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Search results 501 to 600 out of 602 for Becn1

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Type Details Score
Publication
27383629 | J:316639
 
First Author: He MY
Year: 2016
Journal: Open Biol
Title: Nrf2 signalling and autophagy are involved in diabetes mellitus-induced defects in the development of mouse placenta.
Volume: 6
Issue: 7
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Allele
Becn1<tm1.1Bflu> | MGI:5527250
Name: beclin 1, autophagy related; targeted mutation 1.1, Binfeng Lu
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Publication
22904094 | J:212629
First Author: Papanicolaou KN
Year: 2012
Journal: Circ Res
Title: Mitofusins 1 and 2 are essential for postnatal metabolic remodeling in heart.
Volume: 111
Issue: 8
Pages: 1012-26
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Publication
25915474 | J:222854
First Author: Laguna A
Year: 2015
Journal: Nat Neurosci
Title: Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease.
Volume: 18
Issue: 6
Pages: 826-35
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Publication
26590968 | J:384045
First Author: Son JH
Year: 2016
Journal: Arch Pharm Res
Title: Systematic analyses of the ultraviolet radiation resistance-associated gene product (UVRAG) protein interactome by tandem affinity purification.
Volume: 39
Issue: 3
Pages: 370-9
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Publication
27997827 | J:237617
First Author: Menendez-Montes I
Year: 2016
Journal: Dev Cell
Title: Myocardial VHL-HIF Signaling Controls an Embryonic Metabolic Switch Essential for Cardiac Maturation.
Volume: 39
Issue: 6
Pages: 724-739
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Publication
37494420 | J:344559
First Author: Hughes CHK
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: Steroidogenic factor 1 (SF-1; Nr5a1) regulates the formation of the ovarian reserve.
Volume: 120
Issue: 32
Pages: e2220849120
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Publication
40605617 | J:370213
 
First Author: Windley SP
Year: 2025
Journal: Endocrinology
Title: NEDD4 Promotes Sertoli Cell Proliferation and Adult Leydig Cell Differentiation in the Murine Testis.
Volume: 166
Issue: 9
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:77000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342609
       
First Author: UniProt
Year: 2021
Title: Electronic Gene Ontology annotations created by ARBA machine learning models
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Allele
Becn1<tm1c(KOMP)Wtsi> | MGI:6449262
Name: beclin 1, autophagy related; targeted mutation 1c, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready
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Publication
27559856 | J:332366
First Author: Peng Y
Year: 2016
Journal: Autophagy
Title: ABHD5 interacts with BECN1 to regulate autophagy and tumorigenesis of colon cancer independent of PNPLA2.
Volume: 12
Issue: 11
Pages: 2167-2182
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Allele
Becn1<em2Smoc> | MGI:7288471
Name: beclin 1, autophagy related; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Interaction Experiment
Choubey V (2014)
Description: BECN1 is involved in the initiation of mitophagy: It facilitates PARK2 translocation to mitochondria.
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Publication
30581147 | -
First Author: Chang C
Year: 2019
Journal: Mol Cell
Title: Bidirectional Control of Autophagy by BECN1 BARA Domain Dynamics.
Volume: 73
Issue: 2
Pages: 339-353.e6
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Publication
25484083 | -
First Author: Xu C
Year: 2014
Journal: Autophagy
Title: Regulation of autophagy by E3 ubiquitin ligase RNF216 through BECN1 ubiquitination.
