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Search results 501 to 600 out of 692 for Btk

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Type Details Score
DO Term
DOID:0060875 | isolated growth hormone deficiency type III
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Protein
A2BDW0
Organism: Mus musculus/domesticus
Length: 483  
Fragment?: false
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Allele
Tg(IGH-Btk)1Witt | MGI:3836559
Name: transgene insertion 1, Owen N Witte
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:6354564 | C57BL/6JSmoc-Btk<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Protein
Q7TMU1
Organism: Mus musculus/domesticus
Length: 659  
Fragment?: false
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Protein
P97504
Organism: Mus musculus/domesticus
Length: 651  
Fragment?: false
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Protein
P24604
Organism: Mus musculus/domesticus
Length: 630  
Fragment?: false
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Protein
Q3U436
Organism: Mus musculus/domesticus
Length: 630  
Fragment?: false
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Protein
B1AUL5
Organism: Mus musculus/domesticus
Length: 651  
Fragment?: false
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Protein
Q3TH41
Organism: Mus musculus/domesticus
Length: 608  
Fragment?: false
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Protein
B1AUL6
Organism: Mus musculus/domesticus
Length: 655  
Fragment?: false
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Protein
Q8CFK4
Organism: Mus musculus/domesticus
Length: 608  
Fragment?: false
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Allele
Tg(CD19-BTK)1Rwhe | MGI:3709187
Name: transgene insertion 1, Rudolf Hendriks
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(CAG-Btk/EGFP)4Tssk | MGI:7494260
Name: transgene insertion 4, Takehiko Sasaki
Allele Type: Transgenic
Attribute String: Inserted expressed sequence, Reporter
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Allele
Tg(CAG-Btk/EGFP)8Tssk | MGI:7494262
Name: transgene insertion 8, Takehiko Sasaki
Allele Type: Transgenic
Attribute String: Inserted expressed sequence, Reporter
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Allele
Tg(CAG-Btk/EGFP)28Tssk | MGI:7494264
Name: transgene insertion 28, Takehiko Sasaki
Allele Type: Transgenic
Attribute String: Inserted expressed sequence, Reporter
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Publication
16738337 | -
First Author: Rajaiya J
Year: 2006
Journal: Mol Cell Biol
Title: Induction of immunoglobulin heavy-chain transcription through the transcription factor Bright requires TFII-I.
Volume: 26
Issue: 12
Pages: 4758-68
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Protein
Q03526
Organism: Mus musculus/domesticus
Length: 625  
Fragment?: false
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Protein
Q5STT8
Organism: Mus musculus/domesticus
Length: 619  
Fragment?: false
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Protein
Q3U5G1
Organism: Mus musculus/domesticus
Length: 622  
Fragment?: false
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Protein
A1A560
Organism: Mus musculus/domesticus
Length: 618  
Fragment?: false
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Heritable Phenotypic Marker
MGI:96886 | Lyb3
Type: heritable_phenotypic_marker
Organism: mouse, laboratory
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Heritable Phenotypic Marker
MGI:96888 | Lyb5
Type: heritable_phenotypic_marker
Organism: mouse, laboratory
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Publication
299766 | J:5743
First Author: Huber B
Year: 1977
Journal: J Exp Med
Title: Identification of a B-cell surface structure involved in antigen-dependent triggering: absence of this structure on B cells from CBA/N mutant mice.
Volume: 145
Issue: 1
Pages: 10-20
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Publication
299767 | J:5744
First Author: Ahmed A
Year: 1977
Journal: J Exp Med
Title: B-lymphocyte heterogeneity: development and characterization of an alloantiserum which distinguishes B-lymphocyte differentiation alloantigens.
Volume: 145
Issue: 1
Pages: 101-10
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Publication
307021 | J:5989
First Author: Cone RE
Year: 1978
Journal: J Immunol
Title: Molecular identification of a surface structure on B cells (Lyb-3) and its relationship to B cell triggering.
