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Ortiz-S?nchez P |
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2019 |
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Circ Res |
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Umer N |
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2021 |
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Front Cell Dev Biol |
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Xie D |
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2021 |
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Front Cell Neurosci |
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Autophagy Contributes to the Rapamycin-Induced Improvement of Otitis Media. |
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15 |
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Zou Y |
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2020 |
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PLoS One |
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The effect of a ketogenic diet and synergy with rapamycin in a mouse model of breast cancer. |
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15 |
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12 |
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Cox RL |
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Front Mol Neurosci |
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Multiple Critical Periods for Rapamycin Treatment to Correct Structural Defects in Tsc-1-Suppressed Brain. |
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Zormpas-Petridis K |
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Cancer Res |
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Noninvasive MRI Native T(1) Mapping Detects Response to MYCN-targeted Therapies in the Th-MYCN Model of Neuroblastoma. |
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Kim HK |
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2021 |
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Autophagy |
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2023 |
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Front Dement |
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A mild reduction of food intake slows disease progression in an orthologous mouse model of polycystic kidney disease. |
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PLoS Genet |
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12 |
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Zheng Q |
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Biochim Biophys Acta |
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Inhibition of AMPK accentuates prolonged caloric restriction-induced change in cardiac contractile function through disruption of compensatory autophagy. |
| Volume: |
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Turdi S |
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J Mol Cell Cardiol |
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Al-Dwairi A |
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PLoS One |
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Shao L |
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Kidney Int |
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Genetic reduction of cilium length by targeting intraflagellar transport 88 protein impedes kidney and liver cyst formation in mouse models of autosomal polycystic kidney disease. |
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Front Mol Neurosci |
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Ho VW |
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Cancer Res |
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A low carbohydrate, high protein diet slows tumor growth and prevents cancer initiation. |
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Kalish JM |
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Cancer Biol Ther |
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Doxycycline-induced exogenous Bmi-1 expression enhances tumor formation in a murine model of oral squamous cell carcinoma. |
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Conditional knockout of Dkk3 drives Lgr5+ progenitor reprogramming into hair cells in the mouse cochlea. |
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Concina G |
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J Neurosci |
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Stabilizing Immature Dendritic Spines in the Auditory Cortex: A Key Mechanism for mTORC1-Mediated Enhancement of Long-Term Fear Memories. |
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Vardi A |
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Orphanet J Rare Dis |
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Proteomics analysis of a human brain sample from a mucolipidosis type IV patient reveals pathophysiological pathways. |
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Olde Engberink A |
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Neuroscience |
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Rapamycin-Sensitive Late-LTP is Enhanced in the Hippocampus of IL-6 Transgenic Mice. |
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367 |
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Chvojka J |
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2024 |
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Neurobiol Dis |
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Mouse model of focal cortical dysplasia type II generates a wide spectrum of high-frequency activities. |
