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Search results 4601 to 4700 out of 4906 for Isl1

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Type Details Score
Publication
36109497 | J:328990
First Author: Patel T
Year: 2022
Journal: Nat Commun
Title: Transcriptional dynamics of murine motor neuron maturation in vivo and in vitro.
Volume: 13
Issue: 1
Pages: 5427
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Publication
28886366 | J:357902
First Author: Abernathy DG
Year: 2017
Journal: Cell Stem Cell
Title: MicroRNAs Induce a Permissive Chromatin Environment that Enables Neuronal Subtype-Specific Reprogramming of Adult Human Fibroblasts.
Volume: 21
Issue: 3
Pages: 332-348.e9
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Publication
21383076 | J:170321
First Author: Bondue A
Year: 2011
Journal: J Cell Biol
Title: Defining the earliest step of cardiovascular progenitor specification during embryonic stem cell differentiation.
Volume: 192
Issue: 5
Pages: 751-65
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Protein
O55203
Organism: Mus musculus/domesticus
Length: 373  
Fragment?: false
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Protein
A0A0G2JFS7
Organism: Mus musculus/domesticus
Length: 371  
Fragment?: false
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Publication
24590809 | -
First Author: Peng H
Year: 2014
Journal: Cancer Res
Title: LIMD2 is a small LIM-only protein overexpressed in metastatic lesions that regulates cell motility and tumor progression by directly binding to and activating the integrin-linked kinase.
Volume: 74
Issue: 5
Pages: 1390-1403
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Publication
23303138 | J:193503
First Author: Matthews JM
Year: 2013
Journal: Nat Rev Cancer
Title: LIM-domain-only proteins in cancer.
Volume: 13
Issue: 2
Pages: 111-22
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Protein Domain
IPR044115 | LIM_LIMD2
Type: Domain
Description: In general, LIM domains coordinate one or more zinc atoms, and are named after the three proteins (LIN-11, Isl1 and MEC-3) in which they were first found. They consist of two zinc-binding motifs that resemble GATA-like Znf's, however the residues holding the zinc atom(s) are variable, involving Cys, His, Asp or Glu residues. LIM domain-containing proteins have diverse cellular roles such as regulators of gene expression, cyto-architecture, cell adhesion, cell motility, and signal transduction. LIM domain-containing proteins have been shown to be key molecules in a wide variety of human cancers [].LIMD2 binds directly to the kinase domain of integrin-linked kinase (ILK) near the active site and strongly activated ILK kinase activity. Its LIM-domain structure is highly related to LIM1 of PINCH1, a core component of the integrin-linked kinase-parvin-pinch complex [].
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Publication
9334334 | -
First Author: Morcillo P
Year: 1997
Journal: Genes Dev
Title: Chip, a widely expressed chromosomal protein required for segmentation and activity of a remote wing margin enhancer in Drosophila.
Volume: 11
Issue: 20
Pages: 2729-40
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Publication
11782418 | -
First Author: Franks RG
Year: 2002
Journal: Development
Title: SEUSS, a member of a novel family of plant regulatory proteins, represses floral homeotic gene expression with LEUNIG.
Volume: 129
Issue: 1
Pages: 253-63
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Publication
19542312 | -
First Author: Dodgson J
Year: 2009
Journal: Eukaryot Cell
Title: Functional genomics of adhesion, invasion, and mycelial formation in Schizosaccharomyces pombe.
Volume: 8
Issue: 8
Pages: 1298-306
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Publication
26529322 | -
First Author: Lin CJ
Year: 2015
Journal: PLoS Pathog
Title: Transcription Factor SomA Is Required for Adhesion, Development and Virulence of the Human Pathogen Aspergillus fumigatus.
Volume: 11
Issue: 11
Pages: e1005205
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Protein Domain
IPR029005 | LIM-bd/SEUSS
Type: Family
Description: This entry includes the LIM-domain binding proteins and similar proteins, such as protein Chip from Drosophila, SEUSS from Arabidopsis and Adn1 from fission yeasts. The LIM-domain binding protein, binds to the LIM domain of LIM homeodomain proteins which are transcriptional regulators of development. Nuclear LIM interactor (NLI) / LIM domain-binding protein 1 (LDB1) is located in the nuclei of neuronal cells during development, it is co-expressed with Isl1 in early motor neuron differentiation and has a suggested role in the Isl1 dependent development of motor neurons []. It is suggested that these proteins act synergistically to enhance transcriptional efficiency by acting as co-factors for LIM homeodomain and Otx class transcription factors, both of which have essential roles in development [].The Drosophila protein Chip () is required for segmentation and activity of a remote wing margin enhancer []. Chip is a ubiquitous chromosomal factor required for normal expression of diverse genes at many stages of development. It is suggested that Chip cooperates with different LIM domain proteins and other factors to structurally support remote enhancer-promoter interactions [].SEUSS is a transcriptional corepressor from Arabidopsis thaliana []. SEUSS contains two glutamine-rich domains and a highly conserved domain that shares sequence identity with the dimerisation domain of the LIM-domain-binding transcription co-regulators in animals [].Several proteins in this entry are transcriptional regulators in fungi. In fission yeasts, adhesion defective protein 1 (Adn1) is a probable transcriptional regulator involved in cell adhesion []. In Aspergillus fumigatus, the transcriptional activator ptaB forms a complex with somA to control biofilm formation []. In Candida albicans, MFG1 (morphogenetic regulator of filamentous growth protein 1) has a role in all morphogenetically distinct forms of filamentous growth, including invasive growth and biofilm formation, probably by forming a complex with FLO8 and MSS1 which binds the promoter of the FLO11 gene [].
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Publication
23382704 | J:195153
First Author: Schaffer AE
Year: 2013
Journal: PLoS Genet
Title: Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity.
Volume: 9
Issue: 1
Pages: e1003274
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Publication
33869215 | J:313931
 
