Type |
Details |
Score |
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
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•
•
•
•
•
|
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
|
Title: |
Cyagen Biosciences Website. |
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•
•
•
•
•
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Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
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•
•
•
•
•
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Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
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|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
McDowell TL |
Year: |
1999 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Localization of a putative transcriptional regulator (ATRX) at pericentromeric heterochromatin and the short arms of acrocentric chromosomes. |
Volume: |
96 |
Issue: |
24 |
Pages: |
13983-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Law MJ |
Year: |
2010 |
Journal: |
Cell |
Title: |
ATR-X syndrome protein targets tandem repeats and influences allele-specific expression in a size-dependent manner. |
Volume: |
143 |
Issue: |
3 |
Pages: |
367-78 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
181
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
334
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
61
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
89
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
78
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
526
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
12
 |
Fragment?: |
true |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE12454 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee J |
Year: |
2012 |
Journal: |
Cell Death Differ |
Title: |
ATRX induction by mutant huntingtin via Cdx2 modulates heterochromatin condensation and pathology in Huntington's disease. |
Volume: |
19 |
Issue: |
7 |
Pages: |
1109-16 |
|
•
•
•
•
•
|
Publication |
First Author: |
Noh KM |
Year: |
2015 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
ATRX tolerates activity-dependent histone H3 methyl/phos switching to maintain repetitive element silencing in neurons. |
Volume: |
112 |
Issue: |
22 |
Pages: |
6820-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
De La Fuente R |
Year: |
2015 |
Journal: |
Development |
Title: |
ATRX contributes to epigenetic asymmetry and silencing of major satellite transcripts in the maternal genome of the mouse embryo. |
Volume: |
142 |
Issue: |
10 |
Pages: |
1806-17 |
|
•
•
•
•
•
|
Publication |
First Author: |
Drané P |
Year: |
2010 |
Journal: |
Genes Dev |
Title: |
The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3. |
Volume: |
24 |
Issue: |
12 |
Pages: |
1253-65 |
|
•
•
•
•
•
|
Publication |
First Author: |
Iwase S |
Year: |
2011 |
Journal: |
Nat Struct Mol Biol |
Title: |
ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome. |
Volume: |
18 |
Issue: |
7 |
Pages: |
769-76 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gibbons RJ |
Year: |
1997 |
Journal: |
Nat Genet |
Title: |
Mutations in transcriptional regulator ATRX establish the functional significance of a PHD-like domain. |
Volume: |
17 |
Issue: |
2 |
Pages: |
146-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pask A |
Year: |
2000 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
The human sex-reversing ATRX gene has a homologue on the marsupial Y chromosome, ATRY: implications for the evolution of mammalian sex determination. |
Volume: |
97 |
Issue: |
24 |
Pages: |
13198-202 |
|
•
•
•
•
•
|
Allele |
Name: |
ATRX, chromatin remodeler; targeted mutation 1, Richard Gibbons |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Allele |
Name: |
ATRX, chromatin remodeler; endonuclease-mediated mutation 2, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6761590 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2024-05-10 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:2910625 |
Pattern: |
Regionally restricted |
Stage: |
TS25 |
Assay Id: |
MGI:7628670 |
Age: |
embryonic day 17.5 |
Image: |
S1 Control |
Note: |
Gata4 foci co-localized in nuclear speckle with strong Atrx expression. |
Specimen Label: |
S1 Control |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation. |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
ATRX directs binding of PRC2 to Xist RNA and Polycomb targets. |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
ATRX promotes heterochromatin formation to protect cells from G-quadruplex DNA-mediated stress. |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Atrx/? Foxg1/Foxg1<+> |
Background: |
involves: 129P2/OlaHsd * C57BL/6 * FVB/N |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Atrx/? Tg(Nes-cre)2472Pick/? |