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190 |
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Dang LT |
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2020 |
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Front Cell Neurosci |
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Multimodal Analysis of STRADA Function in Brain Development. |
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Kim S |
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Oncol Rep |
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?3-polyunsaturated fatty acids induce cell death through apoptosis and autophagy in glioblastoma cells: In vitro and in vivo. |
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Cifuentes C |
| Year: |
2025 |
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J Hematol Oncol |
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The R-RAS2 GTPase is a signaling hub in triple-negative breast cancer cell metabolism and metastatic behavior. |
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Nalbandian A |
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PLoS One |
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Rapamycin and chloroquine: the in vitro and in vivo effects of autophagy-modifying drugs show promising results in valosin containing protein multisystem proteinopathy. |
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O'Connell AE |
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PLoS Genet |
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Mammalian Hbs1L deficiency causes congenital anomalies and developmental delay associated with Pelota depletion and 80S monosome accumulation. |
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Shinozaki S |
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J Biol Chem |
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Liver-specific inducible nitric-oxide synthase expression is sufficient to cause hepatic insulin resistance and mild hyperglycemia in mice. |
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Uzhachenko RV |
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2025 |
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Front Immunol |
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CD8(+) T-NK cell crosstalk establishes preemptive immunosurveillance to eliminate antigen-escape tumors. |
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Criollo A |
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J Mol Cell Cardiol |
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Polycystin-2-dependent control of cardiomyocyte autophagy. |
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118 |
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A method to measure cardiac autophagic flux in vivo. |
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Front Mol Neurosci |
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Striatal Transcriptome and Interactome Analysis of Shank3-overexpressing Mice Reveals the Connectivity between Shank3 and mTORC1 Signaling. |
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Front Cell Dev Biol |
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Regulation of the somatotropic axis by MYC-mediated miRNA repression. |
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Shao Q |
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Autophagy |
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C9orf72 and smcr8 mutant mice reveal MTORC1 activation due to impaired lysosomal degradation and exocytosis. |
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Portero V |
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Cardiovasc Res |
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Chronically elevated branched chain amino acid levels are pro-arrhythmic. |
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Tandelilin AA |
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BMC Endocr Disord |
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AMPD1 regulates mTORC1-p70 S6 kinase axis in the control of insulin sensitivity in skeletal muscle. |
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Downregulation of LAPTM4B Contributes to the Impairment of the Autophagic Flux via Unopposed Activation of mTORC1 Signaling During Myocardial Ischemia/Reperfusion Injury. |
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2023 |
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PLoS One |
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Mitotic CDK1 and 4E-BP1 II: A single phosphomimetic mutation in 4E-BP1 induces glucose intolerance in mice. |
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Cell Death Dis |
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TREM2 deficiency aggravates renal injury by promoting macrophage apoptosis and polarization via the JAK-STAT pathway in mice. |
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Int J Mol Sci |
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The Effect of Mesenchymal Stem Cells on Dry Eye in Sjogren Syndrome Mouse Model. |
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Free Radic Biol Med |
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AMP-dependent kinase and autophagic flux are involved in aldehyde dehydrogenase-2-induced protection against cardiac toxicity of ethanol. |
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De Angelis ML |
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2024 |
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J Exp Clin Cancer Res |
