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Search results 501 to 508 out of 508 for Apex1

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0.042s

Type

Details

Score

Protein Domain

IPR045080 | BRCT_XRCC1_rpt1

Type:

Domain

Description:

XRCC1 plays a key role in multiple DNA repair pathways by acting as a scaffold that binds to both DNA single strand breaks and gaps, poly (ADP-ribose) and to numerous DNA repair enzymes. It forms homodimers and interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB), DNA ligase III (LIG3), APTX, APLF, and APEX1 [, ]. XRCC1 contains an N-terminal XRCC1-specific domain and two BRCT domains. This entry corresponds to the first (central) BRCT domain []. This domain has been shown to interact with poly(ADP-ribosyl)ated (PARylated) PARP1. Inactivation of the central X1BR1 domain results in DNA damage hypersensitivity due to a defect in S phase-dependent DNA repair [].

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Publication

19556307 | J:151678

First Author:	Sabouri Z
Year:	2009
Journal:	Int Immunol
Title:	Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes.
Volume:	21
Issue:	8
Pages:	947-55

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Publication

21652643 | J:183051

First Author:	Cuneo MJ
Year:	2011
Journal:	Nucleic Acids Res
Title:	The structural basis for partitioning of the XRCC1/DNA ligase III-α BRCT-mediated dimer complexes.
Volume:	39
Issue:	17
Pages:	7816-27

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Publication

29750271 | J:263805

First Author:	Li M
Year:	2018
Journal:	Nucleic Acids Res
Title:	APE1 deficiency promotes cellular senescence and premature aging features.
Volume:	46
Issue:	11
Pages:	5664-5677

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Protein

Q60596

Organism:	Mus musculus/domesticus
Length:	631
Fragment?:	false

•

Protein

Q3TN28

Organism:	Mus musculus/domesticus
Length:	631
Fragment?:	false

•

Protein

Q3TGI0

Organism:	Mus musculus/domesticus
Length:	630
Fragment?:	false

•

Protein

Q3U2B4

Organism:	Mus musculus/domesticus
Length:	631
Fragment?:	false

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