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Search results 501 to 600 out of 613 for Atrx

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Type Details Score
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication        
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication
First Author: McDowell TL
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Localization of a putative transcriptional regulator (ATRX) at pericentromeric heterochromatin and the short arms of acrocentric chromosomes.
Volume: 96
Issue: 24
Pages: 13983-8
Publication
First Author: Law MJ
Year: 2010
Journal: Cell
Title: ATR-X syndrome protein targets tandem repeats and influences allele-specific expression in a size-dependent manner.
Volume: 143
Issue: 3
Pages: 367-78
Protein
Organism: Mus musculus/domesticus
Length: 181  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 334  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 61  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 89  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 78  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 526  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 12  
Fragment?: true
HT Experiment
Series Id: GSE12454
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
Publication
First Author: Lee J
Year: 2012
Journal: Cell Death Differ
Title: ATRX induction by mutant huntingtin via Cdx2 modulates heterochromatin condensation and pathology in Huntington's disease.
Volume: 19
Issue: 7
Pages: 1109-16
Publication
First Author: Noh KM
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: ATRX tolerates activity-dependent histone H3 methyl/phos switching to maintain repetitive element silencing in neurons.
Volume: 112
Issue: 22
Pages: 6820-7
Publication
First Author: De La Fuente R
Year: 2015
Journal: Development
Title: ATRX contributes to epigenetic asymmetry and silencing of major satellite transcripts in the maternal genome of the mouse embryo.
Volume: 142
Issue: 10
Pages: 1806-17
Publication
First Author: Drané P
Year: 2010
Journal: Genes Dev
Title: The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3.
Volume: 24
Issue: 12
Pages: 1253-65
Publication
First Author: Iwase S
Year: 2011
Journal: Nat Struct Mol Biol
Title: ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome.
Volume: 18
Issue: 7
Pages: 769-76
Publication
First Author: Gibbons RJ
Year: 1997
Journal: Nat Genet
Title: Mutations in transcriptional regulator ATRX establish the functional significance of a PHD-like domain.
Volume: 17
Issue: 2
Pages: 146-8
Publication
First Author: Pask A
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: The human sex-reversing ATRX gene has a homologue on the marsupial Y chromosome, ATRY: implications for the evolution of mammalian sex determination.
Volume: 97
Issue: 24
Pages: 13198-202
Allele
Name: ATRX, chromatin remodeler; targeted mutation 1, Richard Gibbons
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
Allele
Name: ATRX, chromatin remodeler; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
GXD Expression
Probe: MGI:6761590
Assay Type: Immunohistochemistry
Annotation Date: 2024-05-10
Strength: Present
Sex: Male
Emaps: EMAPS:2910625
Pattern: Regionally restricted
Stage: TS25
Assay Id: MGI:7628670
Age: embryonic day 17.5
Image: S1 Control
Note: Gata4 foci co-localized in nuclear speckle with strong Atrx expression.
Specimen Label: S1 Control
Detected: true
Specimen Num: 3
Interaction Experiment
Description: Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation.
Interaction Experiment
Description: ATRX directs binding of PRC2 to Xist RNA and Polycomb targets.
Interaction Experiment
Description: ATRX promotes heterochromatin formation to protect cells from G-quadruplex DNA-mediated stress.
Genotype
Symbol: Atrx/? Foxg1/Foxg1<+>
Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Atrx/? Tg(Nes-cre)2472Pick/?
Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Atrx/? Tg(Pax6-cre,GFP)2Pgr/?
Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
DO Term
Interaction Experiment
Description: ATRX partners with cohesin and MeCP2 and contributes to developmental silencing of imprinted genes in the brain.