Background: |
involves: 129P2/OlaHsd * C57BL/6 * FVB/N |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Atrx/? Tg(Pax6-cre,GFP)2Pgr/? |
Background: |
involves: 129P2/OlaHsd * C57BL/6 * FVB/N |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
ATRX partners with cohesin and MeCP2 and contributes to developmental silencing of imprinted genes in the brain. |
|
•
•
•
•
•
|
Allele |
Name: |
ATRX, chromatin remodeler; gene trap P034D09, German Gene Trap Consortium |
Allele Type: |
Gene trapped |
Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6259606 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-12-10 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:3187710 |
Pattern: |
Not Specified |
Stage: |
TS10 |
Assay Id: |
MGI:6259643 |
Age: |
embryonic day 7.0 |
Image: |
S1C |
Note: |
Expression of Xist partially overlaps with Atrx protein in 25% of trophoblast giant cells. |
Specimen Label: |
S1C |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7384877 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2022-11-18 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:160403 |
Pattern: |
Regionally restricted |
Stage: |
TS03 |
Assay Id: |
MGI:7384958 |
Age: |
embryonic day 3.0 |
|
Note: |
There was no colocalization of Atrx with Daxx immunolabeling at the morula stage. |
Specimen Label: |
4c |
Detected: |
true |
Specimen Num: |
9 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7384877 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2022-11-18 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:160362 |
Pattern: |
Regionally restricted |
Stage: |
TS02 |
Assay Id: |
MGI:7384959 |
Age: |
embryonic day 1.0 |
|
Note: |
Daxx gold particles and Atrx gold particles were noted in separate heterochromatin structures. |
Specimen Label: |
2c |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7384877 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2022-11-18 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:160362 |
Pattern: |
Regionally restricted |
Stage: |
TS02 |
Assay Id: |
MGI:7384958 |
Age: |
embryonic day 1.0 |
|
Note: |
Daxx and Atrx colocalization in the nucleus of 2-cell mouse embryos. |
Specimen Label: |
5a |
Detected: |
true |
Specimen Num: |
10 |
|
•
•
•
•
•
|
Allele |
Name: |
ATRX, chromatin remodeler; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Publication |
First Author: |
Sarma K |
Year: |
2014 |
Journal: |
Cell |
Title: |
ATRX directs binding of PRC2 to Xist RNA and Polycomb targets. |
Volume: |
159 |
Issue: |
4 |
Pages: |
869-83 |
|
•
•
•
•
•
|
Publication |
First Author: |
Teng YC |
Year: |
2021 |
Journal: |
Nat Commun |
Title: |
ATRX promotes heterochromatin formation to protect cells from G-quadruplex DNA-mediated stress. |
Volume: |
12 |
Issue: |
1 |
Pages: |
3887 |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
Allele |
Name: |
Fas death domain-associated protein; endonuclease-mediated mutation 2, Guillermina Lozano |
Allele Type: |
Endonuclease-mediated |
|
|
•
•
•
•
•
|
Genotype |
Symbol: |
Atrx/? |
Background: |
chimera involves: 129S6/SvEvTac * C57BL/6J |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7384877 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2022-11-18 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:160331 |
Pattern: |
Regionally restricted |
Stage: |
TS01 |
Assay Id: |
MGI:7384958 |
Age: |
embryonic day 0.5 |
|
Note: |
Daxx accumulated in male and female pronuclei. There was no colocalization of Atrx with Daxx immunolabeling at the late zygote stage. |
Specimen Label: |
4a |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7384877 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2022-11-18 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:160362 |
Pattern: |
Regionally restricted |
Stage: |
TS02 |
Assay Id: |
MGI:7384959 |
Age: |
embryonic day 1.0 |
|
Note: |
Daxx gold particles and Atrx gold particles were noted in a single structure in close proximity to the surface of interchromatin granule cluster. |
Specimen Label: |
