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Search results 4501 to 4600 out of 9662 for Egf

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Type Details Score
Publication
First Author: Ayoub AE
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Transcriptional programs in transient embryonic zones of the cerebral cortex defined by high-resolution mRNA sequencing.
Volume: 108
Issue: 36
Pages: 14950-5
HT Experiment
Series Id: GSE44087
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment
Series Id: GSE24504
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
Publication    
First Author: Mona B
Year: 2017
Journal: Elife
Title: Repression by PRDM13 is critical for generating precision in neuronal identity.
Volume: 6
Publication
First Author: Anderson SR
Year: 2019
Journal: J Neurosci
Title: Complement Targets Newborn Retinal Ganglion Cells for Phagocytic Elimination by Microglia.
Volume: 39
Issue: 11
Pages: 2025-2040
Publication
First Author: Monaghan CE
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: REST corepressors RCOR1 and RCOR2 and the repressor INSM1 regulate the proliferation-differentiation balance in the developing brain.
Volume: 114
Issue: 3
Pages: E406-E415
Publication
First Author: Wang Y
Year: 2002
Journal: Mol Cell Biol
Title: The RAS effector RIN1 directly competes with RAF and is regulated by 14-3-3 proteins.
Volume: 22
Issue: 3
Pages: 916-26
Publication
First Author: Fernlund P
Year: 1983
Journal: J Biol Chem
Title: Beta-hydroxyaspartic acid in vitamin K-dependent proteins.
Volume: 258
Issue: 20
Pages: 12509-12
Publication
First Author: McMullen BA
Year: 1983
Journal: Biochem Biophys Res Commun
Title: The occurrence of beta-hydroxyaspartic acid in the vitamin K-dependent blood coagulation zymogens.
Volume: 115
Issue: 1
Pages: 8-14
Publication
First Author: Stanley TB
Year: 1999
Journal: J Biol Chem
Title: The propeptides of the vitamin K-dependent proteins possess different affinities for the vitamin K-dependent carboxylase.
Volume: 274
Issue: 24
Pages: 16940-4
Publication
First Author: Tsunematsu T
Year: 2010
Journal: Biochem Biophys Res Commun
Title: Distinct functions of human MVB12A and MVB12B in the ESCRT-I dependent on their posttranslational modifications.
Volume: 399
Issue: 2
Pages: 232-7
Publication
First Author: Wunderley L
Year: 2014
Journal: J Cell Sci
Title: The molecular basis for selective assembly of the UBAP1-containing endosome-specific ESCRT-I complex.
Volume: 127
Issue: Pt 3
Pages: 663-72
Publication
First Author: Wiltscheck R
Year: 1997
Journal: Protein Sci
Title: Heteronuclear NMR assignments and secondary structure of the coiled coil trimerization domain from cartilage matrix protein in oxidized and reduced forms.
Volume: 6
Issue: 8
Pages: 1734-45
Publication
First Author: Kong C
Year: 2007
Journal: J Biol Chem
Title: Rin1 interacts with signal-transducing adaptor molecule (STAM) and mediates epidermal growth factor receptor trafficking and degradation.
Volume: 282
Issue: 20
Pages: 15294-301
Publication
First Author: Balaji K
Year: 2013
Journal: Commun Integr Biol
Title: RIN1 regulates cell migration through RAB5 GTPases and ABL tyrosine kinases.
Volume: 6
Issue: 5
Pages: e25421
Protein Domain
Type: Family
Description: This group of plasma glycoproteins includes coagulation factors VII, IX, and X, and proteins C and Z, which belong to MEROPS peptidase family S1, subfamily S1A (chymotrypsin, clan PA(S)). All but protein Z are peptidases and are involved in blood coagulation. The precursors contain a signal sequence, propeptide, Gla domain, two EGF domains (although sometimes only one is detected by Pfam), and a trypsin domain. Except for protein Z, they are further cleaved between the second EGF domain and the trypsin domain into light and heavy chains, which are connected by a disulphide bond. Glutamic acid residues in the Gla domain undergo vitamin K-dependent carboxylation, allowing this region to bind calcium and membrane phospholipid []. The propeptide region is important in providing a recognition site for the gamma-carboxylase []. Typically one aspartic acid residue in the light chain is post-translationally modified to erythro-beta-hydroxyaspartic acid [, ].