Allele
Name: ATRX, chromatin remodeler; gene trap P034D09, German Gene Trap Consortium
Allele Type: Gene trapped
Attribute String: Null/knockout, Reporter
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
GXD Expression
Probe: MGI:6259606
Assay Type: RNA in situ
Annotation Date: 2018-12-10
Strength: Present
Sex: Female
Emaps: EMAPS:3187710
Pattern: Not Specified
Stage: TS10
Assay Id: MGI:6259643
Age: embryonic day 7.0
Image: S1C
Note: Expression of Xist partially overlaps with Atrx protein in 25% of trophoblast giant cells.
Specimen Label: S1C
Detected: true
Specimen Num: 8
GXD Expression  
Probe: MGI:7384877
Assay Type: Immunohistochemistry
Annotation Date: 2022-11-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160403
Pattern: Regionally restricted
Stage: TS03
Assay Id: MGI:7384958
Age: embryonic day 3.0
Note: There was no colocalization of Atrx with Daxx immunolabeling at the morula stage.
Specimen Label: 4c
Detected: true
Specimen Num: 9
GXD Expression  
Probe: MGI:7384877
Assay Type: Immunohistochemistry
Annotation Date: 2022-11-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Pattern: Regionally restricted
Stage: TS02
Assay Id: MGI:7384959
Age: embryonic day 1.0
Note: Daxx gold particles and Atrx gold particles were noted in separate heterochromatin structures.
Specimen Label: 2c
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:7384877
Assay Type: Immunohistochemistry
Annotation Date: 2022-11-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Pattern: Regionally restricted
Stage: TS02
Assay Id: MGI:7384958
Age: embryonic day 1.0
Note: Daxx and Atrx colocalization in the nucleus of 2-cell mouse embryos.
Specimen Label: 5a
Detected: true
Specimen Num: 10
Allele
Name: ATRX, chromatin remodeler; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
Publication
First Author: Sarma K
Year: 2014
Journal: Cell
Title: ATRX directs binding of PRC2 to Xist RNA and Polycomb targets.
Volume: 159
Issue: 4
Pages: 869-83
Publication
First Author: Teng YC
Year: 2021
Journal: Nat Commun
Title: ATRX promotes heterochromatin formation to protect cells from G-quadruplex DNA-mediated stress.
Volume: 12
Issue: 1
Pages: 3887
DO Term
Allele  
Name: Fas death domain-associated protein; endonuclease-mediated mutation 2, Guillermina Lozano
Allele Type: Endonuclease-mediated
Genotype
Symbol: Atrx/?
Background: chimera involves: 129S6/SvEvTac * C57BL/6J
Zygosity: ot
Has Mutant Allele: true
GXD Expression  
Probe: MGI:7384877
Assay Type: Immunohistochemistry
Annotation Date: 2022-11-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160331
Pattern: Regionally restricted
Stage: TS01
Assay Id: MGI:7384958
Age: embryonic day 0.5
Note: Daxx accumulated in male and female pronuclei. There was no colocalization of Atrx with Daxx immunolabeling at the late zygote stage.
Specimen Label: 4a
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:7384877
Assay Type: Immunohistochemistry
Annotation Date: 2022-11-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Pattern: Regionally restricted
Stage: TS02
Assay Id: MGI:7384959
Age: embryonic day 1.0
Note: Daxx gold particles and Atrx gold particles were noted in a single structure in close proximity to the surface of interchromatin granule cluster.