Volume: 120
Issue: 5
Pages: 1733-40
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Publication
6218069 | J:6941
 
First Author: Kemp JD
Year: 1982
Journal: Immunol Rev
Title: Lyb3: a B cell surface antigen associated with triggering secretory differentiation.
Volume: 69
Pages: 127-40
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Publication
3080520 | J:8172
First Author: Smith HR
Year: 1986
Journal: J Immunol
Title: Evidence that Lyb-5 is a differentiation antigen in normal and xid mice.
Volume: 136
Issue: 4
Pages: 1194-200
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Allele
Mpi<Gt(OST90588)Lex> | MGI:3628756
Name: mannose phosphate isomerase; gene trap OST90588, Lexicon Genetics
Allele Type: Gene trapped
Attribute String: Null/knockout, Reporter
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Allele
Tg(CD19-BTK*Y223F)AM02Rwhe | MGI:3709258
Name: transgene insertion AM02, Rudolf Hendriks
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(CD19-BTK*K430R)XK24Rwhe | MGI:3709262
Name: transgene insertion XK24, Rudolf Hendriks
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:6144577 | C57BL/6-Tg(CAG-Btk/EGFP)4Tssk/TsskRbrc
Attribute String: mutant strain, coisogenic, transgenic
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Strain
MGI:6144578 | C57BL/6-Tg(CAG-Btk/EGFP)8Tssk/TsskRbrc
Attribute String: mutant strain, coisogenic, transgenic
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Strain
MGI:6144579 | C57BL/6-Tg(CAG-Btk/EGFP)28Tssk/TsskRbrc
Attribute String: mutant strain, coisogenic, transgenic
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Publication
20052711 | -
First Author: Marcotte DJ
Year: 2010
Journal: Protein Sci
Title: Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases.
Volume: 19
Issue: 3
Pages: 429-39
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Publication
17290574 | -
First Author: Mesci L
Year: 2006
Journal: Turk J Pediatr
Title: A novel mutation leading to a deletion in the SH3 domain of Bruton's tyrosine kinase.
Volume: 48
Issue: 4
Pages: 362-4
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Publication
11102316 | -
 
First Author: Vihinen M
Year: 2000
Journal: Front Biosci
Title: Bruton tyrosine kinase (BTK) in X-linked agammaglobulinemia (XLA).
Volume: 5
Pages: D917-28
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Publication
15944945 | -
First Author: Brunner C
Year: 2005
Journal: Histol Histopathol
Title: Bruton's Tyrosine Kinase is involved in innate and adaptive immunity.
Volume: 20
Issue: 3
Pages: 945-55
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Protein Domain
IPR035574 | BTK_SH3
Type: Domain
Description: Btk (Bruton tyrosine kinase) is a member of the Tec family, which is a group of nonreceptor tyrosine kinases containing Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. Btk also contains an N-terminal pleckstrin homology (PH) domain, which binds the products of PI3K and allows membrane recruitment and activation, and the Tec homology (TH) domain with proline-rich and zinc-binding regions [].Btk is expressed in B-cells, and a variety of myeloid cells including mast cells, platelets, neutrophils, and dendrictic cells [, ]. It interacts with a variety of partners, from cytosolic proteins to nuclear transcription factors, suggesting a diversity of functions. Stimulation of a diverse array of cell surface receptors, including antigen engagement of the B-cell receptor (BCR), leads to PH-mediated membrane translocation of Btk and subsequent phosphorylation by Src kinase and activation []. Btk plays an important role in the life cycle of B-cells including their development, differentiation, proliferation, survival, and apoptosis []. Mutations in Btk cause the primary immunodeficiency disease, X-linked agammaglobulinaemia (XLA) in humans [, ]. This entry represents the SH3 domain of Btk.
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Publication
17627988 | J:140828
First Author: Paolini C
Year: 2007
Journal: J Physiol
Title: Reorganized stores and impaired calcium handling in skeletal muscle of mice lacking calsequestrin-1.
