| Type |
Details |
Score |
| Publication |
| First Author: |
Crewe C |
| Year: |
2019 |
| Journal: |
JCI Insight |
| Title: |
SREBP-regulated adipocyte lipogenesis is dependent on substrate availability and redox modulation of mTORC1. |
| Volume: |
5 |
| Issue: |
15 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang Y |
| Year: |
2021 |
| Journal: |
FASEB J |
| Title: |
Rictor/mTORC2 is involved in endometrial receptivity by regulating epithelial remodeling. |
| Volume: |
35 |
| Issue: |
7 |
| Pages: |
e21731 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ramalho S |
| Year: |
2025 |
| Journal: |
Sci Adv |
| Title: |
NAC regulates metabolism and cell fate in intestinal stem cells. |
| Volume: |
11 |
| Issue: |
2 |
| Pages: |
eadn9750 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Groenewoud MJ |
| Year: |
2013 |
| Journal: |
PLoS One |
| Title: |
Mammalian target of rapamycin complex I (mTORC1) activity in ras homologue enriched in brain (Rheb)-deficient mouse embryonic fibroblasts. |
| Volume: |
8 |
| Issue: |
11 |
| Pages: |
e81649 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Silva J |
| Year: |
2022 |
| Journal: |
Nat Commun |
| Title: |
Ribosome impairment regulates intestinal stem cell identity via ZAK? activation. |
| Volume: |
13 |
| Issue: |
1 |
| Pages: |
4492 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Banerjee R |
| Year: |
2024 |
| Journal: |
Arterioscler Thromb Vasc Biol |
| Title: |
Rictor, an mTORC2 Protein, Regulates Murine Lymphatic Valve Formation Through the AKT-FOXO1 Signaling. |
| Volume: |
44 |
| Issue: |
9 |
| Pages: |
2004-2023 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ballif BA |
| Year: |
2004 |
| Journal: |
Mol Cell Proteomics |
| Title: |
Phosphoproteomic analysis of the developing mouse brain. |
| Volume: |
3 |
| Issue: |
11 |
| Pages: |
1093-101 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
361
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
321
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
319
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
361
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
361
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
360
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
361
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
260
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
271
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
238
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
321
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
319
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Uhle S |
| Year: |
2003 |
| Journal: |
EMBO J |
| Title: |
Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome. |
| Volume: |
22 |
| Issue: |
6 |
| Pages: |
1302-12 |
|
•
•
•
•
•
|
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| First Author: |
Bech-Otschir D |
| Year: |
2001 |
| Journal: |
EMBO J |
| Title: |
COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system. |
| Volume: |
20 |
| Issue: |
7 |
| Pages: |
1630-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Iwasaki K |
| Year: |
2023 |
| Journal: |
Front Endocrinol (Lausanne) |
| Title: |
Decreased IGF1R attenuates senescence and improves function in pancreatic ?-cells. |
| Volume: |
14 |
|
| Pages: |
1203534 |
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•
•
•
•
•
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| Publication |
| First Author: |
Tong L |
| Year: |
2023 |
| Journal: |
J Cachexia Sarcopenia Muscle |
| Title: |
AAV1.NT-3 gene therapy in the SOD1KO mouse model of accelerated sarcopenia. |
| Volume: |
14 |
| Issue: |
5 |
| Pages: |
2204-2215 |
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•
•
•
•
•
|
| Publication |
| First Author: |
Zhang S |
| Year: |
2024 |
| Journal: |
Circulation |
| Title: |
Targeting NPM1 Epigenetically Promotes Postinfarction Cardiac Repair by Reprogramming Reparative Macrophage Metabolism. |
| Volume: |
149 |
| Issue: |
25 |
| Pages: |
1982-2001 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Getz SA |
| Year: |
2016 |
| Journal: |
Neurobiol Dis |
| Title: |
Rapamycin prevents, but does not reverse, aberrant migration in Pten knockout neurons. |
| Volume: |
93 |
|
| Pages: |
12-20 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Getz SA |
| Year: |
2022 |
| Journal: |
J Neurosci |
| Title: |
PTEN Regulates Dendritic Arborization by Decreasing Microtubule Polymerization Rate. |
| Volume: |
42 |
| Issue: |
10 |
| Pages: |
1945-1957 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Barrows CM |
| Year: |
2017 |
| Journal: |
J Neurosci |
| Title: |
PTEN Loss Increases the Connectivity of Fast Synaptic Motifs and Functional Connectivity in a Developing Hippocampal Network. |
| Volume: |
37 |
| Issue: |
36 |
| Pages: |
8595-8611 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chao X |
