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Search results 501 to 600 out of 610 for Axin1

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Type Details Score
Publication
29475039 | J:285676
 
First Author: Suzuki A
Year: 2018
Journal: Mech Dev
Title: Genes and microRNAs associated with mouse cleft palate: A systematic review and bioinformatics analysis.
Volume: 150
Pages: 21-27
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Publication
12702649 | J:82802
First Author: Ruiz S
Year: 2003
Journal: Development
Title: Abnormal epidermal differentiation and impaired epithelial-mesenchymal tissue interactions in mice lacking the retinoblastoma relatives p107 and p130.
Volume: 130
Issue: 11
Pages: 2341-53
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Publication
26586428 | J:228946
First Author: Wei N
Year: 2015
Journal: Cell Rep
Title: SRSF10 Plays a Role in Myoblast Differentiation and Glucose Production via Regulation of Alternative Splicing.
Volume: 13
Issue: 8
Pages: 1647-57
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Publication
24952082 | J:237458
First Author: Street VA
Year: 2014
Journal: J Assoc Res Otolaryngol
Title: Resistance to noise-induced hearing loss in 129S6 and MOLF mice: identification of independent, overlapping, and interacting chromosomal regions.
Volume: 15
Issue: 5
Pages: 721-38
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Publication
34150743 | J:308697
 
First Author: Bukova I
Year: 2021
Journal: Front Cell Dev Biol
Title: Loss of Wiz Function Affects Methylation Pattern in Palate Development and Leads to Cleft Palate.
Volume: 9
Pages: 620692
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Publication
24948604 | J:213869
First Author: Caronia-Brown G
Year: 2014
Journal: Development
Title: The cortical hem regulates the size and patterning of neocortex.
Volume: 141
Issue: 14
Pages: 2855-65
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Publication
23293290 | J:194074
First Author: Ahn Y
Year: 2013
Journal: Development
Title: Lrp4 and Wise interplay controls the formation and patterning of mammary and other skin appendage placodes by modulating Wnt signaling.
Volume: 140
Issue: 3
Pages: 583-93
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Publication
20883684 | J:167091
First Author: Nyeng P
Year: 2011
Journal: Dev Biol
Title: Fibroblast growth factor 10 represses premature cell differentiation during establishment of the intestinal progenitor niche.
Volume: 349
Issue: 1
Pages: 20-34
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Publication
16510873 | J:105811
First Author: Wu X
Year: 2006
Journal: Genes Dev
Title: Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin.
Volume: 20
Issue: 5
Pages: 571-85
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Publication
30037926 | J:266090
First Author: Xia W
Year: 2018
Journal: J Cell Biol
Title: Cold-induced protein RBM3 orchestrates neurogenesis via modulating Yap mRNA stability in cold stress.
Volume: 217
Issue: 10
Pages: 3464-3479
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Publication
34032268 | J:306027
 
First Author: Li H
Year: 2021
Journal: Development
Title: Postnatal prolongation of mammalian nephrogenesis by excess fetal GDNF.
Volume: 148
Issue: 10
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Publication
32253237 | J:293624
 
First Author: Lee S
Year: 2020
Journal: Development
Title: Cleft lip and cleft palate in Esrp1 knockout mice is associated with alterations in epithelial-mesenchymal crosstalk.
Volume: 147
Issue: 21
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Publication
11829488 | J:74612
First Author: Sierra DA
Year: 2002
Journal: Genomics
Title: Evolution of the regulators of G-protein signaling multigene family in mouse and human.
Volume: 79
Issue: 2
Pages: 177-85
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Publication
19515997 | J:154534
First Author: Martinez G
Year: 2009
Journal: Invest Ophthalmol Vis Sci
Title: Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation.
Volume: 50
Issue: 10
Pages: 4794-806
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Publication
20436479 | J:157819
First Author: Shimogori T
Year: 2010
Journal: Nat Neurosci
Title: A genomic atlas of mouse hypothalamic development.
Volume: 13
Issue: 6
Pages: 767-75
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
15226823 | J:93300
First Author: Blackshaw S
Year: 2004
Journal: PLoS Biol
Title: Genomic analysis of mouse retinal development.
Volume: 2
Issue: 9
Pages: E247
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Publication
- | J:157064
     
