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Search results 501 to 600 out of 751 for Cdk1

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Hits by Strain

Type Details Score
UniProt Feature
UniProt Feature
Begin: 186
Description: Phosphothreonine; by CDK1
Type: modified residue
End: 186
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UniProt Feature
UniProt Feature
Begin: 764
Description: Phosphoserine; by CDK1
Type: modified residue
End: 764
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UniProt Feature
UniProt Feature
Begin: 246
Description: Phosphoserine; by CDK1
Type: modified residue
End: 246
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UniProt Feature
UniProt Feature
Begin: 275
Description: Phosphothreonine; by CDK1
Type: modified residue
End: 275
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UniProt Feature
UniProt Feature
Begin: 2085
Description: Phosphothreonine; by CDK1
Type: modified residue
End: 2085
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UniProt Feature
UniProt Feature
Begin: 1997
Description: Phosphothreonine; by CDK1
Type: modified residue
End: 1997
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UniProt Feature
UniProt Feature
Begin: 2069
Description: Phosphoserine; by CDK1
Type: modified residue
End: 2069
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UniProt Feature
UniProt Feature
Begin: 2516
Description: Phosphothreonine; by CDK1
Type: modified residue
End: 2516
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UniProt Feature
UniProt Feature
Begin: 537
Description: Phosphoserine; by CDK1
Type: modified residue
End: 537
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UniProt Feature
UniProt Feature
Begin: 470
Description: Phosphothreonine; by CDK1
Type: modified residue
End: 470
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UniProt Feature
UniProt Feature
Begin: 728
Description: Phosphoserine; by CDK1
Type: modified residue
End: 728
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UniProt Feature
UniProt Feature
Begin: 608
Description: Phosphothreonine; by CDK1
Type: modified residue
End: 608
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UniProt Feature
UniProt Feature
Begin: 172
Description: Phosphoserine; by CDK1
Type: modified residue
End: 172
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UniProt Feature
UniProt Feature
Begin: 172
Description: Phosphoserine; by CDK1
Type: modified residue
End: 172
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UniProt Feature
UniProt Feature
Begin: 382
Description: Phosphoserine; by CDK1
Type: modified residue
End: 382
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UniProt Feature
UniProt Feature
Begin: 29
Description: Phosphoserine; by CDK1
Type: modified residue
End: 29
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UniProt Feature
UniProt Feature
Begin: 1380
Description: Phosphothreonine; by CDK1
Type: modified residue
End: 1380
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UniProt Feature
UniProt Feature
Begin: 1375
Description: Phosphothreonine; by CDK1
Type: modified residue
End: 1375
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UniProt Feature
UniProt Feature
Begin: 172
Description: Phosphoserine; by CDK1
Type: modified residue
End: 172
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UniProt Feature
UniProt Feature
Begin: 172
Description: Phosphoserine; by CDK1
Type: modified residue
End: 172
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UniProt Feature
UniProt Feature
Begin: 172
Description: Phosphoserine; by CDK1
Type: modified residue
End: 172
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UniProt Feature
UniProt Feature
Begin: 278
Description: Phosphothreonine; by CDK1
Type: modified residue
End: 278
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UniProt Feature
UniProt Feature
Begin: 274
Description: Phosphoserine; by CDK1
Type: modified residue
End: 274
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UniProt Feature
UniProt Feature
Begin: 71
Description: Phosphoserine; by CDK1
Type: modified residue
End: 71
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UniProt Feature
UniProt Feature
Begin: 62
Description: Phosphothreonine; by CDK1
Type: modified residue
End: 62
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UniProt Feature
UniProt Feature
Begin: 172
Description: Phosphoserine; by CDK1
Type: modified residue
End: 172
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UniProt Feature
UniProt Feature
Begin: 261
Description: Phosphoserine; by CDK1
Type: modified residue
End: 261
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UniProt Feature
UniProt Feature
Begin: 257
Description: Phosphoserine; by CDK1
Type: modified residue
End: 257
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UniProt Feature
UniProt Feature
Begin: 265
Description: Phosphoserine; by CDK1
Type: modified residue
End: 265
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UniProt Feature
UniProt Feature
Begin: 639
Description: Phosphoserine; by CDK1
Type: modified residue
End: 639
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UniProt Feature
UniProt Feature
Begin: 123
Description: Phosphoserine; by CDK1
Type: modified residue
End: 123
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UniProt Feature
UniProt Feature
Begin: 172
Description: Phosphoserine; by CDK1
Type: modified residue
End: 172
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UniProt Feature
UniProt Feature
Begin: 172
Description: Phosphoserine; by CDK1
Type: modified residue
End: 172
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UniProt Feature
UniProt Feature
Begin: 265
Description: Phosphoserine; by CDK1
Type: modified residue
End: 265
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UniProt Feature
UniProt Feature
Begin: 4546
Description: Phosphothreonine; by CDK1
Type: modified residue
End: 4546
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UniProt Feature
UniProt Feature
Begin: 33
Description: Phosphoserine; by CDK1
Type: modified residue
End: 33
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UniProt Feature
UniProt Feature
Begin: 84
Description: Phosphoserine; by CDK1
Type: modified residue
End: 84
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UniProt Feature
UniProt Feature
Begin: 473
Description: Phosphoserine; by CDK1
Type: modified residue
End: 473
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UniProt Feature
UniProt Feature
Begin: 242
Description: Phosphoserine; by CDK1
Type: modified residue
End: 242
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Publication
23901111 | J:200685
First Author: Nishiyama T
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Aurora B and Cdk1 mediate Wapl activation and release of acetylated cohesin from chromosomes by phosphorylating Sororin.