| Year: |
2022 |
| Journal: |
J Hepatol |
| Title: |
Hepatocytic p62 suppresses ductular reaction and tumorigenesis in mouse livers with mTORC1 activation and defective autophagy. |
| Volume: |
76 |
| Issue: |
3 |
| Pages: |
639-651 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dom?nech-Est?vez E |
| Year: |
2016 |
| Journal: |
J Neurosci |
| Title: |
Akt Regulates Axon Wrapping and Myelin Sheath Thickness in the PNS. |
| Volume: |
36 |
| Issue: |
16 |
| Pages: |
4506-21 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Le Bacquer O |
| Year: |
2019 |
| Journal: |
J Cachexia Sarcopenia Muscle |
| Title: |
4E-BP1 and 4E-BP2 double knockout mice are protected from aging-associated sarcopenia. |
| Volume: |
10 |
| Issue: |
3 |
| Pages: |
696-709 |
|
•
•
•
•
•
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| Publication |
| First Author: |
Bonilla IM |
| Year: |
2023 |
| Journal: |
J Appl Physiol (1985) |
| Title: |
STIM1 ablation impairs exercise-induced physiological cardiac hypertrophy and dysregulates autophagy in mouse hearts. |
| Volume: |
134 |
| Issue: |
5 |
| Pages: |
1287-1299 |
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•
•
•
•
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| First Author: |
Docquier A |
| Year: |
2019 |
| Journal: |
J Physiol |
| Title: |
eIF3f depletion impedes mouse embryonic development, reduces adult skeletal muscle mass and amplifies muscle loss during disuse. |
| Volume: |
597 |
| Issue: |
12 |
| Pages: |
3107-3131 |
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•
•
•
•
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| First Author: |
Weisser I |
| Year: |
2024 |
| Journal: |
J Am Soc Nephrol |
| Title: |
Ablation of Long Noncoding RNA Hoxb3os Exacerbates Cystogenesis in Mouse Polycystic Kidney Disease. |
| Volume: |
35 |
| Issue: |
1 |
| Pages: |
41-55 |
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•
•
•
•
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| First Author: |
Megat S |
| Year: |
2019 |
| Journal: |
J Neurosci |
| Title: |
Differences between Dorsal Root and Trigeminal Ganglion Nociceptors in Mice Revealed by Translational Profiling. |
| Volume: |
39 |
| Issue: |
35 |
| Pages: |
6829-6847 |
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•
•
•
•
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| First Author: |
Salazar G |
| Year: |
2020 |
| Journal: |
Autophagy |
| Title: |
SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence. |
| Volume: |
16 |
| Issue: |
6 |
| Pages: |
1092-1110 |
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| First Author: |
McCoy C |
| Year: |
2025 |
| Journal: |
Front Mol Neurosci |
| Title: |
Focal postnatal deletion of Tsc2 causes epilepsy. |
| Volume: |
18 |
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1686023 |
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| First Author: |
Sar? RM |
| Year: |
2022 |
| Journal: |
eNeuro |
| Title: |
Confirmation of Decreased Rates of Cerebral Protein Synthesis In Vivo in a Mouse Model of Tuberous Sclerosis Complex. |
| Volume: |
9 |
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4 |
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| First Author: |
Pan B |
| Year: |
2019 |
| Journal: |
Front Physiol |
| Title: |
Highly Dynamic Changes in the Activity and Regulation of Macroautophagy in Hearts Subjected to Increased Proteotoxic Stress. |
| Volume: |
10 |
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758 |
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| First Author: |
Rhine MA |
| Year: |
2019 |
| Journal: |
Autism Res |
| Title: |
Hypothesis-driven investigations of diverse pharmacological targets in two mouse models of autism. |
| Volume: |
12 |
| Issue: |
3 |
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401-421 |
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| First Author: |
Wan H |
| Year: |
2020 |
| Journal: |
Autophagy |
| Title: |
WDR45 contributes to neurodegeneration through regulation of ER homeostasis and neuronal death. |
| Volume: |
16 |
| Issue: |
3 |
| Pages: |
531-547 |
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| First Author: |
Wang L |
| Year: |
2022 |
| Journal: |
Autophagy |
| Title: |
Torin 1 alleviates impairment of TFEB-mediated lysosomal biogenesis and autophagy in TGFBI (p.G623_H626del)-linked Thiel-Behnke corneal dystrophy. |
| Volume: |
18 |
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4 |
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765-782 |
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| First Author: |
Ding J |
| Year: |
2018 |
| Journal: |
Front Genet |
| Title: |
Aberrant Protein Turn-Over Associated With Myofibrillar Disorganization in FHL1 Knockout Mice. |
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9 |