First Author: Wang Z
Year: 2021
Journal: Front Cell Dev Biol
Title: Smyd1 Orchestrates Early Heart Development Through Positive and Negative Gene Regulation.
Volume: 9
Pages: 654682
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Publication
18028108 | J:130218
First Author: Al-Mosawie A
Year: 2007
Journal: Eur J Neurosci
Title: Heterogeneity of V2-derived interneurons in the adult mouse spinal cord.
Volume: 26
Issue: 11
Pages: 3003-15
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Publication
30936179 | J:274879
 
First Author: van Eif VWW
Year: 2019
Journal: Development
Title: Transcriptome analysis of mouse and human sinoatrial node cells reveals a conserved genetic program.
Volume: 146
Issue: 8
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Publication
19825428 | J:154096
First Author: Nelander J
Year: 2009
Journal: Gene Expr Patterns
Title: Organization of the human embryonic ventral mesencephalon.
Volume: 9
Issue: 8
Pages: 555-61
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Publication
22343290 | J:182152
First Author: Lee S
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Fusion protein Isl1-Lhx3 specifies motor neuron fate by inducing motor neuron genes and concomitantly suppressing the interneuron programs.
Volume: 109
Issue: 9
Pages: 3383-8
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Publication
25057789 | J:218343
First Author: Heddad Masson M
Year: 2014
Journal: Endocrinology
Title: Foxa1 and Foxa2 regulate α-cell differentiation, glucagon biosynthesis, and secretion.
Volume: 155
Issue: 10
Pages: 3781-92
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Publication
22414758 | J:277556
First Author: Schang AL
Year: 2013
Journal: Neuroendocrinology
Title: Identification and analysis of two novel sites of rat GnRH receptor gene promoter activity: the pineal gland and retina.
Volume: 97
Issue: 2
Pages: 115-31
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Protein
P70662
Organism: Mus musculus/domesticus
Length: 411  
Fragment?: false
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Protein
D3Z1C5
Organism: Mus musculus/domesticus
Length: 373  
Fragment?: false
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Publication
22984072 | -
First Author: Ryan O
Year: 2012
Journal: Science
Title: Global gene deletion analysis exploring yeast filamentous growth.
Volume: 337
Issue: 6100
Pages: 1353-6
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Publication
15277686 | -
First Author: Sridhar VV
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Transcriptional repression of target genes by LEUNIG and SEUSS, two interacting regulatory proteins for Arabidopsis flower development.
Volume: 101
Issue: 31
Pages: 11494-9
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Publication
18031680 | J:132726
First Author: Lewcock JW
Year: 2007
Journal: Neuron
Title: The ubiquitin ligase Phr1 regulates axon outgrowth through modulation of microtubule dynamics.
Volume: 56
Issue: 4
Pages: 604-20
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Publication
36325991 | J:331972
 
First Author: Hummel D
Year: 2022
Journal: Development
Title: Celsr1 suppresses Wnt5a-mediated chemoattraction to prevent incorrect rostral migration of facial branchiomotor neurons.
Volume: 149
Issue: 22
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Publication
16772167 | J:122940
First Author: Shirasaki R
Year: 2006
Journal: Neuron
Title: FGF as a target-derived chemoattractant for developing motor axons genetically programmed by the LIM code.
Volume: 50
Issue: 6
Pages: 841-53
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Publication
35944701 | J:327599
 
