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Search results 501 to 600 out of 622 for Cnp

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Type Details Score
Publication
11885989 | -
First Author: Kozlov G
Year: 2002
Journal: J Biomol NMR
Title: Assignment of the 1H, 13C and 15N resonances of the catalytic domain of the rat 2',3'-cyclic nucleotide 3'-phosphodiesterase.
Volume: 22
Issue: 1
Pages: 99-100
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Protein Domain
IPR008431 | CNPase
Type: Family
Description: This family consists of the eukaryotic protein 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP). 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP) is one of the earliest myelin-related proteins expressed in differentiating oligodendrocytes and Schwann cells. CNP is abundant in the central nervous system and in oligodendrocytes. This protein is also found in mammalian photoreceptor cells, testis and lymphocytes. Although the biological function of CNP is unknown, it is thought to play a significant role in the formation ofthe myelin sheath, where it comprises 4% of total protein. CNP selectively cleaves 2',3'-cyclic nucleotides to produce 2'-nucleotides in vitro. Although physiologically relevant substrates with 2',3'-cyclic termini are still unknown, numerous cyclic phosphate containing RNAs occur transiently within eukaryotic cells. Other known protein families capable of hydrolysing 2',3'-cyclic nucleotides include tRNA ligases and plant cyclic phosphodiesterases. The catalytic domains from all these proteins contain two tetra-peptide motifs H-X-T/S-X, where X is usually a hydrophobic residue. Mutation of either histidine in CNP abolishes enzymatic activity [].
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Allele
Tg(Cnp-EGFP/Rpl10a)JD368Htz | MGI:3850676
Name: transgene insertion JD368, Nathaniel Heintz
Allele Type: Transgenic
Attribute String: Reporter
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Strain
MGI:3850682 | B6;FVB-Tg(Cnp-EGFP/Rpl10a)JD368Htz/J
Attribute String: transgenic, mutant stock
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Allele
Tg(Cnp-TVA,-lacZ)B8Ubc | MGI:5648077
Name: transgene insertion B8, Uppsala University
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Genotype
Genotype
Symbol: Tg(Cnp-EGFP/Rpl10a)JD368Htz/?
Background: either: (involves: C57BL/6 * FVB) or (involves: FVB * Swiss Webster)
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Cnp-EGFP/Rpl10a)JD368Htz/?
Background: B6;FVB-Tg(Cnp-EGFP/Rpl10a)JD368Htz/J
Zygosity: ot
Has Mutant Allele: true
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Protein
Q09J73
Organism: Mus musculus/domesticus
Length: 94  
Fragment?: true
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Publication
24005282 | J:201647
First Author: Bellesi M
Year: 2013
Journal: J Neurosci
Title: Effects of sleep and wake on oligodendrocytes and their precursors.
Volume: 33
Issue: 36
Pages: 14288-300
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Publication
27113499 | J:236372
First Author: Reddy AS
Year: 2017
Journal: Biol Psychiatry
Title: A Comprehensive Analysis of Cell Type-Specific Nuclear RNA From Neurons and Glia of the Brain.
Volume: 81
Issue: 3
Pages: 252-264
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Strain
MGI:5882803 | FVB/N-Tg(Cnp-TVA,-lacZ)B8Ubc/Kctt
Attribute String: mutant strain, transgenic, coisogenic
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Publication
19421151 | J:151346
First Author: Lindberg N
Year: 2009
Journal: Oncogene
Title: Oligodendrocyte progenitor cells can act as cell of origin for experimental glioma.
Volume: 28
Issue: 23
Pages: 2266-75
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Strain
MGI:5882808 | STOCK Cdkn2a<tm1Rdp> Tg(Cnp-TVA,-lacZ)B8Ubc/Kctt
Attribute String: transgenic, targeted mutation, mutant stock
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Publication
28993643 | J:254569
First Author: Marrocco J
Year: 2017
Journal: Nat Commun
Title: A sexually dimorphic pre-stressed translational signature in CA3 pyramidal neurons of BDNF Val66Met mice.
Volume: 8
Issue: 1
Pages: 808
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Publication
27956743 | J:253453
     
