Type |
Details |
Score |
Publication |
First Author: |
Fame RM |
Year: |
2017 |
Journal: |
Cereb Cortex |
Title: |
Subtype-Specific Genes that Characterize Subpopulations of Callosal Projection Neurons in Mouse Identify Molecularly Homologous Populations in Macaque Cortex. |
Volume: |
27 |
Issue: |
3 |
Pages: |
1817-1830 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bort R |
Year: |
2004 |
Journal: |
Development |
Title: |
Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas. |
Volume: |
131 |
Issue: |
4 |
Pages: |
797-806 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lin W |
Year: |
2008 |
Journal: |
Dev Dyn |
Title: |
Proper expression of the Gcn5 histone acetyltransferase is required for neural tube closure in mouse embryos. |
Volume: |
237 |
Issue: |
4 |
Pages: |
928-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Heisig J |
Year: |
2012 |
Journal: |
PLoS Genet |
Title: |
Target gene analysis by microarrays and chromatin immunoprecipitation identifies HEY proteins as highly redundant bHLH repressors. |
Volume: |
8 |
Issue: |
5 |
Pages: |
e1002728 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ota MS |
Year: |
2004 |
Journal: |
Dev Dyn |
Title: |
Twist is required for patterning the cranial nerves and maintaining the viability of mesodermal cells. |
Volume: |
230 |
Issue: |
2 |
Pages: |
216-28 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chassot AA |
Year: |
2012 |
Journal: |
Development |
Title: |
WNT4 and RSPO1 together are required for cell proliferation in the early mouse gonad. |
Volume: |
139 |
Issue: |
23 |
Pages: |
4461-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
López-Tello J |
Year: |
2019 |
Journal: |
Elife |
Title: |
Fetal and trophoblast PI3K p110α have distinct roles in regulating resource supply to the growing fetus in mice. |
Volume: |
8 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Häfner R |
Year: |
2015 |
Journal: |
Mol Cell Endocrinol |
Title: |
Fgfr2 is required for the expansion of the early adrenocortical primordium. |
Volume: |
413 |
|
Pages: |
168-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bard-Chapeau EA |
Year: |
2014 |
Journal: |
PLoS One |
Title: |
Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects. |
Volume: |
9 |
Issue: |
2 |
Pages: |
e89397 |
|
•
•
•
•
•
|
Publication |
First Author: |
Santos R |
Year: |
2016 |
Journal: |
PLoS Biol |
Title: |
Conditional Creation and Rescue of Nipbl-Deficiency in Mice Reveals Multiple Determinants of Risk for Congenital Heart Defects. |
Volume: |
14 |
Issue: |
9 |
Pages: |
e2000197 |
|
•
•
•
•
•
|
Publication |
First Author: |
Takemoto M |
Year: |
2006 |
Journal: |
EMBO J |
Title: |
Large-scale identification of genes implicated in kidney glomerulus development and function. |
Volume: |
25 |
Issue: |
5 |
Pages: |
1160-74 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kelleher AM |
Year: |
2017 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Forkhead box a2 (FOXA2) is essential for uterine function and fertility. |
Volume: |
114 |
Issue: |
6 |
Pages: |
E1018-E1026 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rajan S |
Year: |
2012 |
Journal: |
Physiol Genomics |
Title: |
Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation. |
Volume: |
44 |
Issue: |
2 |
Pages: |
183-97 |
|
•
•
•
•
•
|
Publication |
First Author: |
Richard AF |
Year: |
2011 |
Journal: |
Dev Biol |
Title: |
Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression. |
Volume: |
359 |
Issue: |
2 |
Pages: |
303-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Basta JM |
Year: |
2014 |
Journal: |
Development |
Title: |
Sall1 balances self-renewal and differentiation of renal progenitor cells. |
Volume: |
141 |
Issue: |
5 |
Pages: |
1047-58 |
|
•
•
•
•
•
|
Publication |
First Author: |
Koutelou E |
Year: |
2019 |
Journal: |
Development |
Title: |
USP22 controls multiple signaling pathways that are essential for vasculature formation in the mouse placenta. |
Volume: |
146 |
Issue: |
4 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Lee DR |
Year: |
2022 |
Journal: |
Elife |
Title: |
Transcriptional heterogeneity of ventricular zone cells in the ganglionic eminences of the mouse forebrain. |
Volume: |
11 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Kawaguchi A |
Year: |
2008 |
Journal: |
Development |
Title: |
Single-cell gene profiling defines differential progenitor subclasses in mammalian neurogenesis. |
Volume: |
135 |
Issue: |
18 |
Pages: |
3113-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
MouseBookTM |
Year: |
2005 |
Journal: |
Unpublished |
Title: |
Information obtained from MouseBookTM, Medical Research Council Mammalian Genetics Unit, Harwell, UK. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mayer C |
Year: |
2018 |
Journal: |
Nature |
Title: |
Developmental diversification of cortical inhibitory interneurons. |
Volume: |
555 |
Issue: |
7697 |
Pages: |
457-462 |
|
•
•
•
•
•
|
Publication |
First Author: |
Oeschger FM |
Year: |
2012 |
Journal: |
Cereb Cortex |
Title: |
Gene expression analysis of the embryonic subplate. |
Volume: |
22 |
Issue: |
6 |
Pages: |
1343-59 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wiese CB |
Year: |
2012 |
Journal: |
Front Neurosci |
Title: |
A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. |
Volume: |
6 |
|
Pages: |
130 |
|
•
•
•
•
•
|
Publication |
First Author: |
Guo G |
Year: |
2010 |
Journal: |
Dev Cell |
Title: |
Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. |
Volume: |
18 |
