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Search results 501 to 600 out of 621 for Aqp2

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Type Details Score
Allele
Tg(MAR-Trpv5-cre)#Prae | MGI:4888728
Name: transgene insertion, Jeppe Praetorius
Allele Type: Transgenic
Attribute String: Recombinase
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Allele
Tg(Aqp2-cre/ERT2)4Gsc | MGI:4941815
Name: transgene insertion 4, Gunther Schutz
Allele Type: Transgenic
Attribute String: Inducible, Recombinase
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Genotype
Genotype
Symbol: Aqp2/Aqp2<+>
Background: involves: 129S4/SvJae * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Publication
30271355 | J:276434
 
First Author: Iervolino A
Year: 2018
Journal: Front Physiol
Title: Integrin Beta 1 Is Crucial for Urinary Concentrating Ability and Renal Medulla Architecture in Adult Mice.
Volume: 9
Pages: 1273
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Publication
29790390 | J:281333
First Author: Ramkumar N
Year: 2018
Journal: Am J Physiol Renal Physiol
Title: Collecting duct principal, but not intercalated, cell prorenin receptor regulates renal sodium and water excretion.
Volume: 315
Issue: 3
Pages: F607-F617
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Publication
31653783 | J:292494
First Author: Huang M
Year: 2019
Journal: J Am Soc Nephrol
Title: Integrin-Linked Kinase Deficiency in Collecting Duct Principal Cell Promotes Necroptosis of Principal Cell and Contributes to Kidney Inflammation and Fibrosis.
Volume: 30
Issue: 11
Pages: 2073-2090
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Publication
17475815 | J:148058
First Author: Ronzaud C
Year: 2007
Journal: J Am Soc Nephrol
Title: Impairment of sodium balance in mice deficient in renal principal cell mineralocorticoid receptor.
Volume: 18
Issue: 6
Pages: 1679-87
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Genotype
Genotype
Symbol: Ednrb/Ednrb Tg(AQP2-cre)2Dek/?
Background: involves: C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Publication
18606867 | J:140244
First Author: Okada S
Year: 2008
Journal: FASEB J
Title: Aquaporin-11 knockout mice and polycystic kidney disease animals share a common mechanism of cyst formation.
Volume: 22
Issue: 10
Pages: 3672-84
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Protein Domain
IPR023266 | Aquaporin_11
Type: Family
Description: The aquaporins (AQPs) are a family of integral membrane proteins composed of two subfamilies: the orthodox aquaporins, which transport only water, and the aquaglyceroporins, which transport glycerol, urea, or other small solutes []. AQP1 in pleural mesothelial cells participate in the formation of pleural fluid [], renal AQP2 is involved in levels of solutes []and changes in AQP9 in the hippocampus are related to delayed neuronal death []. Aquaporins contain two tandem repeats, each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).Aquaporin-11 (AQP11) and aquaporin-12 belong to a new aquaporin subfamily termed superaquaporins []. AQP11 is found in the endoplasmic reticulum and has been connected to policystic kidney disease through knock-out experiments []. It has also been shown that although the characteristic NPA motif may not be fully conserved in both tandem repeats, the molecule nevertheless preserves its water-transport function [].
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Publication
17178102 | J:188552
First Author: Yakata K
Year: 2007
Journal: Biochim Biophys Acta
Title: Aquaporin-11 containing a divergent NPA motif has normal water channel activity.
Volume: 1768
Issue: 3
Pages: 688-93
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Publication
19096782 | -
 
First Author: Ishibashi K
Year: 2009
Journal: Handb Exp Pharmacol
Title: New members of mammalian aquaporins: AQP10-AQP12.
Issue: 190
Pages: 251-62
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Publication
24158982 | J:244672
First Author: Rees S
Year: 2014
Journal: J Am Soc Nephrol
Title: Adenylyl cyclase 6 deficiency ameliorates polycystic kidney disease.
Volume: 25
Issue: 2
Pages: 232-7
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Publication
28701310 | J:263971
First Author: Mamuya FA
Year: 2017
Journal: Am J Physiol Renal Physiol
Title: Deletion of β1-integrin in collecting duct principal cells leads to tubular injury and renal medullary fibrosis.
Volume: 313
Issue: 4
Pages: F1026-F1037
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Publication
21918182 | J:180635
First Author: Bugaj V
Year: 2012
Journal: Am J Physiol Cell Physiol
Title: Collecting duct-specific endothelin B receptor knockout increases ENaC activity.