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Fedeli C |
| Year: |
2019 |
| Journal: |
Autophagy |
| Title: |
PSEN2 (presenilin 2) mutants linked to familial Alzheimer disease impair autophagy by altering Ca(2+) homeostasis. |
| Volume: |
15 |
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12 |
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2044-2062 |
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| First Author: |
Tao R |
| Year: |
2015 |
| Journal: |
Diabetes |
| Title: |
Sestrin 3 protein enhances hepatic insulin sensitivity by direct activation of the mTORC2-Akt signaling. |
| Volume: |
64 |
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4 |
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1211-23 |
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| First Author: |
Blagih J |
| Year: |
2015 |
| Journal: |
Immunity |
| Title: |
The energy sensor AMPK regulates T cell metabolic adaptation and effector responses in vivo. |
| Volume: |
42 |
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Werlen G |
| Year: |
2022 |
| Journal: |
Nat Commun |
| Title: |
Dietary glucosamine overcomes the defects in ??-T cell ontogeny caused by the loss of de novo hexosamine biosynthesis. |
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Siuta MA |
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2010 |
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PLoS Biol |
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Dysregulation of the norepinephrine transporter sustains cortical hypodopaminergia and schizophrenia-like behaviors in neuronal rictor null mice. |
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Kim D |
| Year: |
2024 |
| Journal: |
Immunity |
| Title: |
Inhibitory co-receptor Lag3 supports Foxp3(+) regulatory T?cell function by restraining Myc-dependent metabolic programming. |
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57 |
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Wiebe S |
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2023 |
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Mol Brain |
| Title: |
Cell-type-specific translational control of spatial working memory by the cap-binding protein 4EHP. |
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Zhang Y |
| Year: |
2017 |
| Journal: |
J Biol Chem |
| Title: |
Neuronal mTORC1 Is Required for Maintaining the Nonreactive State of Astrocytes. |
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Tan H |
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2017 |
| Journal: |
Immunity |
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Integrative Proteomics and Phosphoproteomics Profiling Reveals Dynamic Signaling Networks and Bioenergetics Pathways Underlying T Cell Activation. |
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Zhang L |
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Cell Rep |
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Mammalian Target of Rapamycin Complex 2 Controls CD8 T Cell Memory Differentiation in a Foxo1-Dependent Manner. |
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Tang Y |
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Nat Commun |
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Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism. |
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Bhattacharya I |
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Arterioscler Thromb Vasc Biol |
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Rictor in perivascular adipose tissue controls vascular function by regulating inflammatory molecule expression. |
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Nat Commun |
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Raptor regulates functional maturation of murine beta cells. |
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J Bone Miner Res |
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Inactivation of mTORC1 Signaling in Osterix-Expressing Cells Impairs B-cell Differentiation. |
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J Neurosci |
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mTORC1 Is Transiently Reactivated in Injured Nerves to Promote c-Jun Elevation and Schwann Cell Dedifferentiation. |
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Raptor determines ?-cell identity and plasticity independent of hyperglycemia in mice. |
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Clenbuterol exerts antidiabetic activity through metabolic reprogramming of skeletal muscle cells. |
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Bentzinger CF |
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Skelet Muscle |
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Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy. |
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Bone Res |
