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Search results 501 to 600 out of 620 for Apoa1

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Type Details Score
Publication
15734841 | J:105136
First Author: Duivenvoorden I
Year: 2005
Journal: Diabetes
Title: Apolipoprotein C3 deficiency results in diet-induced obesity and aggravated insulin resistance in mice.
Volume: 54
Issue: 3
Pages: 664-71
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Publication
17272756 | J:128221
First Author: Harder C
Year: 2007
Journal: Arterioscler Thromb Vasc Biol
Title: Cholesteryl ester transfer protein (CETP) expression protects against diet induced atherosclerosis in SR-BI deficient mice.
Volume: 27
Issue: 4
Pages: 858-64
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Strain
MGI:3829596 | 129S6/SvEvTac-Tg(Alb1-Ren)1Unc/Mmnc
Attribute String: coisogenic, transgenic
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Publication
19696925 | J:152459
First Author: Huby AC
Year: 2009
Journal: PLoS One
Title: Restoration of podocyte structure and improvement of chronic renal disease in transgenic mice overexpressing renin.
Volume: 4
Issue: 8
Pages: e6721
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Publication
23300650 | J:195730
First Author: Huby AC
Year: 2012
Journal: PLoS One
Title: The RenTg mice: a powerful tool to study renin-dependent chronic kidney disease.
Volume: 7
Issue: 12
Pages: e52362
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Publication
21429966 | J:174041
First Author: Toubas J
Year: 2011
Journal: Am J Physiol Renal Physiol
Title: Alteration of connexin expression is an early signal for chronic kidney disease.
Volume: 301
Issue: 1
Pages: F24-32
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Publication
23308073 | J:288927
 
First Author: Fletcher SJ
Year: 2012
Journal: Front Endocrinol (Lausanne)
Title: Transgenic mice overexpressing Renin exhibit glucose intolerance and diet-genotype interactions.
Volume: 3
Pages: 166
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Strain
MGI:3758899 | 129S/SvEv-Tg(Alb1-Ren)2Unc/CofJ
Attribute String: mutant strain, transgenic
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Strain
MGI:4457278 | 129S6/SvEvTac-Tg(Alb1-Ren)2Unc/Mmnc
Attribute String: coisogenic, mutant strain, targeted mutation, transgenic
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Strain
MGI:4458020 | 129S6/SvEvTac-Tg(Alb1-Ren)2Unc
Attribute String: coisogenic, mutant strain, transgenic
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Publication
26886190 | J:286447
First Author: Tanno T
Year: 2016
Journal: J Cardiovasc Pharmacol
Title: Olmesartan Inhibits Cardiac Hypertrophy in Mice Overexpressing Renin Independently of Blood Pressure: Its Beneficial Effects on ACE2/Ang(1-7)/Mas Axis and NADPH Oxidase Expression.
Volume: 67
Issue: 6
Pages: 503-9
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Publication
30369568 | J:286430
First Author: Ichikawa H
Year: 2018
Journal: Int Heart J
Title: Blood Pressure-Independent Effect of Olmesartan on Albuminuria in Mice Overexpressing Renin.
Volume: 59
Issue: 6
Pages: 1445-1453
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Publication
30995068 | J:340194
First Author: He L
Year: 2019
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Renin-angiotensin system promotes colonic inflammation by inducing T(H)17 activation via JAK2/STAT pathway.
Volume: 316
Issue: 6
Pages: G774-G784
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Allele
Tg(Alb1-Ren)3Unc | MGI:4457120
 
Name: transgene insertion 3, University of North Carolina
Allele Type: Transgenic
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Strain
MGI:6430167 | B6;D2J-Apoa1<em1.1Arem>/Mmnc
Attribute String: mutant stock, endonuclease-mediated mutation
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Strain
MGI:6865951 | C57BL/6J-Tg(APOA1*)1Smijd/Mmmh
Attribute String: coisogenic, mutant strain, transgenic
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Genotype
Genotype
Symbol: Tg(Alb1-Ren)2Unc/?
Background: involves: 129S6/SvEvTac * C57BL/6
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Apoa1/Apoa1
Background: involves: 129X1/SvJ * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Apoa1/Apoa1
Background: involves: 129X1/SvJ * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Alb1-Ren)2Unc/?
Background: 129S6/SvEvTac-Tg(Alb1-Ren)2Unc
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Apoc3/Apoc3<+>
Background: involves: 129
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Apoc3/Apoc3
Background: involves: 129
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Apoc3/Apoc3<+>
Background: involves: 129P2/OlaHsd * C57BL/6J
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Apoc3/Apoc3
Background: involves: 129P2/OlaHsd * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Apoc3/Apoc3
Background: B6.129-Apoc3/J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Alb1-Ren)1Unc/?