Volume: 302
Issue: 1
Pages: C188-94
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Publication
18784261 | J:148635
First Author: Ge Y
Year: 2008
Journal: Am J Physiol Renal Physiol
Title: Combined knockout of collecting duct endothelin A and B receptors causes hypertension and sodium retention.
Volume: 295
Issue: 6
Pages: F1635-40
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Publication
26400543 | J:284341
First Author: Lynch IJ
Year: 2015
Journal: Am J Physiol Renal Physiol
Title: Effect of mineralocorticoid treatment in mice with collecting duct-specific knockout of endothelin-1.
Volume: 309
Issue: 12
Pages: F1026-34
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Publication
27707708 | J:283489
First Author: Gao Y
Year: 2016
Journal: Am J Physiol Renal Physiol
Title: Collecting duct-specific knockout of nitric oxide synthase 3 impairs water excretion in a sex-dependent manner.
Volume: 311
Issue: 5
Pages: F1074-F1083
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Publication
24760529 | J:208831
First Author: Kittikulsuth W
Year: 2014
Journal: Physiol Rep
Title: Adenylyl cyclase 4 does not regulate collecting duct water and sodium handling.
Volume: 2
Issue: 3
Pages: e00277
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Publication
25391901 | J:283126
First Author: Hyndman KA
Year: 2015
Journal: Am J Physiol Renal Physiol
Title: NOS1-dependent negative feedback regulation of the epithelial sodium channel in the collecting duct.
Volume: 308
Issue: 3
Pages: F244-51
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Publication
29066445 | J:271838
 
First Author: Hyndman KA
Year: 2017
Journal: J Am Heart Assoc
Title: Collecting Duct Nitric Oxide Synthase 1ß Activation Maintains Sodium Homeostasis During High Sodium Intake Through Suppression of Aldosterone and Renal Angiotensin II Pathways.
Volume: 6
Issue: 10
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Publication
23152297 | J:193142
First Author: Zhang W
Year: 2013
Journal: Am J Physiol Renal Physiol
Title: An Af9 cis-element directly targets Dot1a to mediate transcriptional repression of the αENaC gene.
Volume: 304
Issue: 4
Pages: F367-75
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Publication
23077601 | J:192211
First Author: Zhou Q
Year: 2012
Journal: PLoS One
Title: Spironolactone rescues Dot1a-Af9-mediated repression of endothelin-1 and improves kidney injury in streptozotocin-induced diabetic rats.
Volume: 7
Issue: 10
Pages: e47360
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Genotype
Genotype
Symbol: Edn1/Edn1 Tg(AQP2-cre)2Dek/?
Background: involves: C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ednra/Ednra Tg(AQP2-cre)2Dek/?
Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Edn1/Edn1 Tg(AQP2-cre)2Dek/?
Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nr3c2/Nr3c2 Tg(Aqp2-cre/ERT2)4Gsc/?
Background: involves: C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Adcy3/Adcy3 Tg(AQP2-cre)2Dek/?
Background: involves: C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Adcy4/Adcy4 Tg(AQP2-cre)2Dek/?
Background: involves: C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dot1l/Dot1l Tg(Aqp2-icre)1Gsc/?
Background: involves: C57BL/6J * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Aqp2-icre)1Gsc/?
Background: involves: 129X1/SvJ * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Publication
18067818 | -
First Author: Zhang W
Year: 2007
Journal: Zhonghua Yi Xue Za Zhi
Title: [Effect of hypertonic medium on expression of aquaporin-1 in pleural mesothelial cells: experiment with rats].
Volume: 87
Issue: 35
Pages: 2508-11
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Publication
18419953 | -
First Author: Wang Y
Year: 2008
Journal: Zhongguo Wei Zhong Bing Ji Jiu Yi Xue
Title: [Expression of renal aquaporin 2 after circulatory arrest].
Volume: 20
Issue: 4
Pages: 210-3
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Publication
17526024 | -
First Author: Hwang IK
Year: 2007
Journal: J Neurosci Res
Title: Aquaporin 9 changes in pyramidal cells before and is expressed in astrocytes after delayed neuronal death in the ischemic hippocampal CA1 region of the gerbil.
Volume: 85
Issue: 11
Pages: 2470-9
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Publication
26791826 | J:230822
First Author: Hyndman KA
Year: 2016
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Dynamin-2 is a novel NOS1β interacting protein and negative regulator in the collecting duct.