Protein Domain
Type: Domain
Description: RIN1, a member of the RIN (AKA Ras interaction/interference) family, have multifunctional domains including SH2 and proline-rich (PR) domains in the N-terminal region, and RIN-family homology (RH), VPS9 and Ras-association (RA) domains in the C-terminal region. RIN proteins function as Rab5-GEFs []. Previous studies showed that RIN1 interacts with EGF receptors via its SH2 domain and regulates trafficking and degradation of EGF receptors via its interaction with STAM, indicating a vital role for RIN1 in regulating endosomal trafficking of receptor tyrosine kinases (RTKs) []. RIN1 was first identified as a Ras-binding protein that suppresses the activated RAS2 allele in S. cerevisiae. RIN1 binds to the activated Ras through its carboxyl-terminal domain and this Ras-binding domain also binds to 14-3-3 proteins as Raf-1 does [].The SH2 domain of RIN1 are thought to interact with the phosphotyrosine-containing proteins, but the physiological partners for this domain are unknown. The proline-rich domain in RIN1 is similar to the consensus SH3 binding regions.
Protein Domain
Type: Conserved_site
Description: A sequence of about thirty to forty amino-acid residues long found in the sequence of epidermal growth factor (EGF)has been shown [, , , ]to be present, in a moreor less conserved form, in a large number of other, mostly animal proteins. The list of proteins currently known tocontain one or more copies of an EGF-like pattern is large and varied. The functional significance of EGF domains inwhat appear to be unrelated proteins is not yet clear. However, a common feature is that these repeats are found inthe extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandinG/H synthase). The EGF domain includes six cysteine residues which have been shown (in EGF) to be involved in disulphidebonds. The main structure is a two-stranded β-sheet followed by a loop to a C-terminal short two-stranded sheet.Subdomains between the conserved cysteines vary in length.This entry represents a conserved site in the EGF-like domain.
Publication
First Author: Krishnamoorthy M
Year: 2009
Journal: J Biochem
Title: Heparin binding epidermal growth factor-like growth factor and PD169316 prevent apoptosis in mouse embryonic stem cells.
Volume: 145
Issue: 2
Pages: 177-84
Publication
First Author: Kim YS
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: An unanticipated discourse of HB-EGF with VANGL2 signaling during embryo implantation.
Volume: 120
Issue: 20
Pages: e2302937120
Protein
Organism: Mus musculus/domesticus
Length: 152  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 177  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 248  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 208  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 162  
Fragment?: false
Publication
First Author: Wang Y
Year: 2001
Journal: J Biol Chem
Title: Modification of epidermal growth factor-like repeats with O-fucose. Molecular cloning and expression of a novel GDP-fucose protein O-fucosyltransferase.
Volume: 276
Issue: 43
Pages: 40338-45
Protein
Organism: Mus musculus/domesticus
Length: 159  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 177  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 148  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 248  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 159  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 137  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 152  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 208  
Fragment?: false
Publication
First Author: Fitzgerald K
Year: 1995
Journal: Development
Title: Interchangeability of Caenorhabditis elegans DSL proteins and intrinsic signalling activity of their extracellular domains in vivo.
Volume: 121
Issue: 12
Pages: 4275-82
Publication
First Author: Artavanis-Tsakonas S
Year: 1995
Journal: Science
Title: Notch signaling.
Volume: 268
Issue: 5208
Pages: 225-32
Publication
First Author: Fuentes-Prior P
Year: 2000
Journal: Nature
Title: Structural basis for the anticoagulant activity of the thrombin-thrombomodulin complex.
Volume: 404
Issue: 6777
Pages: 518-25
Publication
First Author: Choowongkomon K
Year: 2005
Journal: J Biol Chem
Title: A structural model for the membrane-bound form of the juxtamembrane domain of the epidermal growth factor receptor.
Volume: 280
Issue: 25
Pages: 24043-52
Publication
First Author: Hubbard SR
Year: 2004
Journal: Nat Rev Mol Cell Biol
Title: Juxtamembrane autoinhibition in receptor tyrosine kinases.
Volume: 5
Issue: 6
Pages: 464-71
Protein Domain
Type: Family
Description: Sorting nexin-5 (SNX5) belongs to the sorting nexin family, which contains a conserved PX (phox homology) domain that is responsible for binding to specific phosphoinositides []. SNX5 also contains a BAR domain that is C terminus to the PX domain. Besides being involved in several stages of intracellular trafficking, SNX5 also plays a role in macropinocytosis and in the internalisation of EGFR after EGF stimulation [, ].
Protein Domain
Type: Family
Description: This is a family of conserved proteins representing the enzyme responsible for adding O-fucose to EGF (epidermal growth factor-like) repeats. Six highly conserved cysteines are present as well as a DXD-like motif (ERD), conserved in mammals, Drosophila, and Caenorhabditis elegans. Both features are characteristic of several glycosyltransferase families. The enzyme is a membrane-bound protein released by proteolysis and, as for most glycosyltransferases, is strongly activated by manganese [].
