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Search results 501 to 600 out of 1112 for Cbs

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Type Details Score
GXD Expression
GXD Expression
     
Probe: MGI:5309643
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1736222
Stage: TS22
Assay Id: MGI:5423001
Age: embryonic day 14.5
Specimen Label: MY212; Specimen EX199
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5309643
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1683322
Stage: TS22
Assay Id: MGI:5423001
Age: embryonic day 14.5
Specimen Label: MY212; Specimen EX199
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5309643
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1700022
Stage: TS22
Assay Id: MGI:5423001
Age: embryonic day 14.5
Specimen Label: MY212; Specimen EX199
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5309643
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1832122
Stage: TS22
Assay Id: MGI:5423001
Age: embryonic day 14.5
Specimen Label: MY212; Specimen EX199
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6448976
Assay Type: RNA in situ
Annotation Date: 2020-08-07
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1754720
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:6448992
Age: embryonic day 12.5
Specimen Label: 4A
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6448976
Assay Type: RNA in situ
Annotation Date: 2020-08-07
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1754723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:6448992
Age: embryonic day 15.5
Specimen Label: 4B
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
   
Probe: MGI:5309643
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876522
Stage: TS22
Assay Id: MGI:5423001
Age: embryonic day 14.5
Note: Expression was not detected in the immune system.
Specimen Label: MY212; Specimen EX199
Detected: false
Specimen Num: 1
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•
GXD Expression
GXD Expression
     
Probe: MGI:5309643
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1741222
Stage: TS22
Assay Id: MGI:5423001
Age: embryonic day 14.5
Specimen Label: MY212; Specimen EX199
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5309643
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754022
Stage: TS22
Assay Id: MGI:5423001
Age: embryonic day 14.5
Specimen Label: MY212; Specimen EX199
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:6448979
Assay Type: Immunohistochemistry
Annotation Date: 2020-08-07
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6448996
Age: postnatal month 3
Note: Weak expression was detected in neurons.
Specimen Label: 6B
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5309643
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3599822
Stage: TS22
Assay Id: MGI:5423001
Age: embryonic day 14.5
Specimen Label: MY212; Specimen EX199
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5309643
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3280922
Stage: TS22
Assay Id: MGI:5423001
Age: embryonic day 14.5
Specimen Label: MY212; Specimen EX199
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6448976
Assay Type: RNA in situ
Annotation Date: 2020-08-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280927
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:6448992
Age: postnatal day 2
Specimen Label: 4D
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
     