Volume: 10
Issue: 12
Pages: 2239-50
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Strain
MGI:6354560 | C57BL/6JSmoc-Becn1<em2Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Allele
Tg(Becn1-EGFP)CZ48Gsat | MGI:4846882
Name: transgene insertion JP115, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
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Strain
MGI:5003600 | STOCK Tg(Becn1-EGFP)CZ48Gsat/Mmucd
Attribute String: mutant stock, transgenic
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HT Experiment
GSE72664 | Sexual Divergence in Microtubule Function: The Novel Intranasal Microtubule Targeting SKIP Normalizes Axonal Transport and Enhances Memory
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Protein Domain
IPR052596 | AMBRA1_autophagy
Type: Family
Description: The AMBRA1 family proteins are substrate-recognition components of the DCX E3 ubiquitin-protein ligase complex, playing a pivotal role in cell cycle control and autophagy. They mediate polyubiquitination and degradation of various target proteins, including BECN1 and cyclin-D, thereby regulating the G1 to S phase transition and maintaining genomic integrity. The AMBRA1 family also modulates the BECN1-PIK3C3 complex, essential for autophagosome nucleation and protein turnover, particularly during neuronal development. Additionally, these proteins are involved in mitophagy, either by interacting with PRKN and LC3 proteins or by acting as cofactors for ubiquitination enzymes. They contribute to Treg differentiation by promoting FOXO3 dephosphorylation and are implicated in intracellular trafficking and transcription regulation. The family's interaction with dynein light chains and protein phosphatase 2A highlights its role in cytoskeletal tethering and signal transduction.
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Publication
30649198 | J:274674
First Author: Melnick AF
Year: 2019
Journal: Biol Reprod
Title: RNF216 is essential for spermatogenesis and male fertility?.
Volume: 100
Issue: 5
Pages: 1132-1134
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Publication
33724554 | J:307636
First Author: Li D
Year: 2021
Journal: FASEB J
Title: RNF216 regulates meiosis and PKA stability in the testes.
Volume: 35
Issue: 4
Pages: e21460
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Publication
37439148 | J:343176
First Author: Yang H
Year: 2023
Journal: Dev Growth Differ
Title: RNF216 affects the stability of STAU2 in the hypothalamus.
Volume: 65
Issue: 7
Pages: 408-417
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Protein Domain
IPR058758 | UBA_RNF216
Type: Domain
Description: This is the predicted UBA domain found in RNF216 and similar animal and fungal sequences.E3 ubiquitin-protein ligase RNF216, also known as Triad domain-containing protein 3 (Triad3A), is a RBR-type E3 ubiquitin-protein ligase that interacts with several components of Toll-like receptor (TLR) signalling and promotes their proteolytic degradation. It negatively regulates the RIG-I RNA sensing pathway through Lys48-linked, ubiquitin-mediated degradation of the tumour necrosis factor receptor-associated factor 3 (TRAF3) adapter following RNA virus infection. It also controls ubiquitination and proteasomal degradation of receptor-interacting protein 1 (RIP1), a serine/threonine protein kinase that is critically involved in tumour necrosis factor receptor-1 (TNF-R1)-induced NF-kappa B activation, following disruption of Hsp90 binding. Moreover, RNF216 is involved in inflammatory diseases through strongly inhibiting autophagy in macrophages. It interacts with and ubiquitinates BECN1, a key regulator in autophagy, thereby contributing to BECN1 degradation. It regulates synaptic strength by ubiquitination of Arc, resulting in its rapid proteasomal degradation. It is also a key negative regulator of sustained Killer cell Ig-like receptor (KIR) with two Ig-like domains and a long cytoplasmic domain 4 (2DL4)-mediated NF-kappaB signalling from internalized 2DL4, which functions by promoting ubiquitylation and degradation of endocytosed receptor from early endosomes [, , , , , , ]. Furthermore,RNF216 interacts with HIV-1 Virion infectivity factor (Vif) protein, which is essential for the productive infection of primary human CD4 T lymphocytes and macrophages []. Mutations in RNF216 may result in Gordon Holmes syndrome, a condition defined by hypogonadotropic hypogonadism and cerebellar ataxia, as well as in autosomal recessive Huntington-like disorder [, ].RNF216 contains a RBR domain that was previously known as RING-BetweenRING-RING domain or TRIAD [two RING fingers and a DRIL (double RING finger linked)]domain. Based on current understanding of the structural biology of RBR ligases, the nomenclature of RBR has been corrected as RING-BRcat (benign-catalytic)-Rcat (required-for-catalysis) recently. The RBR (RING1-BRcat-Rcat) domain use an auto-inhibitory mechanism to modulate ubiquitination activity, as well as a hybrid mechanism that combines aspects from both RING and HECT E3 ligase function to facilitate the ubiquitination reaction.
