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Search results 501 to 600 out of 841 for Cd80

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Type Details Score
Publication
12055251 | J:123794
First Author: Ekkens MJ
Year: 2002
Journal: J Immunol
Title: Memory Th2 effector cells can develop in the absence of B7-1/B7-2, CD28 interactions, and effector Th cells after priming with an intestinal nematode parasite.
Volume: 168
Issue: 12
Pages: 6344-51
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Publication
24387268 | J:209407
First Author: Fuchs YF
Year: 2014
Journal: Clin Exp Immunol
Title: IGRP and insulin vaccination induce CD8+ T cell-mediated autoimmune diabetes in the RIP-CD80GP mouse.
Volume: 176
Issue: 2
Pages: 199-206
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Genotype
Genotype
Symbol: Cd86/Cd86 Icos/Icos
Background: involves: 129S1/Sv * 129S4/SvJaeSor
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Ins1-Cd80)378Psoh/? Tg(Ins2-GP)#Psoh/?
Background: involves: C57BL/6 * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Publication
18845758 | J:140085
First Author: Wing K
Year: 2008
Journal: Science
Title: CTLA-4 control over Foxp3+ regulatory T cell function.
Volume: 322
Issue: 5899
Pages: 271-5
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Publication
22585713 | J:187765
First Author: Moita CF
Year: 2012
Journal: Eur J Immunol
Title: RNAi screen for kinases and phosphatases that play a role in antigen presentation by dendritic cells.
Volume: 42
Issue: 7
Pages: 1843-9
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Publication
10661405 | -
First Author: Ikemizu S
Year: 2000
Journal: Immunity
Title: Structure and dimerization of a soluble form of B7-1.
Volume: 12
Issue: 1
Pages: 51-60
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Publication
11279502 | -
First Author: Stamper CC
Year: 2001
Journal: Nature
Title: Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses.
Volume: 410
Issue: 6828
Pages: 608-11
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Protein Domain
IPR042711 | CD80_IgV
Type: Domain
Description: Glycoproteins B7-1 (CD80) and B7-2 (CD86) are expressed on antigen-presenting cells and deliver the co-stimulatory signal through CD28 and CTLA-4 (CD152) on T cells. Signalling through CD28 augments the T-cell response, whereas CTLA-4 signalling attenuates it []. CD80 contains two Ig-like domains, an amino-terminal immunoglobulin variable (IgV)-like domain characteristic of adhesion molecules and a membrane proximal immunoglobulin constant (IgC)-like domain similar to the constant domains of antigen receptors []. Members of the Ig family are components of immunoglobulin, T-cell receptors, CD1 cell surface glycoproteins, secretory glycoproteins A/C, and Major Histocompatibility Complex (MHC) class I/II molecules. In immunoglobulins, each chain is composed of one variable domain (IgV) and one or more IgC domains. These names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. The IgV domain is responsible for antigen binding, and the IgC domain is involved in oligomerization and molecular interactions [, ].
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Protein Domain
IPR037676 | CD80_IgC
Type: Domain
Description: Glycoproteins B7-1 (CD80) and B7-2 (CD86) are expressed on antigen-presenting cells and deliver the co-stimulatory signal through CD28 and CTLA-4 (CD152) on T cells. Signalling through CD28 augments the T-cell response, whereas CTLA-4 signalling attenuates it []. CD80 contains two Ig-like domains, an amino-terminal immunoglobulin variable (IgV)-like domain characteristic of adhesion molecules and a membrane proximal immunoglobulin constant (IgC)-like domain similar to the constant domains of antigen receptors []. Members of the Ig family are components of immunoglobulin, T-cell receptors, CD1 cell surface glycoproteins, secretory glycoproteins A/C, and Major Histocompatibility Complex (MHC) class I/II molecules. In immunoglobulins, each chain is composed of one variable domain (IgV) and one or more IgC domains. These names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. The IgV domain is responsible for antigen binding, and the IgC domain is involved in oligomerization and molecular interactions [, ].