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A nanoencapsulated oral formulation of fenretinide promotes local and metastatic breast cancer dormancy in HER2/neu transgenic mice. |
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Mao L |
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Delayed administration of a PTEN inhibitor BPV improves functional recovery after experimental stroke. |
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J Cell Sci |
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A conserved role of IQGAP1 in regulating TOR complex 1. |
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J Mol Cell Cardiol |
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RETRACTED: Akt2 knockout alleviates prolonged caloric restriction-induced change in cardiac contractile function through regulation of autophagy. |
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Diabetes |
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Epidermal growth factor receptor inhibition slows progression of diabetic nephropathy in association with a decrease in endoplasmic reticulum stress and an increase in autophagy. |
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Oguro-Ando A |
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Mol Psychiatry |
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Increased CYFIP1 dosage alters cellular and dendritic morphology and dysregulates mTOR. |
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Chen H |
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Oncogene |
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Hepatic cyclooxygenase-2 overexpression induced spontaneous hepatocellular carcinoma formation in mice. |
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Genzer Y |
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Mol Cell Endocrinol |
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Fujimura K |
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Cancer Res |
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KRAS Oncoprotein Expression Is Regulated by a Self-Governing eIF5A-PEAK1 Feed-Forward Regulatory Loop. |
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Qiao L |
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Cell Signal |
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NAA20 recruits Rin2 and promotes triple-negative breast cancer progression by regulating Rab5A-mediated activation of EGFR signaling. |
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Free Radic Biol Med |
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TIGAR alleviates ischemia/reperfusion-induced autophagy and ischemic brain injury. |
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Iffland PH 2nd |
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Exp Neurol |
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Dynamic analysis of 4E-BP1 phosphorylation in neurons with Tsc2 or Depdc5 knockout. |
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Korponay TC |
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Am J Respir Cell Mol Biol |
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High CO(2) Downregulates Skeletal Muscle Protein Anabolism via AMP-activated Protein Kinase ?2-mediated Depressed Ribosomal Biogenesis. |
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Lv XF |
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2020 |
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Theranostics |
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TMEM16A ameliorates vascular remodeling by suppressing autophagy via inhibiting Bcl-2-p62 complex formation. |
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9 |
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Ni S |
| Year: |
2021 |
| Journal: |
Front Cell Dev Biol |
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Coordinated Formation of IMPDH2 Cytoophidium in Mouse Oocytes and Granulosa Cells. |
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Wu L |
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Free Radic Biol Med |
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C1QTNF1 attenuates angiotensin II-induced cardiac hypertrophy via activation of the AMPKa pathway. |
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121 |
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Albanese F |
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2021 |
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Neurobiol Dis |
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Constitutive silencing of LRRK2 kinase activity leads to early glucocerebrosidase deregulation and late impairment of autophagy in vivo. |
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Rifki OF |
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J Mol Cell Cardiol |
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RalGDS-dependent cardiomyocyte autophagy is required for load-induced ventricular hypertrophy. |
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Baraldo M |
| Year: |
2020 |
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J Cachexia Sarcopenia Muscle |
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Skeletal muscle mTORC1 regulates neuromuscular junction stability. |
| Volume: |
11 |
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1 |
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208-225 |
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Xu J |
| Year: |
2023 |
| Journal: |
Cancer Res |
| Title: |
MEN1 Degradation Induced by Neddylation and the CUL4B-DCAF7 Axis Promotes Pancreatic Neuroendocrine Tumor Progression. |
