
107 |
Issue: |
1 |
Pages: |
92-7 |
|
•
•
•
•
•
|
Allele |
Name: |
regulatory region 16; transposon insertion 1H, Colin E Bishop |
Allele Type: |
Transposon induced |
Attribute String: |
Modified regulatory region |
|
•
•
•
•
•
|
Genotype |
Symbol: |
H2az2/H2az2<+> Tg(CAG-Bmp4,-EGFP)1Ypc/? |
Background: |
involves: C57BL/6J * CBA/J * CD-1 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
333
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
159
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
333
 |
Fragment?: |
false |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE17654 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE33912 |
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
Publication |
First Author: |
Tucker AS |
Year: |
1998 |
Journal: |
Science |
Title: |
Transformation of tooth type induced by inhibition of BMP signaling. |
Volume: |
282 |
Issue: |
5391 |
Pages: |
1136-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kaplan FS |
Year: |
2012 |
Journal: |
Dis Model Mech |
Title: |
Fibrodysplasia ossificans progressiva: mechanisms and models of skeletal metamorphosis. |
Volume: |
5 |
Issue: |
6 |
Pages: |
756-62 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, transposon induced mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
transposon induced mutation, mutant strain, coisogenic |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Bmp4/? Gt(ROSA)26Sor/? Tg(Mef2c-cre)2Blk/? |
Background: |
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rr16/Rr16 |
Background: |
FVB/N-Rr16 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Bmp4/Bmp4<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> H2az2/H2az2<+> |
Background: |
involves: 129/Sv * C57BL/6J * CBA/J |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE32321 |
Experiment Type: |
transcription profiling by array |
Study Type: |
Baseline and WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
Publication |
First Author: |
Kan C |
Year: |
2018 |
Journal: |
Bone |
Title: |
Gli1-labeled adult mesenchymal stem/progenitor cells and hedgehog signaling contribute to endochondral heterotopic ossification. |
Volume: |
109 |
|
Pages: |
71-79 |
|
•
•
•
•
•
|
Publication |
First Author: |
Koutmani Y |
Year: |
2019 |
Journal: |
Cell Rep |
Title: |
CRH Promotes the Neurogenic Activity of Neural Stem Cells in the Adult Hippocampus. |
Volume: |
29 |
Issue: |
4 |
Pages: |
932-945.e7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tang SJ |
Year: |
1998 |
Journal: |
Development |
Title: |
The Tlx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development. |
Volume: |
125 |
Issue: |
10 |
Pages: |
1877-87 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lugus JJ |
Year: |
2007 |
Journal: |
Development |
Title: |
GATA2 functions at multiple steps in hemangioblast development and differentiation. |
Volume: |
134 |
Issue: |
2 |
Pages: |
393-405 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chang H |
Year: |
2001 |
Journal: |
Mech Dev |
Title: |
Smad5 is required for mouse primordial germ cell development. |
Volume: |
104 |
Issue: |
1-2 |
Pages: |
61-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xu B |
Year: |
2011 |
Journal: |
Development |
Title: |
Smad1 and its target gene Wif1 coordinate BMP and Wnt signaling activities to regulate fetal lung development. |
Volume: |
138 |
Issue: |
5 |
Pages: |
925-35 |
|
•
•
•
•
•
|
Publication |
First Author: |
Aramaki S |
Year: |
2013 |
Journal: |
Dev Cell |
Title: |
A mesodermal factor, T, specifies mouse germ cell fate by directly activating germline determinants. |
Volume: |
27 |
Issue: |
5 |
Pages: |
516-29 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lin SC |
Year: |
2017 |
Journal: |
Dev Cell |
Title: |
Endothelial-to-Osteoblast Conversion Generates Osteoblastic Metastasis of Prostate Cancer. |
Volume: |
41 |
Issue: |
5 |
Pages: |
467-480.e3 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tsukamoto S |
Year: |
2023 |
Journal: |
Development |
Title: |
Wnt7b expressed by hypertrophic chondrocytes is a stimulatory factor for endochondral ossification that is regulated by Smad4 activity. |