First Author: Whitman MC
Year: 2022
Journal: Dev Biol
Title: TWIST1, a gene associated with Saethre-Chotzen syndrome, regulates extraocular muscle organization in mouse.
Volume: 490
Pages: 126-133
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Publication
19359597 | J:164770
First Author: Lombardi R
Year: 2009
Journal: Circ Res
Title: Genetic fate mapping identifies second heart field progenitor cells as a source of adipocytes in arrhythmogenic right ventricular cardiomyopathy.
Volume: 104
Issue: 9
Pages: 1076-84
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Protein
Q8BGB5
Organism: Mus musculus/domesticus
Length: 128  
Fragment?: false
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Publication
30110642 | J:270401
First Author: Latremoliere A
Year: 2018
Journal: Cell Rep
Title: Neuronal-Specific TUBB3 Is Not Required for Normal Neuronal Function but Is Essential for Timely Axon Regeneration.
Volume: 24
Issue: 7
Pages: 1865-1879.e9
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Publication
37536498 | J:339475
 
First Author: Toren E
Year: 2023
Journal: Mol Metab
Title: The SSBP3 co-regulator is required for glucose homeostasis, pancreatic islet architecture, and beta-cell identity.
Volume: 76
Pages: 101785
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Publication
31668390 | J:292845
 
