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Search results 501 to 547 out of 547 for Ccl5

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Type

Details

Score

Publication

32238474 | J:328906

First Author:	Viau A
Year:	2020
Journal:	J Am Soc Nephrol
Title:	Tubular STAT3 Limits Renal Inflammation in Autosomal Dominant Polycystic Kidney Disease.
Volume:	31
Issue:	5
Pages:	1035-1049

•

Publication

30778357 | J:284587

First Author:	Teschner D
Year:	2019
Journal:	Front Immunol
Title:	CD11b Regulates Fungal Outgrowth but Not Neutrophil Recruitment in a Mouse Model of Invasive Pulmonary Aspergillosis.
Volume:	10

Pages:	123

•

Publication

39234670 | J:360257

First Author:	Polizio AH
Year:	2024
Journal:	Circ Res
Title:	Experimental TET2 Clonal Hematopoiesis Predisposes to Renal Hypertension Through an Inflammasome-Mediated Mechanism.
Volume:	135
Issue:	9
Pages:	933-950

•

Publication

18056919 | J:128946

First Author:	Penido C
Year:	2008
Journal:	Int Immunol
Title:	Involvement of CC chemokines in gammadelta T lymphocyte trafficking during allergic inflammation: the role of CCL2/CCR2 pathway.
Volume:	20
Issue:	1
Pages:	129-39

•

Publication

18308304 | J:135650

First Author:	Ross RJ
Year:	2008
Journal:	Exp Eye Res
Title:	Immunological protein expression profile in Ccl2/Cx3cr1 deficient mice with lesions similar to age-related macular degeneration.
Volume:	86
Issue:	4
Pages:	675-83

•

Publication

23991011 | J:206420

First Author:	Lazarski CA
Year:	2013
Journal:	PLoS One
Title:	IL-4 attenuates Th1-associated chemokine expression and Th1 trafficking to inflamed tissues and limits pathogen clearance.
Volume:	8
Issue:	8
Pages:	e71949

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Publication

24361484 | J:215418

First Author:	Zeng-Brouwers J
Year:	2014
Journal:	Matrix Biol
Title:	De novo expression of circulating biglycan evokes an innate inflammatory tissue response via MyD88/TRIF pathways.
Volume:	35

Pages:	132-42

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Publication

29445379 | J:311186

First Author:	Egarnes B
Year:	2018
Journal:	Front Immunol
Title:	Contribution of Regulatory T Cells in Nucleotide-Binding Oligomerization Domain 2 Response to Influenza Virus Infection.
Volume:	9

Pages:	132

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Publication

37871404 | J:342373

First Author:	Saenz-Pipaon G
Year:	2023
Journal:	Atherosclerosis
Title:	Role of LCN2 in a murine model of hindlimb ischemia and in peripheral artery disease patients, and its potential regulation by miR-138-5P.
Volume:	385

Pages:	117343

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Publication

19560465 | J:356591

First Author:	Zhou W
Year:	2009
Journal:	Gastroenterology
Title:	FoxO4 inhibits NF-kappaB and protects mice against colonic injury and inflammation.
Volume:	137
Issue:	4
Pages:	1403-14

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Publication

21270150 | J:343106

First Author:	Stubblefield Park SR
Year:	2011
Journal:	J Virol
Title:	T cell-, interleukin-12-, and gamma interferon-driven viral clearance in measles virus-infected brain tissue.
Volume:	85
Issue:	7
Pages:	3664-76

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Publication

9625760 | -

First Author:	Cole KE
Year:	1998
Journal:	J Exp Med
Title:	Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3.
Volume:	187
Issue:	12
Pages:	2009-21

•

Publication

9660793 | -

First Author:	Weng Y
Year:	1998
Journal:	J Biol Chem
Title:	Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors.
Volume:	273
Issue:	29
Pages:	18288-91

