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Search results 501 to 600 out of 635 for Agrp

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Type Details Score
Genotype
Genotype
Symbol: Agrp/Agrp<+>
Background: involves: 129S4/SvJaeSor * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Agrp/Agrp
Background: involves: 129S4/SvJaeSor * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Publication
17550779 | J:129853
First Author: Könner AC
Year: 2007
Journal: Cell Metab
Title: Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production.
Volume: 5
Issue: 6
Pages: 438-49
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Publication
29459251 | J:260852
 
First Author: Bruschetta G
Year: 2018
Journal: Mol Metab
Title: Prolyl carboxypeptidase in Agouti-related Peptide neurons modulates food intake and body weight.
Volume: 10
Pages: 28-38
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Protein Domain
IPR036836 | Agouti_dom_sf
Type: Homologous_superfamily
Description: The agouti signaling protein (ASIP or the agouti protein) and its neuropeptide homologue the agouti-related protein (AgRP) are paracrine signaling molecules that act as inverse agonists at distinct subsets of melanocortin receptors. ASIP antagonizes the binding of alpha-melanocyte stimulating hormone (alpha-MSH) to melanocortin 1 receptor (MC1R), switching melanin synthesis from eumelanin (black/brown) to phaeomelanin (red/yellow). The effect of ASIP on pigment type-switching is responsible for a variety of coat color patterns accross a broad range of mammalian species. AgRP is involved in energy balance and acts normally at the MC3R and MC4R to control body weight regulation and metabolism [, ].Sequence similarity between ASIP and AgRP is confined to their Cys-rich C-terminal domains, which are also responsible for melanocortin receptor binding activity in vitro. Approximately 40 residues in length, there are ten cysteine residues in the C-terminal domain that form a network of five disulfide bonds. The agouti C-terminal domain contains a three-stranded antiparallel beta sheet, where the last two strands form a beta hairpin. The hairpin's turn region presents a triplet of residues (Arg-Phe-Phe) known to be essential for melanocortin receptor binding. The agouti C-terminal domain adopts the inhibitor cystine knot (ICK) or knottin fold identified in numerous invertebrate toxins [, ].The agouti domain covers the 10 cysteines involved in disulfide bonds.
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Protein Domain
IPR027300 | Agouti_dom
Type: Domain
Description: The agouti signaling protein (ASIP or the agouti protein) and its neuropeptide homologue the agouti-related protein (AgRP) are paracrine signaling molecules that act as inverse agonists at distinct subsets of melanocortin receptors. ASIP antagonizes the binding of alpha-melanocyte stimulating hormone (alpha-MSH) to melanocortin 1 receptor (MC1R), switching melanin synthesis from eumelanin (black/brown) to phaeomelanin (red/yellow). The effect of ASIP on pigment type-switching is responsible for a variety of coat color patterns accross a broad range of mammalian species. AgRP is involved in energy balance and acts normally at the MC3R and MC4R to control body weight regulation and metabolism [, ].Sequence similarity between ASIP and AgRP is confined to their Cys-rich C-terminal domains, which are also responsible for melanocortin receptor binding activity in vitro. Approximately 40 residues in length, there are ten cysteine residues in the C-terminal domain that form a network of five disulfide bonds. The agouti C-terminal domain contains a three-stranded antiparallel beta sheet, where the last two strands form a beta hairpin. The hairpin's turn region presents a triplet of residues (Arg-Phe-Phe) known to be essential for melanocortin receptor binding. The agouti C-terminal domain adopts the inhibitor cystine knot (ICK) or knottin fold identified in numerous invertebrate toxins [, ].This entry represents the agouti domain which covers the 10 cysteines involved in disulfide bonds.
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Publication
28385803 | J:246634
First Author: Shin AC
Year: 2017
Journal: Diabetes
Title: Insulin Receptor Signaling in POMC, but Not AgRP, Neurons Controls Adipose Tissue Insulin Action.