Volume: 110
Issue: 33
Pages: 13404-9
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UniProt Feature
UniProt Feature
Begin: 3214
Description: Phosphoserine; by CDK1 and CDK2
Type: modified residue
End: 3214
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UniProt Feature
UniProt Feature
Begin: 34
Description: Phosphothreonine; by CDK1 and CDK15
Type: modified residue
End: 34
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UniProt Feature
UniProt Feature
Begin: 164
Description: Phosphoserine; by CDK1 and CDK2
Type: modified residue
End: 164
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UniProt Feature
UniProt Feature
Begin: 291
Description: Phosphoserine; by CDK1 and PKB
Type: modified residue
End: 291
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UniProt Feature
UniProt Feature
Begin: 345
Description: Phosphothreonine; by CDK1 and CDK2
Type: modified residue
End: 345
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UniProt Feature
UniProt Feature
Begin: 90
Description: Phosphoserine; by CDK1 and CDK9
Type: modified residue
End: 90
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UniProt Feature
UniProt Feature
Begin: 198
Description: Phosphothreonine; by CDK1 and CDK2
Type: modified residue
End: 198
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UniProt Feature
UniProt Feature
Begin: 463
Description: Phosphothreonine; by CDK1 and CDK2
Type: modified residue
End: 463
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UniProt Feature
UniProt Feature
Begin: 358
Description: Phosphoserine; by MAPK13 and CDK1
Type: modified residue
End: 358
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UniProt Feature
UniProt Feature
Begin: 528
Description: Phosphoserine; by CDK1 and CDK2
Type: modified residue
End: 528
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UniProt Feature
UniProt Feature
Begin: 245
Description: Phosphothreonine; by CDK1 and MAPK1
Type: modified residue
End: 245
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Interaction Experiment
Lian G (2012)
Description: Filamin a regulates neural progenitor proliferation and cortical size through Wee1-dependent Cdk1 phosphorylation.
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UniProt Feature
UniProt Feature
Begin: 187
Description: Phosphothreonine; by PKB/AKT1, CDK1 and CDK2
Type: modified residue
End: 187
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UniProt Feature
UniProt Feature
Begin: 312
Description: Phosphoserine; by AURKA, CDK1 and CDK2
Type: modified residue
End: 312
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UniProt Feature
UniProt Feature
Begin: 645
Description: Phosphoserine; by CDK5, MAPK1 and CDK1
Type: modified residue
End: 645
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Publication
32351706 | -
 
First Author: Zhong L
Year: 2020
Journal: Cell Discov
Title: Phosphorylation of cGAS by CDK1 impairs self-DNA sensing in mitosis.
Volume: 6
Pages: 26
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Publication
18804442 | -
First Author: Peng Y
Year: 2008
Journal: Dev Cell
Title: The cyclin-dependent kinase Cdk1 directly regulates vacuole inheritance.
Volume: 15
Issue: 3
Pages: 478-85
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Protein
P11440
Organism: Mus musculus/domesticus
Length: 297  
Fragment?: false
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Publication
17942597 | -
First Author: Satyanarayana A
Year: 2008
Journal: Mol Biol Cell
Title: p21 Inhibits Cdk1 in the absence of Cdk2 to maintain the G1/S phase DNA damage checkpoint.