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Publication
27629560 | J:318619
First Author: Dias MV
Year: 2016
Journal: Autophagy
Title: PRNP/prion protein regulates the secretion of exosomes modulating CAV1/caveolin-1-suppressed autophagy.
Volume: 12
Issue: 11
Pages: 2113-2128
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Publication
38387504 | J:373792
First Author: Wang L
Year: 2024
Journal: Kidney Int
Title: Disrupting circadian control of autophagy induces podocyte injury and proteinuria.
Volume: 105
Issue: 5
Pages: 1020-1034
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Publication
26782054 | J:368762
First Author: Amram N
Year: 2016
Journal: Mol Psychiatry
Title: Sexual divergence in microtubule function: the novel intranasal microtubule targeting SKIP normalizes axonal transport and enhances memory.
Volume: 21
Issue: 10
Pages: 1467-76
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Publication
30871407 | J:284821
First Author: Yang H
Year: 2019
Journal: Autophagy
Title: SIGMAR1/Sigma-1 receptor ablation impairs autophagosome clearance.
Volume: 15
Issue: 9
Pages: 1539-1557
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Publication
26389569 | J:337197
First Author: Wang HJ
Year: 2015
Journal: Autophagy
Title: Chronic HMGCR/HMG-CoA reductase inhibitor treatment contributes to dysglycemia by upregulating hepatic gluconeogenesis through autophagy induction.
Volume: 11
Issue: 11
Pages: 2089-2101
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Publication
25576084 | J:219811
First Author: Schwartz-Roberts JL
Year: 2015
Journal: Cancer Res
Title: Interferon regulatory factor-1 signaling regulates the switch between autophagy and apoptosis to determine breast cancer cell fate.
Volume: 75
Issue: 6
Pages: 1046-55
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Publication
28933590 | J:310499
First Author: Muniz-Feliciano L
Year: 2017
Journal: Autophagy
Title: RUBCN/rubicon and EGFR regulate lysosomal degradative processes in the retinal pigment epithelium (RPE) of the eye.
Volume: 13
Issue: 12
Pages: 2072-2085
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Publication
35133431 | J:325414
First Author: Li C
Year: 2022
Journal: Diabetes
Title: PACS-2 Ameliorates Tubular Injury by Facilitating Endoplasmic Reticulum-Mitochondria Contact and Mitophagy in Diabetic Nephropathy.
Volume: 71
Issue: 5
Pages: 1034-1050
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Publication
32909612 | J:301355
First Author: Masuhara K
Year: 2021
Journal: Int Immunol
Title: AMBRA1 controls antigen-driven activation and proliferation of naive T cells.
Volume: 33
Issue: 2
Pages: 107-118
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Publication
29969932 | J:308567
First Author: Li G
Year: 2018
Journal: Autophagy
Title: PTEN? regulates mitophagy and maintains mitochondrial quality control.
Volume: 14
Issue: 10
Pages: 1742-1760
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Publication
24865278 | J:215232
First Author: McMillan EM
Year: 2014
Journal: Biochem J
Title: Autophagy is required and protects against apoptosis during myoblast differentiation.
Volume: 462
Issue: 2
Pages: 267-77
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Publication
31369218 | J:285558
First Author: Fultz R
Year: 2019
Journal: Microbiologyopen
Title: Phagocytosis by macrophages depends on histamine H2 receptor signaling and scavenger receptor 1.
Volume: 8
Issue: 10
Pages: e908
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Publication
33495338 | J:302581
 
First Author: Wijshake T
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Tumor-suppressor function of Beclin 1 in breast cancer cells requires E-cadherin.
Volume: 118
Issue: 5
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Publication
26060891 | J:324319
First Author: Yuan J
Year: 2015
Journal: Autophagy
Title: MYBL2 guides autophagy suppressor VDAC2 in the developing ovary to inhibit autophagy through a complex of VDAC2-BECN1-BCL2L1 in mammals.
Volume: 11
Issue: 7
Pages: 1081-98
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Publication
26378614 | J:319195
First Author: Du TT
Year: 2015
Journal: Autophagy
Title: GBA deficiency promotes SNCA/?-synuclein accumulation through autophagic inhibition by inactivated PPP2A.