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mTORC1 induces plasma membrane depolarization and promotes preosteoblast senescence by regulating the sodium channel Scn1a. |
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The level of protein in the maternal murine diet modulates the facial appearance of the offspring via mTORC1 signaling. |
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Epithelial cell specific Raptor is required for initiation of type 2 mucosal immunity in small intestine. |
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Nat Aging |
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Allosteric activation of a cell-type-specific GPR120 inhibits amyloid pathology of Alzheimer's disease. |
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Nutrient Sensor mTORC1 Regulates Insulin Secretion by Modulating ?-Cell Autophagy. |
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Long-term potentiation at pyramidal cell to somatostatin interneuron synapses controls hippocampal network plasticity and memory. |
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Sci Rep |
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Deng D |
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2024 |
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Bone Res |
| Title: |
Osteoclasts control endochondral ossification via regulating acetyl-CoA availability. |
| Volume: |
12 |
| Issue: |
1 |
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49 |
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•
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| First Author: |
Chuang JH |
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2013 |
| Journal: |
Stem Cell Res |
| Title: |
Differentiation of glutamatergic neurons from mouse embryonic stem cells requires raptor S6K signaling. |
| Volume: |
11 |
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3 |
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| First Author: |
Lu X |
| Year: |
2021 |
| Journal: |
Am J Pathol |
| Title: |
YAP Accelerates Notch-Driven Cholangiocarcinogenesis via mTORC1 in Mice. |
| Volume: |
191 |
| Issue: |
9 |
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1651-1667 |
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•
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| First Author: |
Ou YH |
| Year: |
2011 |
| Journal: |
Mol Cell |
| Title: |
TBK1 directly engages Akt/PKB survival signaling to support oncogenic transformation. |
| Volume: |
41 |
| Issue: |
4 |
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458-70 |
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| First Author: |
Manning JR |
| Year: |
2019 |
| Journal: |
Biochem J |
| Title: |
Loss of GCN5L1 in cardiac cells disrupts glucose metabolism and promotes cell death via reduced Akt/mTORC2 signaling. |
| Volume: |
476 |
| Issue: |
12 |
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1713-1724 |
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| Publication |
| First Author: |
Guridi M |
| Year: |
2016 |
| Journal: |
Skelet Muscle |
| Title: |
Alterations to mTORC1 signaling in the skeletal muscle differentially affect whole-body metabolism. |
| Volume: |
6 |
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| Pages: |
13 |
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Okazaki N |
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2004 |
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DNA Res |
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Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. |
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11 |
| Issue: |
3 |
| Pages: |
205-18 |
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Masutani M |
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2007 |
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EMBO J |
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Reconstitution reveals the functional core of mammalian eIF3. |
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26 |
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14 |
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•
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
324
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1335
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1353
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1333
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
297
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
324
 |
| Fragment?: |
false |
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•
•
•
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| First Author: |
Kunz J |
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1993 |
| Journal: |
Cell |
| Title: |
Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression. |
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73 |