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Publication

9064356 | -

First Author:	Loetscher M
Year:	1996
Journal:	J Exp Med
Title:	Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes.
Volume:	184
Issue:	3
Pages:	963-9

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Publication

11310833 | -

First Author:	García-López MA
Year:	2001
Journal:	Lab Invest
Title:	CXCR3 chemokine receptor distribution in normal and inflamed tissues: expression on activated lymphocytes, endothelial cells, and dendritic cells.
Volume:	81
Issue:	3
Pages:	409-18

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Publication

12173928 | -

First Author:	Booth V
Year:	2002
Journal:	Biochemistry
Title:	The CXCR3 binding chemokine IP-10/CXCL10: structure and receptor interactions.
Volume:	41
Issue:	33
Pages:	10418-25

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Publication

10233762 | -

First Author:	Tensen CP
Year:	1999
Journal:	J Invest Dermatol
Title:	Human IP-9: A keratinocyte-derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3).
Volume:	112
Issue:	5
Pages:	716-22

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Publication

12750173 | -

First Author:	Smit MJ
Year:	2003
Journal:	Blood
Title:	CXCR3-mediated chemotaxis of human T cells is regulated by a Gi- and phospholipase C-dependent pathway and not via activation of MEK/p44/p42 MAPK nor Akt/PI-3 kinase.
Volume:	102
Issue:	6
Pages:	1959-65

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Publication

11085753 | J:65916

First Author:	Hancock WW
Year:	2000
Journal:	J Exp Med
Title:	Requirement of the chemokine receptor CXCR3 for acute allograft rejection.
Volume:	192
Issue:	10
Pages:	1515-20

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Publication

10525042 | -

First Author:	Mach F
Year:	1999
Journal:	J Clin Invest
Title:	Differential expression of three T lymphocyte-activating CXC chemokines by human atheroma-associated cells.
Volume:	104
Issue:	8
Pages:	1041-50

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Publication

15254596 | J:91359

First Author:	Jiang D
Year:	2004
Journal:	J Clin Invest
Title:	Regulation of pulmonary fibrosis by chemokine receptor CXCR3.
Volume:	114
Issue:	2
Pages:	291-9

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Publication

12415259 | J:132575

First Author:	Frigerio S
Year:	2002
Journal:	Nat Med
Title:	Beta cells are responsible for CXCR3-mediated T-cell infiltration in insulitis.
Volume:	8
Issue:	12
Pages:	1414-20

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Publication

17538187 | J:153194

First Author:	Panzer U
Year:	2007
Journal:	J Am Soc Nephrol
Title:	Chemokine receptor CXCR3 mediates T cell recruitment and tissue injury in nephrotoxic nephritis in mice.
Volume:	18
Issue:	7
Pages:	2071-84

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Publication

9466968 | -

First Author:	Qin S
Year:	1998
Journal:	J Clin Invest
Title:	The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions.
Volume:	101
Issue:	4
Pages:	746-54

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Publication

16127166 | -

First Author:	Curbishley SM
Year:	2005
Journal:	Am J Pathol
Title:	CXCR 3 activation promotes lymphocyte transendothelial migration across human hepatic endothelium under fluid flow.
Volume:	167
Issue:	3
Pages:	887-99

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Publication

10605606 | -

First Author:	Loetscher P
Year:	2000
Journal:	Adv Immunol
Title:	Chemokines and their receptors in lymphocyte traffic and HIV infection.
Volume:	74

Pages:	127-80

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Publication

9987599 | -

First Author:	Zlotnik A
Year:	1999
Journal:	Crit Rev Immunol
Title:	Recent advances in chemokines and chemokine receptors.
Volume:	19
Issue:	1
Pages:	1-47

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Publication

17600132 | J:123926

First Author:	Yates CC
Year:	2007
Journal:	Am J Pathol
Title:	Delayed and deficient dermal maturation in mice lacking the CXCR3 ELR-negative CXC chemokine receptor.
Volume:	171
Issue:	2
Pages:	484-95