Volume: 11
Issue: 10
Pages: 1803-20
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Publication
27541856 | J:329777
First Author: Lin M
Year: 2016
Journal: Autophagy
Title: Ehrlichia secretes Etf-1 to induce autophagy and capture nutrients for its growth through RAB5 and class III phosphatidylinositol 3-kinase.
Volume: 12
Issue: 11
Pages: 2145-2166
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Publication
27459239 | J:318383
First Author: Wang J
Year: 2016
Journal: Autophagy
Title: Role for DUSP1 (dual-specificity protein phosphatase 1) in the regulation of autophagy.
Volume: 12
Issue: 10
Pages: 1791-1803
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Publication
35115927 | J:326719
 
First Author: Wu DM
Year: 2021
Journal: Front Pharmacol
Title: Autophagy Induced by Micheliolide Alleviates Acute Irradiation-Induced Intestinal Injury via Inhibition of the NLRP3 Inflammasome.
Volume: 12
Pages: 773150
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Publication
23656588 | -
First Author: Margolin DH
Year: 2013
Journal: N Engl J Med
Title: Ataxia, dementia, and hypogonadotropism caused by disordered ubiquitination.
Volume: 368
Issue: 21
Pages: 1992-2003
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Publication
15107846 | -
First Author: Chuang TH
Year: 2004
Journal: Nat Immunol
Title: Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors.
Volume: 5
Issue: 5
Pages: 495-502
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Publication
25841028 | -
First Author: Santens P
Year: 2015
Journal: Neurology
Title: RNF216 mutations as a novel cause of autosomal recessive Huntington-like disorder.
Volume: 84
Issue: 17
Pages: 1760-6
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Publication
16968706 | -
First Author: Fearns C
Year: 2006
Journal: J Biol Chem
Title: Triad3A regulates ubiquitination and proteasomal degradation of RIP1 following disruption of Hsp90 binding.
Volume: 281
Issue: 45
Pages: 34592-600
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Publication
15367624 | -
First Author: Feng F
Year: 2004
Journal: J Virol
Title: Ring finger protein ZIN interacts with human immunodeficiency virus type 1 Vif.
Volume: 78
Issue: 19
Pages: 10574-81
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Publication
11854271 | -
First Author: Chen D
Year: 2002
Journal: J Biol Chem
Title: A novel zinc finger protein interacts with receptor-interacting protein (RIP) and inhibits tumor necrosis factor (TNF)- and IL1-induced NF-kappa B activation.
Volume: 277
Issue: 18
Pages: 15985-91
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Publication
19893624 | -
First Author: Nakhaei P
Year: 2009
Journal: PLoS Pathog
Title: The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation.
Volume: 5
Issue: 11
Pages: e1000650
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Publication
21270397 | -
First Author: Miah SM
Year: 2011
Journal: J Immunol
Title: Ubiquitylation of an internalized killer cell Ig-like receptor by Triad3A disrupts sustained NF-?B signaling.
Volume: 186
Issue: 5
Pages: 2959-69
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Publication
24945773 | J:215493
First Author: Mabb AM
Year: 2014
Journal: Neuron
Title: Triad3A regulates synaptic strength by ubiquitination of Arc.