Volume: 19
Issue: 1
Pages: 65-77
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Publication
24109598 | -
First Author: Seldin L
Year: 2013
Journal: Mol Biol Cell
Title: NuMA localization, stability, and function in spindle orientation involve 4.1 and Cdk1 interactions.
Volume: 24
Issue: 23
Pages: 3651-62
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Publication
22101338 | -
First Author: Chou HY
Year: 2011
Journal: Cell Cycle
Title: Phosphorylation of NuSAP by Cdk1 regulates its interaction with microtubules in mitosis.
Volume: 10
Issue: 23
Pages: 4083-9
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Publication
19591820 | -
First Author: Althoff F
Year: 2009
Journal: Dev Biol
Title: Drosophila Cyclin J is a mitotically stable Cdk1 partner without essential functions.
Volume: 333
Issue: 2
Pages: 263-72
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HT Experiment
GSE159497 | Loss of hepatocyte cell division leads to liver inflammation and fibrosis
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
21406398 | -
First Author: Löffler H
Year: 2011
Journal: Cancer Res
Title: Cep63 recruits Cdk1 to the centrosome: implications for regulation of mitotic entry, centrosome amplification, and genome maintenance.
Volume: 71
Issue: 6
Pages: 2129-39
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Allele
Eif4ebp1<tm2.1Cvp> | MGI:7512960
 
Name: eukaryotic translation initiation factor 4E binding protein 1; targeted mutation 2.1, Patrick Moore
Allele Type: Targeted
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Strain
MGI:7607313 | C57BL/6-Eif4ebp1<tm2.1Cvp>/Mmucd
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Protein
Q80XU3
Organism: Mus musculus/domesticus
Length: 234  
Fragment?: false
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Protein
A0A087WRY3
Organism: Mus musculus/domesticus
Length: 233  
Fragment?: false
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Publication
15381070 | -
First Author: Grundt K
Year: 2004
Journal: Biochem Biophys Res Commun
Title: Characterisation of the NUCKS gene on human chromosome 1q32.1 and the presence of a homologous gene in different species.
Volume: 323
Issue: 3
Pages: 796-801
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Protein Domain
IPR026633 | NUCKS1
Type: Family
Description: Members of this vertebrate family of proteins are targets for phosphorylation by CDK1 and casein kinase [, ]. They are also phosphorylated upon DNA damage, probably by ATM or ATR [].
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Publication
26653561 | -
 
First Author: He Y
Year: 2015
Journal: Biomed Pharmacother
Title: The tumor-suppressor gene LZTS1 suppresses hepatocellular carcinoma proliferation by impairing PI3K/Akt pathway.
Volume: 76
Pages: 141-6
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Publication
25813822 | -
First Author: Wang XX
Year: 2015
Journal: Pathol Oncol Res
Title: Loss of Leucine Zipper Putative Tumor Suppressor 1 (LZTS1) Expression Contributes to Lymph Node Metastasis of Breast Invasive Micropapillary Carcinoma.
Volume: 21
Issue: 4
Pages: 1021-6
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Publication
24802407 | -
First Author: Xu Z
Year: 2014
Journal: Biochem Biophys Res Commun
Title: miR-214 promotes the proliferation and invasion of osteosarcoma cells through direct suppression of LZTS1.
Volume: 449
Issue: 2
Pages: 190-5
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Protein Domain
IPR033293 | LZTS1
Type: Family
Description: Leucine zipper putative tumor suppressor 1 (LZTS1, FEZ1) plays a role in mitosis []. It is associated with assembled microtubules and is involved in the stabilization of active p34CDC2 (Cdk1) []. LZTS1 plays an important role in ensuring proper Cdk1 activity during M phase. By maintaining high levels of Cdk1 activity, it prevents chromosomes missegregation []. LZTS1 plays an important role in human carcinogenesis [, , ].
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Publication
18243098 | J:177150
First Author: Shimada M
Year: 2008
Journal: Cell
Title: Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression.
Volume: 132
Issue: 2
Pages: 221-32
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Publication
24760772 | J:213598
First Author: Hu J
Year: 2014
Journal: Hum Mol Genet
Title: Formin 1 and filamin B physically interact to coordinate chondrocyte proliferation and differentiation in the growth plate.
Volume: 23
Issue: 17
Pages: 4663-73
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Protein Domain
IPR029874 | FLNB
Type: Family
Description: Filamin family consists of Filamin-A (FLN-A), Filamin-B (FLN-B) and Filamin-C (FLN-C). They are a group of actin binding proteins that may be involved in actin microfilaments organisation [].This entry represents filamin B, which transduces signals from various membrane receptors and intracellular proteins onto the actin cytoskeleton []. In humans it regulates chondrocyte proliferation and differentiation through Cdk1 signalling [].