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13 |
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2226-2247 |
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| First Author: |
Li Y |
| Year: |
2023 |
| Journal: |
Naunyn Schmiedebergs Arch Pharmacol |
| Title: |
USP22 knockdown protects against cerebral ischemia/reperfusion injury via destabilizing PTEN protein and activating the mTOR/TFEB pathway. |
| Volume: |
396 |
| Issue: |
11 |
| Pages: |
3163-3175 |
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•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
779
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
931
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
931
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
927
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
929
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Babaev VR |
| Year: |
2018 |
| Journal: |
Front Immunol |
| Title: |
Loss of Rictor in Monocyte/Macrophages Suppresses Their Proliferation and Viability Reducing Atherosclerosis in LDLR Null Mice. |
| Volume: |
9 |
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215 |
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Yang K |
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2013 |
| Journal: |
Immunity |
| Title: |
T cell exit from quiescence and differentiation into Th2 cells depend on Raptor-mTORC1-mediated metabolic reprogramming. |
| Volume: |
39 |
| Issue: |
6 |
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1043-56 |
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| First Author: |
Kersten K |
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2023 |
| Journal: |
Cell Rep |
| Title: |
Uptake of tumor-derived microparticles induces metabolic reprogramming of macrophages in the early metastatic lung. |
| Volume: |
42 |
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6 |
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| First Author: |
Behzadi P |
| Year: |
2025 |
| Journal: |
Am J Physiol Heart Circ Physiol |
| Title: |
Rapamycin reduces mineral density and promotes beneficial vascular remodeling in a murine model of severe medial arterial calcification. |
| Volume: |
329 |
| Issue: |
1 |
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H191-H205 |
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| First Author: |
Monteiro LB |
| Year: |
2022 |
| Journal: |
Diabetes |
| Title: |
Leptin Signaling Suppression in Macrophages Improves Immunometabolic Outcomes in Obesity. |
| Volume: |
71 |
| Issue: |
7 |
| Pages: |
1546-1561 |
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| First Author: |
Saucisse N |
| Year: |
2021 |
| Journal: |
Cell Rep |
| Title: |
Functional heterogeneity of POMC neurons relies on mTORC1 signaling. |
| Volume: |
37 |
| Issue: |
2 |
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| First Author: |
Chen X |
| Year: |
2022 |
| Journal: |
Sci Adv |
| Title: |
Differential metabolic requirement governed by transcription factor c-Maf dictates innate ??T17 effector functionality in mice and humans. |
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8 |
| Issue: |
21 |
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eabm9120 |
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| First Author: |
Gupta A |
| Year: |
2023 |
| Journal: |
Int J Mol Sci |
| Title: |
mTORC1 Deficiency Prevents the Development of MC903-Induced Atopic Dermatitis through the Downregulation of Type 2 Inflammation. |
| Volume: |
24 |
| Issue: |
6 |
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| First Author: |
Shu L |
| Year: |
2009 |
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Mol Cell Biol |
| Title: |
The mTORC2 complex regulates terminal differentiation of C2C12 myoblasts. |
| Volume: |
29 |
| Issue: |
17 |
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4691-700 |
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| First Author: |
Yang C |
| Year: |
2020 |
| Journal: |
Elife |
| Title: |
Single-cell transcriptome reveals the novel role of T-bet in suppressing the immature NK gene signature. |
| Volume: |
9 |
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| First Author: |
Luis LB |
| Year: |
2022 |
| Journal: |
Cells |
| Title: |
Salmonella Promotes Its Own Survival in B Cells by Inhibiting Autophagy. |
| Volume: |
11 |
| Issue: |
13 |
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| First Author: |
Tassone B |
| Year: |
2017 |
| Journal: |
Cell Death Differ |
| Title: |
Rictor/mTORC2 deficiency enhances keratinocyte stress tolerance via mitohormesis. |
| Volume: |
24 |
| Issue: |
4 |
| Pages: |
731-746 |
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| First Author: |
Zhang Y |
| Year: |
2014 |
| Journal: |
PLoS One |
| Title: |
Rictor is required for early B cell development in bone marrow. |
| Volume: |
9 |
| Issue: |
8 |
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e103970 |
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| First Author: |
Le TDV |
| Year: |
2023 |
| Journal: |
Elife |
| Title: |
Glucagon-like peptide-1 receptor activation stimulates PKA-mediated phosphorylation of Raptor and this contributes to the weight loss effect of liraglutide. |
| Volume: |
12 |
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| First Author: |
Shimobayashi M |
| Year: |
2018 |
| Journal: |
J Clin Invest |
| Title: |
Insulin resistance causes inflammation in adipose tissue. |
| Volume: |
128 |
| Issue: |
4 |
| Pages: |
1538-1550 |
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| First Author: |
Mazier W |
| Year: |
2019 |
| Journal: |
Mol Metab |
| Title: |
mTORC1 and CB1 receptor signaling regulate excitatory glutamatergic inputs onto the hypothalamic paraventricular nucleus in response to energy availability. |
| Volume: |
28 |
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| Pages: |
151-159 |
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| First Author: |
Wilson RL |
| Year: |
2015 |
| Journal: |
PLoS One |
| Title: |
Vitamin D Receptor Gene Ablation in the Conceptus Has Limited Effects on Placental Morphology, Function and Pregnancy Outcome. |
| Volume: |
10 |
| Issue: |
6 |
| Pages: |
e0131287 |
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| First Author: |
Wang Y |
| Year: |
2022 |
| Journal: |
Nat Immunol |
| Title: |
The kinase complex mTORC2 promotes the longevity of virus-specific memory CD4(+) T cells by preventing ferroptosis. |
| Volume: |
23 |
| Issue: |
2 |
| Pages: |
303-317 |
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| First Author: |
Sklarz T |
| Year: |
2017 |
| Journal: |
Eur J Immunol |
| Title: |
mTORC2 regulates multiple aspects of NKT-cell development and function. |
| Volume: |
47 |
| Issue: |
3 |
| Pages: |
516-526 |
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| First Author: |
Ma Y |
| Year: |
2025 |
| Journal: |
Cell Discov |
| Title: |
TMEM41B is an endoplasmic reticulum Ca(2+) release channel maintaining naive T cell quiescence and responsiveness. |
| Volume: |
11 |
| Issue: |
1 |
| Pages: |
18 |
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Wang F |
| Year: |
2021 |
| Journal: |
J Clin Invest |
| Title: |
ZFP91 disturbs metabolic fitness and antitumor activity of tumor-infiltrating T cells. |
| Volume: |
131 |
| Issue: |
19 |
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| First Author: |
Dr?gert K |
| Year: |
2015 |
| Journal: |
Hypertension |
| Title: |
Deletion of Rictor in brain and fat alters peripheral clock gene expression and increases blood pressure. |
| Volume: |
66 |
| Issue: |
2 |
| Pages: |
332-9 |
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| First Author: |
Haissaguerre M |
| Year: |
2018 |
| Journal: |
Mol Metab |
| Title: |
mTORC1-dependent increase in oxidative metabolism in POMC neurons regulates food intake and action of leptin. |
| Volume: |
12 |
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| Pages: |
98-106 |
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| First Author: |
Asrani K |
| Year: |
2017 |
| Journal: |
J Clin Invest |
| Title: |
mTORC1 loss impairs epidermal adhesion via TGF-?/Rho kinase activation. |
| Volume: |
127 |
| Issue: |
11 |
| Pages: |
4001-4017 |
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| First Author: |
Sun W |
| Year: |
2016 |
| Journal: |
Bone |
| Title: |
Rictor is required for optimal bone accrual in response to anti-sclerostin therapy in the mouse. |
| Volume: |
85 |
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| Pages: |
1-8 |
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| First Author: |
Hu T |
| Year: |
2017 |
| Journal: |
Sci Rep |
| Title: |
PDK1 plays a vital role on hematopoietic stem cell function. |
| Volume: |
7 |
| Issue: |
1 |
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4943 |
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| First Author: |
Kim CS |
| Year: |
2020 |
| Journal: |
Cell Metab |
| Title: |
Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle. |
| Volume: |
32 |
| Issue: |
4 |
| Pages: |
629-642.e8 |
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| First Author: |
Xie M |
| Year: |
2022 |
| Journal: |
Biol Reprod |
| Title: |
Loss of Raptor induces Sertoli cells into an undifferentiated state in mice. |
| Volume: |
107 |
| Issue: |
4 |
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1125-1138 |
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Parker SJ |
| Year: |
2018 |
| Journal: |
Am J Physiol Heart Circ Physiol |
| Title: |
Proteomics reveals Rictor as a noncanonical TGF-? signaling target during aneurysm progression in Marfan mice. |
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315 |
| Issue: |
5 |
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H1112-H1126 |
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| First Author: |
Morrison Joly M |
| Year: |
2016 |
| Journal: |
Cancer Res |
| Title: |
Rictor/mTORC2 Drives Progression and Therapeutic Resistance of HER2-Amplified Breast Cancers. |
| Volume: |
76 |
| Issue: |
16 |
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4752-64 |
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| First Author: |
Honor? E |
| Year: |
2022 |
| Journal: |
Mol Brain |
| Title: |
Object location learning in mice requires hippocampal somatostatin interneuron activity and is facilitated by mTORC1-mediated long-term potentiation of their excitatory synapses. |
| Volume: |
15 |
| Issue: |
1 |
| Pages: |
101 |
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| First Author: |
Michon FX |
| Year: |
2023 |
| Journal: |
Mol Brain |
| Title: |
mTORC1-mediated acquisition of reward-related representations by hippocampal somatostatin interneurons. |
| Volume: |
16 |
| Issue: |
1 |
| Pages: |
55 |
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| Publication |
| First Author: |
de Souza GO |
| Year: |
2023 |
| Journal: |
Cells |
| Title: |
mTORC1 Signaling in AgRP Neurons Is Not Required to Induce Major Neuroendocrine Adaptations to Food Restriction. |
| Volume: |
12 |
| Issue: |
20 |
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