| Type |
Details |
Score |
| Publication |
| First Author: |
Ayoub AE |
| Year: |
2011 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Transcriptional programs in transient embryonic zones of the cerebral cortex defined by high-resolution mRNA sequencing. |
| Volume: |
108 |
| Issue: |
36 |
| Pages: |
14950-5 |
|
•
•
•
•
•
|
| HT Experiment |
| Series Id: |
GSE44087 |
| Experiment Type: |
transcription profiling by array |
| Study Type: |
WT vs. Mutant |
| Source: |
ArrayExpress |
|
•
•
•
•
•
|
| HT Experiment |
| Series Id: |
GSE24504 |
| Experiment Type: |
transcription profiling by array |
| Study Type: |
Baseline |
| Source: |
ArrayExpress |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mona B |
| Year: |
2017 |
| Journal: |
Elife |
| Title: |
Repression by PRDM13 is critical for generating precision in neuronal identity. |
| Volume: |
6 |
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Anderson SR |
| Year: |
2019 |
| Journal: |
J Neurosci |
| Title: |
Complement Targets Newborn Retinal Ganglion Cells for Phagocytic Elimination by Microglia. |
| Volume: |
39 |
| Issue: |
11 |
| Pages: |
2025-2040 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Monaghan CE |
| Year: |
2017 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
REST corepressors RCOR1 and RCOR2 and the repressor INSM1 regulate the proliferation-differentiation balance in the developing brain. |
| Volume: |
114 |
| Issue: |
3 |
| Pages: |
E406-E415 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang Y |
| Year: |
2002 |
| Journal: |
Mol Cell Biol |
| Title: |
The RAS effector RIN1 directly competes with RAF and is regulated by 14-3-3 proteins. |
| Volume: |
22 |
| Issue: |
3 |
| Pages: |
916-26 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fernlund P |
| Year: |
1983 |
| Journal: |
J Biol Chem |
| Title: |
Beta-hydroxyaspartic acid in vitamin K-dependent proteins. |
| Volume: |
258 |
| Issue: |
20 |
| Pages: |
12509-12 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
McMullen BA |
| Year: |
1983 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
The occurrence of beta-hydroxyaspartic acid in the vitamin K-dependent blood coagulation zymogens. |
| Volume: |
115 |
| Issue: |
1 |
| Pages: |
8-14 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Stanley TB |
| Year: |
1999 |
| Journal: |
J Biol Chem |
| Title: |
The propeptides of the vitamin K-dependent proteins possess different affinities for the vitamin K-dependent carboxylase. |
| Volume: |
274 |
| Issue: |
24 |
| Pages: |
16940-4 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tsunematsu T |
| Year: |
2010 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Distinct functions of human MVB12A and MVB12B in the ESCRT-I dependent on their posttranslational modifications. |
| Volume: |
399 |
| Issue: |
2 |
| Pages: |
232-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wunderley L |
| Year: |
2014 |
| Journal: |
J Cell Sci |
| Title: |
The molecular basis for selective assembly of the UBAP1-containing endosome-specific ESCRT-I complex. |
| Volume: |
127 |
| Issue: |
Pt 3 |
| Pages: |
663-72 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wiltscheck R |
| Year: |
1997 |
| Journal: |
Protein Sci |
| Title: |
Heteronuclear NMR assignments and secondary structure of the coiled coil trimerization domain from cartilage matrix protein in oxidized and reduced forms. |
| Volume: |
6 |
| Issue: |
8 |
| Pages: |
1734-45 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kong C |
| Year: |
2007 |
| Journal: |
J Biol Chem |
| Title: |
Rin1 interacts with signal-transducing adaptor molecule (STAM) and mediates epidermal growth factor receptor trafficking and degradation. |
| Volume: |
282 |
| Issue: |
20 |
| Pages: |
15294-301 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Balaji K |
| Year: |
2013 |
| Journal: |
Commun Integr Biol |
| Title: |
RIN1 regulates cell migration through RAB5 GTPases and ABL tyrosine kinases. |
| Volume: |
6 |
| Issue: |
5 |
| Pages: |
e25421 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This group of plasma glycoproteins includes coagulation factors VII, IX, and X, and proteins C and Z, which belong to MEROPS peptidase family S1, subfamily S1A (chymotrypsin, clan PA(S)). All but protein Z are peptidases and are involved in blood coagulation. The precursors contain a signal sequence, propeptide, Gla domain, two EGF domains (although sometimes only one is detected by Pfam), and a trypsin domain. Except for protein Z, they are further cleaved between the second EGF domain and the trypsin domain into light and heavy chains, which are connected by a disulphide bond. Glutamic acid residues in the Gla domain undergo vitamin K-dependent carboxylation, allowing this region to bind calcium and membrane phospholipid []. The propeptide region is important in providing a recognition site for the gamma-carboxylase []. Typically one aspartic acid residue in the light chain is post-translationally modified to erythro-beta-hydroxyaspartic acid [, ]. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