Volume: 583
Issue: Pt 2
Pages: 767-84
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Publication
22049211 | J:180615
First Author: Tomasi M
Year: 2012
Journal: Am J Physiol Cell Physiol
Title: Calsequestrin (CASQ1) rescues function and structure of calcium release units in skeletal muscles of CASQ1-null mice.
Volume: 302
Issue: 3
Pages: C575-86
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Publication
15555549 | J:94067
First Author: Matsushita T
Year: 2004
Journal: Biochem Biophys Res Commun
Title: Targeted disruption of mouse ortholog of the human MYH9 responsible for macrothrombocytopenia with different organ involvement: hematological, nephrological, and otological studies of heterozygous KO mice.
Volume: 325
Issue: 4
Pages: 1163-71
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Allele
Myh9<Gt(Betageo-btk)1Dash> | MGI:3511350
Name: myosin, heavy polypeptide 9, non-muscle; gene trap 1, Tadashi Matsushita
Allele Type: Gene trapped
Attribute String: Null/knockout, Reporter
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Allele
Casq1<Gt(OST82566)Lex> | MGI:3530841
Name: calsequestrin 1; gene trap OST82566, Lexicon Genetics
Allele Type: Gene trapped
Attribute String: Null/knockout
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Strain
MGI:6439733 | B6;129S5-Casq1<Gt(OST82566)Lex>/Tac
Attribute String: mutant stock, gene trap
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Publication
29849896 | J:277532
 
First Author: Guarnier FA
Year: 2018
Journal: Oxid Med Cell Longev
Title: Aerobic Training Prevents Heatstrokes in Calsequestrin-1 Knockout Mice by Reducing Oxidative Stress.
Volume: 2018
Pages: 4652480
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Publication
22164205 | J:182265
First Author: Olojo RO
Year: 2011
Journal: PLoS One
Title: Mice null for calsequestrin 1 exhibit deficits in functional performance and sarcoplasmic reticulum calcium handling.
Volume: 6
Issue: 12
Pages: e27036
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Publication
19237502 | J:150541
First Author: Dainese M
Year: 2009
Journal: FASEB J
Title: Anesthetic- and heat-induced sudden death in calsequestrin-1-knockout mice.
Volume: 23
Issue: 6
Pages: 1710-20
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Publication
23148320 | J:205090
First Author: Manno C
Year: 2013
Journal: J Physiol
Title: Dynamic measurement of the calcium buffering properties of the sarcoplasmic reticulum in mouse skeletal muscle.
Volume: 591
Issue: 2
Pages: 423-42
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Publication
16339137 | J:109220
First Author: DeRossi C
Year: 2006
Journal: J Biol Chem
Title: Ablation of mouse phosphomannose isomerase (Mpi) causes mannose 6-phosphate accumulation, toxicity, and embryonic lethality.
Volume: 281
Issue: 9
Pages: 5916-27
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Genotype
Genotype
Symbol: Myh9/Myh9
Background: involves: 129X1/SvJ * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Myh9/Myh9<+>
Background: involves: 129X1/SvJ * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mpi/Mpi
Background: involves: 129S5/SvEvBrd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Casq1/Casq1
Background: involves: 129S5/SvEvBrd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Btk/Btk Tg(IGH-Btk)1Witt/?
Background: involves: 129S4/SvJae * 129X1/SvJ * BALB/c * C3H * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Btk/? Tg(IGH-Btk)1Witt/?
Background: involves: BALB/c * C3H * C57BL/6 * CBA/N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Btk/? Tg(IGH-Btk)1Witt/Tg(IGH-Btk)1Witt
Background: involves: BALB/c * C3H * C57BL/6 * CBA/N
Zygosity: cx
Has Mutant Allele: true
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Publication
312864 | J:6139
First Author: Subbarao B
Year: 1979
Journal: J Immunol
Title: Lyb-7, a new B cell alloantigen controlled by genes linked to the IgCH locus.