Background: involves: 129S6/SvEvTac * C57BL/6
Zygosity: ot
Has Mutant Allele: true
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Protein
P08226
Organism: Mus musculus/domesticus
Length: 311  
Fragment?: false
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Protein
Q00623
Organism: Mus musculus/domesticus
Length: 264  
Fragment?: false
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Protein
Q8C7G5
Organism: Mus musculus/domesticus
Length: 368  
Fragment?: false
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Protein
P06728
Organism: Mus musculus/domesticus
Length: 395  
Fragment?: false
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Protein
Q6GTX3
Organism: Mus musculus/domesticus
Length: 311  
Fragment?: false
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Protein
Q810I7
Organism: Mus musculus/domesticus
Length: 376  
Fragment?: false
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Protein
Q3TX45
Organism: Mus musculus/domesticus
Length: 311  
Fragment?: false
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Protein
G3UWN5
Organism: Mus musculus/domesticus
Length: 232  
Fragment?: true
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Protein
Q01488
Organism: Mus musculus/domesticus
Length: 435  
Fragment?: false
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Protein
Q3UEE7
Organism: Mus musculus/domesticus
Length: 311  
Fragment?: false
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Protein
Q3V2G1
Organism: Mus musculus/domesticus
Length: 264  
Fragment?: false
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Protein
Q9DBN0
Organism: Mus musculus/domesticus
Length: 395  
Fragment?: false
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Protein
Q3UBS0
Organism: Mus musculus/domesticus
Length: 311  
Fragment?: false
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Protein
Q4FK40
Organism: Mus musculus/domesticus
Length: 311  
Fragment?: false
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Protein
G3UZM8
Organism: Mus musculus/domesticus
Length: 146  
Fragment?: true
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Protein
A0A1B0GX15
Organism: Mus musculus/domesticus
Length: 231  
Fragment?: true
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Protein
Q3TXU4
Organism: Mus musculus/domesticus
Length: 311  
Fragment?: false
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Publication
2063194 | -
First Author: Wilson C
Year: 1991
Journal: Science
Title: Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E.
Volume: 252
Issue: 5014
Pages: 1817-22
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Publication
15108119 | -
First Author: Fullerton SM
Year: 2004
Journal: Hum Genet
Title: The effects of scale: variation in the APOA1/C3/A4/A5 gene cluster.
Volume: 115
Issue: 1
Pages: 36-56
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Publication
15234552 | -
First Author: Saito H
Year: 2004
Journal: Prog Lipid Res
Title: Contributions of domain structure and lipid interaction to the functionality of exchangeable human apolipoproteins.
Volume: 43
Issue: 4
Pages: 350-80
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Protein Domain
IPR000074 | ApoA_E
Type: Family
Description: Exchangeable apolipoproteins (apoA, apoC and apoE) have the same genomic structure and are members of a multi-gene family that probably evolved from a common ancestral gene. This entry includes the ApoA1, ApoA4, Apo5 and ApoE proteins. ApoA1, ApoA4 and Apo5 are part of the APOA1/C3/A4/A5 gene cluster on chromosome 11 []. Apolipoproteins function in lipid transport as structural components of lipoprotein particles, cofactors for enzymes and ligands for cell-surface receptors. In particular, apoA1 is the major protein component of high-density lipoproteins; apoA4 is thought to act primarily in intestinal lipid absorption; and apoE is a blood plasma protein that mediates the transport and uptake of cholesterol and lipid by way of its high affinity interaction with different cellular receptors, including the low-density lipoprotein (LDL) receptor. Recent findings with apoA1 and apoE suggest that the tertiary structures of these two members of the human exchangeable apolipoprotein gene family are related []. The three-dimensional structure of the LDL receptor-binding domain of apoE indicates that the protein forms an unusually elongated four-helix bundle that may be stabilised by a tightly packed hydrophobic core that includes leucine zipper-type interactions and by numerous salt bridges on the mostly charged surface. Basic amino acids important for LDL receptor binding are clustered into a surface patch on one long helix [].
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Publication
23674134 | J:201441
First Author: Lenhart PM
Year: 2013
Journal: J Mol Endocrinol
Title: G-protein-coupled receptor 30 interacts with receptor activity-modifying protein 3 and confers sex-dependent cardioprotection.