Volume: 66
Issue: 6
Pages: 1560-1571
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Publication
18854155 | J:149873
First Author: Zhang X
Year: 2008
Journal: Cell
Title: Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity.
Volume: 135
Issue: 1
Pages: 61-73
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Publication
15761497 | J:97407
First Author: Xu AW
Year: 2005
Journal: J Clin Invest
Title: PI3K integrates the action of insulin and leptin on hypothalamic neurons.
Volume: 115
Issue: 4
Pages: 951-8
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Publication
24944899 | J:221261
First Author: Kocalis HE
Year: 2014
Journal: Mol Metab
Title: Rictor/mTORC2 facilitates central regulation of energy and glucose homeostasis.
Volume: 3
Issue: 4
Pages: 394-407
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Protein
P56473
Organism: Mus musculus/domesticus
Length: 131  
Fragment?: false
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Protein
Q03288
Organism: Mus musculus/domesticus
Length: 131  
Fragment?: false
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Protein
Q3UU47
Organism: Mus musculus/domesticus
Length: 131  
Fragment?: false
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Protein
A0A0A6YX09
Organism: Mus musculus/domesticus
Length: 118  
Fragment?: true
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Allele
Agrp<tm1(cre*)Rpa> | MGI:5911621
Name: agouti related neuropeptide; targeted mutation 1, Richard D Palmiter
Allele Type: Targeted
Attribute String: Inducible, Recombinase
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Allele
Tg(Agrp-cre/ERT2)#Jmz | MGI:5909993
Name: transgene insertion, Jeffrey M Zigman
Allele Type: Transgenic
Attribute String: Inducible, Recombinase
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Genotype
Genotype
Symbol: Prkaa2/Prkaa2 Tg(Agrp-cre)1Gsb/?
Background: involves: 129S2/SvPas * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Agrp/Agrp<+> Grin1/Grin1
Background: involves: 129S4/SvJae * 129S4/SvJaeSor
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Agrp/Agrp<+> Tph2/Tph2
Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * C57BL/6NCr
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nhlh2/Nhlh2 Tg(Agrp-cre)1Gsb/?
Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lepr/Lepr Tg(Agrp-cre)1Gsb/?
Background: involves: 129 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Agrp-cre)1Gsb/?
Background: involves: 129 * C57BL/6J * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Publication
16296893 | J:104063
First Author: Xu AW
Year: 2005
Journal: PLoS Biol
Title: Effects of hypothalamic neurodegeneration on energy balance.
Volume: 3
Issue: 12
Pages: e415
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Publication
20071537 | J:157706
First Author: Pierce AA
Year: 2010
Journal: J Neurosci
Title: De novo neurogenesis in adult hypothalamus as a compensatory mechanism to regulate energy balance.
Volume: 30
Issue: 2
Pages: 723-30
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Publication
24374551 | J:209418
First Author: Sasaki T
Year: 2014
Journal: Diabetologia
Title: Hypothalamic SIRT1 prevents age-associated weight gain by improving leptin sensitivity in mice.
Volume: 57
Issue: 4
Pages: 819-31
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Publication
19933998 | J:164160
First Author: Lin HV
Year: 2010
Journal: Diabetes
Title: Divergent regulation of energy expenditure and hepatic glucose production by insulin receptor in agouti-related protein and POMC neurons.
Volume: 59
Issue: 2
Pages: 337-46
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Publication
20022934 | J:168180
First Author: Unger EK
Year: 2010
Journal: Endocrinology
Title: Functional role of c-Jun-N-terminal kinase in feeding regulation.
Volume: 151
Issue: 2
Pages: 671-82
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Publication
35204795 | J:322856
 
First Author: Lee JH
Year: 2022
Journal: Biomolecules
Title: Neuronal GHS-R Differentially Modulates Feeding Patterns under Normal and Obesogenic Conditions.
Volume: 12
Issue: 2
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Allele
Agrp<tm1(cre)Lowl> | MGI:3815085
Name: agouti related neuropeptide; targeted mutation 1, Bradford B Lowell
Allele Type: Targeted
Attribute String: Recombinase
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Genotype
Genotype
Symbol: Agrp/Agrp<+> Tg(Pomc-EGFP)1Low/?