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Publication
9541533 | -
First Author: Halaby DM
Year: 1998
Journal: J Mol Evol
Title: The immunoglobulin superfamily: an insight on its tissular, species, and functional diversity.
Volume: 46
Issue: 4
Pages: 389-400
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Protein Domain
IPR013162 | CD80_C2-set
Type: Domain
Description: The basic structure of immunoglobulin (Ig) molecules is a tetramer of two light chains and two heavy chains linked by disulphide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains: alpha, delta, epsilon, gamma and mu, all consisting of a variable domain (VH) and three (in alpha, delta and gamma) or four (in epsilon and mu) constant domains (CH1 to CH4). Ig molecules are highly modular proteins, in which the variable and constant domains have clear, conserved sequence patterns. The domains in Ig and Ig-like molecules are grouped into four types: V-set (variable; ), C1-set (constant-1; ), C2-set (constant-2; ) and I-set (intermediate; ) []. Structural studies have shown that these domains share a common core Greek-key β-sandwich structure, with the types differing in the number of strands in the β-sheets as well as in their sequence patterns [, ].Immunoglobulin-like domains that are related in both sequence and structure can be found in several diverse protein families. Ig-like domains are involved in a variety of functions, including cell-cell recognition, cell-surface receptors, muscle structure and the immune system []. This entry represents the C2-set type domains found in the T-cell antigen CD80, as well as in related proteins. CD80 (B7-1) is a glycoprotein expressed on antigen-presenting cells []. The shared ligands on CD80 and CD86 (B7-2) deliver the co-stimulatory signal through CD28 and CTLA-4 on T-cells, where CD28 augments the T-cell response and CTLA-4 attenuates it [].
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Publication
15294937 | J:92731
First Author: Zheng X
Year: 2004
Journal: J Immunol
Title: B7-CD28 interaction promotes proliferation and survival but suppresses differentiation of CD4-CD8- T cells in the thymus.
Volume: 173
Issue: 4
Pages: 2253-61
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Publication
17615584 | J:123542
First Author: Karges W
Year: 2007
Journal: Eur J Immunol
Title: The diabetogenic, insulin-specific CD8 T cell response primed in the experimental autoimmune diabetes model in RIP-B7.1 mice.
Volume: 37
Issue: 8
Pages: 2097-103
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Publication
23108101 | J:193764
First Author: Seah SG
Year: 2013
Journal: J Leukoc Biol
Title: Influenza-induced, helper-independent CD8+ T cell responses use CD40 costimulation at the late phase of the primary response.
Volume: 93
Issue: 1
Pages: 145-54
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Publication
15128777 | J:89867
First Author: Terme M
Year: 2004
Journal: J Immunol
Title: IL-4 confers NK stimulatory capacity to murine dendritic cells: a signaling pathway involving KARAP/DAP12-triggering receptor expressed on myeloid cell 2 molecules.
Volume: 172
Issue: 10
Pages: 5957-66
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Publication
15972646 | J:100564
First Author: van Berkel ME
Year: 2005
Journal: J Immunol
Title: ICOS contributes to T cell expansion in CTLA-4 deficient mice.
Volume: 175
Issue: 1
Pages: 182-8
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Publication
9892625 | J:76908
First Author: Mandelbrot DA
Year: 1999
Journal: J Exp Med
Title: B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4).
Volume: 189
Issue: 2
Pages: 435-40
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Publication
17785819 | J:152043
First Author: Liu Q
Year: 2007
Journal: J Immunol
Title: The role of B cells in the development of CD4 effector T cells during a polarized Th2 immune response.
Volume: 179
Issue: 6
Pages: 3821-30
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Publication
7512724 | J:209714
First Author: Harlan DM
Year: 1994
Journal: Proc Natl Acad Sci U S A
Title: Mice expressing both B7-1 and viral glycoprotein on pancreatic beta cells along with glycoprotein-specific transgenic T cells develop diabetes due to a breakdown of T-lymphocyte unresponsiveness.
