|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 501 to 600 out of 877 for Atr

<< First    < Previous  |  Next >    Last >>
0.035s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Protein Domain
IPR026619 | CEP95
Type: Family
Description: Centrosomal protein of 95kDa is localised to the centrosome and the spindle pole []. Its function is not clear. It is phosphorylated upon DNA damage, probably by ATM or ATR [, ].
•
•
•
•
•
Protein Coding Gene
MGI:101845 | Mcm3
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI:1298227 | Mcm6
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI:103199 | Mcm4
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI:1913884 | Mcm8
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI:2445153 | Clspn
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI:1298398 | Mcm7
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI:103197 | Mcm5
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI:105380 | Mcm2
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein
P97311
Organism: Mus musculus/domesticus
Length: 821  
Fragment?: false
•
•
•
•
•
Protein
Q61881
Organism: Mus musculus/domesticus
Length: 719  
Fragment?: false
•
•
•
•
•
Protein
P97310
Organism: Mus musculus/domesticus
Length: 904  
Fragment?: false
•
•
•
•
•
Protein
Q9CWV1
Organism: Mus musculus/domesticus
Length: 833  
Fragment?: false
•
•
•
•
•
Protein
P49718
Organism: Mus musculus/domesticus
Length: 734  
Fragment?: false
•
•
•
•
•
Protein
P49717
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: false
•
•
•
•
•
Protein
P25206
Organism: Mus musculus/domesticus
Length: 812  
Fragment?: false
•
•
•
•
•
Protein Coding Gene
MGI:1328306 | Orc2
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI:1277962 | Hus1
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI:1345150 | Cdc6
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI:1333807 | Rad17
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI:1316678 | Rad1
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI:1328356 | Rad9a
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI:1347043 | Orc4
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI:1354944 | Orc3
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI:1328337 | Orc1
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI:2385231 | Rad9b
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI:1929285 | Orc6
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI:103198 | Cdc25a
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI:1347044 | Orc5
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein
Q9WUJ8
Organism: Mus musculus/domesticus
Length: 262  
Fragment?: false
•
•
•
•
•
Protein
Q6NXW6
Organism: Mus musculus/domesticus
Length: 688  
Fragment?: false
•
•
•
•
•
Protein
Q9QWZ1
Organism: Mus musculus/domesticus
Length: 280  
Fragment?: false
•
•
•
•
•
Protein
Q9WUV0
Organism: Mus musculus/domesticus
Length: 435  
Fragment?: false
•
•
•
•
•
Protein
O88708
Organism: Mus musculus/domesticus
Length: 433  
Fragment?: false
•
•
•
•
•
Protein
P48964
Organism: Mus musculus/domesticus
Length: 514  
Fragment?: false
•
•
•
•
•
Protein
Q60862
Organism: Mus musculus/domesticus
Length: 576  
Fragment?: false
•
•
•
•
•
Protein
Q9JK30
Organism: Mus musculus/domesticus
Length: 715  
Fragment?: false
•
•
•
•
•
Protein
O89033
Organism: Mus musculus/domesticus
Length: 562  
Fragment?: false
•
•
•
•
•
Protein
Q8BQY8
Organism: Mus musculus/domesticus
Length: 280  
Fragment?: false
•
•
•
•
•
Protein
Q9Z1N2
Organism: Mus musculus/domesticus
Length: 840  
Fragment?: false
•
•
•
•
•
Publication
19144319 | J:143718
First Author: Trost M
Year: 2009
Journal: Immunity
Title: The phagosomal proteome in interferon-gamma-activated macrophages.
Volume: 30
Issue: 1
Pages: 143-54
•
•
•
•
•
Publication
19131326 | -
First Author: Sweet SM
Year: 2009
Journal: Mol Cell Proteomics
Title: Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.