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Publication

12884299 | -

First Author:	Xanthou G
Year:	2003
Journal:	Eur J Immunol
Title:	CCR3 functional responses are regulated by both CXCR3 and its ligands CXCL9, CXCL10 and CXCL11.
Volume:	33
Issue:	8
Pages:	2241-50

•

Protein Domain

IPR004070 | Chemokine_CXCR3

Type:

Family

Description:

Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions, and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to play a much broader biological role []. They have a wide range of effects in many different cell types beyond the immune system, including, for example, various cells of the central nervous system [], and endothelial cells, where they may act as either angiogenic or angiostatic factors [].The chemokine family is divided into four classes based on the number and spacing of their conserved cysteines: 2 Cys residues may be adjacent (the CC family); separated by an intervening residue (the CXC family); have only one of the first two Cys residues (C chemokines); or contain both cysteines, separated by three intervening residues (CX3C chemokines).Chemokines exert their effects by binding to rhodopsin-like G protein-coupled receptors on the surface of cells. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium ions, which cause a cellular response, including the onset of chemotaxis. There are over fifty distinct chemokines and least 18 human chemokine receptors []. Although the receptors bind only a single class of chemokines, they often bind several members of the same class with high affinity. Chemokine receptors are preferentially expressed on important functional subsets of dendritic cells, monocytes and lymphocytes, including Langerhans cells and T helper cells [, ]. Chemokines and their receptors can also be subclassified into homeostatic leukocyte homing molecules (CXCR4, CXCR5, CCR7, CCR9) versus inflammatory/inducible molecules (CXCR1, CXCR2, CXCR3, CCR1-6, CX3CR1).The CXC chemokine receptors are a subfamily of chemokine receptors that specifically bind and respond to cytokines of the CXC chemokine family. There are currently seven known CXC chemokine receptors in mammals, CXCR1 through to CXCR7.This entry represents CXCR3, which is expressed in natural killer cells and activated T lymphocytes but not in resting T lymphocytes, B lymphocytes, monocytes or granulocytes [, ]. CXCR3 also appears to be constitutively expressed on endothelial cells of medium and large blood vessels []. CXCR3 is able to regulate leukocyte trafficking and binding to various chemokines inducing various cellular responses, most notably integrin activation, cytoskeletal changes and chemotactic migration [, , , ]. The main role of CXCR3 is the selective recruitment of effector T cells in both normal tissues and inflammation []and it is involved in a number of T cell-mediated inflammatory diseases, such as autoimmune diseases, delayed-type hypersensitivity responses, certain viral diseases and acute transplant rejection []. It has been implicated in atherosclerosis [], pulmonary fibrosis [], type 1 diabetes []and nephrotoxic nephritis [], and has been implicated in wound healing [].CXCR3 is the receptor for CXCL9 (Mig), CXCL10 (IP10) and CXCL11 (I-TAC), [, , , ], which are upregulated in response to interferon-gamma and are potent chemoattractants for activated T cells [, ]. All three chemokines elicit an increase in intracellular Ca2+ levels and activate phosphoinositide 3-kinase and mitogen-activated protein kinase (MAPK) []. CXCR3 is also capable of binding a number of CC chemokines with moderate affinity, including CCL11 (eotaxin), CCL13, CCL20, CCL7, CCL5 []. However, it has been reported that CCL11, despite binding with high affinity, may be neither an agonist or an antagonist of the CXCR3 receptor, but sequesters available CCL11 resulting in a lowered response at other receptors [].