Volume: |
150 |
Issue: |
15 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hayashi Y |
Year: |
2016 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
BMP-SMAD-ID promotes reprogramming to pluripotency by inhibiting p16/INK4A-dependent senescence. |
Volume: |
113 |
Issue: |
46 |
Pages: |
13057-13062 |
|
•
•
•
•
•
|
Publication |
First Author: |
Russell R |
Year: |
2015 |
Journal: |
Nat Commun |
Title: |
Loss of ATM accelerates pancreatic cancer formation and epithelial-mesenchymal transition. |
Volume: |
6 |
|
Pages: |
7677 |
|
•
•
•
•
•
|
Publication |
First Author: |
Belo JA |
Year: |
2000 |
Journal: |
Genesis |
Title: |
Cerberus-like is a secreted BMP and nodal antagonist not essential for mouse development. |
Volume: |
26 |
Issue: |
4 |
Pages: |
265-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kinsella S |
Year: |
2021 |
Journal: |
Cell Rep |
Title: |
Attenuation of apoptotic cell detection triggers thymic regeneration after damage. |
Volume: |
37 |
Issue: |
1 |
Pages: |
109789 |
|
•
•
•
•
•
|
Publication |
First Author: |
Whissell G |
Year: |
2014 |
Journal: |
Nat Cell Biol |
Title: |
The transcription factor GATA6 enables self-renewal of colon adenoma stem cells by repressing BMP gene expression. |
Volume: |
16 |
Issue: |
7 |
Pages: |
695-707 |
|
•
•
•
•
•
|
Publication |
First Author: |
Meng C |
Year: |
2016 |
Journal: |
Biol Reprod |
Title: |
Repulsive Guidance Molecule b (RGMb) Is Dispensable for Normal Gonadal Function in Mice. |
Volume: |
94 |
Issue: |
4 |
Pages: |
78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Slavotinek AM |
Year: |
2011 |
Journal: |
Mol Genet Metab |
Title: |
Eye development genes and known syndromes. |
Volume: |
104 |
Issue: |
4 |
Pages: |
448-56 |
|
•
•
•
•
•
|
Publication |
First Author: |
Galeone A |
Year: |
2020 |
Journal: |
Elife |
Title: |
Regulation of BMP4/Dpp retrotranslocation and signaling by deglycosylation. |
Volume: |
9 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Dietrich S |
Year: |
1998 |
Journal: |
Development |
Title: |
Specification of the hypaxial musculature. |
Volume: |
125 |
Issue: |
12 |
Pages: |
2235-49 |
|
•
•
•
•
•
|
Publication |
First Author: |
Glozak MA |
Year: |
1998 |
Journal: |
Exp Cell Res |
Title: |
BMP4- and RA-induced apoptosis is mediated through the activation of retinoic acid receptor alpha and gamma in P19 embryonal carcinoma cells. |
Volume: |
242 |
Issue: |
1 |
Pages: |
165-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Su HL |
Year: |
2006 |
Journal: |
Dev Biol |
Title: |
Generation of cerebellar neuron precursors from embryonic stem cells. |
Volume: |
290 |
Issue: |
2 |
Pages: |
287-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Napier HR |
Year: |
2007 |
Journal: |
Exp Eye Res |
Title: |
Molecular events in early development of the ciliary body: a question of folding. |
Volume: |
84 |
Issue: |
4 |
Pages: |
615-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Itman C |
Year: |
2008 |
Journal: |
Dev Dyn |
Title: |
SMAD expression in the testis: an insight into BMP regulation of spermatogenesis. |
Volume: |
237 |
Issue: |
1 |
Pages: |
97-111 |
|
•
•
•
•
•
|
Publication |
First Author: |
Osório L |
Year: |
2019 |
Journal: |
J Cell Biol |
Title: |
ISM1 regulates NODAL signaling and asymmetric organ morphogenesis during development. |
Volume: |
218 |
Issue: |
7 |
Pages: |
2388-2402 |
|
•
•
•
•
•
|
Publication |
First Author: |
McAndrews KM |
Year: |
2021 |
Journal: |
Oncogene |
Title: |
αSMA+ fibroblasts suppress Lgr5+ cancer stem cells and restrain colorectal cancer progression. |
Volume: |
40 |
Issue: |
26 |
Pages: |
4440-4452 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bonds JA |
Year: |
2023 |
Journal: |
eNeuro |
Title: |
Why Some Mice Are Smarter than Others: The Impact of Bone Morphogenetic Protein Signaling on Cognition. |
Volume: |
10 |
Issue: |
1 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Chen S |
Year: |
2024 |
Journal: |
EMBO Rep |
Title: |
Terminal α1,2-fucosylation of glycosphingolipids by FUT1 is a key regulator in early cell-fate decisions. |