Protein Domain
Type: Homologous_superfamily
Description: Receptor tyrosine kinases (RTKs) are transmembrane receptors thathave intrinsic, cytoplasmic tyrosine kinase activity. Juxtamembrane regions in RTKs have been shown to play important regulatory functions. Their kinase activity is generally autoinhibited by its JX domain in the absence of ligand-stimulated tyrosine phosphorylation, due to the inhibitory Tyr phosphorylation sites found in the JX domain []. This superfamily represents the JX domain of the EGF receptor [].
Protein Domain
Type: Domain
Description: This domain adopts a fold similar to other EGF domains, with a flat major and a twisted minor beta sheet. Disulphide pairing, however, is not of the usual 1-3, 2-4, 5-6 type; rather 1-2, 3-4, 5-6 pairing is found. Its extended major sheet (strands beta-2 and beta-3 and the connecting loop) projects into thrombin's active site groove. This domain is required for interaction of thrombomodulin with thrombin, and subsequent activation of protein-C [].
Protein Domain
Type: Domain
Description: Ligands of the Delta/Serrate/lag-2 (DSL) family and their receptors, members ofthe lin-12/Notch family, mediate cell-cell interactions that specify cell fate in invertebrates and vertebrates. In Caenorhabditis elegans, two DSL genes, lag-2 and apx-1,influence different cell fate decisions during development []. Molecular interaction between Notch and Serrate, another EGF-homologous transmembrane protein containing a region of striking similarity to Delta, has been shown and the same two EGF repeats of Notch may also constitute a Serrate binding domain [, ].
Publication
First Author: Hald J
Year: 2012
Journal: Diabetologia
Title: Pancreatic islet and progenitor cell surface markers with cell sorting potential.
Volume: 55
Issue: 1
Pages: 154-65
Publication
First Author: Zhao T
Year: 2014
Journal: Development
Title: β-catenin regulates Pax3 and Cdx2 for caudal neural tube closure and elongation.
Volume: 141
Issue: 1
Pages: 148-57
Publication
First Author: Fairfield H
Year: 2015
Journal: Genome Res
Title: Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders.
Volume: 25
Issue: 7
Pages: 948-57
Publication
First Author: Fouillade C
Year: 2013
Journal: Arterioscler Thromb Vasc Biol
Title: Transcriptome analysis for Notch3 target genes identifies Grip2 as a novel regulator of myogenic response in the cerebrovasculature.
Volume: 33
Issue: 1
Pages: 76-86
Publication
First Author: Pajvani UB
Year: 2011
Journal: Nat Med
Title: Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner.
Volume: 17
Issue: 8
Pages: 961-7
Publication
First Author: Jin JZ
Year: 2014
Journal: Dev Dyn
Title: Deciphering TGF-β3 function in medial edge epithelium specification and fusion during mouse secondary palate development.
Volume: 243
Issue: 12
Pages: 1536-43
Publication
First Author: Hitoshi S
Year: 2002
Journal: Genes Dev
Title: Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells.
Volume: 16
Issue: 7
Pages: 846-58
Publication
First Author: Thomas JA
Year: 2003
Journal: Am J Physiol Heart Circ Physiol
Title: IRAK1 deletion disrupts cardiac Toll/IL-1 signaling and protects against contractile dysfunction.
Volume: 285
Issue: 2
Pages: H597-606
Publication  
First Author: Zhang K
Year: 2014
Journal: Neurobiol Dis
Title: Notch1 mediates postnatal neurogenesis in hippocampus enhanced by intermittent hypoxia.
Volume: 64
Pages: 66-78
Publication
First Author: Yao Y
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Reducing Jagged 1 and 2 levels prevents cerebral arteriovenous malformations in matrix Gla protein deficiency.
Volume: 110
Issue: 47
Pages: 19071-6
Publication
First Author: McCright B
Year: 2002
Journal: Development
Title: A mouse model of Alagille syndrome: Notch2 as a genetic modifier of Jag1 haploinsufficiency.
Volume: 129
Issue: 4
Pages: 1075-82
Publication
First Author: Stassart RM
Year: 2013
Journal: Nat Neurosci
Title: A role for Schwann cell-derived neuregulin-1 in remyelination.
Volume: 16
Issue: 1
Pages: 48-54
Publication
First Author: Yang X
Year: 2001
Journal: Neuron
Title: Patterning of muscle acetylcholine receptor gene expression in the absence of motor innervation.