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3 |
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585-96 |
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Hertzler-Schaefer K |
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2014 |
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Cell Rep |
| Title: |
Pten loss induces autocrine FGF signaling to promote skin tumorigenesis. |
| Volume: |
6 |
| Issue: |
5 |
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818-26 |
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| First Author: |
Sun F |
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2020 |
| Journal: |
Cell Rep |
| Title: |
Hepatic DNAJB9 Drives Anabolic Biasing to Reduce Steatosis and Obesity. |
| Volume: |
30 |
| Issue: |
6 |
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1835-1847.e9 |
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| First Author: |
Kohnke S |
| Year: |
2021 |
| Journal: |
Cell Rep |
| Title: |
Nutritional regulation of oligodendrocyte differentiation regulates perineuronal net remodeling in the median eminence. |
| Volume: |
36 |
| Issue: |
2 |
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109362 |
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| First Author: |
Zhou Y |
| Year: |
2024 |
| Journal: |
J Clin Invest |
| Title: |
TSC/mTORC1 mediates mTORC2/AKT1 signaling in c-MYC-induced murine hepatocarcinogenesis via centromere protein M. |
| Volume: |
134 |
| Issue: |
22 |
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•
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| Publication |
| First Author: |
Huang SC |
| Year: |
2016 |
| Journal: |
Immunity |
| Title: |
Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis Is Essential for Macrophage Alternative Activation. |
| Volume: |
45 |
| Issue: |
4 |
| Pages: |
817-830 |
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| First Author: |
Harada Y |
| Year: |
2022 |
| Journal: |
iScience |
| Title: |
Intracellular metabolic adaptation of intraepithelial CD4(+)CD8??(+) T lymphocytes. |
| Volume: |
25 |
| Issue: |
4 |
| Pages: |
104021 |
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| First Author: |
Allington G |
| Year: |
2026 |
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Sci Transl Med |
| Title: |
Developmental genetic determinants of the human cerebrospinal fluid-ventricular system. |
| Volume: |
18 |
| Issue: |
857 |
| Pages: |
eaec4386 |
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| First Author: |
Cullen ER |
| Year: |
2024 |
| Journal: |
Elife |
| Title: |
Hyperactivity of mTORC1- and mTORC2-dependent signaling mediates epilepsy downstream of somatic PTEN loss. |
| Volume: |
12 |
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•
•
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| First Author: |
Moloughney JG |
| Year: |
2016 |
| Journal: |
Mol Cell |
| Title: |
mTORC2 Responds to Glutamine Catabolite Levels to Modulate the Hexosamine Biosynthesis Enzyme GFAT1. |
| Volume: |
63 |
| Issue: |
5 |
| Pages: |
811-26 |
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| First Author: |
Kadam R |
| Year: |
2026 |
| Journal: |
Cell Rep |
| Title: |
Optineurin modulates mTORC2/AKT/STAT3 signaling to control MHC class II expression and adaptive immunity against HSV-1. |
| Volume: |
45 |
| Issue: |
4 |
| Pages: |
117263 |
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| First Author: |
Wang F |
| Year: |
2018 |
| Journal: |
Nat Commun |
| Title: |
Crosstalks between mTORC1 and mTORC2 variagate cytokine signaling to control NK maturation and effector function. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
4874 |
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•
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| Publication |
| First Author: |
Wang Y |
| Year: |
2023 |
| Journal: |
iScience |
| Title: |
Natural ??T17 cell development and functional acquisition is governed by the mTORC2-c-Maf-controlled mitochondrial fission pathway. |
| Volume: |
26 |
| Issue: |
5 |
| Pages: |
106630 |
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| First Author: |
Lee TY |
| Year: |
2021 |
| Journal: |
Autophagy |
| Title: |
Platelet autophagic machinery involved in thrombosis through a novel linkage of AMPK-MTOR to sphingolipid metabolism. |
| Volume: |
17 |
| Issue: |
12 |
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4141-4158 |
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| Publication |
| First Author: |
Cheng C |
| Year: |
2024 |
| Journal: |
J Orthop Translat |
| Title: |
FOXO1-mTOR pathway in vascular pericyte regulates the formation of type H vessels to control bone metabolism. |
| Volume: |
49 |
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| Pages: |
246-263 |
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