Volume: |
25 |
Issue: |
10 |
Pages: |
4433-4464 |
|
•
•
•
•
•
|
Publication |
First Author: |
Crisan M |
Year: |
2016 |
Journal: |
Stem Cell Reports |
Title: |
BMP and Hedgehog Regulate Distinct AGM Hematopoietic Stem Cells Ex Vivo. |
Volume: |
6 |
Issue: |
3 |
Pages: |
383-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Samad TA |
Year: |
2005 |
Journal: |
J Biol Chem |
Title: |
DRAGON, a bone morphogenetic protein co-receptor. |
Volume: |
280 |
Issue: |
14 |
Pages: |
14122-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu D |
Year: |
2015 |
Journal: |
Hum Mol Genet |
Title: |
DLX4 is associated with orofacial clefting and abnormal jaw development. |
Volume: |
24 |
Issue: |
15 |
Pages: |
4340-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gajera CR |
Year: |
2010 |
Journal: |
J Cell Sci |
Title: |
LRP2 in ependymal cells regulates BMP signaling in the adult neurogenic niche. |
Volume: |
123 |
Issue: |
Pt 11 |
Pages: |
1922-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cai J |
Year: |
2009 |
Journal: |
Dev Biol |
Title: |
Genetic interplays between Msx2 and Foxn1 are required for Notch1 expression and hair shaft differentiation. |
Volume: |
326 |
Issue: |
2 |
Pages: |
420-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hegde S |
Year: |
2007 |
Journal: |
Mamm Genome |
Title: |
An intronic sequence mutated in flexed-tail mice regulates splicing of Smad5. |
Volume: |
18 |
Issue: |
12 |
Pages: |
852-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ross AJ |
Year: |
2003 |
Journal: |
Mol Cell Endocrinol |
Title: |
AMH induces mesonephric cell migration in XX gonads. |
Volume: |
211 |
Issue: |
1-2 |
Pages: |
1-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Arezes J |
Year: |
2020 |
Journal: |
Blood |
Title: |
Antibodies against the erythroferrone N-terminal domain prevent hepcidin suppression and ameliorate murine thalassemia. |
Volume: |
135 |
Issue: |
8 |
Pages: |
547-557 |
|
•
•
•
•
•
|
Publication |
First Author: |
Acampora D |
Year: |
2013 |
Journal: |
Development |
Title: |
Otx2 is an intrinsic determinant of the embryonic stem cell state and is required for transition to a stable epiblast stem cell condition. |
Volume: |
140 |
Issue: |
1 |
Pages: |
43-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dean C |
Year: |
2004 |
Journal: |
Development |
Title: |
Bmp7 regulates branching morphogenesis of the lacrimal gland by promoting mesenchymal proliferation and condensation. |
Volume: |
131 |
Issue: |
17 |
Pages: |
4155-65 |
|
•
•
•
•
•
|
Publication |
First Author: |
Halilagic A |
Year: |
2007 |
Journal: |
Dev Biol |
Title: |
Retinoids control anterior and dorsal properties in the developing forebrain. |
Volume: |
303 |
Issue: |
1 |
Pages: |
362-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang Z |
Year: |
2006 |
Journal: |
Dev Biol |
Title: |
Retinoic acid regulates morphogenesis and patterning of posterior foregut derivatives. |
Volume: |
297 |
Issue: |
2 |
Pages: |
433-45 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yamada M |
Year: |
2000 |
Journal: |
Dev Biol |
Title: |
Expression of chick Tbx-2, Tbx-3, and Tbx-5 genes during early heart development: evidence for BMP2 induction of Tbx2. |
Volume: |
228 |
Issue: |
1 |
Pages: |
95-105 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang L |
Year: |
2019 |
Journal: |
Sci Rep |
Title: |
Aberrant expression of a stabilized β-catenin mutant in keratocytes inhibits mouse corneal epithelial stratification. |
Volume: |
9 |
Issue: |
1 |
Pages: |
1919 |
|
•
•
•
•
•
|
Publication |
First Author: |
Botchkarev VA |
Year: |
2001 |
Journal: |
FASEB J |
Title: |
Noggin is required for induction of the hair follicle growth phase in postnatal skin. |
Volume: |
15 |
Issue: |
12 |
Pages: |
2205-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Di Giovanni V |
Year: |
2011 |
Journal: |
Development |
Title: |
Alk3 controls nephron number and androgen production via lineage-specific effects in intermediate mesoderm. |
Volume: |
138 |
Issue: |
13 |
Pages: |
2717-27 |
|
•
•
•
•
•
|
Publication |
First Author: |
Davis S |
Year: |
2004 |