Volume: 122
Issue: 6
Pages: 2279-85
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Publication
6984003 | J:12052
 
First Author: Shen FW
Year: 1982
Journal: Immunol Rev
Title: Some compartments of B cell differentiation.
Volume: 69
Pages: 69-80
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Allele
Hgsnat<Gt(IST11912G1)Tigm> | MGI:4034281
Name: heparan-alpha-glucosaminide N-acetyltransferase; gene trap IST11912G1, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Attribute String: Null/knockout
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Publication
11859127 | -
First Author: Takeba Y
Year: 2002
Journal: J Immunol
Title: Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription.
Volume: 168
Issue: 5
Pages: 2365-70
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Protein Domain
IPR035870 | Txk_SH2
Type: Domain
Description: Txk is a member of the Tec protein tyrosine kinase family. It plays a role in TCR signal transduction, T cell development, and selection which is analogous to the function of Itk. Txk has been shown to interact with IFN-gamma [, ]. Unlike most of the Tec family members Txk lacks a PH domain. Instead Txk has a unique region containing a palmitoylated cysteine string which has a similar membrane tethering function as the PH domain []. This entry includes the SH2 domain of Txk.The Tec protein tyrosine kinase family includes Tec,Btk, Itk, Bmx, and Txk. They contain an NH2-terminal pleckstrin homology (PH) domain (absent in Txk), a proline-rich region, Src-homology 3 (SH3) and SH2 domains, and a COOH-terminal PTK domain. The TH domain consists of a Zn2+-binding Btk motif and a proline-rich region. The Btk motif is found in Tec kinases, Ras GAP, and IGBP and crucial to the function of the PH domain. It is not present in Txk which is not surprising since it lacks a PH domain. The type 1 splice form of the Drosophila homologue also lacks both the PH domain and the Btk motif. The proline-rich regions are highly conserved for the most part with the exception of Bmx whose residues surrounding the PXXP motif are not conserved (TH-like) and Btk29A which is entirely unique with large numbers of glycine residues (TH-extended). Tec family members all lack a C-terminal tyrosine having an autoinhibitory function in its phosphorylated state [, ].
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Publication
17177976 | -
First Author: Maruyama T
Year: 2007
Journal: Clin Exp Immunol
Title: Txk, a member of the non-receptor tyrosine kinase of the Tec family, forms a complex with poly(ADP-ribose) polymerase 1 and elongation factor 1alpha and regulates interferon-gamma gene transcription in Th1 cells.
Volume: 147
Issue: 1
Pages: 164-75
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Publication
23443569 | J:354525
 
First Author: Mosca B
Year: 2013
Journal: Nat Commun
Title: Enhanced dihydropyridine receptor calcium channel activity restores muscle strength in JP45/CASQ1 double knockout mice.
Volume: 4
Pages: 1541
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Publication
28069951 | J:240415
First Author: Manno C
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Calsequestrin depolymerizes when calcium is depleted in the sarcoplasmic reticulum of working muscle.
Volume: 114
Issue: 4
Pages: E638-E647
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Publication
24098358 | J:209040
First Author: Scorzeto M
Year: 2013
Journal: PLoS One
Title: Mitochondrial Ca2+-handling in fast skeletal muscle fibers from wild type and calsequestrin-null mice.
Volume: 8
Issue: 10
Pages: e74919
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Publication
36010545 | J:327913
 
First Author: Serano M
Year: 2022
Journal: Cells
Title: Oxygen Consumption and Basal Metabolic Rate as Markers of Susceptibility to Malignant Hyperthermia and Heat Stroke.
Volume: 11
Issue: 16
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Publication
28465322 | J:247645
First Author: Michelucci A
Year: 2017
Journal: FASEB J
Title: Strenuous exercise triggers a life-threatening response in mice susceptible to malignant hyperthermia.