Volume: 51
Issue: 1
Pages: 191-202
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Publication
12947111 | J:86766
First Author: Jiang XC
Year: 2003
Journal: J Biol Chem
Title: Enlargement of high density lipoprotein in mice via liver X receptor activation requires apolipoprotein E and is abolished by cholesteryl ester transfer protein expression.
Volume: 278
Issue: 49
Pages: 49072-8
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Publication
22355095 | J:184930
First Author: Tep S
Year: 2012
Journal: J Lipid Res
Title: Rescue of Mtp siRNA-induced hepatic steatosis by DGAT2 siRNA silencing.
Volume: 53
Issue: 5
Pages: 859-67
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Publication
21398511 | J:180925
First Author: Tadin-Strapps M
Year: 2011
Journal: J Lipid Res
Title: siRNA-induced liver ApoB knockdown lowers serum LDL-cholesterol in a mouse model with human-like serum lipids.
Volume: 52
Issue: 6
Pages: 1084-97
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Publication
9770530 | J:108651
First Author: Lou XJ
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Fibrinogen deficiency reduces vascular accumulation of apolipoprotein(a) and development of atherosclerosis in apolipoprotein(a) transgenic mice.
Volume: 95
Issue: 21
Pages: 12591-5
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Strain
MGI:4838804 | B6.Cg-Tg(APOA1-CETP)1Dsg Tg(APOB)1102Sgy/Tac
Attribute String: congenic, mutant strain, transgenic
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Publication
7658156 | J:81002
First Author: Grass DS
Year: 1995
Journal: J Lipid Res
Title: Transgenic mice expressing both human apolipoprotein B and human CETP have a lipoprotein cholesterol distribution similar to that of normolipidemic humans.
Volume: 36
Issue: 5
Pages: 1082-91
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Publication
17335774 | J:120331
First Author: Hernandez M
Year: 2007
Journal: Biochem Biophys Res Commun
Title: Critical role of cholesterol ester transfer protein in nicotinic acid-mediated HDL elevation in mice.
Volume: 355
Issue: 4
Pages: 1075-80
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Publication
17068123 | J:132484
First Author: Pandya K
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Fibrosis, not cell size, delineates beta-myosin heavy chain reexpression during cardiac hypertrophy and normal aging in vivo.
Volume: 103
Issue: 45
Pages: 16864-9
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Publication
22100352 | J:183659
First Author: Barrick CJ
Year: 2012
Journal: J Mol Cell Cardiol
Title: Loss of receptor activity-modifying protein 3 exacerbates cardiac hypertrophy and transition to heart failure in a sex-dependent manner.
Volume: 52
Issue: 1
Pages: 165-74
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Strain
MGI:4457122 | 129S6/SvEvTac-Tg(Alb1-Ren)3Unc/Mmnc
Attribute String: coisogenic, mutant strain, targeted mutation, transgenic
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Allele
Apoa1<m1Pgrs> | MGI:6307002
Name: apolipoprotein A-I; mutation 1, Phillipe Gros
Allele Type: Spontaneous
Attribute String: Null/knockout
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Genotype
Genotype
Symbol: Tg(Alb1-Ren)3Unc/?
Background: involves: 129S6/SvEvTac * C57BL/6
Zygosity: ot
Has Mutant Allele: true
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Publication
25941406 | J:221652
First Author: Ã…vall K
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Apolipoprotein CIII links islet insulin resistance to β-cell failure in diabetes.
Volume: 112
Issue: 20
Pages: E2611-9
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Publication
15863838 | J:100499
First Author: Gerritsen G
Year: 2005
Journal: J Lipid Res
Title: ApoC-III deficiency prevents hyperlipidemia induced by apoE overexpression.
Volume: 46
Issue: 7
Pages: 1466-73
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Publication
11590213 | J:72320
First Author: Jong MC
Year: 2001
Journal: J Lipid Res
Title: Apolipoprotein C-III deficiency accelerates triglyceride hydrolysis by lipoprotein lipase in wild-type and apoE knockout mice.
Volume: 42
Issue: 10
Pages: 1578-85
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Publication
18263930 | J:135252
First Author: Gerritsen G
Year: 2008
Journal: J Lipid Res
Title: ApoE2-associated hypertriglyceridemia is ameliorated by increased levels of apoA-V but unaffected by apoC-III deficiency.
Volume: 49
Issue: 5
Pages: 1048-55
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Publication
22914621 | J:187220
First Author: Lauring B
Year: 2012
Journal: Sci Transl Med
Title: Niacin lipid efficacy is independent of both the niacin receptor GPR109A and free fatty acid suppression.