First Author: Gray JD
Year: 2016
Journal: Mol Psychiatry
Title: Translational profiling of stress-induced neuroplasticity in the CA3 pyramidal neurons of BDNF Val66Met mice.
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Publication
16310165 | -
First Author: Mou DL
Year: 2006
Journal: Biochem Biophys Res Commun
Title: Cellular entry of Hantaan virus A9 strain: specific interactions with beta3 integrins and a novel 70kDa protein.
Volume: 339
Issue: 2
Pages: 611-7
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Protein Domain
IPR002532 | Hanta_Gc
Type: Domain
Description: The medium (M) genome segment of Hantaviruses (family Bunyaviridae) encodes the two virion glycoproteins [], Gn and Gc (also known as G1 and G2, respectively) as a polyprotein precursor [, ]. Gn and Gc forms homotetramers at the surface of the virion, which attach the virion to host cell receptors including integrin beta3/ITGB3 and induce internalization, predominantly through clathrin-dependent endocytosis [, ]. This entry represents the polyprotein region which forms the Gc glycoprotein. It has been shown that the N-terminal region of glycoprotein Gc has the conserved CNP motif, suggested to be an integrin-binding motif []. Gc protein has a typical class II fusion protein fold consisting of a central β-sandwich domain (termed domain I) made of eight β-strands arranged in two antiparallel β-sheets, domain II which has an elongated shape with two subdomains (a central, opened β-barrel proximal to domain I and a distal β-sandwich 'tip'), and domain III, which has an Ig-like fold [, ].
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HT Experiment
GSE208683 | Single-nuclei transcriptome sequencing of 5xFAD mouse brain hemisphere with myelin dysfunction
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE178295 | Single-nuclei transcriptome sequencing of mouse grey and white matter under myelin abnormalities
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Strain
MGI:5882806 | STOCK Cdkn2a<tm1Cjs> Tg(Cnp-TVA,-lacZ)B8Ubc/Kctt
Attribute String: mutant stock, targeted mutation, transgenic
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Strain
MGI:5882805 | STOCK Cdkn2a<tm2.1Rdp> Tg(Cnp-TVA,-lacZ)B8Ubc/Kctt
Attribute String: transgenic, targeted mutation, mutant stock
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Publication
22865458 | J:191293
First Author: Dougherty JD
Year: 2012
Journal: Cancer Res
Title: Candidate pathways for promoting differentiation or quiescence of oligodendrocyte progenitor-like cells in glioma.
Volume: 72
Issue: 18
Pages: 4856-68
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Publication
28852070 | J:256454
First Author: Bae CR
Year: 2017
Journal: Sci Rep
Title: Overexpression of C-type Natriuretic Peptide in Endothelial Cells Protects against Insulin Resistance and Inflammation during Diet-induced Obesity.
Volume: 7
Issue: 1
Pages: 9807
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Publication
19805384 | J:153212
First Author: Schmidt H
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: C-type natriuretic peptide (CNP) is a bifurcation factor for sensory neurons.
Volume: 106
Issue: 39
Pages: 16847-52
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Publication
25012822 | J:211104
 