Volume: 91
Issue: 8
Pages: 3137-41
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Genotype
Genotype
Symbol: Tg(Ins1-Cd80)378Psoh/? Tg(Ins2-GP)#Psoh/? Tg(TcrLCMV)327Sdz/?
Background: involves: C57BL/6 * DBA/2 * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Publication
18835195 | J:141441
First Author: Hao Z
Year: 2008
Journal: Immunity
Title: Fas receptor expression in germinal-center B cells is essential for T and B lymphocyte homeostasis.
Volume: 29
Issue: 4
Pages: 615-27
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Publication
31112530 | J:337611
First Author: Sivaram N
Year: 2019
Journal: J Clin Invest
Title: Tumor-intrinsic PIK3CA represses tumor immunogenecity in a model of pancreatic cancer.
Volume: 129
Issue: 8
Pages: 3264-3276
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Publication
16771859 | J:111948
First Author: Oderup C
Year: 2006
Journal: Immunology
Title: Cytotoxic T lymphocyte antigen-4-dependent down-modulation of costimulatory molecules on dendritic cells in CD4+ CD25+ regulatory T-cell-mediated suppression.
Volume: 118
Issue: 2
Pages: 240-9
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Publication
20870175 | J:164647
First Author: Yokosuka T
Year: 2010
Journal: Immunity
Title: Spatiotemporal basis of CTLA-4 costimulatory molecule-mediated negative regulation of T cell activation.
Volume: 33
Issue: 3
Pages: 326-39
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Publication
18097026 | J:130895
First Author: Shalev I
Year: 2008
Journal: J Immunol
Title: Targeted deletion of fgl2 leads to impaired regulatory T cell activity and development of autoimmune glomerulonephritis.
Volume: 180
Issue: 1
Pages: 249-60
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Publication
36073543 | J:334209
 
First Author: Moore C
Year: 2022
Journal: JCI Insight
Title: Exogenous signaling repairs defective T cell signaling inside the tumor microenvironment for better immunity.
Volume: 7
Issue: 17
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Publication
23018463 | J:190610
First Author: Yamamoto S
Year: 2012
Journal: J Immunol
Title: Cutting edge: Pseudomonas aeruginosa abolishes established lung transplant tolerance by stimulating B7 expression on neutrophils.
Volume: 189
Issue: 9
Pages: 4221-5
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Publication
21037578 | J:167325
First Author: Pelletier N
Year: 2010
Journal: Nat Immunol
Title: Plasma cells negatively regulate the follicular helper T cell program.
Volume: 11
Issue: 12
Pages: 1110-8
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Publication
35028603 | J:332451
First Author: Abusarah J
Year: 2021
Journal: Cell Rep Med
Title: Engineering immunoproteasome-expressing mesenchymal stromal cells: A potent cellular vaccine for lymphoma and melanoma in mice.
Volume: 2
Issue: 12
Pages: 100455
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Publication
29150240 | J:253563
First Author: Chang YH
Year: 2017
Journal: Immunity
Title: Dichotomous Expression of TNF Superfamily Ligands on Antigen-Presenting Cells Controls Post-priming Anti-viral CD4+ T Cell Immunity.
Volume: 47
Issue: 5
Pages: 943-958.e9
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Publication
35578835 | J:325655
   
First Author: Miyao T
Year: 2022
Journal: Elife
Title: Integrative analysis of scRNA-seq and scATAC-seq revealed transit-amplifying thymic epithelial cells expressing autoimmune regulator.
Volume: 11
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Publication
16126897 | J:101425
First Author: Schneider H
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: CTLA-4 up-regulation of lymphocyte function-associated antigen 1 adhesion and clustering as an alternate basis for coreceptor function.
Volume: 102
Issue: 36
Pages: 12861-6
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Publication
16517699 | J:129539
First Author: Zheng SG
Year: 2006
Journal: J Immunol
Title: TGF-beta requires CTLA-4 early after T cell activation to induce FoxP3 and generate adaptive CD4+CD25+ regulatory cells.
