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Search results 501 to 568 out of 568 for Adam17

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Type Details Score
Publication
35757773 | J:334874
 
First Author: Hedges JF
Year: 2022
Journal: Front Immunol
Title: An ADAM17-Neutralizing Antibody Reduces Inflammation and Mortality While Increasing Viral Burden in a COVID-19 Mouse Model.
Volume: 13
Pages: 918881
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Publication
28084316 | J:244044
 
First Author: Hurst LA
Year: 2017
Journal: Nat Commun
Title: TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling.
Volume: 8
Pages: 14079
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Publication
32400009 | J:293902
First Author: Kruse T
Year: 2020
Journal: EMBO J
Title: Mechanisms of site-specific dephosphorylation and kinase opposition imposed by PP2A regulatory subunits.
Volume: 39
Issue: 13
Pages: e103695
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Protein
Q9Z0F8
Organism: Mus musculus/domesticus
Length: 827  
Fragment?: false
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Protein
E9PXU2
Organism: Mus musculus/domesticus
Length: 846  
Fragment?: false
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Protein
Q3UV09
Organism: Mus musculus/domesticus
Length: 827  
Fragment?: false
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Protein
B7ZNJ0
Organism: Mus musculus/domesticus
Length: 827  
Fragment?: false
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Protein
Q3UNK7
Organism: Mus musculus/domesticus
Length: 846  
Fragment?: false
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Protein
Q3UEW9
Organism: Mus musculus/domesticus
Length: 827  
Fragment?: false
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Publication
8437211 | -
First Author: Will C
Year: 1993
Journal: J Virol
Title: Marburg virus gene 4 encodes the virion membrane protein, a type I transmembrane glycoprotein.
Volume: 67
Issue: 3
Pages: 1203-10
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Publication
17005688 | -
First Author: Shimojima M
Year: 2006
Journal: J Virol
Title: Tyro3 family-mediated cell entry of Ebola and Marburg viruses.
Volume: 80
Issue: 20
Pages: 10109-16
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Publication
16775318 | -
First Author: Marzi A
Year: 2006
Journal: J Virol
Title: The signal peptide of the ebolavirus glycoprotein influences interaction with the cellular lectins DC-SIGN and DC-SIGNR.
Volume: 80
Issue: 13
Pages: 6305-17
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Publication
11152533 | -
First Author: Ito H
Year: 2001
Journal: J Virol
Title: Ebola virus glycoprotein: proteolytic processing, acylation, cell tropism, and detection of neutralizing antibodies.
Volume: 75
Issue: 3
Pages: 1576-80
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Publication
12482654 | -
First Author: Sui J
Year: 2002
Journal: Virology
Title: Evidence against Ebola virus sGP binding to human neutrophils by a specific receptor.
Volume: 303
Issue: 1
Pages: 9-14
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Publication
16051836 | -
First Author: Wahl-Jensen VM
Year: 2005
Journal: J Virol
Title: Effects of Ebola virus glycoproteins on endothelial cell activation and barrier function.
Volume: 79
Issue: 16
Pages: 10442-50
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Publication
15681442 | -
First Author: Wahl-Jensen V
Year: 2005
Journal: J Virol
Title: Role of Ebola virus secreted glycoproteins and virus-like particles in activation of human macrophages.
Volume: 79
Issue: 4
Pages: 2413-9
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Protein Domain
IPR014625 | GPC_FiloV
Type: Family
Description: Proteins in this family include the envelope glycoprotein and the pre-small/secreted glycoprotein from Filoviridae []. The envelope glycoprotein can be cleaved into 3 chains: GP1, GP2 and GP2-delta.GP1 is responsible for binding to the receptor(s), such as CD209 and CLEC4M, on target cells. These interactions not only facilitate virus cell entry, but also allow capture of viral particles by dendritic cells (DCs) and subsequent transmission to susceptible cells without DCs infection (trans infection) [].GP2 acts as a class I viral fusion protein. It is responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane []. GP1,2 peplomers mediates endothelial cell activation and decreases endothelial barrier function. It mediates activation of primary macrophages. At terminal stages of the viral infection, when its expression is high, GP1,2 down-modulates the expression of various host cell surface molecules that are essential for immune surveillance and cell adhesion [].GP2delta is part of the complex GP1,2delta released by host ADAM17 metalloprotease. This secreted complex may play a role in the pathogenesis of the virus by efficiently blocking the neutralizing antibodies that would otherwise neutralize the virus surface glycoproteins GP1,2. Might therefore contribute to the lack of inflammatory reaction seen during infection in spite the of extensive necrosis and massive virus production. GP1,2delta does not seem to be involved in activation of primary macrophage [].pre-small/secreted glycoprotein sGP seems to possess an anti-inflammatory activity as it can reverse the barrier-decreasing effects of TNF alpha. It might therefore contribute to the lack of inflammatory reaction seen during infection in spite the of extensive necrosis and massive virus production. It does not seem to be involved in activation of primary macrophages. It does not seem to interact specifically with neutrophils [, , , ].
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Protein
Q3UEC0
Organism: Mus musculus/domesticus
Length: 502  
Fragment?: true
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Publication
28855301 | J:273534
First Author: Thornton P
Year: 2017
Journal: EMBO Mol Med
Title: TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant.
Volume: 9
Issue: 10
Pages: 1366-1378
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Publication
11897009 | J:126011
 