Volume: 31
Issue: 8
Pages: 3649-3662
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Publication
25567323 | J:242257
First Author: Martins C
Year: 2015
Journal: Brain
Title: Neuroinflammation, mitochondrial defects and neurodegeneration in mucopolysaccharidosis III type C mouse model.
Volume: 138
Issue: Pt 2
Pages: 336-55
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Publication
31157913 | J:302267
First Author: Nagel L
Year: 2019
Journal: Histol Histopathol
Title: HGSNAT enzyme deficiency results in accumulation of heparan sulfate in podocytes and basement membranes.
Volume: 34
Issue: 12
Pages: 1377-1385
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Publication
29788236 | J:281816
First Author: Tordo J
Year: 2018
Journal: Brain
Title: A novel adeno-associated virus capsid with enhanced neurotropism corrects a lysosomal transmembrane enzyme deficiency.
Volume: 141
Issue: 7
Pages: 2014-2031
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Publication
36858249 | J:342185
 
First Author: Ludwig J
Year: 2023
Journal: Exp Eye Res
Title: Histological characterization of retinal degeneration in mucopolysaccharidosis type IIIC.
Volume: 229
Pages: 109433
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Genotype
Genotype
Symbol: Blnk/Blnk<+> Btk/Btk Tg(IGH-Btk)1Witt/?
Background: involves: 129S4/SvJae * 129X1/SvJ * BALB/c * C3H * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Publication
17383541 | -
 
First Author: Felices M
Year: 2007
Journal: Adv Immunol
Title: Tec kinases in T cell and mast cell signaling.
Volume: 93
Pages: 145-84
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Publication
20206686 | -
First Author: Bradshaw JM
Year: 2010
Journal: Cell Signal
Title: The Src, Syk, and Tec family kinases: distinct types of molecular switches.
Volume: 22
Issue: 8
Pages: 1175-84
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Publication
9382842 | -
First Author: Lockyer PJ
Year: 1997
Journal: Curr Biol
Title: Distinct subcellular localisations of the putative inositol 1,3,4,5-tetrakisphosphate receptors GAP1IP4BP and GAP1m result from the GAP1IP4BP PH domain directing plasma membrane targeting.
Volume: 7
Issue: 12
Pages: 1007-10
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Publication
25294679 | J:305893
 
First Author: Schurmans S
Year: 2015
Journal: Adv Biol Regul
Title: The Ras/Rap GTPase activating protein RASA3: from gene structure to in vivo functions.
Volume: 57
Pages: 153-61
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Protein Domain
IPR028555 | RASAL1
Type: Family
Description: GAP1 (GTPase-activating protein 1) family members include RASA2 (GAP1m), RASAL (RASAL1), GAP1(IP4BP or RASA3), and CAPRI (RASA4). They all display Ras GAP activity. With the exception of RASA2, they all possess an arginine finger-dependent GAP activity on Rap1 [, ]. They contain N-terminal tandem C2 domain repeats, a centrally located Ras-GAP domain, and a PH (pleckstrin homology) domain containing a Btk motif [].RASAL, like Ca2+ -promoted Ras inactivator (CAPRI, or RASAL4), is a cytosolic protein that undergoes a rapid translocation to the plasma membrane in response to receptor-mediated elevation in the concentration of intracellular free Ca2+, a translocation that activates its ability to function as a RasGAP. However, unlike RASAL4, RASAL undergoes an oscillatory translocation to the plasma membrane that occurs in synchrony with repetitive Ca2+ spikes. Its tandem C2 domains bind phospholipids upon an elevation in the intracellular free Ca2+ concentration ([Ca2+]i) [].