First Author: University of California, Davis
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the University of California, Davis
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
26916619 | J:234831
 
First Author: Chimge NO
Year: 2016
Journal: Nat Commun
Title: RUNX1 prevents oestrogen-mediated AXIN1 suppression and β-catenin activation in ER-positive breast cancer.
Volume: 7
Pages: 10751
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Publication
28830684 | J:261308
First Author: Ye X
Year: 2017
Journal: Exp Cell Res
Title: Axin1 up-regulated 1 accelerates stress-induced cardiomyocytes apoptosis through activating Wnt/β-catenin signaling.
Volume: 359
Issue: 2
Pages: 441-448
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Publication
27530555 | J:259566
 
First Author: Mah KM
Year: 2016
Journal: Sci Rep
Title: The γ-Protocadherin-C3 isoform inhibits canonical Wnt signalling by binding to and stabilizing Axin1 at the membrane.
Volume: 6
Pages: 31665
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Publication
21808024 | J:181818
First Author: Zhang X
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Mechanistic insight into Myc stabilization in breast cancer involving aberrant Axin1 expression.
Volume: 109
Issue: 8
Pages: 2790-5
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UniProt Feature
UniProt Feature
Begin: 108
Description: PPPSP motif; required for interaction with AXIN1
Type: short sequence motif
End: 112
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Interaction Experiment
Li VS (2012)
Description: Wnt signaling through inhibition of -catenin degradation in an intact Axin1 complex.
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Protein Coding Gene
MGI:2387989 | Csrnp1
Type: protein_coding_gene
Organism: mouse, laboratory
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Allele
Axin1<Fu-ki> | MGI:1856036
 