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Publication
12972555 | -
First Author: Porter LA
Year: 2003
Journal: Mol Biol Cell
Title: Spy1 interacts with p27Kip1 to allow G1/S progression.
Volume: 14
Issue: 9
Pages: 3664-74
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Protein
Q5IBH7
Organism: Mus musculus/domesticus
Length: 310  
Fragment?: false
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Protein
Q5IBH6
Organism: Mus musculus/domesticus
Length: 268  
Fragment?: false
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Protein
B9EIX3
Organism: Mus musculus/domesticus
Length: 173  
Fragment?: false
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Protein
Q8CDE8
Organism: Mus musculus/domesticus
Length: 236  
Fragment?: false
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Protein
A0A7D9NM65
Organism: Mus musculus/domesticus
Length: 172  
Fragment?: false
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Protein
A2AQG6
Organism: Mus musculus/domesticus
Length: 115  
Fragment?: true
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Protein
B8JJB9
Organism: Mus musculus/domesticus
Length: 309  
Fragment?: false
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Protein
Q9D5G0
Organism: Mus musculus/domesticus
Length: 173  
Fragment?: false
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Protein
A0A0G2JEI8
Organism: Mus musculus/domesticus
Length: 231  
Fragment?: false
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Protein
I6XKQ3
Organism: Mus musculus/domesticus
Length: 339  
Fragment?: false
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Protein
B2RWC8
Organism: Mus musculus/domesticus
Length: 283  
Fragment?: false
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Publication
17671428 | -
First Author: McAndrew CW
Year: 2007
Journal: Cell Cycle
Title: Spy1 enhances phosphorylation and degradation of the cell cycle inhibitor p27.
Volume: 6
Issue: 15
Pages: 1937-45
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Publication
28666995 | -
First Author: McGrath DA
Year: 2017
Journal: EMBO J
Title: Structural basis of divergent cyclin-dependent kinase activation by Spy1/RINGO proteins.
Volume: 36
Issue: 15
Pages: 2251-2262
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Publication
16244663 | -
First Author: Byeon IJ
Year: 2005
Journal: Nat Struct Mol Biol
Title: Sequential phosphorylation and multisite interactions characterize specific target recognition by the FHA domain of Ki67.
Volume: 12
Issue: 11
Pages: 987-93
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Protein Domain
IPR020984 | Speedy
Type: Family
Description: Speedy (Spy1, also known as RINGO A) is a cell cycle regulatory protein which binds and activates CDK1 and CDK2 [], protein kinases that allows progression through G1/S phase and further replication events. Spy1 activates CDK2 inducing a conformational change of the CDK2 T-loop that avoids its phosphorylation []. Spy1 expression overcomes a p27-induced cell cycle arrest to allow for DNA synthesis, so cell cycle progression occurs due to an interaction between Spy1 and p27 [].
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Protein Domain
IPR021043 | NIFK_FHA_Ki67-binding
Type: Domain
Description: This entry represents eukaryotic proteins that contain a domain of approximately 40 amino acids in length. These proteins are found in association with . There are two conserved sequence motifs: TPVCTP and LERRKS. This domain is found on the human nucleolar protein hNIFK. It binds to the fork-head-associated domain of human Ki67. High-affinity binding requires sequential phosphorylation by two kinases, CDK1 and GSK3, yielding pThr238, pThr234 and pSer230. This interaction is involved in cell cycle regulation [].
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HT Experiment
GSE190681 | RNA Ligase RTCB-mediated mRNA Alternative Splicing is Required for Mouse Oocyte Development and Maintenance
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Protein
P60853
Organism: Mus musculus/domesticus
Length: 599  
Fragment?: false
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Protein
A1L146
Organism: Mus musculus/domesticus
Length: 598  
Fragment?: true
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Protein
A0PJT4
Organism: Mus musculus/domesticus
Length: 599  
Fragment?: false
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Publication
11504921 | -
First Author: Ishii H
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates mitosis.
Volume: 98
Issue: 18
Pages: 10374-9
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Publication
17718912 | -
 
First Author: Vecchione A
Year: 2007
Journal: Cell Div
Title: Fez1/Lzts1 a new mitotic regulator implicated in cancer development.
Volume: 2
Pages: 24
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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