Background: involves: 129S4/SvJaeSor * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Agrp/Agrp<+> Lep/Lep
Background: involves: 129S4/SvJaeSor * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Agrp/Agrp<+> Slc17a6/Slc17a6
Background: involves: 129S4/SvJaeSor * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Agrp-cre)1Gsb/?
Background: involves: 129 * C57BL/6J * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor Tg(Agrp-cre)1Gsb/?
Background: involves: C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Publication
21642975 | J:174009
First Author: Klöckener T
Year: 2011
Journal: Nat Neurosci
Title: High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons.
Volume: 14
Issue: 7
Pages: 911-8
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Strain
MGI:4452354 | STOCK Agrp<tm1(cre)Lowl>/J
Attribute String: mutant stock, targeted mutation
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Genotype
Genotype
Symbol: Agrp/Agrp<+> Slc32a1/Slc32a1
Background: involves: 129S6/SvEvTac * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Agrp/Agrp<+> Lepr/Lepr
Background: involves: 129S6/SvEvTac
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rock1/Rock1 Agrp/Agrp<+>
Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tbx3/Tbx3 Agrp/Agrp<+>
Background: involves: C57BL/6J
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nampt/Nampt Agrp/Agrp<+>
Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6JBomTac
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Agrp/Agrp<+> Slc32a1/Slc32a1
Background: involves: 129S6/SvEvTac * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Agrp-cre)1Gsb/?
Background: involves: 129S4/SvJaeSor * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Agrp/Agrp<+> Klf4/Klf4
Background: involves: 129S6/SvEvTac
Zygosity: cn
Has Mutant Allele: true
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Publication
16098827 | J:129837
First Author: Ren D
Year: 2005
Journal: Cell Metab
Title: Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice.
Volume: 2
Issue: 2
Pages: 95-104
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Publication
30067966 | J:270674
First Author: Ravussin A
Year: 2018
Journal: Cell Rep
Title: Loss of Nucleobindin-2 Causes Insulin Resistance in Obesity without Impacting Satiety or Adiposity.
Volume: 24
Issue: 5
Pages: 1085-1092.e6
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Publication
21195353 | J:169476
First Author: Wang H
Year: 2011
Journal: Cell Metab
Title: Deficiency of lipoprotein lipase in neurons modifies the regulation of energy balance and leads to obesity.
Volume: 13
Issue: 1
Pages: 105-13
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Publication
31730854 | J:291579
First Author: Bai L
Year: 2019
Journal: Cell
Title: Genetic Identification of Vagal Sensory Neurons That Control Feeding.
Volume: 179
Issue: 5
Pages: 1129-1143.e23
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Publication
28051110 | J:348871
 
First Author: Lee NK
Year: 2017
Journal: Sci Rep
Title: Agouti Related Peptide Secreted Via Human Mesenchymal Stem Cells Upregulates Proteasome Activity in an Alzheimer's Disease Model.
Volume: 7
Pages: 39340
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Publication
18460329 | J:136219
First Author: Anderson KA
Year: 2008
Journal: Cell Metab
Title: Hypothalamic CaMKK2 contributes to the regulation of energy balance.
Volume: 7
Issue: 5
Pages: 377-88
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Publication
21642978 | J:173466
First Author: Purkayastha S
Year: 2011
Journal: Nat Med
Title: Uncoupling the mechanisms of obesity and hypertension by targeting hypothalamic IKK-β and NF-κB.
Volume: 17
Issue: 7
Pages: 883-7
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Publication
24199146 | J:221319
First Author: Schneeberger M
Year: 2012
Journal: Mol Metab
Title: Deletion of miRNA processing enzyme Dicer in POMC-expressing cells leads to pituitary dysfunction, neurodegeneration and development of obesity.