Name: axin 1; kinky
Allele Type: Spontaneous
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Strain
MGI:2164905 | STOCK Axin<Fu-ki>
Attribute String: mutant stock, spontaneous mutation
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Genotype
Genotype
Symbol: Axin1/Axin1<+>
Background: mixed
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Axin1/Axin1
Background: mixed
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Axin1/Axin1
Background: involves: BTBR
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Axin1/Axin1
Background: involves: Bagg albino * CF * fancier's mice
Zygosity: hm
Has Mutant Allele: true
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Allele
Tg(TetO-Axin1,EGFP)TA6Cos | MGI:5292559
Name: transgene insertion TA6, Frank Costantini
Allele Type: Transgenic
Attribute String: Epitope tag, Inducible, Inserted expressed sequence, Reporter
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Allele
Tg(TetO-Axin1,-EGFP)TA32Cos | MGI:4947394
Name: transgene insertion TA32, Franklin Costantini
Allele Type: Transgenic
Attribute String: Epitope tag, Inducible, Inserted expressed sequence, Reporter
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Strain
MGI:5292562 | B6.Cg-Tg(TetO-Axin1,EGFP)TA6Cos/J
Attribute String: congenic, mutant strain, transgenic
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Allele
Axin1<em1Smoc> | MGI:7288414
Name: axin 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Genotype
Genotype
Symbol: Axin1/Axin1
Background: involves: BTBR * C57BL/6J * CBA/J
Zygosity: ht
Has Mutant Allele: true
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Allele
Axin1<tm2Cos> | MGI:3580423
Name: axin 1; targeted mutation 2, Frank Costantini
Allele Type: Targeted
Attribute String: Inserted expressed sequence, Modified isoform(s)
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Allele
Gt(ROSA)26Sor<tm1(CAG-Axin1,-lacZ)Kini> | MGI:6726261
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Karolinska Institutet
Allele Type: Targeted
Attribute String: Conditional ready, Inserted expressed sequence, Reporter
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Strain
MGI:7623307 | C57BL/6JSmoc-Axin1<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:5650479 | (BTBR.Cg-Axin1<Fu-ki> Itpr3<tf>/+ Itpr3<tf> x M. spretus)F1
Attribute String: F1 hybrid
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Publication
17123792 | J:119927
First Author: Yu HM
Year: 2007
Journal: Mech Dev
Title: Impaired neural development caused by inducible expression of Axin in transgenic mice.
Volume: 124
Issue: 2
Pages: 146-56
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Genotype
Genotype
Symbol: Axin1/Axin1
Background: involves: 129S6/SvEvTac * FVB/N
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Axin1/Axin1<+>
Background: involves: 129S6/SvEvTac * FVB/N
Zygosity: ht
Has Mutant Allele: true
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Publication
31242033 | J:306371
First Author: Jensen LD
Year: 2019
Journal: Arterioscler Thromb Vasc Biol
Title: Disruption of the Extracellular Matrix Progressively Impairs Central Nervous System Vascular Maturation Downstream of β-Catenin Signaling.
Volume: 39
Issue: 7
Pages: 1432-1447
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Publication
26763102 | J:229916
First Author: Cui Y
Year: 2016
Journal: FEBS Lett
Title: Exosomes derived from mineralizing osteoblasts promote ST2 cell osteogenic differentiation by alteration of microRNA expression.
Volume: 590
Issue: 1
Pages: 185-92
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Genotype
Genotype
Symbol: Axin1/Axin1
Background: involves: 129S6/SvEvTac * FVB/N
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Lck-cre)1Cwi/? Tg(TetO-Axin1,-EGFP)TA32Cos/?
Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Publication
32698014 | J:300777
First Author: Koirala S
Year: 2020
Journal: Cell Rep
Title: Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase.
Volume: 32
Issue: 3
Pages: 107922
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Publication
33122431 | J:298801
First Author: Lee EJ
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: TAZ/Wnt-β-catenin/c-MYC axis regulates cystogenesis in polycystic kidney disease.
Volume: 117
Issue: 46
Pages: 29001-29012
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Publication
17726538 | J:129366
First Author: Gingras S
Year: 2007
Journal: PLoS One
Title: Characterization of a family of novel cysteine- serine-rich nuclear proteins (CSRNP).
Volume: 2
Issue: 8
Pages: e808
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Publication
31337618 | J:279990
First Author: Schatoff EM
Year: 2019
Journal: Cancer Discov
Title: Distinct Colorectal Cancer-Associated APC Mutations Dictate Response to Tankyrase Inhibition.
Volume: 9
Issue: 10
Pages: 1358-1371
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Publication
28659575 | J:248365
First Author: Kang DH
Year: 2017
Journal: Nat Commun
Title: Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells.
Volume: 8
Issue: 1
Pages: 40
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Publication
33144683 | J:301475
First Author: Alula KM
Year: 2021
Journal: Oncogene
Title: Nuclear partitioning of Prohibitin 1 inhibits Wnt/β-catenin-dependent intestinal tumorigenesis.
Volume: 40
Issue: 2
Pages: 369-383
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Publication
33225507 | J:341815
First Author: Yue Y
Year: 2021
Journal: FASEB J
Title: Tiam1 mediates Rac1 activation and contraction-induced glucose uptake in skeletal muscle cells.
Volume: 35
Issue: 2
Pages: e21210