First Author: Gunn TM
Year: 2002
Journal: BMC Genet
Title: Identification and preliminary characterization of mouse Adam33.
Volume: 3
Pages: 2
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Publication
24756098 | J:286374
First Author: Somineni HK
Year: 2014
Journal: J Endocrinol
Title: Daily exercise training protects against albuminuria and angiotensin converting enzyme 2 shedding in db/db diabetic mice.
Volume: 221
Issue: 2
Pages: 235-51
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Publication
23646149 | J:200870
First Author: Chodavarapu H
Year: 2013
Journal: PLoS One
Title: Rosiglitazone treatment of type 2 diabetic db/db mice attenuates urinary albumin and angiotensin converting enzyme 2 excretion.
Volume: 8
Issue: 4
Pages: e62833
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Publication
21712436 | J:174621
First Author: Spin JM
Year: 2011
Journal: Physiol Genomics
Title: Transcriptional profiling and network analysis of the murine angiotensin II-induced abdominal aortic aneurysm.
Volume: 43
Issue: 17
Pages: 993-1003
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Publication
21704645 | J:178566
First Author: Raman D
Year: 2011
Journal: Toxicol Appl Pharmacol
Title: Chemokines, macrophage inflammatory protein-2 and stromal cell-derived factor-1α, suppress amyloid β-induced neurotoxicity.
Volume: 256
Issue: 3
Pages: 300-13
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Publication
24329494 | J:325804
First Author: Takayanagi T
Year: 2014
Journal: Clin Sci (Lond)
Title: Caveolin 1 is critical for abdominal aortic aneurysm formation induced by angiotensin II and inhibition of lysyl oxidase.
Volume: 126
Issue: 11
Pages: 785-94
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Publication
27623510 | J:238331
First Author: Mahnke K
Year: 2017
Journal: J Invest Dermatol
Title: Down-Regulation of CD62L Shedding in T Cells by CD39+ Regulatory T Cells Leads to Defective Sensitization in Contact Hypersensitivity Reactions.
Volume: 137
Issue: 1
Pages: 106-114
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Publication
21081501 | J:168499
First Author: Delarasse C
Year: 2011
Journal: J Biol Chem
Title: The purinergic receptor P2X7 triggers alpha-secretase-dependent processing of the amyloid precursor protein.
Volume: 286
Issue: 4
Pages: 2596-606
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Publication
22759926 | J:197509
First Author: Gil-Bea FJ
Year: 2012
Journal: Neurobiol Dis
Title: Cholinergic denervation exacerbates amyloid pathology and induces hippocampal atrophy in Tg2576 mice.
Volume: 48
Issue: 3
Pages: 439-46
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Publication
23401241 | J:232308
First Author: Fiorentino L
Year: 2013
Journal: EMBO Mol Med
Title: Loss of TIMP3 underlies diabetic nephropathy via FoxO1/STAT1 interplay.
Volume: 5
Issue: 3
Pages: 441-55
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Publication
15920158 | J:98813
First Author: Mahmoodi M
Year: 2005
Journal: Am J Pathol
Title: Lack of tissue inhibitor of metalloproteinases-3 results in an enhanced inflammatory response in antigen-induced arthritis.
Volume: 166
Issue: 6
Pages: 1733-40
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Publication
23299479 | J:214565
First Author: Hewing NJ
Year: 2013
Journal: Invest Ophthalmol Vis Sci
Title: Intravitreal injection of TIMP3 or the EGFR inhibitor erlotinib offers protection from oxygen-induced retinopathy in mice.
Volume: 54
Issue: 1
Pages: 864-70
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Publication
34575873 | J:311396
 