Issue: |
4 |
Pages: |
675-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2016 |
|
Title: |
Automatic assignment of GO terms using logical inference, based on on inter-ontology links |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Gray PA |
Year: |
2004 |
Journal: |
Science |
Title: |
Mouse brain organization revealed through direct genome-scale TF expression analysis. |
Volume: |
306 |
Issue: |
5705 |
Pages: |
2255-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Visel A |
Year: |
2004 |
Journal: |
Nucleic Acids Res |
Title: |
GenePaint.org: an atlas of gene expression patterns in the mouse embryo. |
Volume: |
32 |
Issue: |
Database issue |
Pages: |
D552-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bedogni F |
Year: |
2021 |
Journal: |
Front Mol Neurosci |
Title: |
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. |
Volume: |
14 |
|
Pages: |
686034 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2009 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
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|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GUDMAP Consortium |
Year: |
2004 |
Journal: |
www.gudmap.org |
Title: |
GUDMAP: the GenitoUrinary Development Molecular Anatomy Project |
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
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|
|
•
•
•
•
•
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Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
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•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
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Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
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•
•
•
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•
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Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
|
Title: |
Cyagen Biosciences Website. |
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|
•
•
•
•
•
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Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
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•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
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•
•
•
•
•
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Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
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•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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•
•
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Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
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|
|
•
•
•
•
•
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
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|
•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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|
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•
•
•
•
•
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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|
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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•
•
•
•
•
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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|
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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•
•
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•
|
HT Experiment |
|
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
Publication |
First Author: |
AlAbdi L |
Year: |
2018 |
Journal: |
J Biol Chem |
Title: |
The transcription factor Vezf1 represses the expression of the antiangiogenic factor Cited2 in endothelial cells. |
Volume: |
293 |
Issue: |
28 |
Pages: |
11109-11118 |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Negative feedback regulation of NF-B action by CITED2 in the nucleus. |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7286085 |
Assay Type: |
RNA in situ |
Annotation Date: |
2022-06-17 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1607512 |
Pattern: |
Regionally restricted |
Stage: |
TS12 |
Assay Id: |
MGI:7286311 |
Age: |
embryonic day 8.0 |
|
Note: |
Abnormal expression in a subset of Cited2 null embryos. Expression was either not detected or there was a left-sided bias. |
Specimen Label: |
2D |
Detected: |
true |
Specimen Num: |
24 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7286085 |
Assay Type: |
RNA in situ |
Annotation Date: |
2022-06-17 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1607512 |
Pattern: |
Regionally restricted |
Stage: |
TS12 |
Assay Id: |
MGI:7286311 |
Age: |
embryonic day 8.0 |
|
Note: |
Abnormal expression in a subset of Cited2 null embryos. Expression was either not detected or there was a left-sided bias. |
Specimen Label: |
2F |
Detected: |
true |
Specimen Num: |
26 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7286085 |
Assay Type: |
RNA in situ |
Annotation Date: |
2022-06-17 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1607512 |
Pattern: |
Regionally restricted |
Stage: |
TS12 |
Assay Id: |
MGI:7286311 |
Age: |
embryonic day 8.0 |
|
Note: |
Abnormal expression in a subset of Cited2 null embryos. Expression was either not detected or there was a left-sided bias. |
Specimen Label: |
2H |
Detected: |
true |
Specimen Num: |
28 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7286085 |
Assay Type: |