Volume: 8
Issue: 5
Pages: 904-12
•
•
•
•
•
Protein
A0A0A6YXT4
Organism: Mus musculus/domesticus
Length: 158  
Fragment?: true
•
•
•
•
•
Protein Domain
IPR026644 | CEP170
Type: Family
Description: Centrosomal protein of 170kDa (Cep170) plays a role in microtubule organisation []. Human Cep170 is constantly expressed throughout the cell cycle but phosphorylated during mitosis. Cep170 is a substrate of Polo-like kinase 1 (Plk1) []. It is associated with the mature mother centriole. Upon DNA damage, it is phosphorylated probably by ATM or ATR [, , ].
•
•
•
•
•
Protein Domain
IPR044039 | DUF5745
Type: Domain
Description: This is a domain of unknown function with homology to the CH domain. This domain can be found in CEP95CEP95 is localised to the centrosome and the spindle pole []. Its function is not clear. It is phosphorylated upon DNA damage, probably by ATM or ATR [, ].
•
•
•
•
•
Protein
O35280
Organism: Mus musculus/domesticus
Length: 476  
Fragment?: false
•
•
•
•
•
Protein Coding Gene
MGI:88350 | Cdc25c
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein
P48967
Organism: Mus musculus/domesticus
Length: 447  
Fragment?: false
•
•
•
•
•
Publication
19367708 | -
First Author: Zanivan S
Year: 2008
Journal: J Proteome Res
Title: Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry.
Volume: 7
Issue: 12
Pages: 5314-26
•
•
•
•
•
Protein
Q8C8M1
Organism: Mus musculus/domesticus
Length: 221  
Fragment?: false
•
•
•
•
•
Protein
Q8K3A4
Organism: Mus musculus/domesticus
Length: 235  
Fragment?: false
•
•
•
•
•
Protein
F6U6D4
Organism: Mus musculus/domesticus
Length: 180  
Fragment?: true
•
•
•
•
•
Protein
Q8BRD4
Organism: Mus musculus/domesticus
Length: 181  
Fragment?: true
•
•
•
•
•
Protein
Q3TSV3
Organism: Mus musculus/domesticus
Length: 257  
Fragment?: true
•
•
•
•
•
Protein
E9Q1D4
Organism: Mus musculus/domesticus
Length: 235  
Fragment?: false
•
•
•
•
•
Protein
A0A0N4SW48
Organism: Mus musculus/domesticus
Length: 142  
Fragment?: false
•
•
•
•
•
Protein
D3YUX9
Organism: Mus musculus/domesticus
Length: 129  
Fragment?: true
•
•
•
•
•
Protein
B1ARX5
Organism: Mus musculus/domesticus
Length: 163  
Fragment?: true
•
•
•
•
•
Protein
Q8BPX6
Organism: Mus musculus/domesticus
Length: 270  
Fragment?: false
•
•
•
•
•
Protein
D3YUE0
Organism: Mus musculus/domesticus
Length: 47  
Fragment?: true
•
•
•
•
•
Protein
D3Z1Z9
Organism: Mus musculus/domesticus
Length: 94  
Fragment?: true
•
•
•
•
•
Protein
Q9CRN1
Organism: Mus musculus/domesticus
Length: 120  
Fragment?: true
•
•
•
•
•
Protein
F6S522
Organism: Mus musculus/domesticus
Length: 387  
Fragment?: true
•
•
•
•
•
Protein
Q3T9R3
Organism: Mus musculus/domesticus
Length: 108  
Fragment?: false
•
•
•
•
•
Protein
D3YVY1
Organism: Mus musculus/domesticus
Length: 53  
Fragment?: true
•
•
•
•
•
Protein
D3Z0C1
Organism: Mus musculus/domesticus
Length: 156  
Fragment?: true
•
•
•
•
•
Protein
F6UTU1
Organism: Mus musculus/domesticus
Length: 322  
Fragment?: true
•
•
•
•
•
Protein
D3Z7I5
Organism: Mus musculus/domesticus
Length: 179  
Fragment?: true
•
•
•
•
•
Protein
E9Q6L5
Organism: Mus musculus/domesticus
Length: 758  
Fragment?: false
•
•
•
•
•
Protein
B1ARX7
Organism: Mus musculus/domesticus
Length: 261  
Fragment?: true
•
•
•
•
•
Protein
I6L9G2
Organism: Mus musculus/domesticus
Length: 585  
Fragment?: false
•
•
•
•
•
Protein
Q3UH46
Organism: Mus musculus/domesticus
Length: 687  
Fragment?: false
•
•
•
•
•
Protein
A0A0N4SW91
Organism: Mus musculus/domesticus
Length: 44  
Fragment?: false
•
•
•
•
•
Publication
12766152 | -
First Author: Chini CC
Year: 2003
Journal: J Biol Chem
Title: Human claspin is required for replication checkpoint control.
