Type |
Details |
Score |
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
503
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
503
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
112
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
145
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
142
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
124
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
140
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
487
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang J |
Year: |
2007 |
Journal: |
Cancer Cell |
Title: |
LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB. |
Volume: |
12 |
Issue: |
3 |
Pages: |
239-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen J |
Year: |
2002 |
Journal: |
Biochem Biophys Res Commun |
Title: |
A novel gene IC53 stimulates ECV304 cell proliferation and is upregulated in failing heart. |
Volume: |
294 |
Issue: |
1 |
Pages: |
161-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jiang H |
Year: |
2005 |
Journal: |
J Biol Chem |
Title: |
Cdk5 activator-binding protein C53 regulates apoptosis induced by genotoxic stress via modulating the G2/M DNA damage checkpoint. |
Volume: |
280 |
Issue: |
21 |
Pages: |
20651-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jiang H |
Year: |
2009 |
Journal: |
Cell Res |
Title: |
Tumor suppressor protein C53 antagonizes checkpoint kinases to promote cyclin-dependent kinase 1 activation. |
Volume: |
19 |
Issue: |
4 |
Pages: |
458-68 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xie YH |
Year: |
2003 |
Journal: |
Cell Res |
Title: |
Cloning and characterization of human IC53-2, a novel CDK5 activator binding protein. |
Volume: |
13 |
Issue: |
2 |
Pages: |
83-91 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wamsley JJ |
Year: |
2017 |
Journal: |
Cell Cycle |
Title: |
LZAP is a novel Wip1 binding partner and positive regulator of its phosphatase activity in vitro. |
Volume: |
16 |
Issue: |
2 |
Pages: |
213-223 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
CDK5RAP3 (also known as C53 or LZAP) serves as a probable tumour suppressor initially identified as a CDK5R1 interactor controllingcell proliferation [, ]. It negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation [, ]. It also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint [, ]. It has been shown to bind Wip1 and stimulates its phosphatase activity []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu J |
Year: |
2010 |
Journal: |
J Biol Chem |
Title: |
A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signaling. |
Volume: |
285 |
Issue: |
20 |
Pages: |
15126-36 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|