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Protein Domain
IPR037773 | RASA2_PH
Type: Domain
Description: GAP1 (GTPase-activating protein 1) family members include RASA2 (GAP1m), RASAL (RASAL1), GAP1(IP4BP or RASA3), and CAPRI (RASA4). They all display Ras GAP activity. With the exception of RASA2, they all possess an arginine finger-dependent GAP activity on Rap1 [, ]. They contain N-terminal tandem C2 domain repeats, a centrally located Ras-GAP domain, and a PH (pleckstrin homology) domain containing a Btk motif [].This entry represents the PH domain of Ras GTPase-activating protein 2 (RASA2, also known as GAP1m). The tandem C2 domains of RASA2, like those of GAP1IP4BP, do not contain the conserved C2 motif that is known to be required for calcium-dependent phospholipid binding. RASA2 is regulated by the binding of its PH domains to phophoinositides, PIP3 (phosphatidylinositol 3,4,5-trisphosphate) []. It suppresses RAS, enhancing the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, allowing control of cellular proliferation and differentiation []. RASA2 also binds to inositol 1,3,4,5-tetrakisphosphate (IP4) [].
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Protein Domain
IPR037774 | RASA3_PH
Type: Domain
Description: GAP1 (GTPase-activating protein 1) family members include RASA2 (GAP1m), RASAL (RASAL1), GAP1(IP4BP or RASA3), and CAPRI (RASA4). They all display Ras GAP activity. With the exception of RASA2, they all possess an arginine finger-dependent GAP activity on Rap1 [, ]. They contain N-terminal tandem C2 domain repeats, a centrally located Ras-GAP domain, and a PH (pleckstrin homology) domain containing a Btk motif [].This entry represents the PH domain of Ras GTPase-activating protein 3 (RASA3, also known as GAP1 or IP4BP). The RASA3 PH domain binds to phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) and I(1,3,4,5)P4 []. Its C2 domains, like those of RASA2 (GAP1M), do not contain the C2 motif that is known to be required for calcium-dependent phospholipid binding [].
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Protein Domain
IPR037777 | RASA4_PH
Type: Domain
Description: GAP1 (GTPase-activating protein 1) family members include RASA2 (GAP1m), RASAL (RASAL1), GAP1(IP4BP or RASA3), and CAPRI (RASA4). They all display Ras GAP activity. With the exception of RASA2, they all possess an arginine finger-dependent GAP activity on Rap1 [, ]. They contain N-terminal tandem C2 domain repeats, a centrally located Ras-GAP domain, and a PH (pleckstrin homology) domain containing a Btk motif [].This entry represents the PH domain of Ras GTPase-activating protein 4 (RASA4, also known as CAPRI). Both CAPRI and RASAL are calcium-activated RasGAPs that inactivate Ras at the plasma membrane. Its tandem C2 domains bind phospholipids upon an elevation in the intracellular free Ca2+ concentration ([Ca2+]i). CAPRI and RASAL differ in that CAPRI is an amplitude sensor while RASAL senses calcium oscillations [, ]. This difference between them resides not in their C2 domains, but in their PH domains leading to speculation that this might reflect an association with either phosphoinositides and/or proteins [].
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Publication
24143248 | J:209116
First Author: Yarotskyy V
Year: 2013
Journal: PLoS One
Title: Accelerated activation of SOCE current in myotubes from two mouse models of anesthetic- and heat-induced sudden death.
Volume: 8
Issue: 10
Pages: e77633
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Publication
27189940 | J:235459
First Author: Mosca B
Year: 2016
Journal: J Biol Chem
Title: Role of the JP45-Calsequestrin Complex on Calcium Entry in Slow Twitch Skeletal Muscles.
Volume: 291
Issue: 28
Pages: 14555-65
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Publication
35704026 | J:343336
 
First Author: Pan X
Year: 2022
Journal: J Exp Med
Title: Glucosamine amends CNS pathology in mucopolysaccharidosis IIIC mouse expressing misfolded HGSNAT.
Volume: 219
Issue: 8
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Genotype
Genotype
Symbol: Btk/? Tg(CD19-BTK*K430R)XK24Rwhe/?
Background: involves: 129P2/OlaHsd * C57BL/6 * FVB
Zygosity: cx
Has Mutant Allele: true
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Publication
10074452 | -
First Author: Lockyer PJ
Year: 1999
Journal: Curr Biol
Title: Identification of the ras GTPase-activating protein GAP1(m) as a phosphatidylinositol-3,4,5-trisphosphate-binding protein in vivo.