First Author: Witas R
Year: 2021
Journal: Int J Mol Sci
Title: Defective Efferocytosis in a Murine Model of Sjögren's Syndrome Is Mediated by Dysfunctional Mer Tyrosine Kinase Receptor.
Volume: 22
Issue: 18
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Publication
26426268 | J:330455
First Author: Meyer zu Horste G
Year: 2015
Journal: J Neuropathol Exp Neurol
Title: Neuronal ADAM10 Promotes Outgrowth of Small-Caliber Myelinated Axons in the Peripheral Nervous System.
Volume: 74
Issue: 11
Pages: 1077-85
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Publication
31381863 | J:298593
First Author: Wichert R
Year: 2019
Journal: FASEB J
Title: Meprin β induces activities of A disintegrin and metalloproteinases 9, 10, and 17 by specific prodomain cleavage.
Volume: 33
Issue: 11
Pages: 11925-11940
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Publication
27283741 | J:246999
First Author: Brandes RP
Year: 2016
Journal: Arterioscler Thromb Vasc Biol
Title: The Cytosolic NADPH Oxidase Subunit NoxO1 Promotes an Endothelial Stalk Cell Phenotype.
Volume: 36
Issue: 8
Pages: 1558-65
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Publication
27806985 | J:286428
First Author: Chodavarapu H
Year: 2016
Journal: Am J Physiol Regul Integr Comp Physiol
Title: High-fat diet-induced glucose dysregulation is independent of changes in islet ACE2 in mice.
Volume: 311
Issue: 6
Pages: R1223-R1233
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Publication
36907286 | J:351751
 
First Author: Lee HJ
Year: 2023
Journal: Pharmacol Res
Title: Inhibition of CDK4/6 regulates AD pathology, neuroinflammation and cognitive function through DYRK1A/STAT3 signaling.
Volume: 190
Pages: 106725
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Publication
21652675 | J:176939
First Author: Jurak Begonja A
Year: 2011
Journal: Blood
Title: FlnA-null megakaryocytes prematurely release large and fragile platelets that circulate poorly.
Volume: 118
Issue: 8
Pages: 2285-95
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Publication
31662486 | J:280798
 
First Author: Sundaram B
Year: 2019
Journal: Sci Signal
Title: iRhom2 inhibits bile duct obstruction-induced liver fibrosis.
Volume: 12
Issue: 605
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Publication
24014829 | J:286424
First Author: Xia H
Year: 2013
Journal: Circ Res
Title: Brain angiotensin-converting enzyme type 2 shedding contributes to the development of neurogenic hypertension.
Volume: 113
Issue: 9
Pages: 1087-1096
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Publication
33950315 | J:310482
First Author: Düsterhöft S
Year: 2021
Journal: Cell Mol Life Sci
Title: The iRhom homology domain is indispensable for ADAM17-mediated TNFα and EGF receptor ligand release.
Volume: 78
Issue: 11
Pages: 5015-5040
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Publication
17107962 | J:118158
First Author: Dyczynska E
Year: 2007
Journal: J Biol Chem
Title: Proteolytic processing of delta-like 1 by ADAM proteases.
Volume: 282
Issue: 1
Pages: 436-44
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Publication
21570469 | J:178049
First Author: Cisse M
Year: 2011
Journal: Mol Cell Neurosci
Title: ERK1-independent α-secretase cut of β-amyloid precursor protein via M1 muscarinic receptors and PKCα/ε.
Volume: 47
Issue: 3
Pages: 223-32
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Publication
24037740 | J:202953
First Author: Rayego-Mateos S
Year: 2013
Journal: J Pathol
Title: TWEAK transactivation of the epidermal growth factor receptor mediates renal inflammation.
Volume: 231
Issue: 4
Pages: 480-94
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Publication
24662289 | J:217238
First Author: Herzog C
Year: 2014
Journal: J Biol Chem
Title: ADAM10 is the major sheddase responsible for the release of membrane-associated meprin A.
Volume: 289
Issue: 19
Pages: 13308-22
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Publication
24164679 | J:217854
First Author: Dewitz C
Year: 2014
Journal: FEBS J
Title: T-cell immunoglobulin and mucin domain 2 (TIM-2) is a target of ADAM10-mediated ectodomain shedding.
Volume: 281
Issue: 1
Pages: 157-74
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Publication
24878322 | J:217929
First Author: Garbers C
Year: 2014
Journal: Biochim Biophys Acta
Title: The interleukin-6 receptor Asp358Ala single nucleotide polymorphism rs2228145 confers increased proteolytic conversion rates by ADAM proteases.
Volume: 1842
Issue: 9
Pages: 1485-94
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Publication
26554003 | J:228065
First Author: Goth CK
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: A systematic study of modulation of ADAM-mediated ectodomain shedding by site-specific O-glycosylation.
Volume: 112
Issue: 47
Pages: 14623-8
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Publication
26193076 | J:231240
First Author: Kim EY
Year: 2015
Journal: Biochim Biophys Acta
Title: Syndecan-4 ectodomain evokes mobilization of podocyte TRPC6 channels and their associated pathways: An essential role for integrin signaling.
Volume: 1853
Issue: 10 Pt A
Pages: 2610-20
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Publication
26961870 | J:234201
First Author: Franke M
Year: 2016
Journal: J Biol Chem
Title: Human and Murine Interleukin 23 Receptors Are Novel Substrates for A Disintegrin and Metalloproteases ADAM10 and ADAM17.
Volume: 291
Issue: 20
Pages: 10551-61
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Publication
28671983 | J:248513
First Author: Du X
Year: 2017
Journal: PLoS One
Title: Isoflurane promotes phagocytosis of apoptotic neutrophils through AMPK-mediated ADAM17/Mer signaling.
Volume: 12
Issue: 7
Pages: e0180213
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Publication
28414309 | J:248155
First Author: Nandhu MS
Year: 2017
Journal: Oncogene
Title: Tumor-derived fibulin-3 activates pro-invasive NF-κB signaling in glioblastoma cells and their microenvironment.
Volume: 36
Issue: 34
Pages: 4875-4886
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Publication
28053235 | J:247866
First Author: Jiang C
Year: 2017
Journal: J Immunol
Title: Inactivation of Rab11a GTPase in Macrophages Facilitates Phagocytosis of Apoptotic Neutrophils.
Volume: 198
Issue: 4
Pages: 1660-1672
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Publication
31575895 | J:284660
First Author: Ikeda A
Year: 2019
Journal: Sci Rep
Title: ADAM10 is Expressed by Ameloblasts, Cleaves the RELT TNF Receptor Extracellular Domain and Facilitates Enamel Development.
Volume: 9
Issue: 1
Pages: 14086
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Publication
33275517 | J:303463
First Author: Viveiros A
Year: 2021
Journal: Am J Physiol Heart Circ Physiol
Title: Sex differences in COVID-19: candidate pathways, genetics of ACE2, and sex hormones.
Volume: 320
Issue: 1
Pages: H296-H304
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Publication
28160627 | J:320874
 