First Author: Sogawa C
Year: 2014
Journal: Reprod Biol Endocrinol
Title: Mutant phenotype analysis suggests potential roles for C-type natriuretic peptide receptor (NPR-B) in male mouse fertility.
Volume: 12
Pages: 64
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Publication
34260913 | J:320628
First Author: Watanabe-Takano H
Year: 2021
Journal: Cell Rep
Title: Mechanical load regulates bone growth via periosteal Osteocrin.
Volume: 36
Issue: 2
Pages: 109380
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Publication
18775416 | J:141154
First Author: Tsuji T
Year: 2008
Journal: Biochem Biophys Res Commun
Title: Hypomorphic mutation in mouse Nppc gene causes retarded bone growth due to impaired endochondral ossification.
Volume: 376
Issue: 1
Pages: 186-90
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Publication
9824501 | J:50739
First Author: Määttä JA
Year: 1998
Journal: Immunology
Title: Encephalitogenicity of myelin-associated oligodendrocytic basic protein and 2',3'-cyclic nucleotide 3'-phosphodiesterase for BALB/c and SJL mice.
Volume: 95
Issue: 3
Pages: 383-8
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Publication
16319309 | J:129669
First Author: Aguirre A
Year: 2005
Journal: J Neurosci
Title: Overexpression of the epidermal growth factor receptor confers migratory properties to nonmigratory postnatal neural progenitors.
Volume: 25
Issue: 48
Pages: 11092-106
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Publication
16265668 | J:156149
First Author: Song J
Year: 2006
Journal: Glia
Title: His36Pro point-mutated proteolipid protein retained in the endoplasmic reticulum of oligodendrocytes in the shaking pup.
Volume: 53
Issue: 3
Pages: 257-65
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Publication
26014585 | J:250184
 