Probe: MGI:5309643
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1833322
Stage: TS22
Assay Id: MGI:5423001
Age: embryonic day 14.5
Specimen Label: MY212; Specimen EX199
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:6448976
Assay Type: RNA in situ
Annotation Date: 2020-08-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267121
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:6448992
Age: embryonic day 12.5
Note: Expression was detected in the vertebral bodies and arches.
Specimen Label: 3-1A/B
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:6448976
Assay Type: RNA in situ
Annotation Date: 2020-08-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3273921
Stage: TS21
Assay Id: MGI:6448992
Age: embryonic day 12.5
Specimen Label: 3-1A/B
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:5309643
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3287022
Stage: TS22
Assay Id: MGI:5423001
Age: embryonic day 14.5
Specimen Label: MY212; Specimen EX199
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5309643
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1752522
Stage: TS22
Assay Id: MGI:5423001
Age: embryonic day 14.5
Specimen Label: MY212; Specimen EX199
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:5309643
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1821522
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5423001
Age: embryonic day 14.5
Image: MY212; Specimen EX199
Specimen Label: MY212; Specimen EX199
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5309643
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3557722
Stage: TS22
Assay Id: MGI:5423001
Age: embryonic day 14.5
Specimen Label: MY212; Specimen EX199
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:6448976
Assay Type: RNA in situ
Annotation Date: 2020-08-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1801027
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:6448992
Age: postnatal day 0
Note: Expression was detected in chondroblasts of ribs.
Specimen Label: 3-1C
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:5309643
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1702122
Stage: TS22
Assay Id: MGI:5423001
Age: embryonic day 14.5
Specimen Label: MY212; Specimen EX199
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:5309643
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1756322
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5423001
Age: embryonic day 14.5
Image: MY212; Specimen EX199
Specimen Label: MY212; Specimen EX199
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5309643
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1668822
Stage: TS22
Assay Id: MGI:5423001
Age: embryonic day 14.5
Specimen Label: MY212; Specimen EX199
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6448976
Assay Type: RNA in situ
Annotation Date: 2020-08-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3273020
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:6448991
Age: embryonic day 12.5
Specimen Label: 2C
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6448976
Assay Type: RNA in situ
Annotation Date: 2020-08-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3273021
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6448991
Age: embryonic day 13.5
Specimen Label: 2D
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:6448976
Assay Type: RNA in situ
Annotation Date: 2020-08-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3273020
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:6448992
Age: embryonic day 12.5
Note: Expression was detected in pharyngolaryngeal cartilage.
Specimen Label: 2E
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6448976
Assay Type: RNA in situ
Annotation Date: 2020-08-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3273028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6448992
Age: postnatal adult
Specimen Label: not shown
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:6448976
Assay Type: RNA in situ
Annotation Date: 2020-08-07
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1608915
Pattern: Regionally restricted
Stage: TS15
Assay Id: MGI:6448991
Age: embryonic day 9.5
Note: Strongest expression was noted in brain vesicles.
Specimen Label: 2A
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:5309643
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1757722
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5423001
Age: embryonic day 14.5
Image: MY212; Specimen EX199
Specimen Label: MY212; Specimen EX199
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6448976
Assay Type: RNA in situ
Annotation Date: 2020-08-07
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1757720
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:6448992
Age: embryonic day 12.5
Specimen Label: 2E
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:6448979
Assay Type: Immunohistochemistry
Annotation Date: 2020-08-07
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1757728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6448996
Age: postnatal month 3
Note: Weak expression was detected in neurons.
Specimen Label: 6B
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5309643
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1757522
Stage: TS22
Assay Id: MGI:5423001
Age: embryonic day 14.5
Specimen Label: MY212; Specimen EX199
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5309643
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1738322
Stage: TS22
Assay Id: MGI:5423001
Age: embryonic day 14.5
Specimen Label: MY212; Specimen EX199
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5309643
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1802422
Stage: TS22
Assay Id: MGI:5423001
Age: embryonic day 14.5
Specimen Label: MY212; Specimen EX199
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6448976
Assay Type: RNA in situ
Annotation Date: 2020-08-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3567627
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:6448992
Age: postnatal day 0
Specimen Label: 3-1C
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6448976
Assay Type: RNA in situ
Annotation Date: 2020-08-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3567628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6448992
Age: postnatal adult
Specimen Label: not shown
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:6448976
Assay Type: RNA in situ
Annotation Date: 2020-08-07
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1689417
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:6448991
Age: embryonic day 10.5
Note: Strongest expression was noted in brain vesicles.
Specimen Label: 2B
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6448976
Assay Type: RNA in situ
Annotation Date: 2020-08-07
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689427
Pattern: Uniform
Stage: TS27
Assay Id: MGI:6448992
Age: postnatal day 0
Specimen Label: 4C
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
   
Probe: MGI:6448976
Assay Type: RNA in situ
Annotation Date: 2020-08-07
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6448992
Age: postnatal month 3
Specimen Label: 4F
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
   