Volume: 176
Issue: 6
Pages: 3321-9
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Publication
34541473 | J:313521
First Author: Kanemaru H
Year: 2021
Journal: iScience
Title: A mechanism of cooling hot tumors: Lactate attenuates inflammation in dendritic cells.
Volume: 24
Issue: 9
Pages: 103067
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Publication
19586920 | J:154884
First Author: Malhotra S
Year: 2009
Journal: J Biol Chem
Title: B cell antigen receptor endocytosis and antigen presentation to T cells require Vav and dynamin.
Volume: 284
Issue: 36
Pages: 24088-97
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Publication
36674855 | J:336238
 
First Author: Ford SL
Year: 2023
Journal: Int J Mol Sci
Title: Toll-like Receptor 9 Induced Dendritic Cell Activation Promotes Anti-Myeloperoxidase Autoimmunity and Glomerulonephritis.
Volume: 24
Issue: 2
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Publication
19272591 | J:148548
First Author: Vecchiarelli A
Year: 2009
Journal: Cell Immunol
Title: The GITRL-GITR system alters TLR-4 expression on DC during fungal infection.
Volume: 257
Issue: 1-2
Pages: 13-22
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Publication
31015515 | J:275560
First Author: Wang H
Year: 2019
Journal: Nat Commun
Title: Mettl3-mediated mRNA m6A methylation promotes dendritic cell activation.
Volume: 10
Issue: 1
Pages: 1898
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Publication
24095736 | J:203553
First Author: Metzger TC
Year: 2013
Journal: Cell Rep
Title: Lineage tracing and cell ablation identify a post-Aire-expressing thymic epithelial cell population.
Volume: 5
Issue: 1
Pages: 166-79
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Publication
22745171 | J:188415
First Author: Thaventhiran JE
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Activation of the Hippo pathway by CTLA-4 regulates the expression of Blimp-1 in the CD8+ T cell.
Volume: 109
Issue: 33
Pages: E2223-9
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Publication
25526312 | J:315815
First Author: Wing JB
Year: 2014
Journal: Immunity
Title: Regulatory T cells control antigen-specific expansion of Tfh cell number and humoral immune responses via the coreceptor CTLA-4.
Volume: 41
Issue: 6
Pages: 1013-25
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Publication
19710208 | J:153768
First Author: Tomura M
Year: 2009
Journal: Int Immunol
Title: Time-lapse observation of cellular function with fluorescent probe reveals novel CTL-target cell interactions.
Volume: 21
Issue: 10
Pages: 1145-50
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Publication
35145298 | J:338344
First Author: Sugiura D
Year: 2022
Journal: Nat Immunol
Title: PD-1 agonism by anti-CD80 inhibits T cell activation and alleviates autoimmunity.
Volume: 23
Issue: 3
Pages: 399-410
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Publication
12958312 | J:86592
First Author: Hostager BS
Year: 2003
Journal: J Biol Chem
Title: Tumor necrosis factor receptor-associated factor 2 (TRAF2)-deficient B lymphocytes reveal novel roles for TRAF2 in CD40 signaling.
Volume: 278
Issue: 46
Pages: 45382-90
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Publication
26648560 | J:269549
First Author: Yu F
Year: 2016
Journal: Mol Med Rep
Title: Connexin43 knockdown in bone marrow‑derived dendritic cells by small interfering RNA leads to a diminished T-cell stimulation.
Volume: 13
Issue: 1
Pages: 895-900
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7522127 | J:20540
First Author: Howe CJ
Year: 1994
Journal: Cell Immunol
Title: Characterization of the stability of human and murine thymic B cell/thymocyte rosettes and investigation of unusual immunophenotypic findings.
Volume: 158
Issue: 1
Pages: 218-27
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Publication
9175836 | J:40625
First Author: Shiratori T
Year: 1997
Journal: Immunity
Title: Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2.