Volume: 9
Issue: 5
Pages: 265-8
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Publication
28369144 | J:248058
First Author: Gustafsson MO
Year: 2017
Journal: PLoS One
Title: ANKRD54 preferentially selects Bruton's Tyrosine Kinase (BTK) from a Human Src-Homology 3 (SH3) domain library.
Volume: 12
Issue: 4
Pages: e0174909
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Publication
17052212 | -
First Author: Yarwood S
Year: 2006
Journal: Biochem Soc Trans
Title: The GAP1 family of GTPase-activating proteins: spatial and temporal regulators of small GTPase signalling.
Volume: 34
Issue: Pt 5
Pages: 846-50
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Publication
19433443 | -
First Author: Kupzig S
Year: 2009
Journal: Mol Cell Biol
Title: The ability of GAP1IP4BP to function as a Rap1 GTPase-activating protein (GAP) requires its Ras GAP-related domain and an arginine finger rather than an asparagine thumb.
Volume: 29
Issue: 14
Pages: 3929-40
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Publication
16431904 | -
First Author: Kupzig S
Year: 2006
Journal: J Biol Chem
Title: GAP1 family members constitute bifunctional Ras and Rap GTPase-activating proteins.
Volume: 281
Issue: 15
Pages: 9891-900
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Publication
17640920 | -
First Author: Jin H
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Epigenetic silencing of a Ca(2+)-regulated Ras GTPase-activating protein RASAL defines a new mechanism of Ras activation in human cancers.
Volume: 104
Issue: 30
Pages: 12353-8
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Publication
21460216 | -
First Author: Dai Y
Year: 2011
Journal: J Biol Chem
Title: Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities.
Volume: 286
Issue: 22
Pages: 19905-16
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Publication
10339589 | J:55122
First Author: Yamadori T
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Bruton's tyrosine kinase activity is negatively regulated by Sab, the Btk-SH3 domain-binding protein.
Volume: 96
Issue: 11
Pages: 6341-6
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Publication
8777721 | J:31230
First Author: Liao XC
Year: 1995
Journal: Immunity
Title: Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk.
Volume: 3
Issue: 6
Pages: 757-69
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Publication
15304502 | J:119327
First Author: Shao Y
Year: 2004
Journal: J Biol Chem
Title: Differential regulation of the B cell receptor-mediated signaling by the E3 ubiquitin ligase Cbl.
Volume: 279
Issue: 42
Pages: 43646-53
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Publication
15539154 | J:93888
First Author: Stork B
Year: 2004
Journal: Immunity
Title: Grb2 and the non-T cell activation linker NTAL constitute a Ca(2+)-regulating signal circuit in B lymphocytes.
Volume: 21
Issue: 5
Pages: 681-91
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Publication
25646432 | J:220007
First Author: Feng M
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Macrophages eat cancer cells using their own calreticulin as a guide: roles of TLR and Btk.
Volume: 112
Issue: 7
Pages: 2145-50
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Publication
26851222 | J:299348
First Author: Guo B
Year: 2016
Journal: J Immunol
Title: RasGRP1 Is an Essential Signaling Molecule for Development of B1a Cells with Autoantigen Receptors.
Volume: 196
Issue: 6
Pages: 2583-90
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Publication
30712845 | J:271176
First Author: Yin S
Year: 2019
Journal: Cancer Cell
Title: A Murine Model of Chronic Lymphocytic Leukemia Based on B Cell-Restricted Expression of Sf3b1 Mutation and Atm Deletion.
Volume: 35
Issue: 2
Pages: 283-296.e5
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Publication
28755662 | J:259881
   
First Author: Shaheen S
Year: 2017
Journal: Elife
Title: Substrate stiffness governs the initiation of B cell activation by the concerted signaling of PKCβ and focal adhesion kinase.
Volume: 6
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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