Volume: 82
Issue: 6
Pages: 1299-316
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Protein Domain
IPR060330 | RNF216_N
Type: Domain
Description: This entry represents a tri-helical domain found towards the N-terminal of E3 ubiquitin-protein ligase RNF216 (RING finger protein 216), also known as TRIAD3A. The specific function of this domain remains to be determined. The very N-terminal region contains multiple disordered regions and is subject to extensive sumoylation.E3 ubiquitin-protein ligase RNF216, also known as Triad domain-containing protein 3 (Triad3A), is a RBR-type E3 ubiquitin-protein ligase that interacts with several components of Toll-like receptor (TLR) signalling and promotes their proteolytic degradation. It negatively regulates the RIG-I RNA sensing pathway through Lys48-linked, ubiquitin-mediated degradation of the tumour necrosis factor receptor-associated factor 3 (TRAF3) adapter following RNA virus infection. It also controls ubiquitination and proteasomal degradation of receptor-interacting protein 1 (RIP1), a serine/threonine protein kinase that is critically involved in tumour necrosis factor receptor-1 (TNF-R1)-induced NF-kappa B activation, following disruption of Hsp90 binding. Moreover, RNF216 is involved in inflammatory diseases through strongly inhibiting autophagy in macrophages. It interacts with and ubiquitinates BECN1, a key regulator in autophagy, thereby contributing to BECN1 degradation. It regulates synaptic strength by ubiquitination of Arc, resulting in its rapid proteasomal degradation. It is also a key negative regulator of sustained Killer cell Ig-like receptor (KIR) with two Ig-like domains and a long cytoplasmic domain 4 (2DL4)-mediated NF-kappaB signalling from internalized 2DL4, which functions by promoting ubiquitylation and degradation of endocytosed receptor from early endosomes [, , , , , , ]. Furthermore, RNF216 interacts with HIV-1 Virion infectivity factor (Vif) protein, which is essential for the productive infection of primary human CD4 T lymphocytes and macrophages []. Mutations in RNF216 may result in Gordon Holmes syndrome, a condition defined by hypogonadotropic hypogonadism and cerebellar ataxia, as well as in autosomal recessive Huntington-like disorder [, ].RNF216 contains a RBR domain that was previously known as RING-BetweenRING-RING domain or TRIAD [two RING fingers and a DRIL (double RING finger linked)]domain. Based on current understanding of the structural biology of RBR ligases, the nomenclature of RBR has been corrected as RING-BRcat (benign-catalytic)-Rcat (required-for-catalysis) recently. The RBR (RING1-BRcat-Rcat) domain use an auto-inhibitory mechanism to modulate ubiquitination activity, as well as a hybrid mechanism that combines aspects from both RING and HECT E3 ligase function to facilitate the ubiquitination reaction.
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Protein Domain
IPR047546 | Rcat_RBR_RNF216
Type: Domain
Description: This entry represents the Rcat domain of RNF216 and similar proteins from animals and fungi. It is essential for RBR E3 ligase activity and adopts the same fold as the BRcat domain.E3 ubiquitin-protein ligase RNF216, also known as Triad domain-containing protein 3 (Triad3A), is a RBR-type E3 ubiquitin-protein ligase that interacts with several components of Toll-like receptor (TLR) signalling and promotes their proteolytic degradation. It negatively regulates the RIG-I RNA sensing pathway through Lys48-linked, ubiquitin-mediated degradation of the tumour necrosis factor receptor-associated factor 3 (TRAF3) adapter following RNA virus infection. It also controls ubiquitination and proteasomal degradation of receptor-interacting protein 1 (RIP1), a serine/threonine protein kinase that is critically involved in tumour necrosis factor receptor-1 (TNF-R1)-induced NF-kappa B activation, following disruption of Hsp90 binding. Moreover, RNF216 is involved in inflammatory diseases through strongly inhibiting autophagy in macrophages. It interacts with and ubiquitinates BECN1, a key regulator in autophagy, thereby contributing to BECN1 degradation. It regulates synaptic strength by ubiquitination of Arc, resulting in its rapid proteasomal degradation. It is also a key negative regulator of sustained Killer cell Ig-like receptor (KIR) with two Ig-like domains and a long cytoplasmic domain 4 (2DL4)-mediated NF-kappaB signalling from internalized 2DL4, which functions by promoting ubiquitylation and degradation of endocytosed receptor from early endosomes [, , , , , , ]. Furthermore, RNF216 interacts with HIV-1 Virion infectivity factor (Vif) protein, which is essential for the productive infection of primary human CD4 T lymphocytes and macrophages []. Mutations in RNF216 may result in Gordon Holmes syndrome, a condition defined by hypogonadotropic hypogonadism and cerebellar ataxia, as well as in autosomal recessive Huntington-like disorder [, ].RNF216 contains a RBR domain that was previously known as RING-BetweenRING-RING domain or TRIAD [two RING fingers and a DRIL (double RING finger linked)]domain. Based on current understanding of the structural biology of RBR ligases, the nomenclature of RBR has been corrected as RING-BRcat (benign-catalytic)-Rcat (required-for-catalysis) recently. The RBR (RING1-BRcat-Rcat) domain use an auto-inhibitory mechanism to modulate ubiquitination activity, as well as a hybrid mechanism that combines aspects from both RING and HECT E3 ligase function to facilitate the ubiquitination reaction.