First Author: Nakao K
Year: 2015
Journal: Sci Rep
Title: The Local CNP/GC-B system in growth plate is responsible for physiological endochondral bone growth.
Volume: 5
Pages: 10554
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Publication
33172989 | J:300066
First Author: Zhang H
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Type I interferon remodels lysosome function and modifies intestinal epithelial defense.
Volume: 117
Issue: 47
Pages: 29862-29871
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Publication
28115362 | J:239606
First Author: Sreedharan S
Year: 2017
Journal: Cancer Res
Title: Mouse Models of Pediatric Supratentorial High-grade Glioma Reveal How Cell-of-Origin Influences Tumor Development and Phenotype.
Volume: 77
Issue: 3
Pages: 802-812
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Publication
28122246 | J:254513
First Author: Jiang Y
Year: 2017
Journal: Cell Rep
Title: Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin.
Volume: 18
Issue: 4
Pages: 977-990
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Publication
33555315 | J:313261
First Author: Hinman JD
Year: 2021
Journal: Hum Mol Genet
Title: miR-142-3p regulates cortical oligodendrocyte gene co-expression networks associated with tauopathy.
Volume: 30
Issue: 1
Pages: 103-118
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Publication
19013281 | J:150404
First Author: Heiman M
Year: 2008
Journal: Cell
Title: A translational profiling approach for the molecular characterization of CNS cell types.
Volume: 135
Issue: 4
Pages: 738-48
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Publication
3114716 | -
First Author: Yoo DW
Year: 1987
Journal: Nucleic Acids Res
Title: Nucleotide sequence of the M segment of the genomic RNA of Hantaan virus 76-118.
Volume: 15
Issue: 15
Pages: 6299-300
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Publication
32937107 | -
First Author: Serris A
Year: 2020
Journal: Cell
Title: The Hantavirus Surface Glycoprotein Lattice and Its Fusion Control Mechanism.
Volume: 183
Issue: 2
Pages: 442-456.e16
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Publication
11886265 | -
First Author: Jin M
Year: 2002
Journal: Virology
Title: Hantaan virus enters cells by clathrin-dependent receptor-mediated endocytosis.
Volume: 294
Issue: 1
Pages: 60-9
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HT Experiment
GSE80437 | RNA-sequencing of mouse knockout models for Cnp, Plp1, and Ugt8 in the frontal cortex and cerebellum
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
26655697 | J:235897
First Author: Li Z
Year: 2015
Journal: Cell Metab
Title: Hypothalamic Amylin Acts in Concert with Leptin to Regulate Food Intake.
Volume: 22
Issue: 6
Pages: 1059-67
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Publication
27526204 | J:238235
First Author: von Schimmelmann M
Year: 2016
Journal: Nat Neurosci
Title: Polycomb repressive complex 2 (PRC2) silences genes responsible for neurodegeneration.
Volume: 19
Issue: 10
Pages: 1321-30
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Publication
25801706 | J:221599
First Author: Israelson A
Year: 2015
Journal: Neuron
Title: Macrophage migration inhibitory factor as a chaperone inhibiting accumulation of misfolded SOD1.
Volume: 86
Issue: 1
Pages: 218-32
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Publication
32075970 | J:288473
First Author: Forbes TA
Year: 2020
Journal: Nat Commun
Title: Environmental enrichment ameliorates perinatal brain injury and promotes functional white matter recovery.
Volume: 11
Issue: 1
Pages: 964
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Publication
27783711 | -
First Author: Guardado-Calvo P
Year: 2016
Journal: PLoS Pathog
Title: Mechanistic Insight into Bunyavirus-Induced Membrane Fusion from Structure-Function Analyses of the Hantavirus Envelope Glycoprotein Gc.
Volume: 12
Issue: 10
Pages: e1005813
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Publication
8897953 | J:36239
First Author: Huang H
Year: 1996
Journal: Am J Physiol
Title: Isolation, mapping, and regulated expression of the gene encoding mouse C-type natriuretic peptide.
Volume: 271
Issue: 4 Pt 2
Pages: H1565-75
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Publication
11259675 | J:75620
First Author: Chusho H
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Dwarfism and early death in mice lacking C-type natriuretic peptide.
Volume: 98
Issue: 7
Pages: 4016-21
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Publication
11157071 | J:297523
First Author: Zhou C
Year: 2001
Journal: J Neurosci
Title: Atp-binding cassette transporter ABC2/ABCA2 in the rat brain: a novel mammalian lysosome-associated membrane protein and a specific marker for oligodendrocytes but not for myelin sheaths.
Volume: 21
Issue: 3
Pages: 849-57
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Publication
30837646 | J:283177
First Author: de Faria O Jr
Year: 2019
Journal: Sci Rep
Title: TMEM10 Promotes Oligodendrocyte Differentiation and is Expressed by Oligodendrocytes in Human Remyelinating Multiple Sclerosis Plaques.
Volume: 9
Issue: 1
Pages: 3606
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Publication
9022669 | J:38648
First Author: Ohta S
Year: 1996
Journal: Eur J Biochem
Title: Molecular cloning and characterization of a transcription factor for the C-type natriuretic peptide gene promoter.
Volume: 242
Issue: 3
Pages: 460-6
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Publication
28594915 | J:245453
First Author: Nakade Y
Year: 2017
Journal: PLoS One
Title: Conophylline inhibits non-alcoholic steatohepatitis in mice.
Volume: 12
Issue: 6
Pages: e0178436
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Publication
2579197 | J:7749
First Author: Inuzuka T
Year: 1985
Journal: J Neurochem
Title: Myelin-associated glycoprotein and other proteins in Trembler mice.
Volume: 44
Issue: 3
Pages: 793-7
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Publication
6202376 | J:26989
First Author: Matthieu JM
Year: 1984
Journal: Brain Res
Title: Myelination in the CNS of mld mutant mice: comparison between composition and structure.
Volume: 315
Issue: 1
Pages: 149-58
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Publication
16245024 | J:102038
First Author: Noveroske JK
Year: 2005
Journal: Mamm Genome
Title: A new ENU-induced allele of mouse quaking causes severe CNS dysmyelination.
Volume: 16
Issue: 9
Pages: 672-82
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Publication
11279272 | J:68451
First Author: Zhang Y
Year: 2001
Journal: J Neurochem
Title: Distinct molecular mechanisms lead to diminished myelin basic protein and 2',3'-cyclic nucleotide 3'-phosphodiesterase in qk(v) dysmyelination.
Volume: 77
Issue: 1
Pages: 165-72
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Publication
29962937 | J:310594
 