Specimen Label: 2d
Detected: true
Specimen Num: 4
Protein Domain
Type: Domain
Description: This is a cysteine-rich domain termed ADD (ATRX-DNMT3-DNMT3L, AD-DATRX) found in ATRX proteins. Chromatin-associated human protein ATRX was originally identified because mutations in the ATRX gene cause a severe form of syndromal X-linked mental retardation called ATR-X syndrome. Mutations or knockdown of ATRX expression cause diverse effects, including altered patterns of DNA methylation, a telomere-dysfunction phenotype, aberrant chromosome segregation, premature sister chromatid separation and changes in gene expression. ATRX localizes predominantly to large, tandemly repeated regions (such as telomeres, centromeres and ribosomal DNA) associated with heterochromatin, and studies show that it directs H3.3 deposition to pericentric and telomeric heterochromatin. The ADD domain of ATRX, in which most syndrome-causing mutations occur, engages the N-terminal tail of histone H3 through two rigidly oriented binding pockets, one for unmodified Lys4 and the other for di- or trimethylated Lys9. Mutations in the ATRX ADD domain cause mislocalization of ATRX protein to heterochromatin, and this may contribute to understanding the underlying etiology of ATRX syndrome. Structure analysis of the ADD domain of ATRX revealed that it contains a PHD zinc-finger domain packed against a GATA-like zinc finger. Same structure is also found in the DNMT3 DNA methyltransferases and DNMT3L [, , ].
Publication
First Author: Sun C
Year: 2023
Journal: Cell Death Dis
Title: The histone chaperone function of Daxx is dispensable for embryonic development.
Volume: 14
Issue: 8
Pages: 565
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Genotype
Symbol: Daxx/Daxx
Background: C57BL/6-Daxx
Zygosity: hm
Has Mutant Allele: true
GXD Expression
Probe: MGI:6259606
Assay Type: RNA in situ
Annotation Date: 2018-12-10
Strength: Present
Sex: Female
Emaps: EMAPS:1604210
Pattern: Regionally restricted
Stage: TS10
Assay Id: MGI:6259643
Age: embryonic day 7.0
Image: S1B
Note: There was no overlap of the Xist expression domain with the Atrx protein in the two nuclei from chorion shown in the figure. Only 5.8% of chorion nuclei show partial overlap of expression.
Specimen Label: S1B
Detected: true
Specimen Num: 7
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
GXD Expression  
Probe: MGI:7384877
Assay Type: Immunohistochemistry
Annotation Date: 2022-11-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Pattern: Regionally restricted
Stage: TS02
Assay Id: MGI:7384958
Age: embryonic day 1.0
Note: At late two-cell stage, colocalization of Daxx and ATRX was detectable both in the ring-shaped heterochromatin zones associated with the nucleolus precursor body (NPB) periphery and in NPB-unassociated heterochromatin patches. Some zones of Daxx localization did not overlap with ATRX (and vise versa). ATRX was found in 60% Daxx-positive heterochromatin areas associated with NPBs and in 80% Daxx-positive heterochromatin clumps located outside the NPBs.
Specimen Label: 4b
Detected: true
Specimen Num: 8
DO Term
Protein
Organism: Mus musculus/domesticus
Length: 520  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 347  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 238  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 158  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 922  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 208  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 995  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 385  
Fragment?: true
Publication
First Author: Argentaro A
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Structural consequences of disease-causing mutations in the ATRX-DNMT3-DNMT3L (ADD) domain of the chromatin-associated protein ATRX.
Volume: 104
Issue: 29
Pages: 11939-44
Publication
First Author: Baker SA
Year: 2013
Journal: Cell
Title: An AT-hook domain in MeCP2 determines the clinical course of Rett syndrome and related disorders.
Volume: 152
Issue: 5
Pages: 984-96
Publication
First Author: Chatzinikolaou G
Year: 2017
Journal: Nat Cell Biol
Title: ERCC1-XPF cooperates with CTCF and cohesin to facilitate the developmental silencing of imprinted genes.
Volume: 19
Issue: 5
Pages: 421-432
Publication
First Author: Pathania M
Year: 2017
Journal: Cancer Cell
Title: H3.3K27M Cooperates with Trp53 Loss and PDGFRA Gain in Mouse Embryonic Neural Progenitor Cells to Induce Invasive High-Grade Gliomas.
Volume: 32
Issue: 5
Pages: 684-700.e9
Publication
First Author: Christophorou MA
Year: 2014
Journal: Nature
Title: Citrullination regulates pluripotency and histone H1 binding to chromatin.