Journal: |
Dev Biol |
Title: |
BMP receptor IA is required in the mammalian embryo for endodermal morphogenesis and ectodermal patterning. |
Volume: |
270 |
Issue: |
1 |
Pages: |
47-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bei M |
Year: |
2004 |
Journal: |
Dev Dyn |
Title: |
Msx2 controls ameloblast terminal differentiation. |
Volume: |
231 |
Issue: |
4 |
Pages: |
758-65 |
|
•
•
•
•
•
|
Publication |
First Author: |
Arnold JS |
Year: |
2006 |
Journal: |
Hum Mol Genet |
Title: |
Tissue-specific roles of Tbx1 in the development of the outer, middle and inner ear, defective in 22q11DS patients. |
Volume: |
15 |
Issue: |
10 |
Pages: |
1629-39 |
|
•
•
•
•
•
|
Publication |
First Author: |
Puligilla C |
Year: |
2007 |
Journal: |
Dev Dyn |
Title: |
Disruption of fibroblast growth factor receptor 3 signaling results in defects in cellular differentiation, neuronal patterning, and hearing impairment. |
Volume: |
236 |
Issue: |
7 |
Pages: |
1905-17 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang L |
Year: |
2024 |
Journal: |
Mol Metab |
Title: |
Two-step regulation by matrix Gla protein in brown adipose cell differentiation. |
Volume: |
80 |
|
Pages: |
101870 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen Y |
Year: |
2015 |
Journal: |
Biochem Biophys Res Commun |
Title: |
BTG/Tob family members Tob1 and Tob2 inhibit proliferation of mouse embryonic stem cells via Id3 mRNA degradation. |
Volume: |
462 |
Issue: |
3 |
Pages: |
208-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yoshikawa M |
Year: |
2016 |
Journal: |
Mol Cell Neurosci |
Title: |
Runx1 contributes to the functional switching of bone morphogenetic protein 4 (BMP4) from neurite outgrowth promoting to suppressing in dorsal root ganglion. |
Volume: |
72 |
|
Pages: |
114-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Meynard D |
Year: |
2009 |
Journal: |
Nat Genet |
Title: |
Lack of the bone morphogenetic protein BMP6 induces massive iron overload. |
Volume: |
41 |
Issue: |
4 |
Pages: |
478-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen J |
Year: |
2007 |
Journal: |
Genesis |
Title: |
The TGF-beta pseudoreceptor gene Bambi is dispensable for mouse embryonic development and postnatal survival. |
Volume: |
45 |
Issue: |
8 |
Pages: |
482-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yu J |
Year: |
2004 |
Journal: |
J Biol Chem |
Title: |
Altered expression of genes of the Bmp/Smad and Wnt/calcium signaling pathways in the cone-only Nrl-/- mouse retina, revealed by gene profiling using custom cDNA microarrays. |
Volume: |
279 |
Issue: |
40 |
Pages: |
42211-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mungrue IN |
Year: |
2011 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Abcc6 deficiency causes increased infarct size and apoptosis in a mouse cardiac ischemia-reperfusion model. |
Volume: |
31 |
Issue: |
12 |
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Inhibiting Bone Morphogenetic Protein 4 Type I Receptor Signaling Promotes Remyelination by Potentiating Oligodendrocyte Differentiation. |
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Loss of scleraxis in mice leads to geometric and structural changes in cortical bone, as well as asymmetry in fracture healing. |
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Proc Natl Acad Sci U S A |
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Disruption of bone morphogenetic protein receptor 2 (BMPR2) in mammary tumors promotes metastases through cell autonomous and paracrine mediators. |
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J Biol Chem |
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Bone morphogenetic protein (BMP) type II receptor is required for BMP-mediated growth arrest and differentiation in pulmonary artery smooth muscle cells. |
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283 |
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2022 |
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Blood |
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139 |
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