First Author: Ter-Avetisyan G
Year: 2018
Journal: Front Cell Neurosci
Title: Loss of Axon Bifurcation in Mesencephalic Trigeminal Neurons Impairs the Maximal Biting Force in Npr2-Deficient Mice.
Volume: 12
Pages: 153
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Publication
22987720 | J:190645
First Author: Tsuji T
Year: 2012
Journal: Mol Reprod Dev
Title: CNP/NPR2 signaling maintains oocyte meiotic arrest in early antral follicles and is suppressed by EGFR-mediated signaling in preovulatory follicles.
Volume: 79
Issue: 11
Pages: 795-802
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Publication
24431432 | J:205571
First Author: Ter-Avetisyan G
Year: 2014
Journal: J Neurosci
Title: Bifurcation of axons from cranial sensory neurons is disabled in the absence of Npr2-induced cGMP signaling.
Volume: 34
Issue: 3
Pages: 737-47
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Publication
15722353 | J:98753
First Author: Tsuji T
Year: 2005
Journal: J Biol Chem
Title: A loss-of-function mutation in natriuretic peptide receptor 2 (Npr2) gene is responsible for disproportionate dwarfism in cn/cn mouse.
Volume: 280
Issue: 14
Pages: 14288-92
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Publication
19369543 | J:147956
First Author: Sargiannidou I
Year: 2009
Journal: J Neurosci
Title: Connexin32 mutations cause loss of function in Schwann cells and oligodendrocytes leading to PNS and CNS myelination defects.
Volume: 29
Issue: 15
Pages: 4736-49
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Publication
16179391 | J:101455
First Author: Scotland RS
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: C-type natriuretic peptide inhibits leukocyte recruitment and platelet-leukocyte interactions via suppression of P-selectin expression.
Volume: 102
Issue: 40
Pages: 14452-7
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Publication
31974587 | J:348107
 
First Author: Yamashita T
Year: 2020
Journal: Endocrinology
Title: C-Type Natriuretic Peptide Restores Growth Impairment Under Enzyme Replacement in Mice With Mucopolysaccharidosis VII.
Volume: 161
Issue: 2
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Publication
28990933 | J:252598
First Author: Kanai Y
Year: 2017
Journal: J Clin Invest
Title: Circulating osteocrin stimulates bone growth by limiting C-type natriuretic peptide clearance.
Volume: 127
Issue: 11
Pages: 4136-4147
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Publication
9950655 | J:53666
First Author: Zhao L
Year: 1999
Journal: Circulation
Title: NPR-A-Deficient mice show increased susceptibility to hypoxia-induced pulmonary hypertension.
Volume: 99
Issue: 5
Pages: 605-7
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Publication
15093694 | J:102436
First Author: Steinmetz M
Year: 2004
Journal: Regul Pept
Title: Diverging vasorelaxing effects of C-type natriuretic peptide in renal resistance arteries and aortas of GC-A-deficient mice.
Volume: 119
Issue: 1-2
Pages: 31-7
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Publication
33262386 | J:299598
First Author: Ozaki T
Year: 2020
Journal: Sci Rep
Title: Evaluation of FGFR inhibitor ASP5878 as a drug candidate for achondroplasia.
Volume: 10
Issue: 1
Pages: 20915
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Publication
12621153 | J:126213
First Author: Yamahara K
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Significance and therapeutic potential of the natriuretic peptides/cGMP/cGMP-dependent protein kinase pathway in vascular regeneration.
Volume: 100
Issue: 6
Pages: 3404-9
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Publication
20555027 | J:169505
First Author: Inuzuka M
Year: 2010
Journal: Endocrinology
Title: C-type natriuretic peptide as a new regulator of food intake and energy expenditure.
Volume: 151
Issue: 8
Pages: 3633-42
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Publication
22199120 | J:196859
First Author: Frantz S
Year: 2013
Journal: Eur Heart J
Title: Stress-dependent dilated cardiomyopathy in mice with cardiomyocyte-restricted inactivation of cyclic GMP-dependent protein kinase I.
Volume: 34
Issue: 16
Pages: 1233-44
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Publication
22271248 | J:321139
First Author: Kondo E
Year: 2012
Journal: Calcif Tissue Int
Title: Skeletal analysis of the long bone abnormality (lbab/lbab) mouse, a novel chondrodysplastic C-type natriuretic peptide mutant.
Volume: 90
Issue: 4
Pages: 307-18
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Publication
29501420 | J:269662
 