Probe: MGI:6448979
Assay Type: Immunohistochemistry
Annotation Date: 2020-08-07
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6448996
Age: postnatal month 3
Specimen Label: 6B
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6448979
Assay Type: Immunohistochemistry
Annotation Date: 2020-08-07
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3521728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6448996
Age: postnatal month 3
Specimen Label: 6D
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:5309643
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1768022
Stage: TS22
Assay Id: MGI:5423001
Age: embryonic day 14.5
Note: Expression was not detected in the skull (base and vault).
Specimen Label: MY212; Specimen EX199
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5309643
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2672022
Stage: TS22
Assay Id: MGI:5423001
Age: embryonic day 14.5
Note: Expression was not detected in whisker follicle.
Specimen Label: MY212; Specimen EX199
Detected: false
Specimen Num: 1
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Allele
Cbs<tm1Unc> | MGI:1857139
Name: cystathionine beta-synthase; targeted mutation 1, University of North Carolina
Allele Type: Targeted
Attribute String: Null/knockout
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Protein Domain
IPR000644 | CBS_dom
Type: Domain
Description: CBS domains are evolutionarily conserved structural domains found in a variety of non functionally-related proteins from all kingdoms of life. These domains pair together to form a intramolecular dimeric structure (CBS pair), termed Bateman domain [, , , ]. CBS domains have been shown to bind mainly ligands with an adenosyl group such as AMP, ATP and S-AdoMet, but may also bind metal ions, or nucleic acids [, ]. Hence, they play an essential role in the regulation of the activities of numerous proteins, and mutations in them are associated with several hereditary diseases [, , ]. CBS domains are found attached to a wide range of other protein domains suggesting that CBS domains may play a regulatory role making proteins sensitive to adenosyl-carrying ligands. The region containing the CBS domains in cystathionine-beta synthase is involved in regulation by S-AdoMet []. CBS domain pairs from AMPK bind AMP or ATP []. The CBS domains from IMPDH, which bind ATP, have shown to have a role in the regulation of adenylate nucleotide synthesis [, ].
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Publication
2329008 | J:10449
First Author: Locker J
Year: 1990
Journal: Immunogenetics
Title: The rat MHC and cystathionine beta-synthase gene are syntenic on chromosome 20.
Volume: 31
Issue: 4
Pages: 271-4
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Publication
19158324 | J:146959
First Author: Li S
Year: 2009
Journal: Am J Physiol Endocrinol Metab
Title: Regulation of homocysteine homeostasis through the transcriptional coactivator PGC-1alpha.
Volume: 296
Issue: 3
Pages: E543-8
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Publication
30753104 | J:287221
First Author: Partearroyo T
Year: 2019
Journal: FASEB J
Title: Betaine-homocysteine S-methyltransferase deficiency causes increased susceptibility to noise-induced hearing loss associated with plasma hyperhomocysteinemia.
Volume: 33
Issue: 5
Pages: 5942-5956
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Publication
17937387 | J:147857
First Author: Liu SP
Year: 2007
Journal: Hepatology
Title: Glycine N-methyltransferase-/- mice develop chronic hepatitis and glycogen storage disease in the liver.
Volume: 46
Issue: 5
Pages: 1413-25
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Publication
26166573 | J:224837
First Author: Dutchak PA
Year: 2015
Journal: Cell Rep
Title: Regulation of Hematopoiesis and Methionine Homeostasis by mTORC1 Inhibitor NPRL2.
Volume: 12
Issue: 3
Pages: 371-9
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Publication
11707078 | J:69673
First Author: Davisson MT
Year: 2001
Journal: Genomics
Title: Evolutionary breakpoints on human chromosome 21.
Volume: 78
Issue: 1-2
Pages: 99-106
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Publication
34702858 | J:312368
First Author: Imbard A
Year: 2021
Journal: Sci Rep
Title: Liver and brain differential expression of one-carbon metabolism genes during ontogenesis.
Volume: 11
Issue: 1
Pages: 21132
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Publication
30938680 | J:274697
   
First Author: Celaya AM
Year: 2019
Journal: Elife
Title: Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss.
Volume: 8
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Publication
12466855 | J:80501
First Author: Gitton Y
Year: 2002
Journal: Nature
Title: A gene expression map of human chromosome 21 orthologues in the mouse.
Volume: 420
Issue: 6915
Pages: 586-90
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Publication
12466854 | J:80502
First Author: Reymond A
Year: 2002
Journal: Nature
Title: Human chromosome 21 gene expression atlas in the mouse.
Volume: 420
Issue: 6915
Pages: 582-6
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Publication
24154525 | J:205051
First Author: Miller JA
Year: 2013
Journal: Development
Title: Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates.
Volume: 140
Issue: 22
Pages: 4633-44
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Publication
- | J:77000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
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Publication
- | J:66660
       