Volume: 507
Issue: 7490
Pages: 104-8
Publication
First Author: Aapola U
Year: 2000
Journal: Genomics
Title: Isolation and initial characterization of a novel zinc finger gene, DNMT3L, on 21q22.3, related to the cytosine-5-methyltransferase 3 gene family.
Volume: 65
Issue: 3
Pages: 293-8
Protein Domain
Type: Domain
Description: One of the largest protein families in the human genome is the zinc fingerfamily that contains members involved in the regulation of transcriptionprocesses. The zinc finger domains have been classified based on the order ofcysteine (C) and histidine (H) residues. Zinc fingers are thought to mediateprotein-DNA and protein-protein interactions. The ADD (ATRX, DNMT3, DNMT3L)domain is a cysteine-rich region that consists of a C2C2-type zinc finger anda closely located domain of an imperfect PHD-type zinc finger with C4C4. The region between the two subdomains has a constant length, andit contains identical and conserved amino acids [, ]. The ADD domain binds to the histone H3 tail that is unmethylated at lysine 4 [, ].The ADD domain is present in chromatin-associated proteins that play a role inestablishing and/or maintaining a normal pattern of DNA methylation:DNMT3A, DNMT3B, DNA methyltransferases.DNMT3L, a DNMT3-like enzymatically inactive regulatory factor.ATRX, a large nuclear protein predominantly localized to heterochromatinand nuclear PML bodies. At the C terminus is a helicase/ATPase domain, which characterises ATRX as a member of the SNF2 (SWI/SNF) family of chromatin-associated proteins. The ADD domain is composed of three clearly distinguishable modules that packtogether through extensive hydrophobic interactions to form a single globulardomain. Packed against this GATA-like finger is a second subdomain,which binds two zinc ions and closely resembles the structure reported forseveral PHD fingers. Finally, there is a long C-terminal α-helix that runsout from the PHD finger and makes extensive hydrophobic contacts with the N-terminal GATA finger, bringing the N- and C-termini of the ADD domain closetogether. This combination of fused GATA-like and PHD fingers within a singledomain is thus far unique [, ].
Publication
First Author: Rouleau N
Year: 2002
Journal: Mol Biol Cell
Title: Novel ATPase of SNF2-like protein family interacts with androgen receptor and modulates androgen-dependent transcription.
Volume: 13
Issue: 6
Pages: 2106-19
Publication
First Author: Liu Z
Year: 2020
Journal: EMBO J
Title: SUMOylated PRC1 controls histone H3.3 deposition and genome integrity of embryonic heterochromatin.
Volume: 39
Issue: 13
Pages: e103697
Publication
First Author: Udugama M
Year: 2015
Journal: Nucleic Acids Res
Title: Histone variant H3.3 provides the heterochromatic H3 lysine 9 tri-methylation mark at telomeres.
Volume: 43
Issue: 21
Pages: 10227-37
Publication
First Author: Xie S
Year: 1999
Journal: Gene
Title: Cloning, expression and chromosome locations of the human DNMT3 gene family.
Volume: 236
Issue: 1
Pages: 87-95
Publication
First Author: Datta J
Year: 2005
Journal: Cancer Res
Title: Physical and functional interaction of DNA methyltransferase 3A with Mbd3 and Brg1 in mouse lymphosarcoma cells.
Volume: 65
Issue: 23
Pages: 10891-900
Publication
First Author: Ooi SK
Year: 2007
Journal: Nature
Title: DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA.
Volume: 448
Issue: 7154
Pages: 714-7
Publication
First Author: Otani J
Year: 2009
Journal: EMBO Rep
Title: Structural basis for recognition of H3K4 methylation status by the DNA methyltransferase 3A ATRX-DNMT3-DNMT3L domain.
Volume: 10
Issue: 11
Pages: 1235-41
Protein
Organism: Mus musculus/domesticus
Length: 740  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 421  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 421  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 908  
Fragment?: false