RNA in situ |
Annotation Date: |
2022-06-17 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603912 |
Pattern: |
Regionally restricted |
Stage: |
TS12 |
Assay Id: |
MGI:7286311 |
Age: |
embryonic day 8.0 |
|
Note: |
Abnormal expression in a subset of Cited2 null embryos. Expression was either not detected or there was a left-sided bias. |
Specimen Label: |
2C |
Detected: |
true |
Specimen Num: |
23 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7286085 |
Assay Type: |
RNA in situ |
Annotation Date: |
2022-06-17 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603912 |
Pattern: |
Regionally restricted |
Stage: |
TS12 |
Assay Id: |
MGI:7286311 |
Age: |
embryonic day 8.0 |
|
Note: |
Abnormal expression in a subset of Cited2 null embryos. Expression was either not detected or there was a left-sided bias. |
Specimen Label: |
2E |
Detected: |
true |
Specimen Num: |
25 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7286085 |
Assay Type: |
RNA in situ |
Annotation Date: |
2022-06-17 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603912 |
Pattern: |
Regionally restricted |
Stage: |
TS12 |
Assay Id: |
MGI:7286311 |
Age: |
embryonic day 8.0 |
|
Note: |
Abnormal expression in a subset of Cited2 null embryos. Expression was either not detected or there was a left-sided bias. |
Specimen Label: |
2G |
Detected: |
true |
Specimen Num: |
27 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tien ES |
Year: |
2004 |
Journal: |
J Biol Chem |
Title: |
Identification of the CREB-binding protein/p300-interacting protein CITED2 as a peroxisome proliferator-activated receptor alpha coregulator. |
Volume: |
279 |
Issue: |
23 |
Pages: |
24053-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
De Guzman RN |
Year: |
2004 |
Journal: |
J Biol Chem |
Title: |
Interaction of the TAZ1 domain of the CREB-binding protein with the activation domain of CITED2: regulation by competition between intrinsically unstructured ligands for non-identical binding sites. |
Volume: |
279 |
Issue: |
4 |
Pages: |
3042-9 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Homologous_superfamily |
Description: |
TAZ (Transcription Adaptor putative Zinc finger) domains are zinc-containing domains found in the homologous transcriptional co-activators CREB-binding protein (CBP) and the P300. CBP and P300 are histone acetyltransferases () that catalyse the reversible acetylation of all four histones in nucleosomes, acting to regulate transcription via chromatin remodelling. These large nuclear proteins interact with numerous transcription factors and viral oncoproteins, including p53 tumour suppressor protein, E1A oncoprotein, MyoD, and GATA-1, and are involved in cell growth, differentiation and apoptosis []. Both CBP and P300 have two copies of the TAZ domain, one in the N-terminal region, the other in the C-terminal region. The TAZ1 domain of CBP and P300 forms a complex with CITED2 (CBP/P300-interacting transactivator with ED-rich tail), inhibiting the activity of the hypoxia inducible factor (HIF-1alpha) and thereby attenuating the cellular response to low tissue oxygen concentration []. Adaptation to hypoxia is mediated by transactivation of hypoxia-responsive genes by hypoxia-inducible factor-1 (HIF-1) in complex with the CBP and p300 transcriptional coactivators [].Proteins containing this domain also include a group of land-plant specific proteins, know as the BTB/POZ and TAZ domain-containing (BT) protein. The reports of their interaction with CUL3 are contradictory. They are multifunctional scaffold proteins essential for male and female gametophyte development []. The TAZ domain adopts an all-alpha fold with zinc-binding sites in the loops connecting the helices. The TAZ1 domain in P300 and the TAZ2 (CH3) domain in CBP have each been shown to have four amphipathic helices, organised by three zinc-binding clusters with HCCC-type coordination [, , ]. |
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Publication |
First Author: |
De Guzman RN |
Year: |
2000 |
Journal: |
J Mol Biol |
Title: |
Solution structure of the TAZ2 (CH3) domain of the transcriptional adaptor protein CBP. |
Volume: |
303 |
Issue: |
2 |
Pages: |
243-53 |
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Publication |
First Author: |
Freedman SJ |
Year: |
2002 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha. |
Volume: |
99 |
Issue: |
8 |
Pages: |
5367-72 |
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•
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Publication |
First Author: |
Freedman SJ |
Year: |
2003 |
Journal: |
Nat Struct Biol |
Title: |
Structural basis for negative regulation of hypoxia-inducible factor-1alpha by CITED2. |
Volume: |
10 |
Issue: |
7 |
Pages: |
504-12 |
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•
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Publication |
First Author: |
De Guzman RN |
Year: |
2005 |
Journal: |
Biochemistry |
Title: |
CBP/p300 TAZ1 domain forms a structured scaffold for ligand binding. |
Volume: |
44 |
Issue: |
2 |
Pages: |
490-7 |
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Publication |
First Author: |
Robert HS |
Year: |
2009 |
Journal: |
Plant J |
Title: |
BTB and TAZ domain scaffold proteins perform a crucial function in Arabidopsis development. |
Volume: |
58 |
Issue: |
1 |
Pages: |
109-21 |
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Protein Domain |
Type: |
Domain |
Description: |