Volume: 30
Issue: 2
Pages: 399-410
Publication
First Author: Jaworski A
Year: 2006
Journal: J Neurosci
Title: Neuromuscular synapse formation in mice lacking motor neuron- and skeletal muscle-derived Neuregulin-1.
Volume: 26
Issue: 2
Pages: 655-61
Publication
First Author: Anthony TE
Year: 2005
Journal: Genes Dev
Title: Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells.
Volume: 19
Issue: 9
Pages: 1028-33
Publication
First Author: You Y
Year: 2011
Journal: J Immunol
Title: Marginal zone B cells regulate antigen capture by marginal zone macrophages.
Volume: 186
Issue: 4
Pages: 2172-81
Publication  
First Author: Dave JM
Year: 2022
Journal: J Clin Invest
Title: JAGGED1/NOTCH3 activation promotes aortic hypermuscularization and stenosis in elastin deficiency.
Volume: 132
Issue: 5
Publication
First Author: Mori M
Year: 2015
Journal: Development
Title: Notch3-Jagged signaling controls the pool of undifferentiated airway progenitors.
Volume: 142
Issue: 2
Pages: 258-67
Allele
Name: advillin; targeted mutation 1, Paul A Heppenstall
Allele Type: Targeted
Attribute String: Conditional ready, Inserted expressed sequence
Genotype
Symbol: Jag1/Jag1<+> Notch2/Notch2<+>
Background: involves: 129S1/Sv * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Notch1/Notch1 Tg(Pax2-cre)1Akg/?
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Jag1/Jag1<+> Notch2/Notch2<+>
Background: involves: 129S1/Sv
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Notch2/Notch2 Speer6-ps1/Speer6-ps1<+>
Background: involves: 129S1/Sv * C57BL/6 * DBA
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Notch1/Notch1<+> Notch2/Notch2
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Notch1/Notch1 Notch2/Notch2 Tg(Prrx1-cre)1Cjt/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Shiomi T
Year: 2011
Journal: Am J Respir Cell Mol Biol
Title: TNF-α-converting enzyme/a disintegrin and metalloprotease-17 mediates mechanotransduction in murine tracheal epithelial cells.
Volume: 45
Issue: 2
Pages: 376-85
Publication
First Author: Mulherkar R
Year: 1993
Journal: FEBS Lett
Title: Enhancing factor protein from mouse small intestines belongs to the phospholipase A2 family.
Volume: 317
Issue: 3
Pages: 263-6
Publication
First Author: Crotty T
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Diacylglycerol kinase delta regulates protein kinase C and epidermal growth factor receptor signaling.
Volume: 103
Issue: 42
Pages: 15485-90
Publication
First Author: Galcheva-Gargova Z
Year: 1996
Journal: Science
Title: Binding of zinc finger protein ZPR1 to the epidermal growth factor receptor.
Volume: 272
Issue: 5269
Pages: 1797-802
Publication
First Author: Yoon S
Year: 2013
Journal: J Biol Chem
Title: Dopamine D2 receptor-mediated epidermal growth factor receptor transactivation through a disintegrin and metalloprotease regulates dopaminergic neuron development via extracellular signal-related kinase activation.
Volume: 288
Issue: 40
Pages: 28435-46
Publication
First Author: Zaiss DM
Year: 2006
Journal: Science
Title: Amphiregulin, a TH2 cytokine enhancing resistance to nematodes.
Volume: 314
Issue: 5806
Pages: 1746
Publication
First Author: Peng C
Year: 2010
Journal: FASEB J
Title: RSK2 mediates NF-{kappa}B activity through the phosphorylation of IkappaBalpha in the TNF-R1 pathway.
Volume: 24
Issue: 9
Pages: 3490-9
Publication
First Author: Apostolopoulos J
Year: 2000
Journal: Immunity
Title: Ly6d-L, a cell surface ligand for mouse Ly6d.
Volume: 12
Issue: 2
Pages: 223-32
Publication
First Author: Downward J
Year: 1984
Journal: Nature
Title: Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences.
Volume: 307
Issue: 5951
Pages: 521-7
Publication
First Author: Murray JC
Year: 1992
Journal: Nat Genet
Title: Linkage of Rieger syndrome to the region of the epidermal growth factor gene on chromosome 4.
Volume: 2
Issue: 1
Pages: 46-9
Publication
First Author: McNeil A
Year: 1995
Journal: Infect Immun
Title: Salmonella typhimurium displays normal invasion of mice with defective epidermal growth factor receptors.
Volume: 63
Issue: 7
Pages: 2770-2
Publication
First Author: Aubrecht J
Year: 1995
Journal: Biochem Pharmacol
Title: Induction of cytochrome P-4502B1-related mouse cytochrome P-450 and regulation of its expression by epidermal growth factor/transforming growth factor alpha in primary hepatocyte culture.