2d |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This is a cysteine-rich domain termed ADD (ATRX-DNMT3-DNMT3L, AD-DATRX) found in ATRX proteins. Chromatin-associated human protein ATRX was originally identified because mutations in the ATRX gene cause a severe form of syndromal X-linked mental retardation called ATR-X syndrome. Mutations or knockdown of ATRX expression cause diverse effects, including altered patterns of DNA methylation, a telomere-dysfunction phenotype, aberrant chromosome segregation, premature sister chromatid separation and changes in gene expression. ATRX localizes predominantly to large, tandemly repeated regions (such as telomeres, centromeres and ribosomal DNA) associated with heterochromatin, and studies show that it directs H3.3 deposition to pericentric and telomeric heterochromatin. The ADD domain of ATRX, in which most syndrome-causing mutations occur, engages the N-terminal tail of histone H3 through two rigidly oriented binding pockets, one for unmodified Lys4 and the other for di- or trimethylated Lys9. Mutations in the ATRX ADD domain cause mislocalization of ATRX protein to heterochromatin, and this may contribute to understanding the underlying etiology of ATRX syndrome. Structure analysis of the ADD domain of ATRX revealed that it contains a PHD zinc-finger domain packed against a GATA-like zinc finger. Same structure is also found in the DNMT3 DNA methyltransferases and DNMT3L [, , ]. |
|
•
•
•
•
•
|
Publication |
First Author: |
Sun C |
Year: |
2023 |
Journal: |
Cell Death Dis |
Title: |
The histone chaperone function of Daxx is dispensable for embryonic development. |
Volume: |
14 |
Issue: |
8 |
Pages: |
565 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Daxx/Daxx |
Background: |
C57BL/6-Daxx |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6259606 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-12-10 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1604210 |
Pattern: |
Regionally restricted |
Stage: |
TS10 |
Assay Id: |
MGI:6259643 |
Age: |
embryonic day 7.0 |
Image: |
S1B |
Note: |
There was no overlap of the Xist expression domain with the Atrx protein in the two nuclei from chorion shown in the figure. Only 5.8% of chorion nuclei show partial overlap of expression. |
Specimen Label: |
S1B |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7384877 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2022-11-18 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:160362 |
Pattern: |
Regionally restricted |
Stage: |
TS02 |
Assay Id: |
MGI:7384958 |
Age: |
embryonic day 1.0 |
|
Note: |
At late two-cell stage, colocalization of Daxx and ATRX was detectable both in the ring-shaped heterochromatin zones associated with the nucleolus precursor body (NPB) periphery and in NPB-unassociated heterochromatin patches. Some zones of Daxx localization did not overlap with ATRX (and vise versa). ATRX was found in 60% Daxx-positive heterochromatin areas associated with NPBs and in 80% Daxx-positive heterochromatin clumps located outside the NPBs. |
Specimen Label: |
4b |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
520
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
347
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
238
 |
Fragment?: |
true |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
158
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
922
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
208
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
995
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
385
 |
Fragment?: |
true |
|
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•
•
•
•
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Publication |
First Author: |
Argentaro A |
Year: |
2007 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Structural consequences of disease-causing mutations in the ATRX-DNMT3-DNMT3L (ADD) domain of the chromatin-associated protein ATRX. |
Volume: |
104 |
Issue: |
29 |
Pages: |
11939-44 |
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•
•
•
•
•
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Publication |
First Author: |
Baker SA |
Year: |
2013 |
Journal: |
Cell |
Title: |
An AT-hook domain in MeCP2 determines the clinical course of Rett syndrome and related disorders. |
Volume: |
152 |
Issue: |
5 |
Pages: |
984-96 |
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•
•
•
•
•
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Publication |
First Author: |
Chatzinikolaou G |
Year: |
2017 |
Journal: |
Nat Cell Biol |
Title: |
ERCC1-XPF cooperates with CTCF and cohesin to facilitate the developmental silencing of imprinted genes. |
Volume: |
19 |
Issue: |
5 |
Pages: |
421-432 |
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•
•
•
•
•
|
Publication |
First Author: |
Pathania M |
Year: |
2017 |
Journal: |
Cancer Cell |
Title: |
H3.3K27M Cooperates with Trp53 Loss and PDGFRA Gain in Mouse Embryonic Neural Progenitor Cells to Induce Invasive High-Grade Gliomas. |
Volume: |
32 |
Issue: |
5 |
Pages: |
684-700.e9 |
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•
•
•
•
•
|
Publication |
First Author: |
Christophorou MA |
Year: |
2014 |
Journal: |
Nature |
Title: |
Citrullination regulates pluripotency and histone H1 binding to chromatin. |
Volume: |
507 |
Issue: |
7490 |
Pages: |
104-8 |
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•
•
•
•
•
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Publication |
