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Search results 501 to 532 out of 532 for Cpe

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0.019s

Type

Details

Score

Protein Domain

IPR003897 | Clenterotox

Type:

Family

Description:

Clostridial species are one of the major causes of food poisoning/gastro-intestinal illnesses. They are Gram-positive, spore-forming rods that occur naturally in the soil []. Among the family are: Clostridium botulinum, which produces one of the most potent toxins in existence; Clostridium tetani, causative agent of tetanus; and Clostridium perfringens, commonly found in wound infections and diarrhoea cases. The use of toxins to damage the host is a method deployed by many bacterial pathogens.The major virulence factor of C. perfringens is the CPE enterotoxin, which is secreted upon invasion of the host gut, and contributes to food poisoning and other gastrointestinal illnesses []. It has a molecular weight of 35.3kDa, and is responsible for the disintegration of tight junctions between endothelial cells in the gut []. This mechanism is mediated by host claudins-3 and -4, situated at the tight junctions.Two more host receptors have been characterised and expressed in vivo[]. Named CPE-R and RVP1, these may be utilised in the passage of Clostridial species through the gut wall, although the regulatory mechanisms have not been elucidated.This entry also includes HA-70 from Clostridium botulinum C phage. The hemagglutinin (HA) components of the progenitor toxin protects the structural integrity of botulinum neurotoxin. The structure of HA70 from type C and D toxin (HA70/C/D) has been revealed [, ].

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Publication

34720883 | J:312735

First Author:	Van Hoecke L
Year:	2021
Journal:	Front Cell Neurosci
Title:	Involvement of the Choroid Plexus in the Pathogenesis of Niemann-Pick Disease Type C.
Volume:	15

Pages:	757482

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Publication

29472246 | J:262255

First Author:	Steeland S
Year:	2018
Journal:	EMBO Mol Med
Title:	Counteracting the effects of TNF receptor-1 has therapeutic potential in Alzheimer's disease.
Volume:	10
Issue:	4

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Publication

15975937 | J:100435

First Author:	Currle DS
Year:	2005
Journal:	Development
Title:	Direct and indirect roles of CNS dorsal midline cells in choroid plexus epithelia formation.
Volume:	132
Issue:	15
Pages:	3549-59

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Publication

26826184 | J:246427

First Author:	Sousa Martins JP
Year:	2016
Journal:	J Cell Sci
Title:	DAZL and CPEB1 regulate mRNA translation synergistically during oocyte maturation.
Volume:	129
Issue:	6
Pages:	1271-82

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Publication

20926679 | J:165095

First Author:	Alves-Sampaio A
Year:	2010
Journal:	J Neurosci
Title:	NMDA-mediated regulation of DSCAM dendritic local translation is lost in a mouse model of Down's syndrome.
Volume:	30
Issue:	40
Pages:	13537-48

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Publication

21859894 | J:178399

First Author:	Roepke TK
Year:	2011
Journal:	FASEB J
Title:	KCNE2 forms potassium channels with KCNA3 and KCNQ1 in the choroid plexus epithelium.
Volume:	25
Issue:	12
Pages:	4264-73

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Publication

25605874 | J:220024

First Author:	Ding T
Year:	2015
Journal:	J Lipid Res
Title:	All members in the sphingomyelin synthase gene family have ceramide phosphoethanolamine synthase activity.
Volume:	56
Issue:	3
Pages:	537-45

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Publication

25667419 | J:228568

First Author:	Bickert A
Year:	2015
Journal:	J Lipid Res
Title:	Functional characterization of enzymes catalyzing ceramide phosphoethanolamine biosynthesis in mice.
Volume:	56
Issue:	4
Pages:	821-35

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Publication

21173229 | J:169014

First Author:	Ward SV
Year:	2011
Journal:	Proc Natl Acad Sci U S A
Title:	RNA editing enzyme adenosine deaminase is a restriction factor for controlling measles virus replication that also is required for embryogenesis.
Volume:	108
Issue:	1
Pages:	331-6

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Publication

16172982 | J:105760

First Author:	Swetloff A
Year:	2005
Journal:	Int J Dev Biol
Title:	Changes in E2F5 intracellular localization in mouse and human choroid plexus epithelium with development.
Volume:	49
Issue:	7
Pages:	859-65

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Publication

1628827 | J:1385

First Author:	Sallés FJ
Year:	1992
Journal:	Genes Dev
Title:	Isolation of novel murine maternal mRNAs regulated by cytoplasmic polyadenylation.
Volume:	6
Issue:	7
Pages:	1202-12

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Publication

18782762 | J:142952

First Author:	Ling J
Year:	2008
Journal:	J Biol Chem
Title:	Structural constraints for the binding of short peptides to claudin-4 revealed by surface plasmon resonance.
Volume:	283
Issue:	45
Pages:	30585-95

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Publication

30335155 | J:269516

First Author:	Dai XX
Year:	2019
Journal:	Nucleic Acids Res
Title:	A combinatorial code for mRNA 3'-UTR-mediated translational control in the mouse oocyte.
Volume:	47
Issue:	1
Pages:	328-340