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Publication
15790973 | J:98523
First Author: Yu HM
Year: 2005
Journal: Development
Title: The role of Axin2 in calvarial morphogenesis and craniosynostosis.
Volume: 132
Issue: 8
Pages: 1995-2005
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Publication
27578179 | J:307219
First Author: Huraskin D
Year: 2016
Journal: Development
Title: Wnt/β-catenin signaling via Axin2 is required for myogenesis and, together with YAP/Taz and Tead1, active in IIa/IIx muscle fibers.
Volume: 143
Issue: 17
Pages: 3128-42
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Publication
30257989 | J:271154
First Author: Wang W
Year: 2019
Journal: Mol Cancer Res
Title: Oncogenic STRAP Supports Hepatocellular Carcinoma Growth by Enhancing Wnt/β-Catenin Signaling.
Volume: 17
Issue: 2
Pages: 521-531
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Publication
28520221 | J:316180
First Author: Maruyama T
Year: 2017
Journal: J Bone Miner Res
Title: Rap1b Is an Effector of Axin2 Regulating Crosstalk of Signaling Pathways During Skeletal Development.
Volume: 32
Issue: 9
Pages: 1816-1828
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Publication
12948650 | -
First Author: Copp AJ
Year: 2003
Journal: Trends Neurosci
Title: Dishevelled: linking convergent extension with neural tube closure.
Volume: 26
Issue: 9
Pages: 453-5
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Protein Domain
IPR015506 | Dsh/Dvl-rel
Type: Family
Description: This entry includes the dishevelled (Dsh) proteins and dixin (also known as coiled-coil-DIX1, Ccd1).The transduction mechanism requires dishevelled protein (Dsh), a cytoplasmic phosphoprotein that acts directly downstream of frizzled []. In addition to its role in Wnt signalling, Dsh is also involved in generating planar polarity in Drosophila and has been implicated in the Notch signal transduction cascade. Furthermore, Dsh plays a vital molecular role in neural tube closure. Disruption of dishevelled signalling in Xenopus and inactivation of the genes encoding dishevelled 1 and dishevelled 2 (Dvl1 and Dvl2) in the mouse yield similar phenotypes, in which the neural tube fails to close []. Three human and mouse homologues of Dsh have been cloned (DVL-1 to 3); it is believed that these proteins, like their Drosophila counterpart, are involved in signal transduction. Human and murine orthologues share more than 95% sequence identity and are each 40-50% identical to Drosophila Dsh.Sequence similarity amongst Dsh proteins is concentrated around three conserved domains: at the N terminus lies a DIX domain (mutations mapping to this region reduce or completely disrupt Wg signalling); a PDZ (or DHR) domain, often found in proteins involved in protein-protein interactions, lies within the central portion of the protein (point mutations within this module have been shown to have little effect on Wg-mediated signal transduction); and a DEP domain is located towards the C terminus and is conserved among a set of proteins that regulate various GTPases. Whilst genetic and molecular assays have shown this module to be dispensable for Wg signalling, it is thought to be important in planar polarity signalling in flies [].Ccd1 is another DIX domain-possessing protein that forms complexes with the Dishevelled homologue Dvl and Axin. Ccd1 is a positive regulator of Wnt signalling []. It regulates JNK activation by AXIN1 and DVL2 [].
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Publication
32665357 | J:296321
First Author: Jackson DN
Year: 2020
Journal: Cancer Res
Title: The Synthetic Small Molecule FL3 Combats Intestinal Tumorigenesis via Axin1-Mediated Inhibition of Wnt/β-Catenin Signaling.
Volume: 80
Issue: 17
Pages: 3519-3529
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Publication
15262978 | -
First Author: Wong CK
Year: 2004
Journal: J Biol Chem
Title: The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms.
Volume: 279
Issue: 38
Pages: 39366-73
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Publication
36604170 | J:338247
First Author: Steffen DM
Year: 2023
Journal: J Neurosci
Title: A Unique Role for Protocadherin γC3 in Promoting Dendrite Arborization through an Axin1-Dependent Mechanism.
Volume: 43
Issue: 6
Pages: 918-935
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Publication
15941831 | J:99718
First Author: Yu HM
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Development of a unique system for spatiotemporal and lineage-specific gene expression in mice.
Volume: 102
Issue: 24
Pages: 8615-20
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Publication
15857680 | J:97956
First Author: Shiomi K
Year: 2005
Journal: Brain Res Mol Brain Res
Title: Identification and differential expression of multiple isoforms of mouse Coiled-coil-DIX1 (Ccd1), a positive regulator of Wnt signaling.
Volume: 135
Issue: 1-2
Pages: 169-80
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Protein
F2Z453
Organism: Mus musculus/domesticus
Length: 117  
Fragment?: false
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Protein
Q3V330
Organism: Mus musculus/domesticus
Length: 345  
Fragment?: false
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Publication
12072470 | -
First Author: Penton A
Year: 2002
Journal: Genetics
Title: A mutational analysis of dishevelled in Drosophila defines novel domains in the dishevelled protein as well as novel suppressing alleles of axin.
Volume: 161
Issue: 2
Pages: 747-62
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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