Volume: 4
Issue: 148
Pages: 148ra115
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Publication
8254057 | J:81265
First Author: Linton MF
Year: 1993
Journal: J Clin Invest
Title: Transgenic mice expressing high plasma concentrations of human apolipoprotein B100 and lipoprotein(a).
Volume: 92
Issue: 6
Pages: 3029-37
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Strain
MGI:4458018 | 129S6/SvEvTac-Adm<tm1Unc> Tg(Alb1-Ren)2Unc
Attribute String: targeted mutation, transgenic, mutant strain, coisogenic
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Publication
10751392 | J:63306
First Author: Ueda Y
Year: 2000
Journal: J Biol Chem
Title: Relationship between expression levels and atherogenesis in scavenger receptor class B, type I transgenics.
Volume: 275
Issue: 27
Pages: 20368-73
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Publication
7657833 | J:118801
First Author: Callow MJ
Year: 1995
Journal: J Clin Invest
Title: Atherogenesis in transgenic mice with human apolipoprotein B and lipoprotein (a).
Volume: 96
Issue: 3
Pages: 1639-46
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Publication
24115030 | J:222212
First Author: Hurt-Camejo E
Year: 2013
Journal: Arterioscler Thromb Vasc Biol
Title: Expression of type IIA secretory phospholipase A2 inhibits cholesteryl ester transfer protein activity in transgenic mice.
Volume: 33
Issue: 12
Pages: 2707-14
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Publication
12034874 | J:89252
First Author: Caron KM
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: A genetically clamped renin transgene for the induction of hypertension.
Volume: 99
Issue: 12
Pages: 8248-52
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Strain
MGI:6306976 | BcA68/Pgrs
Attribute String: recombinant congenic (RC)
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Genotype
Genotype
Symbol: Apoa1/Apoa1
Background: involves: 129X1/SvJ * C57BL/6J
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Adm/Adm<+> Tg(Alb1-Ren)2Unc/?
Background: 129S6/SvEvTac-Adm Tg(Alb1-Ren)2Unc
Zygosity: cx
Has Mutant Allele: true
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Publication
31291759 | J:307017
First Author: Li Y
Year: 2019
Journal: Arterioscler Thromb Vasc Biol
Title: Hepatic Forkhead Box Protein A3 Regulates ApoA-I (Apolipoprotein A-I) Expression, Cholesterol Efflux, and Atherogenesis.
Volume: 39
Issue: 8
Pages: 1574-1587
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Publication
34437091 | J:360149
 
First Author: Han YH
Year: 2021
Journal: Science
Title: Enterically derived high-density lipoprotein restrains liver injury through the portal vein.
Volume: 373
Issue: 6553
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Publication
27572261 | J:269693
   
First Author: Iqbal AJ
Year: 2016
Journal: Elife
Title: Acute exposure to apolipoprotein A1 inhibits macrophage chemotaxis in vitro and monocyte recruitment in vivo.
Volume: 5
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Publication
16054053 | J:117028
First Author: Kennedy MA
Year: 2005
Journal: Cell Metab
Title: ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation.
Volume: 1
Issue: 2
Pages: 121-31
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Publication
29066772 | J:256367
First Author: Murano T
Year: 2017
Journal: Sci Rep
Title: Transcription factor TFEB cell-autonomously modulates susceptibility to intestinal epithelial cell injury in vivo.
Volume: 7
Issue: 1
Pages: 13938
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Publication
37626055 | J:339682
First Author: Hendrix S
Year: 2023
Journal: Nat Commun
Title: Hepatic SREBP signaling requires SPRING to govern systemic lipid metabolism in mice and humans.
Volume: 14
Issue: 1
Pages: 5181
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Protein Coding Gene
MGI:1930124 | Apom
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
23542898 | J:213303
First Author: Graham MJ
Year: 2013
Journal: Circ Res
Title: Antisense oligonucleotide inhibition of apolipoprotein C-III reduces plasma triglycerides in rodents, nonhuman primates, and humans.
Volume: 112
Issue: 11
Pages: 1479-90
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Publication
11557675 | J:103233
First Author: Sentman ML
Year: 2001
Journal: Arterioscler Thromb Vasc Biol
Title: Extracellular superoxide dismutase deficiency and atherosclerosis in mice.
Volume: 21
Issue: 9
Pages: 1477-82
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Publication
11551841 | J:72104
First Author: Hirano T
Year: 2001
Journal: Am J Physiol Endocrinol Metab
Title: Apoprotein C-III deficiency markedly stimulates triglyceride secretion in vivo: comparison with apoprotein E.