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Protein Domain
IPR047545 | BRcat_RBR_RNF216
Type: Domain
Description: This entry represents the BRcat domain of RNF216 and similar proteins from animals and fungi. This domain adopts the same fold as the Rcat domain while lacking the catalytic cysteine residue and ubiquitination activity.E3 ubiquitin-protein ligase RNF216, also known as Triad domain-containing protein 3 (Triad3A), is a RBR-type E3 ubiquitin-protein ligase that interacts with several components of Toll-like receptor (TLR) signalling and promotes their proteolytic degradation. It negatively regulates the RIG-I RNA sensing pathway through Lys48-linked, ubiquitin-mediated degradation of the tumour necrosis factor receptor-associated factor 3 (TRAF3) adapter following RNA virus infection. It also controls ubiquitination and proteasomal degradation of receptor-interacting protein 1 (RIP1), a serine/threonine protein kinase that is critically involved in tumour necrosis factor receptor-1 (TNF-R1)-induced NF-kappa B activation, following disruption of Hsp90 binding. Moreover, RNF216 is involved in inflammatory diseases through strongly inhibiting autophagy in macrophages. It interacts with and ubiquitinates BECN1, a key regulator in autophagy, thereby contributing to BECN1 degradation. It regulates synaptic strength by ubiquitination of Arc, resulting in its rapid proteasomal degradation. It is also a key negative regulator of sustained Killer cell Ig-like receptor (KIR) with two Ig-like domains and a long cytoplasmic domain 4 (2DL4)-mediated NF-kappaB signalling from internalized 2DL4, which functions by promoting ubiquitylation and degradation of endocytosed receptor from early endosomes [, , , , , , ]. Furthermore, RNF216 interacts with HIV-1 Virion infectivity factor (Vif) protein, which is essential for the productive infection of primary human CD4 T lymphocytes and macrophages []. Mutations in RNF216 may result in Gordon Holmes syndrome, a condition defined by hypogonadotropic hypogonadism and cerebellar ataxia, as well as in autosomal recessive Huntington-like disorder [, ].RNF216 contains a RBR domain that was previously known as RING-BetweenRING-RING domain or TRIAD [two RING fingers and a DRIL (double RING finger linked)]domain. Based on current understanding of the structural biology of RBR ligases, the nomenclature of RBR has been corrected as RING-BRcat (benign-catalytic)-Rcat (required-for-catalysis) recently. The RBR (RING1-BRcat-Rcat) domain use an auto-inhibitory mechanism to modulate ubiquitination activity, as well as a hybrid mechanism that combines aspects from both RING and HECT E3 ligase function to facilitate the ubiquitination reaction.