Volume: 278
Issue: 32
Pages: 30057-62
•
•
•
•
•
Publication
11090622 | -
First Author: Kumagai A
Year: 2000
Journal: Mol Cell
Title: Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts.
Volume: 6
Issue: 4
Pages: 839-49
•
•
•
•
•
Publication
15096610 | -
First Author: Lin SY
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation.
Volume: 101
Issue: 17
Pages: 6484-9
•
•
•
•
•
Publication
22865885 | J:320043
First Author: Muñoz IM
Year: 2012
Journal: J Biol Chem
Title: Family with sequence similarity 60A (FAM60A) protein is a cell cycle-fluctuating regulator of the SIN3-HDAC1 histone deacetylase complex.
Volume: 287
Issue: 39
Pages: 32346-53
•
•
•
•
•
Publication
22984288 | J:320045
First Author: Smith KT
Year: 2012
Journal: Mol Cell Proteomics
Title: Human family with sequence similarity 60 member A (FAM60A) protein: a new subunit of the Sin3 deacetylase complex.
Volume: 11
Issue: 12
Pages: 1815-28
•
•
•
•
•
Publication
12459258 | -
First Author: Nikali K
Year: 2002
Journal: Gene
Title: cDNA cloning, expression profile and genomic structure of a novel human transcript on chromosome 10q24, and its analyses as a candidate gene for infantile onset spinocerebellar ataxia.
Volume: 299
Issue: 1-2
Pages: 111-5
•
•
•
•
•
Publication
19413330 | J:192795
First Author: Gauci S
Year: 2009
Journal: Anal Chem
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Volume: 81
Issue: 11
Pages: 4493-501
•
•
•
•
•
Publication
9396801 | -
First Author: Kovalenko OV
Year: 1997
Journal: Nucleic Acids Res
Title: A novel nucleic acid-binding protein that interacts with human rad51 recombinase.
Volume: 25
Issue: 24
Pages: 4946-53
•
•
•
•
•
Publication
20811708 | -
First Author: Kim JW
Year: 2010
Journal: Int J Oncol
Title: Involvement of C12orf32 overexpression in breast carcinogenesis.
Volume: 37
Issue: 4
Pages: 861-7
•
•
•
•
•
Publication
12791985 | -
First Author: Zou L
Year: 2003
Journal: Science
Title: Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes.
Volume: 300
Issue: 5625
Pages: 1542-8
•
•
•
•
•
Protein Domain
IPR026161 | FAM178
Type: Family
Description: This entry represents the FAM178 family, whose members are metazoan proteins and include FAM178A and FAM178B. The human FAM178A protein has been shown to be widely expressed []and is phosphorylated upon DNA damage, probably by ATM (ataxia telangiectasia mutated) or ATR (ATM and Rad3-related) [, ].FAM178A, also known as SLF2 (SMC5-SMC6 complex localization factor 2), forms a complex with RAD18 and SLF1, and together they define a pathway that suppresses genome instability by recruiting the SMC5/6 cohesion complex to DNA lesions [, ].