RIN1, a member of the RIN (AKA Ras interaction/interference) family, have multifunctional domains including SH2 and proline-rich (PR) domains in the N-terminal region, and RIN-family homology (RH), VPS9 and Ras-association (RA) domains in the C-terminal region. RIN proteins function as Rab5-GEFs []. Previous studies showed that RIN1 interacts with EGF receptors via its SH2 domain and regulates trafficking and degradation of EGF receptors via its interaction with STAM, indicating a vital role for RIN1 in regulating endosomal trafficking of receptor tyrosine kinases (RTKs) []. RIN1 was first identified as a Ras-binding protein that suppresses the activated RAS2 allele in S. cerevisiae. RIN1 binds to the activated Ras through its carboxyl-terminal domain and this Ras-binding domain also binds to 14-3-3 proteins as Raf-1 does [].The SH2 domain of RIN1 are thought to interact with the phosphotyrosine-containing proteins, but the physiological partners for this domain are unknown. The proline-rich domain in RIN1 is similar to the consensus SH3 binding regions. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Conserved_site |
| Description: |
A sequence of about thirty to forty amino-acid residues long found in the sequence of epidermal growth factor (EGF)has been shown [, , , ]to be present, in a moreor less conserved form, in a large number of other, mostly animal proteins. The list of proteins currently known tocontain one or more copies of an EGF-like pattern is large and varied. The functional significance of EGF domains inwhat appear to be unrelated proteins is not yet clear. However, a common feature is that these repeats are found inthe extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandinG/H synthase). The EGF domain includes six cysteine residues which have been shown (in EGF) to be involved in disulphidebonds. The main structure is a two-stranded β-sheet followed by a loop to a C-terminal short two-stranded sheet.Subdomains between the conserved cysteines vary in length.This entry represents a conserved site in the EGF-like domain. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Krishnamoorthy M |
| Year: |
2009 |
| Journal: |
J Biochem |
| Title: |
Heparin binding epidermal growth factor-like growth factor and PD169316 prevent apoptosis in mouse embryonic stem cells. |
| Volume: |
145 |
| Issue: |
2 |
| Pages: |
177-84 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kim YS |
| Year: |
2023 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
An unanticipated discourse of HB-EGF with VANGL2 signaling during embryo implantation. |
| Volume: |
120 |
| Issue: |
20 |
| Pages: |
e2302937120 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
152
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
177
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
248
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
208
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
162
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang Y |
| Year: |
2001 |
| Journal: |
J Biol Chem |
| Title: |
Modification of epidermal growth factor-like repeats with O-fucose. Molecular cloning and expression of a novel GDP-fucose protein O-fucosyltransferase. |
| Volume: |
276 |
| Issue: |
43 |
| Pages: |
40338-45 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
159
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
177
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
148
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
248
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
159
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
137
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
152
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
208
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fitzgerald K |
| Year: |
1995 |
| Journal: |
Development |
| Title: |
Interchangeability of Caenorhabditis elegans DSL proteins and intrinsic signalling activity of their extracellular domains in vivo. |
| Volume: |
121 |
| Issue: |
12 |
| Pages: |
4275-82 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Artavanis-Tsakonas S |
| Year: |
1995 |
| Journal: |
Science |
| Title: |
Notch signaling. |
| Volume: |
268 |
| Issue: |
5208 |
| Pages: |