TAZ (Transcription Adaptor putative Zinc finger) domains are zinc-containing domains found in the homologous transcriptional co-activators CREB-binding protein (CBP) and the P300. CBP and P300 are histone acetyltransferases () that catalyse the reversible acetylation of all four histones in nucleosomes, acting to regulate transcription via chromatin remodelling. These large nuclear proteins interact with numerous transcription factors and viral oncoproteins, including p53 tumour suppressor protein, E1A oncoprotein, MyoD, and GATA-1, and are involved in cell growth, differentiation and apoptosis []. Both CBP and P300 have two copies of the TAZ domain, one in the N-terminal region, the other in the C-terminal region. The TAZ1 domain of CBP and P300 forms a complex with CITED2 (CBP/P300-interacting transactivator with ED-rich tail), inhibiting the activity of the hypoxia inducible factor (HIF-1alpha) and thereby attenuating the cellular response to low tissue oxygen concentration []. Adaptation to hypoxia is mediated by transactivation of hypoxia-responsive genes by hypoxia-inducible factor-1 (HIF-1) in complex with the CBP and p300 transcriptional coactivators [].Proteins containing this domain also include a group of land-plant specific proteins, know as the BTB/POZ and TAZ domain-containing (BT) protein. The reports of their interaction with CUL3 are contradictory. They are multifunctional scaffold proteins essential for male and female gametophyte development []. The TAZ domain adopts an all-alpha fold with zinc-binding sites in the loops connecting the helices. The TAZ1 domain in P300 and the TAZ2 (CH3) domain in CBP have each been shown to have four amphipathic helices, organised by three zinc-binding clusters with HCCC-type coordination [, , ].Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. Some of these domains bind zinc, but many do not; instead binding other metals such as iron, or no metal at all. For example, some family members form salt bridges to stabilise the finger-like folds. They were first identified as a DNA-binding motif in transcription factor TFIIIA from Xenopus laevis (African clawed frog), however they are now recognised to bind DNA, RNA, protein and/or lipid substrates [, , , , ]. Their binding properties depend on the amino acid sequence of the finger domains and of the linker between fingers, as well as on the higher-order structures andthe number of fingers. Znf domains are often found in clusters, where fingers can have different binding specificities. There are many superfamilies of Znf motifs, varying in both sequence and structure. They display considerable versatility in binding modes, even between members of the same class (e.g. some bind DNA, others protein), suggesting that Znf motifs are stable scaffolds that have evolved specialised functions. For example, Znf-containing proteins function in gene transcription, translation, mRNA trafficking, cytoskeleton organisation, epithelial development, cell adhesion, protein folding, chromatin remodelling and zinc sensing, to name but a few []. Zinc-binding motifs are stable structures, and they rarely undergo conformational changes upon binding their target. |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
714
 |
Fragment?: |
false |
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Publication |
First Author: |
Ponting CP |
Year: |
1996 |
Journal: |
Trends Biochem Sci |
Title: |
ZZ and TAZ: new putative zinc fingers in dystrophin and other proteins. |
Volume: |
21 |
Issue: |
1 |
Pages: |
11-13 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1589
 |
Fragment?: |
true |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2412
 |
Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2441
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2429
 |
Fragment?: |
true |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2403
 |
Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2441
 |
Fragment?: |
false |
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Publication |
First Author: |
Matthews JM |
Year: |
2002 |
Journal: |
IUBMB Life |
Title: |
Zinc fingers--folds for many occasions. |
Volume: |
54 |
Issue: |
6 |
Pages: |
351-5 |
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Publication |
First Author: |
Gamsjaeger R |
Year: |
2007 |
Journal: |
Trends Biochem Sci |
Title: |
Sticky fingers: zinc-fingers as protein-recognition motifs. |
Volume: |
32 |
Issue: |
2 |
Pages: |
63-70 |
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Publication |
First Author: |
Hall TM |
Year: |
2005 |
Journal: |
Curr Opin Struct Biol |
Title: |
Multiple modes of RNA recognition by zinc finger proteins. |
Volume: |
15 |
Issue: |
3 |
Pages: |
367-73 |
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Publication |
First Author: |
Brown RS |
Year: |
2005 |
Journal: |
Curr Opin Struct Biol |
Title: |
Zinc finger proteins: getting a grip on RNA. |
Volume: |
15 |
Issue: |
1 |
Pages: |
94-8 |
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Publication |
First Author: |
Klug A |
Year: |
1999 |
Journal: |
J Mol Biol |
Title: |
Zinc finger peptides for the regulation of gene expression. |
Volume: |
293 |
Issue: |
2 |
Pages: |
215-8 |
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Publication |
First Author: |
Laity JH |
Year: |
2001 |
Journal: |
Curr Opin Struct Biol |
Title: |
Zinc finger proteins: new insights into structural and functional diversity. |
Volume: |
11 |
Issue: |
1 |
Pages: |
39-46 |
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