First Author: Balic JJ
Year: 2017
Journal: Cytokine
Title: Interleukin-11-driven gastric tumourigenesis is independent of trans-signalling.
Volume: 92
Pages: 118-123
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Publication
11882657 | J:76537
First Author: Eto K
Year: 2002
Journal: J Biol Chem
Title: Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions.
Volume: 277
Issue: 20
Pages: 17804-10
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Publication
25933166 | J:235248
First Author: Cooley LF
Year: 2015
Journal: PLoS One
Title: Increased B Cell ADAM10 in Allergic Patients and Th2 Prone Mice.
Volume: 10
Issue: 5
Pages: e0124331
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Publication
27046120 | J:258344
First Author: Lee M
Year: 2016
Journal: Invest Ophthalmol Vis Sci
Title: Interphotoreceptor Retinoid-Binding Protein Mitigates Cellular Oxidative Stress and Mitochondrial Dysfunction Induced by All-trans-Retinal.
Volume: 57
Issue: 4
Pages: 1553-62
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Publication
28512108 | J:267327
First Author: Xu J
Year: 2017
Journal: Circ Res
Title: Clinical Relevance and Role of Neuronal AT1 Receptors in ADAM17-Mediated ACE2 Shedding in Neurogenic Hypertension.
Volume: 121
Issue: 1
Pages: 43-55
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Publication
20856819 | J:165123
First Author: Gossens K
Year: 2010
Journal: PLoS One
Title: Deficiency of the metalloproteinase-disintegrin ADAM8 is associated with thymic hyper-cellularity.
Volume: 5
Issue: 9
Pages: e12766
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Publication
24454948 | J:286319
First Author: Xiao F
Year: 2014
Journal: PLoS One
Title: Characterization of angiotensin-converting enzyme 2 ectodomain shedding from mouse proximal tubular cells.
Volume: 9
Issue: 1
Pages: e85958
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Publication
38892263 | J:351195
 
First Author: Azzopardi SA
Year: 2024
Journal: Int J Mol Sci
Title: Role of iRhom2 in Olfaction: Implications for Odorant Receptor Regulation and Activity-Dependent Adaptation.
Volume: 25
Issue: 11
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Publication
16236709 | J:104096
First Author: Cissé MA
Year: 2005
Journal: J Biol Chem
Title: The disintegrin ADAM9 indirectly contributes to the physiological processing of cellular prion by modulating ADAM10 activity.
Volume: 280
Issue: 49
Pages: 40624-31
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Publication
26203177 | J:226274
First Author: Light A
Year: 2015
Journal: Biol Reprod
Title: LH-Induced Steroidogenesis in the Mouse Ovary, but Not Testis, Requires Matrix Metalloproteinase 2- and 9-Mediated Cleavage of Upregulated EGF Receptor Ligands.
Volume: 93
Issue: 3
Pages: 65
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Protein
O35598
Organism: Mus musculus/domesticus
Length: 749  
Fragment?: false
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Protein
E9PYF2
Organism: Mus musculus/domesticus
Length: 513  
Fragment?: false
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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