Volume: 310
Issue: 7
Pages: R570-7
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Publication
23608660 | J:202017
First Author: Hyndman KA
Year: 2013
Journal: Hypertension
Title: Renal collecting duct NOS1 maintains fluid-electrolyte homeostasis and blood pressure.
Volume: 62
Issue: 1
Pages: 91-8
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Publication
18391099 | J:280539
First Author: Schneider MP
Year: 2008
Journal: Hypertension
Title: Collecting duct-derived endothelin regulates arterial pressure and Na excretion via nitric oxide.
Volume: 51
Issue: 6
Pages: 1605-10
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Publication
15314687 | J:91968
First Author: Ahn D
Year: 2004
Journal: J Clin Invest
Title: Collecting duct-specific knockout of endothelin-1 causes hypertension and sodium retention.
Volume: 114
Issue: 4
Pages: 504-11
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Publication
23558339 | J:199948
First Author: Pavlov TS
Year: 2013
Journal: FASEB J
Title: Regulation of ENaC in mice lacking renal insulin receptors in the collecting duct.
Volume: 27
Issue: 7
Pages: 2723-32
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Publication
16868309 | J:116002
First Author: Ge Y
Year: 2006
Journal: Am J Physiol Renal Physiol
Title: Collecting duct-specific knockout of the endothelin B receptor causes hypertension and sodium retention.
Volume: 291
Issue: 6
Pages: F1274-80
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Publication
31904281 | J:294612
First Author: Zhang D
Year: 2020
Journal: Am J Physiol Renal Physiol
Title: Loss of circadian gene Bmal1 in the collecting duct lowers blood pressure in male, but not female, mice.
Volume: 318
Issue: 3
Pages: F710-F719
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Publication
24431204 | J:207417
First Author: Kittikulsuth W
Year: 2014
Journal: Am J Physiol Renal Physiol
Title: Lack of an effect of collecting duct-specific deletion of adenylyl cyclase 3 on renal Na+ and water excretion or arterial pressure.
Volume: 306
Issue: 6
Pages: F597-607
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Genotype
Genotype
Symbol: Adcy3/Adcy3 Adcy6/Adcy6 Tg(AQP2-cre)2Dek/?
Background: involves: 129X1/SvJ * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Aqp2/Aqp2<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S6/SvEvTac * C57BL/6N
Zygosity: cn
Has Mutant Allele: true
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Publication
15809071 | J:97446
First Author: Itoh T
Year: 2005
Journal: Biochem Biophys Res Commun
Title: Identification of a novel aquaporin, AQP12, expressed in pancreatic acinar cells.
Volume: 330
Issue: 3
Pages: 832-8
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Protein Domain
IPR016697 | Aquaporin_11/12
Type: Family
Description: The aquaporins (AQPs) are a family of integral membrane proteins composed of two subfamilies: the orthodox aquaporins, which transport only water, and the aquaglyceroporins, which transport glycerol, urea, or other small solutes []. AQP1 in pleural mesothelial cells participate in the formation of pleural fluid [], renal AQP2 is involved in levels of solutes []and changes in AQP9 in the hippocampus are related to delayed neuronal death []. Aquaporins contain two tandem repeats, each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).Aquaporins 11 and 12 are classified as members of a new AQP subfamily: the subcellular AQPs []. AQP 11 and 12 appear to be more distantly related to the other mammalian aquaporins and aquaglyceroporins. AQP11 is functionally distinct from other proteins of the aquaporin superfamily and could represent a new aquaporin subfamily []. In members of the subcellular AQPs, one of the two asparagine-proline-alanine (NPA) motifs are not completely conserved. They play a crucial role in selective water conduction and function as water channels []. This group represents an aquaporin types 11 and 12.
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Protein Domain
IPR023265 | Aquaporin_12
Type: Family
Description: The aquaporins (AQPs) are a family of integral membrane proteins composed of two subfamilies: the orthodox aquaporins, which transport only water, and the aquaglyceroporins, which transport glycerol, urea, or other small solutes []. AQP1 in pleural mesothelial cells participate in the formation of pleural fluid [], renal AQP2 is involved in levels of solutes []and changes in AQP9 in the hippocampus are related to delayed neuronal death []. Aquaporins contain two tandem repeats, each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).Aquaporin-11 and aquaporin-12 (AQP12) belong to a new aquaporin subfamily termed superaquaporins []. AQP12 is exclusively found in pancreatic acinar cells [], and is not localised in the plasma membrane. No specific localisation has yet been established for this subfamily, but its presence in the pancreas implies some role in the secretion of digestive enzymes []and fluids in the pancreatic cells []. A structural characteristic of AQP12 is the lack of a cytoplasmic N-terminal region, by contrast with all other known aquaporins.