•
•
•
•
•
Protein Domain
IPR026065 | FAM60A
Type: Family
Description: SIN3-HDAC complex-associated factor (also known as FAM60A) is found in eukaryotes. It has been shown to be a subunit of the Sin3 deacetylase complex (Sin3/HDAC), important for the repression of genes involved in the TGF-beta signaling pathway [, ]. Human FAM60A protein has been shown to be up-regulated in squamous cell carcinoma (SCC), adenocarcinoma (AC), colon, ovary, rectum and stomach tumors. Human FAM60A is phosphorylated upon DNA damage, probably by ATM or ATR [].
•
•
•
•
•
Protein Domain
IPR024146 | Claspin
Type: Family
Description: Claspin is an essential protein for the ATR-Chk1-dependent activation ofthe DNA replication checkpoint response in Xenopus and human cells [, ]. DNA damage induces the formation of a complex between Claspin and BRCA1, a second regulator of Chk1 activation. It is thought that ATR regulates Claspin phosphorylation in response to DNA damage and replication stress, resulting in recruitment and phosphorylation of BRCA1. BRCA1 and Claspin then function to activate Chk1 [].This entry represents both claspin and claspin homologues found mainly in Drosophila.
•
•
•
•
•
Protein Domain
IPR026632 | RAD51-assoc_prot_1
Type: Family
Description: RAD51-associated protein 1 may participate in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair []. It functionally cooperates with PALB2 in promoting of D-loop formation by RAD51 [, ]. It binds to single and double stranded DNA, and is capable of aggregating DNA []. It also binds RNA []. It is phosphorylated upon DNA damage, probably by ATM or ATR [, , ].
•
•
•
•
•
Protein Domain
IPR026943 | Ubinuclein-2
Type: Family
Description: This entry represents ubinuclein-2 (UBN2). It contains a conserved HIRA-binding domain, which directly interacts with the N-terminal WD repeats of HIRA []. UBN2 and UBN1 are believed to be the orthologs of Hpc2p, a subunit of the HIR complex (a nucleosome assembly complex involved in regulation of histone gene transcription) in budding yeast []. It is phosphorylated upon DNA damage, probably by ATM or ATR [].
•
•
•
•
•
Protein Domain
IPR029293 | RHNO1
Type: Family
Description: This entry represents Rad9, Rad1, Hus1-interacting nuclear orphan protein 1 (RHINO or RHNO1), which plays a role in DNA damage response (DDR) signalling upon genotoxic stresses such as ionizing radiation (IR) during the S phase []. RHNO1 is recruited to sites of DNA damage through interaction with the Rad9-Rad1-Hus1 (9-1-1) complex and ATR activator TopBP1. It plays a role in ATR-mediated activation of Chk1 driven by TopBP1 and 9-1-1 []. It is involved in mammary carcinogenesis [].
•
•
•
•
•
Protein Domain
IPR033349 | ATRIP
Type: Family
Description: The function of the ATR-ATRIP (ATR-interacting protein) protein kinase complex is crucial for the cellular response to replication stress and DNA damage. ATRIP is a regulatory partner of ATR. The binding of ATRIP to replication protein A-coated ssDNA at sites of DNA damage drives ATR activation and enables the ATR-ATRIP complex to stimulate phosphorylation of substrates, such as Rad17 or Chk1, and the initiation of checkpoint signalling []. ATRIP deacetylation by SIRT2 promotes ATR-ATRIP bindingto RPA-ssDNA [].
•
•
•
•
•
Publication
18669648 | -
First Author: Dephoure N
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: A quantitative atlas of mitotic phosphorylation.
Volume: 105
Issue: 31
Pages: 10762-7
•
•
•
•
•
Protein Coding Gene
MGI:1915395 | Etaa1
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_CAROLIEiJ_G0016111 | -
Type: protein_coding_gene
Organism: Mus caroli
•
•
•
•
•
Protein Coding Gene
MGP_129S1SvImJ_G0018060 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_AJ_G0018033 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_AKRJ_G0017997 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_BALBcJ_G0018001 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_C3HHeJ_G0017815 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI_C57BL6J_1915395 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_C57BL6NJ_G0018453 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom