| Type |
Details |
Score |
| GXD Expression |
| Probe: |
MGI:5309219 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1768022 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:5422807 |
| Age: |
embryonic day 14.5 |
|
| Note: |
Expression was not detected in the skull (base and vault). |
| Specimen Label: |
MH120; Specimen MH178 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1868228 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6693250 |
| Age: |
postnatal adult |
| Image: |
UC Davis_1875139 |
|
| Specimen Label: |
UC Davis_1875139 |
| Detected: |
true |
| Specimen Num: |
73 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1868228 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6693250 |
| Age: |
postnatal adult |
| Image: |
UC Davis_1875140 |
|
| Specimen Label: |
UC Davis_1875140 |
| Detected: |
true |
| Specimen Num: |
74 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5309219 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2012-06-12 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:2672022 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:5422807 |
| Age: |
embryonic day 14.5 |
| Image: |
MH120; Specimen MH178 |
| Note: |
Expression was detected in whisker follicle. |
| Specimen Label: |
MH120; Specimen MH178 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Present |
| Sex: |
Female |
| Emaps: |
EMAPS:1881228 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6693250 |
| Age: |
postnatal adult |
| Image: |
UC Davis_1875146 |
|
| Specimen Label: |
UC Davis_1875146 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Present |
| Sex: |
Female |
| Emaps: |
EMAPS:1881228 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6693250 |
| Age: |
postnatal adult |
| Image: |
UC Davis_1875147 |
|
| Specimen Label: |
UC Davis_1875147 |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7531087 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2023-09-27 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:2770820 |
| Pattern: |
Not Specified |
| Stage: |
TS20 |
| Assay Id: |
MGI:7531161 |
| Age: |
embryonic day 12.5 |
| Image: |
S1B E12.5 |
|
| Specimen Label: |
S1B E12.5 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6236285 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2023-09-29 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:2770820 |
| Pattern: |
Not Specified |
| Stage: |
TS20 |
| Assay Id: |
MGI:7531475 |
| Age: |
embryonic day 12.5 |
| Image: |
1A E12.5 |
|
| Specimen Label: |
1A E12.5 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6236285 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2023-09-29 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:2770820 |
| Pattern: |
Regionally restricted |
| Stage: |
TS20 |
| Assay Id: |
MGI:7531511 |
| Age: |
embryonic day 12.5 |
| Image: |
1B E12.5 with Jag1 |
| Note: |
Proximity signals were observed for JAG1 in the ureteric mesenchyme and ureteric epithelium. |
| Specimen Label: |
1B E12.5 with Jag1 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3611823 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2019-07-16 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3674021 |
|
| Stage: |
TS21 |
| Assay Id: |
MGI:6323246 |
| Age: |
embryonic day 13.0 |
|
| Note: |
Authors report expression not detected at early stages of tooth development. |
| Specimen Label: |
Notch3 E13 not shown |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3611823 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2019-07-16 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3674021 |
|
| Stage: |
TS21 |
| Assay Id: |
MGI:6323246 |
| Age: |
embryonic day 13.5 |
|
| Note: |
Authors report expression not detected at early stages of tooth development. |
| Specimen Label: |
Notch3 E13.5 not shown |
| Detected: |
false |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3611823 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2019-07-16 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3674022 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:6323246 |
| Age: |
embryonic day 14.0 |
|
| Note: |
Authors report expression not detected at early stages of tooth development. |
| Specimen Label: |
Notch3 E14 not shown |
| Detected: |
false |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1235
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
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Bettenhausen B |
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1995 |
| Journal: |
Development |
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Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta. |
| Volume: |
121 |
| Issue: |
8 |
| Pages: |
2407-18 |
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•
•
•
•
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| Publication |
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Moretti J |
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| Journal: |
PLoS Biol |
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The translation initiation factor 3f (eIF3f) exhibits a deubiquitinase activity regulating Notch activation. |
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•
•
|
| Publication |
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Walker NM |
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Am J Physiol Gastrointest Liver Physiol |
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The role of receptor MAS in microglia-driven retinal vascular development. |
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4 |
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•
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Carofino BL |
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2013 |
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Dis Model Mech |
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A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL). |
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6 |
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1494-506 |
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•
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Turgeon N |
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2013 |
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PLoS One |
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HDAC1 and HDAC2 restrain the intestinal inflammatory response by regulating intestinal epithelial cell differentiation. |
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The threonine that carries fucose, but not fucose, is required for Cripto to facilitate Nodal signaling. |
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•
•
•
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Choi HY |
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2024 |
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Exp Mol Med |
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NOTCH localizes to mitochondria through the TBC1D15-FIS1 interaction and is stabilized via blockade of E3 ligase and CDK8 recruitment to reprogram tumor-initiating cells. |
| Volume: |
56 |
| Issue: |
2 |
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461-477 |
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•
•
•
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| Publication |
| First Author: |
Hartman BH |
| Year: |
2010 |
| Journal: |
J Assoc Res Otolaryngol |
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Delta/notch-like EGF-related receptor (DNER) is expressed in hair cells and neurons in the developing and adult mouse inner ear. |
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11 |
| Issue: |
2 |
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•
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Pedrosa AR |
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Arterioscler Thromb Vasc Biol |
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Endothelial Jagged1 antagonizes Dll4 regulation of endothelial branching and promotes vascular maturation downstream of Dll4/Notch1. |
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35 |
| Issue: |
5 |
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•
•
•
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Maass JC |
| Year: |
2015 |
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Front Cell Neurosci |
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Changes in the regulation of the Notch signaling pathway are temporally correlated with regenerative failure in the mouse cochlea. |
| Volume: |
9 |
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110 |
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•
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2019 |
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Int J Mol Sci |
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KRIT1 Deficiency Promotes Aortic Endothelial Dysfunction. |
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2017 |
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J Am Heart Assoc |
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Essentiality of Regulator of G Protein Signaling 6 and Oxidized Ca2+/Calmodulin-Dependent Protein Kinase II in Notch Signaling and Cardiovascular Development. |
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6 |
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11 |
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2023 |
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Biochem Biophys Rep |
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Vil-Cre specific Slfn3KO mice exhibit sex-specific differences in lung, stomach, cecum, kidney, and proximal colon differentiation markers and Slfn family members expression levels. |
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J Mol Cell Cardiol |
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miRNA-34a reduces neointima formation through inhibiting smooth muscle cell proliferation and migration. |
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2017 |
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SUMOylation Negatively Regulates Angiogenesis by Targeting Endothelial NOTCH Signaling. |
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2018 |
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DNER modulates the length, polarity and synaptogenesis of spiral ganglion neurons via the Notch signaling pathway. |
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Mandula JK |
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2024 |
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Immunity |
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Jagged2 targeting in lung cancer activates anti-tumor immunity via Notch-induced functional reprogramming of tumor-associated macrophages. |
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57 |
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CD51 labels periosteal injury-responsive osteoprogenitors. |
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J Clin Invest |
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Nat Cell Biol |
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Perinatal angiogenesis from pre-existing coronary vessels via DLL4-NOTCH1 signalling. |
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9 |