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Publication
24244568 | J:202522
First Author: He W
Year: 2013
Journal: PLoS One
Title: Generation of a tenascin-C-CreER2 knockin mouse line for conditional DNA recombination in renal medullary interstitial cells.
Volume: 8
Issue: 11
Pages: e79839
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Publication
27413199 | J:281080
First Author: Tinning AR
Year: 2016
Journal: Am J Physiol Renal Physiol
Title: Vascular endothelial growth factor signaling is necessary for expansion of medullary microvessels during postnatal kidney development.
Volume: 311
Issue: 3
Pages: F586-99
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Publication
23195676 | J:192571
First Author: Li L
Year: 2013
Journal: Am J Physiol Renal Physiol
Title: Reduced ENaC activity and blood pressure in mice with genetic knockout of the insulin receptor in the renal collecting duct.
Volume: 304
Issue: 3
Pages: F279-88
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Publication
19710172 | J:153635
First Author: Zhang X
Year: 2009
Journal: Development
Title: beta1 integrin is necessary for ureteric bud branching morphogenesis and maintenance of collecting duct structural integrity.
Volume: 136
Issue: 19
Pages: 3357-66
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Publication
29739889 | J:262495
First Author: Xu S
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Farnesoid X receptor is essential for the survival of renal medullary collecting duct cells under hypertonic stress.
Volume: 115
Issue: 21
Pages: 5600-5605
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Publication
32914211 | J:309788
First Author: Alam G
Year: 2020
Journal: Pflugers Arch
Title: Activation of farnesoid X receptor (FXR) induces crystallin zeta expression in mouse medullary collecting duct cells.
Volume: 472
Issue: 11
Pages: 1631-1641
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Publication
20947633 | J:185897
First Author: Christensen BM
Year: 2010
Journal: J Am Soc Nephrol
Title: Sodium and potassium balance depends on αENaC expression in connecting tubule.
Volume: 21
Issue: 11
Pages: 1942-51
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Publication
19145237 | J:162703
First Author: Raphael KL
Year: 2009
Journal: Kidney Int
Title: Inactivation of Pkd1 in principal cells causes a more severe cystic kidney disease than in intercalated cells.
Volume: 75
Issue: 6
Pages: 626-33
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Publication
17913832 | J:145100
First Author: Ge Y
Year: 2007
Journal: Am J Physiol Renal Physiol
Title: Role of prostaglandins in collecting duct-derived endothelin-1 regulation of blood pressure and water excretion.
Volume: 293
Issue: 6
Pages: F1805-10
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Publication
27141055 | J:290542
First Author: Chen D
Year: 2016
Journal: Hypertension
Title: Impact of Angiotensin Type 1A Receptors in Principal Cells of the Collecting Duct on Blood Pressure and Hypertension.
Volume: 67
Issue: 6
Pages: 1291-7
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Publication
21290301 | J:168534
 
First Author: Hofmeister MV
Year: 2011
Journal: Adv Exp Med Biol
Title: The TRPV5 promoter as a tool for generation of transgenic mouse models.
Volume: 704
Pages: 277-86
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(AQP2-cre)2Dek/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Protein
Q8BYF0
Organism: Mus musculus/domesticus
Length: 225  
Fragment?: true
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Protein
A0A0X1KG63
Organism: Mus musculus/domesticus
Length: 216  
Fragment?: true
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Publication
20864687 | J:185899
First Author: Rieg T
Year: 2010
Journal: J Am Soc Nephrol
Title: Adenylate cyclase 6 determines cAMP formation and aquaporin-2 phosphorylation and trafficking in inner medulla.
Volume: 21
Issue: 12
Pages: 2059-68
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Publication
9388476 | J:44349
First Author: Ma T
Year: 1997
Journal: Biochem Biophys Res Commun
Title: Cloning of a novel water and urea-permeable aquaporin from mouse expressed strongly in colon, placenta, liver, and heart.