First Author: Ma Q
Year: 2018
Journal: Exp Neurol
Title: C-type natriuretic peptide functions as an innate neuroprotectant in neonatal hypoxic-ischemic brain injury in mouse via natriuretic peptide receptor 2.
Volume: 304
Pages: 58-66
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Publication
19805191 | J:153667
First Author: Zhao Z
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Regulation of axonal development by natriuretic peptide hormones.
Volume: 106
Issue: 42
Pages: 18016-21
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Publication
12193576 | J:81461
First Author: Miyazawa T
Year: 2002
Journal: Endocrinology
Title: Cyclic GMP-dependent protein kinase II plays a critical role in C-type natriuretic peptide-mediated endochondral ossification.
Volume: 143
Issue: 9
Pages: 3604-10
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Publication
25105365 | J:215744
First Author: Moyes AJ
Year: 2014
Journal: J Clin Invest
Title: Endothelial C-type natriuretic peptide maintains vascular homeostasis.
Volume: 124
Issue: 9
Pages: 4039-51
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Publication
30319353 | J:314839
 
First Author: Dumoulin A
Year: 2018
Journal: Front Mol Neurosci
Title: S-palmitoylation Is Required for the Control of Growth Cone Morphology of DRG Neurons by CNP-Induced cGMP Signaling.
Volume: 11
Pages: 345
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Publication
37216506 | J:345103
First Author: Zhou GF
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: ARL6IP1 mediates small-molecule-induced alleviation of Alzheimer pathology through FXR1-dependent BACE1 translation initiation.
Volume: 120
Issue: 22
Pages: e2220148120
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Publication
34031239 | J:317263
 
First Author: Xi G
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: The mRNA-destabilizing protein Tristetraprolin targets "meiosis arrester" Nppc mRNA in mammalian preovulatory follicles.
Volume: 118
Issue: 22
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Publication
23127564 | J:192266
First Author: Sogawa C
Year: 2013
Journal: Am J Pathol
Title: C-type natriuretic peptide specifically acts on the pylorus and large intestine in mouse gastrointestinal tract.
Volume: 182
Issue: 1
Pages: 172-9
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Publication
20616347 | J:163374
First Author: Sogawa C
Year: 2010
Journal: Am J Pathol
Title: Gastrointestinal tract disorder in natriuretic peptide receptor B gene mutant mice.
Volume: 177
Issue: 2
Pages: 822-8
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Publication
37227779 | J:354498
 
First Author: Werner F
Year: 2023
Journal: JCI Insight
Title: Ablation of C-type natriuretic peptide/cGMP signaling in fibroblasts exacerbates adverse cardiac remodeling in mice.
Volume: 8
Issue: 13
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Publication
31092737 | J:292977
 
First Author: Li H
Year: 2019
Journal: JCI Insight
Title: Gene suppressing therapy for Pelizaeus-Merzbacher disease using artificial microRNA.
Volume: 4
Issue: 10
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Publication
22870295 | J:189658
First Author: Miura K
Year: 2012
Journal: PLoS One
Title: An overgrowth disorder associated with excessive production of cGMP due to a gain-of-function mutation of the natriuretic peptide receptor 2 gene.
Volume: 7
Issue: 8
Pages: e42180
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Publication
30239744 | J:268918
First Author: Inoue SI
Year: 2019
Journal: Hum Mol Genet
Title: C-type natriuretic peptide improves growth retardation in a mouse model of cardio-facio-cutaneous syndrome.
Volume: 28
Issue: 1
Pages: 74-83
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