Volume: 50
Issue: 6
Pages: 781-5
Publication
First Author: Zhang J
Year: 1996
Journal: Anal Biochem
Title: A yeast three-hybrid method to clone ternary protein complex components.
Volume: 242
Issue: 1
Pages: 68-72
Publication
First Author: Boockvar JA
Year: 2003
Journal: Mol Cell Neurosci
Title: Constitutive EGFR signaling confers a motile phenotype to neural stem cells.
Volume: 24
Issue: 4
Pages: 1116-30
Publication
First Author: Oved S
Year: 2006
Journal: J Biol Chem
Title: Conjugation to Nedd8 instigates ubiquitylation and down-regulation of activated receptor tyrosine kinases.
Volume: 281
Issue: 31
Pages: 21640-51
Publication
First Author: Rech AJ
Year: 2013
Journal: Cancer Discov
Title: Dynamic interplay of oncogenes and T cells induces PD-L1 in the tumor microenvironment.
Volume: 3
Issue: 12
Pages: 1330-2
Publication
First Author: Reincke M
Year: 2015
Journal: Nat Genet
Title: Mutations in the deubiquitinase gene USP8 cause Cushing's disease.
Volume: 47
Issue: 1
Pages: 31-8
Publication
First Author: De S
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Erlotinib protects against LPS-induced endotoxicity because TLR4 needs EGFR to signal.
Volume: 112
Issue: 31
Pages: 9680-5
Publication  
First Author: Yan L
Year: 2023
Journal: Front Cell Dev Biol
Title: Deficiency of Wdr60 and Wdr34 cause distinct neural tube malformation phenotypes in early embryos.
Volume: 11
Pages: 1084245
Publication
First Author: Paria BC
Year: 1999
Journal: Development
Title: Heparin-binding EGF-like growth factor interacts with mouse blastocysts independently of ErbB1: a possible role for heparan sulfate proteoglycans and ErbB4 in blastocyst implantation.
Volume: 126
Issue: 9
Pages: 1997-2005
Publication  
First Author: Nakaniwa M
Year: 2019
Journal: Gene Expr Patterns
Title: Primary cilia in murine palatal rugae development.
Volume: 34
Pages: 119062
Publication
First Author: Mine N
Year: 2005
Journal: Development
Title: HB-EGF promotes epithelial cell migration in eyelid development.
Volume: 132
Issue: 19
Pages: 4317-26
Publication
First Author: Iwamoto R
Year: 2017
Journal: J Cell Sci
Title: ErbB1 and ErbB4 generate opposing signals regulating mesenchymal cell proliferation during valvulogenesis.
Volume: 130
Issue: 7
Pages: 1321-1332
Publication
First Author: Jackson LF
Year: 2003
Journal: EMBO J
Title: Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling.
Volume: 22
Issue: 11
Pages: 2704-16
Publication
First Author: Kimura R
Year: 2005
Journal: Cell Struct Funct
Title: Soluble form of heparin-binding EGF-like growth factor contributes to retinoic acid-induced epidermal hyperplasia.
Volume: 30
Issue: 2
Pages: 35-42
Publication
First Author: Zhang H
Year: 2008
Journal: Circ Res
Title: Heparin-binding epidermal growth factor-like growth factor signaling in flow-induced arterial remodeling.
Volume: 102
Issue: 10
Pages: 1275-85
Publication
First Author: Brandt-Bohne U
Year: 2007
Journal: Biochem J
Title: MEGF9: a novel transmembrane protein with a strong and developmentally regulated expression in the nervous system.
Volume: 401
Issue: 2
Pages: 447-57
Publication
First Author: Minegishi K
Year: 2017
Journal: Dev Cell
Title: A Wnt5 Activity Asymmetry and Intercellular Signaling via PCP Proteins Polarize Node Cells for Left-Right Symmetry Breaking.
Volume: 40
Issue: 5
Pages: 439-452.e4
Publication
First Author: Araujo DJ
Year: 2015
Journal: Genes Dev
Title: FoxP1 orchestration of ASD-relevant signaling pathways in the striatum.
Volume: 29
Issue: 20
Pages: 2081-96
Protein
Organism: Mus musculus/domesticus
Length: 220  
Fragment?: false
Publication
First Author: García-García MJ
Year: 2008
Journal: Development
Title: Chato, a KRAB zinc-finger protein, regulates convergent extension in the mouse embryo.
Volume: 135
Issue: 18
Pages: 3053-62