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Protein Domain
IPR047544 | RING-HC_RBR_RNF216
Type: Domain
Description: This entry represents the RING domain of RNF216 and similar proteins from animals and fungi. It is a C3HC4-type RING-HC finger motif required for RBR-mediated ubiquitination.E3 ubiquitin-protein ligase RNF216, also known as Triad domain-containing protein 3 (Triad3A), is a RBR-type E3 ubiquitin-protein ligase that interacts with several components of Toll-like receptor (TLR) signalling and promotes their proteolytic degradation. It negatively regulates the RIG-I RNA sensing pathway through Lys48-linked, ubiquitin-mediated degradation of the tumour necrosis factor receptor-associated factor 3 (TRAF3) adapter following RNA virus infection. It also controls ubiquitination and proteasomal degradation of receptor-interacting protein 1 (RIP1), a serine/threonine protein kinase that is critically involved in tumour necrosis factor receptor-1 (TNF-R1)-induced NF-kappa B activation, following disruption of Hsp90 binding. Moreover, RNF216 is involved in inflammatory diseases through strongly inhibiting autophagy in macrophages. It interacts with and ubiquitinates BECN1, a key regulator in autophagy, thereby contributing to BECN1 degradation. It regulates synaptic strength by ubiquitination of Arc, resulting in its rapid proteasomal degradation. It is also a key negative regulator of sustained Killer cell Ig-like receptor (KIR) with two Ig-like domains and a long cytoplasmic domain 4 (2DL4)-mediated NF-kappaB signalling from internalized 2DL4, which functions by promoting ubiquitylation and degradation of endocytosed receptor from early endosomes [, , , , , , ]. Furthermore, RNF216 interacts with HIV-1 Virion infectivity factor (Vif) protein, which is essential for the productive infection of primary human CD4 T lymphocytes and macrophages []. Mutations in RNF216 may result in Gordon Holmes syndrome, a condition defined by hypogonadotropic hypogonadism and cerebellar ataxia, as well as in autosomal recessive Huntington-like disorder [, ].RNF216 contains a RBR domain that was previously known as RING-BetweenRING-RING domain or TRIAD [two RING fingers and a DRIL (double RING finger linked)]domain. Based on current understanding of the structural biology of RBR ligases, the nomenclature of RBR has been corrected as RING-BRcat (benign-catalytic)-Rcat (required-for-catalysis) recently. The RBR (RING1-BRcat-Rcat) domain use an auto-inhibitory mechanism to modulate ubiquitination activity, as well as a hybrid mechanism that combines aspects from both RING and HECT E3 ligase function to facilitate the ubiquitination reaction.
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Publication
23242143 | J:303226
First Author: Martinet W
Year: 2013
Journal: Autophagy
Title: Immunohistochemical analysis of macroautophagy: recommendations and limitations.
Volume: 9
Issue: 3
Pages: 386-402
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Publication
39596118 | J:361432
 
First Author: Armeli F
Year: 2024
Journal: Int J Mol Sci
Title: FAAH Inhibition Counteracts Neuroinflammation via Autophagy Recovery in AD Models.
Volume: 25
Issue: 22
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Publication
26649827 | J:228300
First Author: Kimmey JM
Year: 2015
Journal: Nature
Title: Unique role for ATG5 in neutrophil-mediated immunopathology during M. tuberculosis infection.
Volume: 528
Issue: 7583
Pages: 565-9
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Publication
34998453 | -
First Author: Cotton TR
Year: 2022
Journal: Mol Cell
Title: Structural basis of K63-ubiquitin chain formation by the Gordon-Holmes syndrome RBR E3 ubiquitin ligase RNF216.
Volume: 82
Issue: 3
Pages: 598-615.e8
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Publication
39193909 | J:371483
First Author: Zhang Z
Year: 2025
Journal: Autophagy
Title: MLKL-USP7-UBA52 signaling is indispensable for autophagy in brain through maintaining ubiquitin homeostasis.
Volume: 21
Issue: 2
Pages: 424-446
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Publication
41147487 | J:389714
First Author: S Narasimhan KK
Year: 2025
Journal: Autophagy
Title: Trans-synaptic signaling through GRID1/glutamate receptor delta-1 and CBLN1/cerebellin-1 facilitates autophagic flux in central amygdala and prevents chronic pain.
Volume: 21
Issue: 12
Pages: 3216-3239
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Publication
37908119 | J:381961
First Author: Wang H
Year: 2024
Journal: Autophagy
Title: CKLF induces microglial activation via triggering defective mitophagy and mitochondrial dysfunction.
Volume: 20
Issue: 3
Pages: 590-613
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Protein
P58283
Organism: Mus musculus/domesticus
Length: 853  
Fragment?: false
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Publication
30653446 | J:341773
First Author: Niu C
Year: 2019
Journal: Autophagy
Title: Metformin alleviates hyperglycemia-induced endothelial impairment by downregulating autophagy via the Hedgehog pathway.
Volume: 15
Issue: 5
Pages: 843-870
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