Volume: 2
Issue: 2
Pages: 74-85
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Genotype
Genotype
Symbol: A/a Agrp/Agrp<+>
Background: involves: 129S4/SvJaeSor * KK/Upj
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Agrp/Agrp<+> Lepr/Lepr Tg(Pomc1-hrGFP)1Lowl/?
Background: involves: 129S6/SvEvTac * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Agrp/Agrp<+> Slc32a1/Slc32a1 Tg(Pomc1-hrGFP)1Lowl/?
Background: involves: 129S6/SvEvTac * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Agrp/Agrp<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Agrp/Agrp<+> Tg(CAG-Bgeo/GFP)21Lbe/?
Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Agrp/Agrp<+> Tg(Npy-hrGFP)1Lowl/?
Background: involves: 129S6/SvEvTac * FVB
Zygosity: cn
Has Mutant Allele: true
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Publication
9892020 | J:51862
First Author: Yang YK
Year: 1999
Journal: Mol Endocrinol
Title: Characterization of Agouti-related protein binding to melanocortin receptors.
Volume: 13
Issue: 1
Pages: 148-55
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Publication
23897430 | J:205020
First Author: Kim SG
Year: 2013
Journal: Mol Cell Biol
Title: Control of energy balance by hypothalamic gene circuitry involving two nuclear receptors, neuron-derived orphan receptor 1 and glucocorticoid receptor.
Volume: 33
Issue: 19
Pages: 3826-34
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Publication
11882520 | J:75872
First Author: Tsuruta Y
Year: 2002
Journal: Am J Physiol Endocrinol Metab
Title: Hyperleptinemia in A(y)/a mice upregulates arcuate cocaine- and amphetamine-regulated transcript expression.
Volume: 282
Issue: 4
Pages: E967-73
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Publication
17374695 | J:126508
First Author: Lee M
Year: 2007
Journal: Am J Physiol Endocrinol Metab
Title: Transgenic MSH overexpression attenuates the metabolic effects of a high-fat diet.
Volume: 293
Issue: 1
Pages: E121-31
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Publication
19270710 | J:149375
First Author: Cao L
Year: 2009
Journal: Nat Med
Title: Molecular therapy of obesity and diabetes by a physiological autoregulatory approach.
Volume: 15
Issue: 4
Pages: 447-54
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Publication
32895383 | J:297247
First Author: Bentsen MA
Year: 2020
Journal: Nat Commun
Title: Transcriptomic analysis links diverse hypothalamic cell types to fibroblast growth factor 1-induced sustained diabetes remission.
Volume: 11
Issue: 1
Pages: 4458
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Publication
31245789 | J:286156
First Author: Mirzadeh Z
Year: 2019
Journal: Nat Metab
Title: Perineuronal Net Formation during the Critical Period for Neuronal Maturation in the Hypothalamic Arcuate Nucleus.
Volume: 1
Issue: 2
Pages: 212-221
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Publication
29522093 | J:260503
First Author: Pan W
Year: 2018
Journal: Endocrinology
Title: Essential Role for Hypothalamic Calcitonin Receptor‒Expressing Neurons in the Control of Food Intake by Leptin.
Volume: 159
Issue: 4
Pages: 1860-1872
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Publication
20967882 | J:167571
First Author: Nilsson IA
Year: 2011
Journal: Glia
Title: Evidence of hypothalamic degeneration in the anorectic anx/anx mouse.
Volume: 59
Issue: 1
Pages: 45-57
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Publication
17909095 | J:132419
First Author: Tolle V
Year: 2008
Journal: Diabetes
Title: In vivo evidence for inverse agonism of Agouti-related peptide in the central nervous system of proopiomelanocortin-deficient mice.
Volume: 57
Issue: 1
Pages: 86-94
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Publication
17334640 | J:125256
First Author: Asakawa A
Year: 2007
Journal: Int J Mol Med
Title: Ins2Akita mice exhibit hyperphagia and anxiety behavior via the melanocortin system.
Volume: 19
Issue: 4
Pages: 649-52
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Publication
18403487 | J:145370
First Author: Gong L
Year: 2008
Journal: Endocrinology
Title: Signal transducer and activator of transcription-3 is required in hypothalamic agouti-related protein/neuropeptide Y neurons for normal energy homeostasis.