First Author: |
Aapola U |
Year: |
2000 |
Journal: |
Genomics |
Title: |
Isolation and initial characterization of a novel zinc finger gene, DNMT3L, on 21q22.3, related to the cytosine-5-methyltransferase 3 gene family. |
Volume: |
65 |
Issue: |
3 |
Pages: |
293-8 |
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Protein Domain |
Type: |
Domain |
Description: |
One of the largest protein families in the human genome is the zinc fingerfamily that contains members involved in the regulation of transcriptionprocesses. The zinc finger domains have been classified based on the order ofcysteine (C) and histidine (H) residues. Zinc fingers are thought to mediateprotein-DNA and protein-protein interactions. The ADD (ATRX, DNMT3, DNMT3L)domain is a cysteine-rich region that consists of a C2C2-type zinc finger anda closely located domain of an imperfect PHD-type zinc finger with C4C4. The region between the two subdomains has a constant length, andit contains identical and conserved amino acids [, ]. The ADD domain binds to the histone H3 tail that is unmethylated at lysine 4 [, ].The ADD domain is present in chromatin-associated proteins that play a role inestablishing and/or maintaining a normal pattern of DNA methylation:DNMT3A, DNMT3B, DNA methyltransferases.DNMT3L, a DNMT3-like enzymatically inactive regulatory factor.ATRX, a large nuclear protein predominantly localized to heterochromatinand nuclear PML bodies. At the C terminus is a helicase/ATPase domain, which characterises ATRX as a member of the SNF2 (SWI/SNF) family of chromatin-associated proteins. The ADD domain is composed of three clearly distinguishable modules that packtogether through extensive hydrophobic interactions to form a single globulardomain. Packed against this GATA-like finger is a second subdomain,which binds two zinc ions and closely resembles the structure reported forseveral PHD fingers. Finally, there is a long C-terminal α-helix that runsout from the PHD finger and makes extensive hydrophobic contacts with the N-terminal GATA finger, bringing the N- and C-termini of the ADD domain closetogether. This combination of fused GATA-like and PHD fingers within a singledomain is thus far unique [, ]. |
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Publication |
First Author: |
Rouleau N |
Year: |
2002 |
Journal: |
Mol Biol Cell |
Title: |
Novel ATPase of SNF2-like protein family interacts with androgen receptor and modulates androgen-dependent transcription. |
Volume: |
13 |
Issue: |
6 |
Pages: |
2106-19 |
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•
•
•
•
•
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Publication |
First Author: |
Liu Z |
Year: |
2020 |
Journal: |
EMBO J |
Title: |
SUMOylated PRC1 controls histone H3.3 deposition and genome integrity of embryonic heterochromatin. |
Volume: |
39 |
Issue: |
13 |
Pages: |
e103697 |
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•
•
•
•
•
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Publication |
First Author: |
Udugama M |
Year: |
2015 |
Journal: |
Nucleic Acids Res |
Title: |
Histone variant H3.3 provides the heterochromatic H3 lysine 9 tri-methylation mark at telomeres. |
Volume: |
43 |
Issue: |
21 |
Pages: |
10227-37 |
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•
•
•
•
•
|
Publication |
First Author: |
Xie S |
Year: |
1999 |
Journal: |
Gene |
Title: |
Cloning, expression and chromosome locations of the human DNMT3 gene family. |
Volume: |
236 |
Issue: |
1 |
Pages: |
87-95 |
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•
•
•
•
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Publication |
First Author: |
Datta J |
Year: |
2005 |
Journal: |
Cancer Res |
Title: |
Physical and functional interaction of DNA methyltransferase 3A with Mbd3 and Brg1 in mouse lymphosarcoma cells. |
Volume: |
65 |
Issue: |
23 |
Pages: |
10891-900 |
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•
•
•
•
•
|
Publication |
First Author: |
Ooi SK |
Year: |
2007 |
Journal: |
Nature |
Title: |
DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA. |
Volume: |
448 |
Issue: |
7154 |
Pages: |
714-7 |
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•
•
•
•
•
|
Publication |
First Author: |
Otani J |
Year: |
2009 |
Journal: |
EMBO Rep |
Title: |
Structural basis for recognition of H3K4 methylation status by the DNA methyltransferase 3A ATRX-DNMT3-DNMT3L domain. |
Volume: |
10 |
Issue: |
11 |
Pages: |
1235-41 |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
740
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
421
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
421
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
908
 |
Fragment?: |
false |
|
•
•
•
•
•
|