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2016 |
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Sci Rep |
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Canonical Notch signaling plays an instructive role in auditory supporting cell development. |
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6 |
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•
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Cell Rep |
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YAP targetome reveals activation of SPEM in gastric pre-neoplastic progression and regeneration. |
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•
•
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| First Author: |
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| Year: |
2018 |
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Cell Stem Cell |
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Notch-Induced miR-708 Antagonizes Satellite Cell Migration and Maintains Quiescence. |
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23 |
| Issue: |
6 |
| Pages: |
859-868.e5 |
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•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
448
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chandrakesan P |
| Year: |
2017 |
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Mol Cancer |
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Dclk1, a tumor stem cell marker, regulates pro-survival signaling and self-renewal of intestinal tumor cells. |
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16 |
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1 |
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30 |
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•
•
•
•
|
| Publication |
| First Author: |
Andersson ER |
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2018 |
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Gastroenterology |
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Mouse Model of Alagille Syndrome and Mechanisms of Jagged1 Missense Mutations. |
| Volume: |
154 |
| Issue: |
4 |
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1080-1095 |
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•
•
•
•
•
|
| Publication |
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Zhang Y |
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2007 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Conserved signal peptide of Notch3 inhibits interaction with proteasome. |
| Volume: |
355 |
| Issue: |
1 |
| Pages: |
245-51 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
2318
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1964
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1154
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1964
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Vasquez EG |
| Year: |
2022 |
| Journal: |
Cell Stem Cell |
| Title: |
Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia. |
| Volume: |
29 |
| Issue: |
8 |
| Pages: |
1213-1228.e8 |
|
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•
•
•
•
|
| Publication |
| First Author: |
Sakamoto K |
| Year: |
2021 |
| Journal: |
Immunity |
| Title: |
Disruption of the endopeptidase ADAM10-Notch signaling axis leads to skin dysbiosis and innate lymphoid cell-mediated hair follicle destruction. |
| Volume: |
54 |
| Issue: |
10 |
| Pages: |
2321-2337.e10 |
|
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•
•
•
•
|
| Publication |
| First Author: |
Fujimaki S |
| Year: |
2022 |
| Journal: |
Nat Metab |
| Title: |
The endothelial Dll4-muscular Notch2 axis regulates skeletal muscle mass. |
| Volume: |
4 |
| Issue: |
2 |
| Pages: |
180-189 |
|
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•
•
•
•
|
| Publication |
| First Author: |
Najumudeen AK |
| Year: |
2021 |
| Journal: |
Nat Genet |
| Title: |
The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer. |
| Volume: |
53 |
| Issue: |
1 |
| Pages: |
16-26 |
|
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•
•
•
•
|
| Publication |
| First Author: |
Gillers BS |
| Year: |
2015 |
| Journal: |
Circ Res |
| Title: |
Canonical wnt signaling regulates atrioventricular junction programming and electrophysiological properties. |
| Volume: |
116 |
| Issue: |
3 |
| Pages: |
398-406 |
|
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•
•
•
•
|
| Publication |
| First Author: |
Zhu L |
| Year: |
2016 |
| Journal: |
Cell |
| Title: |
Multi-organ Mapping of Cancer Risk. |
| Volume: |
166 |
| Issue: |
5 |
| Pages: |
1132-1146.e7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lüdtke TH |
| Year: |
2019 |
| Journal: |
Am J Physiol Lung Cell Mol Physiol |
| Title: |
Mesothelial mobilization in the developing lung and heart differs in timing, quantity, and pathway dependency. |
| Volume: |
316 |
| Issue: |
5 |
| Pages: |
L767-L783 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ouadah Y |
| Year: |
2019 |
| Journal: |
Cell |
| Title: |
Rare Pulmonary Neuroendocrine Cells Are Stem Cells Regulated by Rb, p53, and Notch. |
| Volume: |
179 |
| Issue: |
2 |
| Pages: |
403-416.e23 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liu P |
| Year: |
2016 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Anabolic actions of Notch on mature bone. |
| Volume: |
113 |
| Issue: |
15 |
| Pages: |
E2152-61 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yu VW |
| Year: |
2015 |
| Journal: |
J Exp Med |
| Title: |
Specific bone cells produce DLL4 to generate thymus-seeding progenitors from bone marrow. |
| Volume: |
212 |
| Issue: |
5 |
| Pages: |
759-74 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chang W |
| Year: |
2020 |
| Journal: |
Cell Stem Cell |
| Title: |
Hormonal Suppression of Stem Cells Inhibits Symmetric Cell Division and Gastric Tumorigenesis. |
| Volume: |
26 |
| Issue: |
5 |
| Pages: |
739-754.e8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Harro CM |
| Year: |
2021 |
| Journal: |
J Clin Invest |
| Title: |
Methyltransferase inhibitors restore SATB1 protective activity against cutaneous T cell lymphoma in mice. |
| Volume: |
131 |
| Issue: |
3 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Guimaraes EL |
| Year: |
2024 |
| Journal: |
Science |
| Title: |
Corpora cavernosa fibroblasts mediate penile erection. |
| Volume: |
383 |
| Issue: |
6683 |
| Pages: |
eade8064 |
|
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•
•
•
•
|
| Publication |
| First Author: |
Francis R |
| Year: |
2019 |
| Journal: |
Sci Adv |
| Title: |
Gastrointestinal transcription factors drive lineage-specific developmental programs in organ specification and cancer. |
| Volume: |
5 |
| Issue: |
12 |
| Pages: |
eaax8898 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Garcia TX |
| Year: |
2017 |
| Journal: |
Stem Cells Dev |
| Title: |
The NOTCH Ligand JAG1 Regulates GDNF Expression in Sertoli Cells. |
| Volume: |
26 |
| Issue: |
8 |
| Pages: |
585-598 |
|
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•
•
•
•
|
| Publication |
| First Author: |
Baghdadi MB |
| Year: |
2018 |
| Journal: |
Nature |
| Title: |
Reciprocal signalling by Notch-Collagen V-CALCR retains muscle stem cells in their niche. |
| Volume: |
557 |
| Issue: |
7707 |
| Pages: |
714-718 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Vanderkerken M |
| Year: |
2020 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
TAO-kinase 3 governs the terminal differentiation of NOTCH2-dependent splenic conventional dendritic cells. |
| Volume: |
117 |
| Issue: |
49 |
| Pages: |
31331-31342 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cheng CW |
| Year: |
2019 |
| Journal: |
Cell |
| Title: |
Ketone Body Signaling Mediates Intestinal Stem Cell Homeostasis and Adaptation to Diet. |
| Volume: |
178 |
| Issue: |
5 |
| Pages: |
1115-1131.e15 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1624
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1214
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Houzelstein D |
| Year: |
2002 |
| Journal: |
Mol Cell Biol |
| Title: |
Growth and early postimplantation defects in mice deficient for the bromodomain-containing protein Brd4. |
| Volume: |
22 |
| Issue: |
11 |
| Pages: |
3794-802 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ling H |
| Year: |
2013 |
| Journal: |
Cancer Res |
| Title: |
Cyclin D1-dependent induction of luminal inflammatory breast tumors by activated notch3. |
| Volume: |
73 |
| Issue: |
19 |
| Pages: |
5963-73 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liu H |
| Year: |
2018 |
| Journal: |
J Vasc Res |
| Title: |
Evaluation of Notch3 Deficiency in Diabetes-Induced Pericyte Loss in the Retina. |
| Volume: |
55 |
| Issue: |
5 |
| Pages: |
308-318 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jespersen K |
| Year: |
2020 |
| Journal: |
Sci Rep |
| Title: |
Enhanced Notch3 signaling contributes to pulmonary emphysema in a Murine Model of Marfan syndrome. |
| Volume: |
10 |
| Issue: |
1 |
| Pages: |
10949 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ratelade J |
| Year: |
2020 |
| Journal: |
Circulation |
| Title: |
Reducing Hypermuscularization of the Transitional Segment Between Arterioles and Capillaries Protects Against Spontaneous Intracerebral Hemorrhage. |
| Volume: |
141 |
| Issue: |
25 |
| Pages: |
2078-2094 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Morrison SJ |
| Year: |
2002 |
| Journal: |
J Immunol |
| Title: |
A genetic determinant that specifically regulates the frequency of hematopoietic stem cells. |
| Volume: |
168 |
| Issue: |
2 |
| Pages: |
635-42 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Neves KB |
| Year: |
2019 |
| Journal: |
JCI Insight |
| Title: |
ER stress and Rho kinase activation underlie the vasculopathy of CADASIL. |
| Volume: |
4 |
| Issue: |
23 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Daido W |
| Year: |
2023 |
| Journal: |
Cell Commun Signal |
| Title: |
Nestin and Notch3 collaboratively regulate angiogenesis, collagen production, and endothelial-mesenchymal transition in lung endothelial cells. |
| Volume: |
21 |
| Issue: |
1 |
| Pages: |
247 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Talora C |
| Year: |
2006 |
| Journal: |
Blood |
| Title: |
Cross talk among Notch3, pre-TCR, and Tal1 in T-cell development and leukemogenesis. |
| Volume: |
107 |
| Issue: |
8 |
| Pages: |
3313-20 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yu YR |
| Year: |
2013 |
| Journal: |
Am J Respir Cell Mol Biol |
| Title: |
CCR2 deficiency, dysregulation of Notch signaling, and spontaneous pulmonary arterial hypertension. |
| Volume: |
48 |
| Issue: |
5 |
| Pages: |
647-54 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pekkonen P |
| Year: |
2014 |
| Journal: |
Cell Cycle |
| Title: |
KSHV viral cyclin interferes with T-cell development and induces lymphoma through Cdk6 and Notch activation in vivo. |
| Volume: |
13 |
| Issue: |
23 |
| Pages: |
3670-84 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
128
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
734
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
156
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
305
 |
| Fragment?: |
false |
|
•
•
•
•
•
|