First Author: Piccand J
Year: 2019
Journal: Mol Metab
Title: Rfx6 promotes the differentiation of peptide-secreting enteroendocrine cells while repressing genetic programs controlling serotonin production.
Volume: 29
Pages: 24-39
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Protein
Q91XC0
Organism: Mus musculus/domesticus
Length: 547  
Fragment?: false
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Protein
P63254
Organism: Mus musculus/domesticus
Length: 77  
Fragment?: false
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Protein
P25801
Organism: Mus musculus/domesticus
Length: 158  
Fragment?: false
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Protein
Q924W9
Organism: Mus musculus/domesticus
Length: 156  
Fragment?: false
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Protein
Q71FD7
Organism: Mus musculus/domesticus
Length: 375  
Fragment?: false
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Protein
Q91XD2
Organism: Mus musculus/domesticus
Length: 341  
Fragment?: false
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Protein
Q9QXD8
Organism: Mus musculus/domesticus
Length: 668  
Fragment?: false
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Protein
P97314
Organism: Mus musculus/domesticus
Length: 193  
Fragment?: false
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Protein
P50462
Organism: Mus musculus/domesticus
Length: 194  
Fragment?: false
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Protein
P97315
Organism: Mus musculus/domesticus
Length: 193  
Fragment?: false
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Protein
Q8VI36
Organism: Mus musculus/domesticus
Length: 591  
Fragment?: false
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Protein
Q9DCT8
Organism: Mus musculus/domesticus
Length: 208  
Fragment?: false
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Protein
O70433
Organism: Mus musculus/domesticus
Length: 279  
Fragment?: false
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Protein
Q9R059
Organism: Mus musculus/domesticus
Length: 289  
Fragment?: false
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Protein
Q6Q6R3
Organism: Mus musculus/domesticus
Length: 204  
Fragment?: false
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Protein
P97447
Organism: Mus musculus/domesticus
Length: 280  
Fragment?: false
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Protein
Q99JW4
Organism: Mus musculus/domesticus
Length: 325  
Fragment?: false
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Protein
P61969
Organism: Mus musculus/domesticus
Length: 165  
Fragment?: false
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Protein
Q7TQJ8
Organism: Mus musculus/domesticus
Length: 398  
Fragment?: false
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Protein
Q9EQG3
Organism: Mus musculus/domesticus
Length: 652  
Fragment?: false
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Protein
Q62394
Organism: Mus musculus/domesticus
Length: 352  
Fragment?: false
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Protein
Q62523
Organism: Mus musculus/domesticus
Length: 564  
Fragment?: false
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Protein
Q9Z1Y4
Organism: Mus musculus/domesticus
Length: 480  
Fragment?: false
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Protein
Q8BFW7
Organism: Mus musculus/domesticus
Length: 613  
Fragment?: false
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Protein
Q8BZL8
Organism: Mus musculus/domesticus
Length: 145  
Fragment?: false
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Protein
Q9CZW7
Organism: Mus musculus/domesticus
Length: 121  
Fragment?: false
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Protein
A0A1L1SUR8
Organism: Mus musculus/domesticus
Length: 72  
Fragment?: true
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Protein
A0A3Q4EC95
Organism: Mus musculus/domesticus
Length: 164  
Fragment?: true
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Protein
Q7TQE2
Organism: Mus musculus/domesticus
Length: 533  
Fragment?: false
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Protein
Q545C7
Organism: Mus musculus/domesticus
Length: 194  
Fragment?: false
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Protein
Q543D7
Organism: Mus musculus/domesticus
Length: 279  
Fragment?: false
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Protein
Q542S1
Organism: Mus musculus/domesticus
Length: 165  
Fragment?: false
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Protein
A0A0G2JF37
Organism: Mus musculus/domesticus
Length: 84  
Fragment?: false
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Protein
Q3TAG5
Organism: Mus musculus/domesticus
Length: 420  
Fragment?: false
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Protein
E0CY33
Organism: Mus musculus/domesticus
Length: 68  
Fragment?: true
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Protein
E0CXD7
Organism: Mus musculus/domesticus
Length: 60  
Fragment?: false
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Protein
A2BHP2
Organism: Mus musculus/domesticus
Length: 144  
Fragment?: true
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Protein
E9QP62
Organism: Mus musculus/domesticus
Length: 387  
Fragment?: false
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Protein
A0A1D5RMM8
Organism: Mus musculus/domesticus
Length: 1062  
Fragment?: false
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Protein
Q71V27
Organism: Mus musculus/domesticus
Length: 193  
Fragment?: false
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Protein
Q9DAH0
Organism: Mus musculus/domesticus
Length: 279  
Fragment?: false
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Protein
A0A1W2P7N8
Organism: Mus musculus/domesticus
Length: 84  
Fragment?: true
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Protein
F6YHE5
Organism: Mus musculus/domesticus
Length: 292  
Fragment?: true
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Protein
F7C957
Organism: Mus musculus/domesticus
Length: 151  
Fragment?: true
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Protein
A2BHP1
Organism: Mus musculus/domesticus
Length: 156  
Fragment?: false
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Protein
A2BHP3
Organism: Mus musculus/domesticus
Length: 228  
Fragment?: false
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Protein
Q9EPW6
Organism: Mus musculus/domesticus
Length: 238  
Fragment?: true
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Protein
A0A0A0MQA9
Organism: Mus musculus/domesticus
Length: 112  
Fragment?: true
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Protein
A0A140LHC6
Organism: Mus musculus/domesticus
Length: 65  
Fragment?: true
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Protein
A2BI37
Organism: Mus musculus/domesticus
Length: 485  
Fragment?: false
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Protein
A2AEY1
Organism: Mus musculus/domesticus
Length: 234  
Fragment?: true
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Protein
A2AEY2
Organism: Mus musculus/domesticus
Length: 323  
Fragment?: false
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Protein
D3Z589
Organism: Mus musculus/domesticus
Length: 898  
Fragment?: false
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Protein
A8CVP4
Organism: Mus musculus/domesticus
Length: 325  
Fragment?: false
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Protein
Q9JJQ5
Organism: Mus musculus/domesticus
Length: 216  
Fragment?: true
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Protein
A0A0R4J1I1
Organism: Mus musculus/domesticus
Length: 205  
Fragment?: false
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Protein
A0A494B990
Organism: Mus musculus/domesticus
Length: 290  
Fragment?: false
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Protein
A2AEX6
Organism: Mus musculus/domesticus
Length: 309  
Fragment?: false
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Protein
F2Z455
Organism: Mus musculus/domesticus
Length: 280  
Fragment?: false
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Protein
F6W1Y9
Organism: Mus musculus/domesticus
Length: 60  
Fragment?: true
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Protein
A0A5F8MPN3
Organism: Mus musculus/domesticus
Length: 927  
Fragment?: false
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Protein
F8VQ28
Organism: Mus musculus/domesticus
Length: 591  
Fragment?: false
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Protein
Q8CGJ0
Organism: Mus musculus/domesticus
Length: 81  
Fragment?: true
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Protein
Q3TMB5
Organism: Mus musculus/domesticus
Length: 478  
Fragment?: false
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Protein
Q3TCR9
Organism: Mus musculus/domesticus
Length: 564  
Fragment?: false
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Protein
F6WY65
Organism: Mus musculus/domesticus
Length: 137  
Fragment?: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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Cambridge CB2 3EH, United Kingdom