Volume: 281
Issue: 4
Pages: E665-9
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Publication
26160324 | J:258766
First Author: Li H
Year: 2015
Journal: Cardiovasc Res
Title: Aggravated restenosis and atherogenesis in ApoCIII transgenic mice but lack of protection in ApoCIII knockouts: the effect of authentic triglyceride-rich lipoproteins with and without ApoCIII.
Volume: 107
Issue: 4
Pages: 579-89
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Publication
28825717 | J:254382
First Author: Khetarpal SA
Year: 2017
Journal: Nat Med
Title: A human APOC3 missense variant and monoclonal antibody accelerate apoC-III clearance and lower triglyceride-rich lipoprotein levels.
Volume: 23
Issue: 9
Pages: 1086-1094
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Publication
20577049 | J:163781
First Author: Yang X
Year: 2010
Journal: J Clin Invest
Title: Identification and validation of genes affecting aortic lesions in mice.
Volume: 120
Issue: 7
Pages: 2414-22
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Publication
9539774 | J:47464
First Author: Sanan DA
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Low density lipoprotein receptor-negative mice expressing human apolipoprotein B-100 develop complex atherosclerotic lesions on a chow diet: no accentuation by apolipoprotein(a).
Volume: 95
Issue: 8
Pages: 4544-9
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Publication
25593281 | J:249180
First Author: Patel KM
Year: 2015
Journal: Circ Res
Title: Macrophage sortilin promotes LDL uptake, foam cell formation, and atherosclerosis.
Volume: 116
Issue: 5
Pages: 789-96
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Publication
28600283 | J:247994
First Author: Berger JM
Year: 2017
Journal: J Lipid Res
Title: Inhibition of PCSK9 does not improve lipopolysaccharide-induced mortality in mice.
Volume: 58
Issue: 8
Pages: 1661-1669
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Publication
20976059 | J:166224
First Author: Kassim SH
Year: 2010
Journal: PLoS One
Title: Gene therapy in a humanized mouse model of familial hypercholesterolemia leads to marked regression of atherosclerosis.
Volume: 5
Issue: 10
Pages: e13424
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Publication
30065034 | J:265164
First Author: Gurley SB
Year: 2018
Journal: Diabetes
Title: Inflammation and Immunity Pathways Regulate Genetic Susceptibility to Diabetic Nephropathy.
Volume: 67
Issue: 10
Pages: 2096-2106
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Publication
14978280 | J:88650
First Author: Caron KM
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Cardiac hypertrophy and sudden death in mice with a genetically clamped renin transgene.
Volume: 101
Issue: 9
Pages: 3106-11
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Publication
17360661 | J:125933
First Author: Caron K
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Adrenomedullin gene expression differences in mice do not affect blood pressure but modulate hypertension-induced pathology in males.
Volume: 104
Issue: 9
Pages: 3420-5
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Publication
26891738 | J:231607
First Author: Hoekstra M
Year: 2016
Journal: J Lipid Res
Title: HDL is redundant for adrenal steroidogenesis in LDLR knockout mice with a human-like lipoprotein profile.
Volume: 57
Issue: 4
Pages: 631-7
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Publication
19164809 | J:159778
First Author: Parks BW
Year: 2009
Journal: Arterioscler Thromb Vasc Biol
Title: ApoE-dependent modulation of HDL and atherosclerosis by G2A in LDL receptor-deficient mice independent of bone marrow-derived cells.
Volume: 29
Issue: 4
Pages: 539-47
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Publication
18787185 | J:159797
First Author: Teupser D
Year: 2008
Journal: Arterioscler Thromb Vasc Biol
Title: Effect of macrophage overexpression of murine liver X receptor-alpha (LXR-alpha) on atherosclerosis in LDL-receptor deficient mice.
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First Author: Park JG
Year: 2016
Journal: Arterioscler Thromb Vasc Biol
Title: Loss of Transcription Factor CREBH Accelerates Diet-Induced Atherosclerosis in Ldlr-/- Mice.
Volume: 36
Issue: 9
Pages: 1772-81
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First Author: Johnson LA
Year: 2013
Journal: J Lipid Res
Title: Diabetic atherosclerosis in APOE*4 mice: synergy between lipoprotein metabolism and vascular inflammation.
Volume: 54
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First Author: Huang Y
Year: 2013
Journal: J Clin Invest
Title: Myeloperoxidase, paraoxonase-1, and HDL form a functional ternary complex.
Volume: 123
Issue: 9
Pages: 3815-28
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