First Author: Mouse Genome Database and National Center for Biotechnology Information Editorial Staff Collaboration
Year: 2001
Title: LocusLink Collaboration
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
14681479 | J:122989
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Protein Domain
IPR016761 | UCP019454_CBS
Type: Family
Description: This group represents an uncharacterised protein with two CBS domains.
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Publication
14722619 | -
First Author: Scott JW
Year: 2004
Journal: J Clin Invest
Title: CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations.
Volume: 113
Issue: 2
Pages: 274-84
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Protein Domain
IPR017158 | Tscrpt-reg_CBS-contain_prd
Type: Family
Description: This entry represents a family of predicted transcriptional regulators, which contain CBS domains.
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Protein Domain
IPR044729 | CBS_bac
Type: Domain
Description: CBS domains are evolutionarily conserved structural domains found in a variety of non functionally-related proteins from all kingdoms of life. These domains pair together to form a intramolecular dimeric structure (CBS pair), termed Bateman domain [, , , ]. CBS domains have been shown to bind mainly ligands with an adenosyl group such as AMP, ATP and S-AdoMet, but may also bind metal ions, or nucleic acids [, ]. Hence, they play an essential role in the regulation of the activities of numerous proteins, and mutations in them are associated with several hereditary diseases [, , ]. CBS domains are found attached to a wide range of other protein domains suggesting that CBS domains may play a regulatory role making proteins sensitive to adenosyl-carrying ligands. The region containing the CBS domains in cystathionine-beta synthase is involved in regulation by S-AdoMet []. CBS domain pairs from AMPK bind AMP or ATP []. The CBS domains from IMPDH, which bind ATP, have shown to have a role in the regulation of adenylate nucleotide synthesis [, ].This entry represents a group of uncharacterised bacterial proteins containing a pair of CBS domains.
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Protein
F6RJZ6
Organism: Mus musculus/domesticus
Length: 73  
Fragment?: true
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Protein Domain
IPR046342 | CBS_dom_sf
Type: Homologous_superfamily
Description: CBS domains are evolutionarily conserved structural domains found in a variety of non functionally-related proteins from all kingdoms of life. These domains pair together to form a intramolecular dimeric structure (CBS pair), termed Bateman domain [, , , ]. CBS domains have been shown to bind mainly ligands with an adenosyl group such as AMP, ATP and S-AdoMet, but may also bind metal ions, or nucleic acids [, ]. Hence, they play an essential role in the regulation of the activities of numerous proteins, and mutations in them are associated with several hereditary diseases [, , ]. CBS domains are found attached to a wide range of other protein domains suggesting that CBS domains may play a regulatory role making proteins sensitive to adenosyl-carrying ligands. The region containing the CBS domains in cystathionine-beta synthase is involved in regulation by S-AdoMet []. CBS domain pairs from AMPK bind AMP or ATP []. The CBS domains from IMPDH, which bind ATP, have shown to have a role in the regulation of adenylate nucleotide synthesis [, ].
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Publication
10531273 | -
First Author: Radulovic S
Year: 1999
Journal: Infect Immun
Title: Identification and molecular analysis of the gene encoding Rickettsia typhi hemolysin.
Volume: 67
Issue: 11
Pages: 6104-8
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Protein Domain
IPR044751 | Ion_transp-like_CBS
Type: Domain
Description: This CBS domain is found associated with CorC_HlyC domain and/or CNNM domain, domains that are related to metal ion transport. This domain consists of a CBS pair which is thought to play a regulatory role, although its exact function is not clear. This domain is found in highly conserved proteins that either have unknown function or are predicted to be hemolysins, exotoxins involved in lysis of red blood cells in vitro [].
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Publication
26276391 | J:264470
First Author: Nakatsu Y
Year: 2015
Journal: J Biol Chem
Title: Prolyl isomerase Pin1 negatively regulates AMP-activated protein kinase (AMPK) by associating with the CBS domain in the γ subunit.
Volume: 290
Issue: 40
Pages: 24255-66
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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