Volume: 6
Issue: 5
Pages: 583-9
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Publication
12753741 | J:83470
First Author: Kim MY
Year: 2003
Journal: Immunity
Title: CD4(+)CD3(-) accessory cells costimulate primed CD4 T cells through OX40 and CD30 at sites where T cells collaborate with B cells.
Volume: 18
Issue: 5
Pages: 643-54
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Publication
17540342 | J:122284
First Author: He T
Year: 2007
Journal: Biochem Biophys Res Commun
Title: Bidirectional membrane molecule transfer between dendritic and T cells.
Volume: 359
Issue: 2
Pages: 202-8
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Publication
17974483 | J:130293
First Author: Lin Y
Year: 2008
Journal: Clin Immunol
Title: TSLP-induced placental DC activation and IL-10(+) NK cell expansion: comparative study based on BALB/c x C57BL/6 and NOD/SCID x C57BL/6 pregnant models.
Volume: 126
Issue: 1
Pages: 104-17
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Publication
19465908 | J:150140
First Author: Yoshimoto T
Year: 2009
Journal: Nat Immunol
Title: Basophils contribute to T(H)2-IgE responses in vivo via IL-4 production and presentation of peptide-MHC class II complexes to CD4+ T cells.
Volume: 10
Issue: 7
Pages: 706-12
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Publication
28439878 | J:249605
First Author: Brunk F
Year: 2017
Journal: Eur J Immunol
Title: Dissecting and modeling the emergent murine TEC compartment during ontogeny.
Volume: 47
Issue: 7
Pages: 1153-1159
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Publication
31732168 | J:305617
First Author: Trivedi N
Year: 2019
Journal: Immunity
Title: Liver Is a Generative Site for the B Cell Response to Ehrlichia muris.
Volume: 51
Issue: 6
Pages: 1088-1101.e5
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Publication
17617592 | J:131077
First Author: Bour-Jordan H
Year: 2007
Journal: J Immunol
Title: Constitutive expression of B7-1 on B cells uncovers autoimmunity toward the B cell compartment in the nonobese diabetic mouse.
Volume: 179
Issue: 2
Pages: 1004-12
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Publication
23335749 | J:193497
First Author: Kim G
Year: 2013
Journal: J Immunol
Title: A novel role for IL-27 in mediating the survival of activated mouse CD4 T lymphocytes.
Volume: 190
Issue: 4
Pages: 1510-8
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Publication
15972645 | J:100562
First Author: Chikuma S
Year: 2005
Journal: J Immunol
Title: B7-independent inhibition of T cells by CTLA-4.
Volume: 175
Issue: 1
Pages: 177-81
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Publication
24510964 | J:209925
First Author: White AJ
Year: 2014
Journal: J Immunol
Title: An essential role for medullary thymic epithelial cells during the intrathymic development of invariant NKT cells.
Volume: 192
Issue: 6
Pages: 2659-66
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Publication
9457671 | J:45874
First Author: Borriello F
Year: 1998
Journal: Mamm Genome
Title: Characterization and localization of Mox2, the gene encoding the murine homolog of the rat MRC OX-2 membrane glycoprotein.
Volume: 9
Issue: 2
Pages: 114-8
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Publication
15650768 | J:96185
First Author: Miyazaki D
Year: 2005
Journal: J Clin Invest
Title: Macrophage inflammatory protein-1alpha as a costimulatory signal for mast cell-mediated immediate hypersensitivity reactions.
Volume: 115
Issue: 2
Pages: 434-42
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Publication
18055812 | J:132514
First Author: Jabs DA
Year: 2007
Journal: Invest Ophthalmol Vis Sci
Title: Autoimmune Th2-mediated dacryoadenitis in MRL/MpJ mice becomes Th1-mediated in IL-4 deficient MRL/MpJ mice.
Volume: 48
Issue: 12
Pages: 5624-9
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Publication
17479111 | J:139267
First Author: Hoffmann U
Year: 2007
Journal: Cell Death Differ
Title: CD44v7 ligation downregulates the inflammatory immune response in Crohn's disease patients by apoptosis induction in mononuclear cells from the lamina propria.