Volume: 149
Issue: 7
Pages: 3346-54
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Publication
35470501 | J:337186
First Author: Naser W
Year: 2022
Journal: FASEB J
Title: Cytokine-inducible SH2 domain containing protein contributes to regulation of adiposity, food intake, and glucose metabolism.
Volume: 36
Issue: 5
Pages: e22320
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Publication
24996410 | J:323636
First Author: Torres-Andrade R
Year: 2014
Journal: Exp Physiol
Title: The increase in body weight induced by lack of methyl CpG binding protein-2 is associated with altered leptin signalling in the hypothalamus.
Volume: 99
Issue: 9
Pages: 1229-40
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Publication
24053666 | J:202687
 
First Author: Byerly MS
Year: 2013
Journal: BMC Physiol
Title: Estrogen-related receptor β deficiency alters body composition and response to restraint stress.
Volume: 13
Pages: 10
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Publication
12072562 | J:77345
First Author: Sainsbury A
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Important role of hypothalamic Y2 receptors in body weight regulation revealed in conditional knockout mice.
Volume: 99
Issue: 13
Pages: 8938-43
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Publication
30636247 | J:349129
First Author: Fernández-Gayol O
Year: 2019
Journal: Neuroendocrinology
Title: Different Responses to a High-Fat Diet in IL-6 Conditional Knockout Mice Driven by Constitutive GFAP-Cre and Synapsin 1-Cre Expression.
Volume: 109
Issue: 2
Pages: 113-130
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Publication
30500912 | J:269695
First Author: Loganathan N
Year: 2019
Journal: Endocrinology
Title: Bisphenol A Alters Bmal1, Per2, and Rev-Erba mRNA and Requires Bmal1 to Increase Neuropeptide Y Expression in Hypothalamic Neurons.
Volume: 160
Issue: 1
Pages: 181-192
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Publication
11796511 | J:74978
First Author: Tschöp M
Year: 2002
Journal: Endocrinology
Title: GH-releasing peptide-2 increases fat mass in mice lacking NPY: indication for a crucial mediating role of hypothalamic agouti-related protein.
Volume: 143
Issue: 2
Pages: 558-68
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Publication
17065347 | J:116549
First Author: Patel HR
Year: 2006
Journal: Diabetes
Title: Neuropeptide Y deficiency attenuates responses to fasting and high-fat diet in obesity-prone mice.
Volume: 55
Issue: 11
Pages: 3091-8
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Publication
14559977 | J:125996
First Author: Arens J
Year: 2003
Journal: Physiol Genomics
Title: Age-dependent hypothalamic expression of neuropeptides in wild-type and melanocortin-4 receptor-deficient mice.
Volume: 16
Issue: 1
Pages: 38-46
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Publication
28580287 | J:350427
First Author: Loh K
Year: 2017
Journal: Mol Metab
Title: Insulin controls food intake and energy balance via NPY neurons.
Volume: 6
Issue: 6
Pages: 574-584
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Publication
16367788 | J:104309
First Author: Fetissov SO
Year: 2005
Journal: Eur J Neurosci
Title: Alterations of arcuate nucleus neuropeptidergic development in contactin-deficient mice: comparison with anorexia and food-deprived mice.
Volume: 22
Issue: 12
Pages: 3217-28
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Publication
20923696 | J:170180
First Author: Zheng Q
Year: 2010
Journal: Neuroscience
Title: Enhanced anorexigenic signaling in lean obesity resistant syndecan-3 null mice.
Volume: 171
Issue: 4
Pages: 1032-40
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Publication
16174655 | J:105686
First Author: Egecioglu E
Year: 2006
Journal: Am J Physiol Endocrinol Metab
Title: Growth hormone receptor deficiency results in blunted ghrelin feeding response, obesity, and hypolipidemia in mice.
Volume: 290
Issue: 2
Pages: E317-25
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