•

Publication

29813086 | J:263298

First Author:	Jehle J
Year:	2018
Journal:	PLoS One
Title:	Elevated levels of 2-arachidonoylglycerol promote atherogenesis in ApoE-/- mice.
Volume:	13
Issue:	5
Pages:	e0197751

•

Publication

28434702 | J:317103

First Author:	Xuan H
Year:	2018
Journal:	J Vasc Surg
Title:	Inhibition or deletion of angiotensin II type 1 receptor suppresses elastase-induced experimental abdominal aortic aneurysms.
Volume:	67
Issue:	2
Pages:	573-584.e2

•

Publication

24574405 | J:214429

First Author:	Reynaud JM
Year:	2014
Journal:	J Virol
Title:	Human herpesvirus 6A infection in CD46 transgenic mice: viral persistence in the brain and increased production of proinflammatory chemokines via Toll-like receptor 9.
Volume:	88
Issue:	10
Pages:	5421-36

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Publication

32508844 | J:305735

First Author:	Joly-Amado A
Year:	2020
Journal:	Front Immunol
Title:	CCL2 Overexpression in the Brain Promotes Glial Activation and Accelerates Tau Pathology in a Mouse Model of Tauopathy.
Volume:	11

Pages:	997

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Publication

28886701 | J:277535

First Author:	Ellman DG
Year:	2017
Journal:	BMC Neurosci
Title:	The loss-of-function disease-mutation G301R in the Na⁺/K⁺-ATPase α₂ isoform decreases lesion volume and improves functional outcome after acute spinal cord injury in mice.
Volume:	18
Issue:	1
Pages:	66

•

Publication

34935438 | J:334875

First Author:	Olivarria GM
Year:	2022
Journal:	J Virol
Title:	Microglia Do Not Restrict SARS-CoV-2 Replication following Infection of the Central Nervous System of K18-Human ACE2 Transgenic Mice.
Volume:	96
Issue:	4
Pages:	e0196921

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Protein

P51682

Organism:	Mus musculus/domesticus
Length:	354
Fragment?:	false

•

Protein

Q3TDA4

Organism:	Mus musculus/domesticus
Length:	354
Fragment?:	false

•

Publication

10699158 | -

First Author:	Murphy PM
Year:	2000
Journal:	Pharmacol Rev
Title:	International union of pharmacology. XXII. Nomenclature for chemokine receptors.
Volume:	52
Issue:	1
Pages:	145-76

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Protein

O88410

Organism:	Mus musculus/domesticus
Length:	367
Fragment?:	false

•

Publication

9269754 | -

First Author:	Ayehunie S
Year:	1997
Journal:	Blood
Title:	Human immunodeficiency virus-1 entry into purified blood dendritic cells through CC and CXC chemokine coreceptors.
Volume:	90
Issue:	4
Pages:	1379-86

•

Publication

9689100 | J:49070

First Author:	Ma Q
Year:	1998
Journal:	Proc Natl Acad Sci U S A
Title:	Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice.
Volume:	95
Issue:	16
Pages:	9448-53

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Publication

11544102 | -

First Author:	Horuk R
Year:	2001
Journal:	Cytokine Growth Factor Rev
Title:	Chemokine receptors.
Volume:	12
Issue:	4
Pages:	313-35

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Publication

10601351 | -

First Author:	Charbonnier AS
Year:	1999
Journal:	J Exp Med
Title:	Macrophage inflammatory protein 3alpha is involved in the constitutive trafficking of epidermal langerhans cells.
Volume:	190
Issue:	12
Pages:	1755-68

•

Publication

9500790 | -

First Author:	Sallusto F
Year:	1998
Journal:	J Exp Med
Title:	Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes.
Volume:	187
Issue:	6
Pages:	875-83

•

Publication

7592998 | -

First Author:	Strieter RM
Year:	1995
Journal:	J Biol Chem
Title:	The functional role of the ELR motif in CXC chemokine-mediated angiogenesis.
Volume:	270
Issue:	45
Pages:	27348-57

•

Publication

10714678 | -

First Author:	Zlotnik A
Year:	2000
Journal:	Immunity
Title:	Chemokines: a new classification system and their role in immunity.
Volume:	12
Issue:	2
Pages:	121-7

•

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