Volume: 14
Issue: 8
Pages: 1542-51
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Publication
23690575 | J:197416
First Author: Yamaguchi T
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Construction of self-recognizing regulatory T cells from conventional T cells by controlling CTLA-4 and IL-2 expression.
Volume: 110
Issue: 23
Pages: E2116-25
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Publication
20382883 | J:161007
First Author: Liu H
Year: 2010
Journal: J Immunol
Title: Induction of distinct neurologic disease manifestations during relapsing fever requires T lymphocytes.
Volume: 184
Issue: 10
Pages: 5859-64
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Publication
28746783 | J:249055
First Author: D'Souza L
Year: 2017
Journal: Immunology
Title: CD73 expression identifies a subset of IgM+ antigen-experienced cells with memory attributes that is T cell and CD40 signalling dependent.
Volume: 152
Issue: 4
Pages: 602-612
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Publication
32582168 | J:324379
 
First Author: Cha H
Year: 2020
Journal: Front Immunol
Title: Adjustments of γδ T Cells in the Lung of Schistosoma japonicum-Infected C56BL/6 Mice.
Volume: 11
Pages: 1045
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Publication
20035831 | J:156875
First Author: Mao XJ
Year: 2010
Journal: Neurosci Lett
Title: TNF-alpha receptor 1 deficiency reduces antigen-presenting capacity of Schwann cells and ameliorates experimental autoimmune neuritis in mice.
Volume: 470
Issue: 1
Pages: 19-23
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Publication
10618409 | J:126142
First Author: Herrera PL
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: A mouse CD8 T cell-mediated acute autoimmune diabetes independent of the perforin and Fas cytotoxic pathways: possible role of membrane TNF.
Volume: 97
Issue: 1
Pages: 279-84
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Publication
34561228 | J:317095
First Author: Kaaij MH
Year: 2021
Journal: J Immunol
Title: Overexpression of Transmembrane TNF Drives Development of Ectopic Lymphoid Structures in the Bone Marrow and B Cell Lineage Alterations in Experimental Spondyloarthritis.
Volume: 207
Issue: 9
Pages: 2337-2346
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Publication
37799325 | J:347137
First Author: Ikeda H
Year: 2023
Journal: JTO Clin Res Rep
Title: Immunologic Significance of CD80/CD86 or Major Histocompatibility Complex-II Expression in Thymic Epithelial Tumors.
Volume: 4
Issue: 10
Pages: 100573
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Publication
17668901 | J:124351
First Author: Roy V
Year: 2007
Journal: Eur J Immunol
Title: Immune mechanisms leading to abnormal B cell selection and activation in New Zealand Black mice.
Volume: 37
Issue: 9
Pages: 2645-56
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Publication
12391201 | J:118780
First Author: Hu HM
Year: 2002
Journal: J Immunol
Title: CD28, TNF receptor, and IL-12 are critical for CD4-independent cross-priming of therapeutic antitumor CD8+ T cells.
Volume: 169
Issue: 9
Pages: 4897-904
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Publication
10229827 | J:110890
First Author: Martín-Fontecha A
Year: 1999
Journal: J Immunol
Title: Triggering of murine NK cells by CD40 and CD86 (B7-2).
Volume: 162
Issue: 10
Pages: 5910-6
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Publication
12047751 | J:113529
First Author: Reiter R
Year: 2002
Journal: Immunology
Title: Impaired germinal centre formation and humoral immune response in the absence of CD28 and interleukin-4.
Volume: 106
Issue: 2
Pages: 222-8
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Publication
19234153 | J:145529
First Author: Melli K
Year: 2009
Journal: J Immunol
Title: Amplification of autoimmune response through induction of dendritic cell maturation in inflamed tissues.
Volume: 182
Issue: 5
Pages: 2590-600
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Publication
15356099 | J:94170
First Author: Singh UP
Year: 2004
Journal: J Leukoc Biol
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