225-32 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fuentes-Prior P |
| Year: |
2000 |
| Journal: |
Nature |
| Title: |
Structural basis for the anticoagulant activity of the thrombin-thrombomodulin complex. |
| Volume: |
404 |
| Issue: |
6777 |
| Pages: |
518-25 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Choowongkomon K |
| Year: |
2005 |
| Journal: |
J Biol Chem |
| Title: |
A structural model for the membrane-bound form of the juxtamembrane domain of the epidermal growth factor receptor. |
| Volume: |
280 |
| Issue: |
25 |
| Pages: |
24043-52 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hubbard SR |
| Year: |
2004 |
| Journal: |
Nat Rev Mol Cell Biol |
| Title: |
Juxtamembrane autoinhibition in receptor tyrosine kinases. |
| Volume: |
5 |
| Issue: |
6 |
| Pages: |
464-71 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Sorting nexin-5 (SNX5) belongs to the sorting nexin family, which contains a conserved PX (phox homology) domain that is responsible for binding to specific phosphoinositides []. SNX5 also contains a BAR domain that is C terminus to the PX domain. Besides being involved in several stages of intracellular trafficking, SNX5 also plays a role in macropinocytosis and in the internalisation of EGFR after EGF stimulation [, ]. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This is a family of conserved proteins representing the enzyme responsible for adding O-fucose to EGF (epidermal growth factor-like) repeats. Six highly conserved cysteines are present as well as a DXD-like motif (ERD), conserved in mammals, Drosophila, and Caenorhabditis elegans. Both features are characteristic of several glycosyltransferase families. The enzyme is a membrane-bound protein released by proteolysis and, as for most glycosyltransferases, is strongly activated by manganese []. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Homologous_superfamily |
| Description: |
Receptor tyrosine kinases (RTKs) are transmembrane receptors thathave intrinsic, cytoplasmic tyrosine kinase activity. Juxtamembrane regions in RTKs have been shown to play important regulatory functions. Their kinase activity is generally autoinhibited by its JX domain in the absence of ligand-stimulated tyrosine phosphorylation, due to the inhibitory Tyr phosphorylation sites found in the JX domain []. This superfamily represents the JX domain of the EGF receptor []. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
This domain adopts a fold similar to other EGF domains, with a flat major and a twisted minor beta sheet. Disulphide pairing, however, is not of the usual 1-3, 2-4, 5-6 type; rather 1-2, 3-4, 5-6 pairing is found. Its extended major sheet (strands beta-2 and beta-3 and the connecting loop) projects into thrombin's active site groove. This domain is required for interaction of thrombomodulin with thrombin, and subsequent activation of protein-C []. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
Ligands of the Delta/Serrate/lag-2 (DSL) family and their receptors, members ofthe lin-12/Notch family, mediate cell-cell interactions that specify cell fate in invertebrates and vertebrates. In Caenorhabditis elegans, two DSL genes, lag-2 and apx-1,influence different cell fate decisions during development []. Molecular interaction between Notch and Serrate, another EGF-homologous transmembrane protein containing a region of striking similarity to Delta, has been shown and the same two EGF repeats of Notch may also constitute a Serrate binding domain [, ]. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hald J |
| Year: |
2012 |
| Journal: |
Diabetologia |
| Title: |
Pancreatic islet and progenitor cell surface markers with cell sorting potential. |
| Volume: |
55 |
| Issue: |
1 |
| Pages: |
154-65 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhao T |
| Year: |
2014 |
| Journal: |
Development |
| Title: |
β-catenin regulates Pax3 and Cdx2 for caudal neural tube closure and elongation. |
| Volume: |
141 |
| Issue: |
1 |
| Pages: |
148-57 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fairfield H |
| Year: |
2015 |
| Journal: |
Genome Res |
| Title: |
Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders. |
| Volume: |
25 |
| Issue: |
7 |
| Pages: |
948-57 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fouillade C |
| Year: |
2013 |
| Journal: |
Arterioscler Thromb Vasc Biol |
| Title: |
Transcriptome analysis for Notch3 target genes identifies Grip2 as a novel regulator of myogenic response in the cerebrovasculature. |
| Volume: |
33 |
| Issue: |
1 |
| Pages: |
76-86 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pajvani UB |
| Year: |
2011 |
| Journal: |
Nat Med |
| Title: |
Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner. |
| Volume: |
17 |
| Issue: |
8 |
| Pages: |
961-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jin JZ |
| Year: |
2014 |
| Journal: |
Dev Dyn |
| Title: |
Deciphering TGF-β3 function in medial edge epithelium specification and fusion during mouse secondary palate development. |
| Volume: |
243 |
| Issue: |
12 |
| Pages: |
1536-43 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hitoshi S |
| Year: |
2002 |
| Journal: |
Genes Dev |
| Title: |
Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells. |
| Volume: |
16 |
| Issue: |
7 |
| Pages: |
846-58 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Thomas JA |
| Year: |
2003 |
| Journal: |
Am J Physiol Heart Circ Physiol |
| Title: |
IRAK1 deletion disrupts cardiac Toll/IL-1 signaling and protects against contractile dysfunction. |
| Volume: |
285 |
| Issue: |
2 |
| Pages: |
H597-606 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang K |
| Year: |
2014 |
| Journal: |
Neurobiol Dis |
| Title: |
Notch1 mediates postnatal neurogenesis in hippocampus enhanced by intermittent hypoxia. |
| Volume: |
64 |
|
| Pages: |
66-78 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yao Y |
| Year: |
2013 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Reducing Jagged 1 and 2 levels prevents cerebral arteriovenous malformations in matrix Gla protein deficiency. |
| Volume: |
110 |
| Issue: |
47 |
| Pages: |
19071-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
McCright B |
| Year: |
2002 |
| Journal: |
Development |
| Title: |
A mouse model of Alagille syndrome: Notch2 as a genetic modifier of Jag1 haploinsufficiency. |
| Volume: |
129 |
| Issue: |
4 |
| Pages: |
1075-82 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Stassart RM |
| Year: |
2013 |
| Journal: |
Nat Neurosci |
| Title: |
A role for Schwann cell-derived neuregulin-1 in remyelination. |
| Volume: |
16 |
| Issue: |
1 |
| Pages: |
48-54 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yang X |
| Year: |
2001 |
| Journal: |
Neuron |
| Title: |
Patterning of muscle acetylcholine receptor gene expression in the absence of motor innervation. |
| Volume: |
30 |
| Issue: |
2 |
| Pages: |
399-410 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jaworski A |
| Year: |
2006 |
| Journal: |
J Neurosci |
| Title: |
Neuromuscular synapse formation in mice lacking motor neuron- and skeletal muscle-derived Neuregulin-1. |
| Volume: |
26 |
| Issue: |
2 |
| Pages: |
655-61 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Anthony TE |
| Year: |
2005 |
| Journal: |
Genes Dev |
| Title: |
Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells. |
| Volume: |
19 |
| Issue: |
9 |
| Pages: |
1028-33 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
You Y |
| Year: |
2011 |
| Journal: |
J Immunol |
| Title: |
Marginal zone B cells regulate antigen capture by marginal zone macrophages. |
| Volume: |
186 |
| Issue: |
4 |
| Pages: |
2172-81 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dave JM |
| Year: |
2022 |
| Journal: |
J Clin Invest |
| Title: |
JAGGED1/NOTCH3 activation promotes aortic hypermuscularization and stenosis in elastin deficiency. |
| Volume: |
132 |
| Issue: |
5 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mori M |
| Year: |
2015 |
| Journal: |
Development |
| Title: |
Notch3-Jagged signaling controls the pool of undifferentiated airway progenitors. |
| Volume: |
142 |
| Issue: |
2 |
| Pages: |
258-67 |
|
•
•
•
•
•
|
| Allele |
| Name: |
advillin; targeted mutation 1, Paul A Heppenstall |
| Allele Type: |
Targeted |
| Attribute String: |
Conditional ready, Inserted expressed sequence |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Jag1/Jag1<+> Notch2/Notch2<+> |
| Background: |
involves: 129S1/Sv * C57BL/6J |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Notch1/Notch1 Tg(Pax2-cre)1Akg/? |
| Background: |
involves: 129S1/Sv * 129X1/SvJ |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Jag1/Jag1<+> Notch2/Notch2<+> |
| Background: |
involves: 129S1/Sv |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Notch2/Notch2 Speer6-ps1/Speer6-ps1<+> |
| Background: |
involves: 129S1/Sv * C57BL/6 * DBA |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Notch1/Notch1<+> Notch2/Notch2 |
| Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Notch1/Notch1 Notch2/Notch2 Tg(Prrx1-cre)1Cjt/? |
| Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
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| Protein |
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220
 |
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false |
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