Volume: 240
Issue: 2
Pages: 324-8
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Publication
17283064 | J:121376
First Author: Chu JY
Year: 2007
Journal: Mol Cell Biol
Title: Phenotypes developed in secretin receptor-null mice indicated a role for secretin in regulating renal water reabsorption.
Volume: 27
Issue: 7
Pages: 2499-511
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Publication
9806845 | J:51114
First Author: Koyama N
Year: 1998
Journal: Genomics
Title: Cloning and functional expression of human aquaporin8 cDNA and analysis of its gene.
Volume: 54
Issue: 1
Pages: 169-72
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Publication
20668095 | J:164449
First Author: Cai Q
Year: 2010
Journal: Am J Physiol Renal Physiol
Title: Vasopressin increases expression of UT-A1, UT-A3, and ER chaperone GRP78 in the renal medulla of mice with a urinary concentrating defect.
Volume: 299
Issue: 4
Pages: F712-9
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Publication
17913837 | J:127547
First Author: Cai Q
Year: 2007
Journal: Am J Physiol Renal Physiol
Title: Vasopressin receptor subtype 2 activation increases cell proliferation in the renal medulla of AQP1 null mice.
Volume: 293
Issue: 6
Pages: F1858-64
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Publication
10737773 | J:61675
First Author: Ma T
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: Nephrogenic diabetes insipidus in mice lacking aquaporin-3 water channels.
Volume: 97
Issue: 8
Pages: 4386-91
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Publication
24464484 | J:206661
First Author: Zhang X
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Farnesoid X receptor (FXR) gene deficiency impairs urine concentration in mice.
Volume: 111
Issue: 6
Pages: 2277-82
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Publication
8594870 | J:156006
First Author: Breton S
Year: 1995
Journal: Am J Physiol
Title: Depletion of intercalated cells from collecting ducts of carbonic anhydrase II-deficient (CAR2 null) mice.
Volume: 269
Issue: 6 Pt 2
Pages: F761-74
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Publication
12167603 | J:113545
First Author: Klein JD
Year: 2002
Journal: Am J Physiol Renal Physiol
Title: Impaired urine concentration and absence of tissue ACE: involvement of medullary transport proteins.
Volume: 283
Issue: 3
Pages: F517-24
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Publication
29070571 | J:281975
First Author: Alsady M
Year: 2018
Journal: Am J Physiol Renal Physiol
Title: Lithium induces aerobic glycolysis and glutaminolysis in collecting duct principal cells.
Volume: 314
Issue: 2
Pages: F230-F239
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Publication
33332450 | J:300260
First Author: Xue J
Year: 2020
Journal: PLoS One
Title: Genetic deletion of connexin 37 causes polyuria and polydipsia.
Volume: 15
Issue: 12
Pages: e0244251
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Publication
21051735 | J:185892
First Author: Christensen BM
Year: 2011
Journal: J Am Soc Nephrol
Title: alphaENaC-mediated lithium absorption promotes nephrogenic diabetes insipidus.
Volume: 22
Issue: 2
Pages: 253-61
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Publication
22622456 | J:186840
First Author: Evans LC
Year: 2012
Journal: Am J Physiol Renal Physiol
Title: A urine-concentrating defect in 11β-hydroxysteroid dehydrogenase type 2 null mice.
Volume: 303
Issue: 4
Pages: F494-502
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Publication
27000064 | J:280493
First Author: Wang F
Year: 2016
Journal: J Am Soc Nephrol
Title: Antidiuretic Action of Collecting Duct (Pro)Renin Receptor Downstream of Vasopressin and PGE2 Receptor EP4.
Volume: 27
Issue: 10
Pages: 3022-3034
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Publication
11773623 | J:130418
First Author: Nejsum LN
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Functional requirement of aquaporin-5 in plasma membranes of sweat glands.
Volume: 99
Issue: 1
Pages: 511-6
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Publication
31386675 | J:278040
First Author: Nair AV
Year: 2019
Journal: PLoS One
Title: Sex-dependent differences in water homeostasis in wild-type and V-ATPase B1-subunit deficient mice.
Volume: 14
Issue: 8
Pages: e0219940
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Publication
29242247 | J:260672
First Author: Wu Q
Year: 2018
Journal: J Am Soc Nephrol
Title: CHIP Regulates Aquaporin-2 Quality Control and Body Water Homeostasis.
Volume: 29
Issue: 3
Pages: 936-948
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Publication
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