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Publication

17176632 | J:288314

First Author:	Barnard DL
Year:	2006
Journal:	Antivir Chem Chemother
Title:	Evaluation of immunomodulators, interferons and known in vitro SARS-coV inhibitors for inhibition of SARS-coV replication in BALB/c mice.
Volume:	17
Issue:	5
Pages:	275-84

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Publication

33876770 | J:305106

First Author:	Vecchio AJ
Year:	2021
Journal:	Proc Natl Acad Sci U S A
Title:	Structural basis for Clostridium perfringens enterotoxin targeting of claudins at tight junctions in mammalian gut.
Volume:	118
Issue:	15

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Publication

22684008 | -

First Author:	Yamashita S
Year:	2012
Journal:	FEBS Lett
Title:	Carbohydrate recognition mechanism of HA70 from Clostridium botulinum deduced from X-ray structures in complexes with sialylated oligosaccharides.
Volume:	586
Issue:	16
Pages:	2404-10

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Publication

10073577 | J:53201

First Author:	Lei Y
Year:	1999
Journal:	DNA Cell Biol
Title:	Identification of mouse CPX-1, a novel member of the metallocarboxypeptidase gene family with highest similarity to CPX-2.
Volume:	18
Issue:	2
Pages:	175-85

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Publication

9584130 | J:48569

First Author:	Grove EA
Year:	1998
Journal:	Development
Title:	The hem of the embryonic cerebral cortex is defined by the expression of multiple Wnt genes and is compromised in Gli3-deficient mice.
Volume:	125
Issue:	12
Pages:	2315-25

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Publication

22357733 | J:186787

First Author:	Damkier HH
Year:	2012
Journal:	Am J Physiol Cell Physiol
Title:	Genetic ablation of Slc4a10 alters the expression pattern of transporters involved in solute movement in the mouse choroid plexus.
Volume:	302
Issue:	10
Pages:	C1452-9

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Publication

19369449 | J:149678

First Author:	Damkier HH
Year:	2009
Journal:	Am J Physiol Cell Physiol
Title:	Nhe1 is a luminal Na+/H+ exchanger in mouse choroid plexus and is targeted to the basolateral membrane in Ncbe/Nbcn2-null mice.
Volume:	296
Issue:	6
Pages:	C1291-300

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Publication

9662053 | J:48377

First Author:	Utsunomiya N
Year:	1998
Journal:	Diabetologia
Title:	Organization of the human carboxypeptidase E gene and molecular scanning for mutations in Japanese subjects with NIDDM or obesity.
Volume:	41
Issue:	6
Pages:	701-5

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Publication

24586322 | J:213445

First Author:	Rutledge CE
Year:	2014
Journal:	PLoS One
Title:	Efficient translation of Dnmt1 requires cytoplasmic polyadenylation and Musashi binding elements.
Volume:	9
Issue:	2
Pages:	e88385

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Publication

24391755 | J:356996

First Author:	Janssen SF
Year:	2013
Journal:	PLoS One
Title:	Gene expression and functional annotation of the human and mouse choroid plexus epithelium.
Volume:	8
Issue:	12
Pages:	e83345

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Publication

29956324 | J:290560

First Author:	Christensen HL
Year:	2018
Journal:	J Physiol
Title:	The choroid plexus sodium-bicarbonate cotransporter NBCe2 regulates mouse cerebrospinal fluid pH.
Volume:	596
Issue:	19
Pages:	4709-4728

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Publication

6887246 | -

First Author:	Rees DC
Year:	1983
Journal:	J Mol Biol
Title:	Refined crystal structure of carboxypeptidase A at 1.54 A resolution.
Volume:	168
Issue:	2
Pages:	367-87

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Publication

1449602 | -

First Author:	Osterman AL
Year:	1992
Journal:	J Protein Chem
Title:	Primary structure of carboxypeptidase T: delineation of functionally relevant features in Zn-carboxypeptidase family.
Volume:	11
Issue:	5
Pages:	561-70

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Publication

21349154 | J:276394

First Author:	Gonzalez AM
Year:	2011
Journal:	Fluids Barriers CNS
Title:	Ecrg4 expression and its product augurin in the choroid plexus: impact on fetal brain development, cerebrospinal fluid homeostasis and neuroprogenitor cell response to CNS injury.
Volume:	8
Issue:	1
Pages:	6

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Publication

- | J:321881

First Author:	Abdoli A
Year:	2022
Journal:	bioRxiv
Title:	Omicron-based vaccine candidate elicits potent neutralizing antibodies in the animal model.

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Publication

17244818 | J:168198

First Author:	Kalinina E
Year:	2007
Journal:	FASEB J
Title:	A novel subfamily of mouse cytosolic carboxypeptidases.
Volume:	21
Issue:	3
Pages:	836-50

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Publication

1548696 | -

First Author:	Guasch A
Year:	1992
Journal:	J Mol Biol
Title:	Three-dimensional structure of porcine pancreatic procarboxypeptidase A. A comparison of the A and B zymogens and their determinants for inhibition and activation.
Volume:	224
Issue:	1
Pages:	141-57

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Publication

7674922 | -

First Author:	Rawlings ND
Year:	1995
Journal:	Methods Enzymol
Title:	Evolutionary families of metallopeptidases.
Volume:	248

Pages:	183-228

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