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Search results 501 to 597 out of 597 for Dvl2

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Type Details Score
Publication
18351675 | J:122362
First Author: Harwood BN
Year: 2008
Journal: Dev Dyn
Title: Members of the WNT signaling pathways are widely expressed in mouse ovaries, oocytes, and cleavage stage embryos.
Volume: 237
Issue: 4
Pages: 1099-111
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Publication
19515997 | J:154534
First Author: Martinez G
Year: 2009
Journal: Invest Ophthalmol Vis Sci
Title: Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation.
Volume: 50
Issue: 10
Pages: 4794-806
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Publication
- | J:29126
     
First Author: The Jackson Laboratory DNA Panel Mapping Resource
Year: 1999
Journal: Database Release
Title: JAX Interspecific Backcross BSS and BSB Public Mapping Data
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Publication
- | J:46439
     
First Author: Freeman TC
Year: 1998
Journal: MGI Direct Data Submission
Title: Expression Mapping of Mouse Genes
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Publication
15226823 | J:93300
First Author: Blackshaw S
Year: 2004
Journal: PLoS Biol
Title: Genomic analysis of mouse retinal development.
Volume: 2
Issue: 9
Pages: E247
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Interaction Experiment
Zhang Y (2011)
Description: GABARAPL1 negatively regulates Wnt/-catenin signaling by mediating Dvl2 degradation through the autophagy pathway.
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Interaction Experiment
Zhao D (2021)
Description: Targeting E3 Ubiquitin Ligase WWP1 Prevents Cardiac Hypertrophy Through Destabilizing DVL2 via Inhibition of K27-Linked Ubiquitination.
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Publication
21691068 | -
First Author: Zhang Y
Year: 2011
Journal: Cell Physiol Biochem
Title: GABARAPL1 negatively regulates Wnt/β-catenin signaling by mediating Dvl2 degradation through the autophagy pathway.
Volume: 27
Issue: 5
Pages: 503-12
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Publication
34139860 | -
First Author: Zhao D
Year: 2021
Journal: Circulation
Title: Targeting E3 Ubiquitin Ligase WWP1 Prevents Cardiac Hypertrophy Through Destabilizing DVL2 via Inhibition of K27-Linked Ubiquitination.
Volume: 144
Issue: 9
Pages: 694-711
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Allele
Tg(Dvl2)7Gsb | MGI:1891523
Name: transgene insertion 7, Gregory S Barsh
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Genotype
Genotype
Symbol: Tg(Dvl2)7Gsb/?
Background: either: FVB/N or (involves: C57BL/6 * FVB/N)
Zygosity: ot
Has Mutant Allele: true
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Allele
Tg(Dvl2/EGFP)1Awb | MGI:3608679
Name: transgene insertion 1, Anthony Wynshaw-Boris
Allele Type: Transgenic
Attribute String: Reporter
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Allele
Tg(Dvl2/EGFP)2Awb | MGI:3715908
Name: transgene insertion 2, Anthony Wynshaw-Boris
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Dvl2*/EGFP)3Awb | MGI:3715909
Name: transgene insertion 3, Anthony Wynshaw-Boris
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Dvl2*/EGFP)4Awb | MGI:3715911
Name: transgene insertion 4, Anthony Wynshaw-Boris
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Dvl2*K446M/EGFP)5Awb | MGI:3715920
Name: transgene insertion 5, Anthony Wynshaw-Boris
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Publication
28334810 | J:242589
First Author: Seo HS
Year: 2017
Journal: Hum Mol Genet
Title: Bimodal regulation of Dishevelled function by Vangl2 during morphogenesis.
Volume: 26
Issue: 11
Pages: 2053-2061
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Genotype
Genotype
Symbol: Vangl2/Vangl2 Tg(Dvl2/EGFP)2Awb/?
Background: involves: LPT/LeJ
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dvl1/Dvl1 Dvl2/Dvl2 Tg(Dvl2/EGFP)2Awb/?
Background: involves: 129S6/SvEvTac
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dvl1/Dvl1 Dvl2/Dvl2 Tg(Dvl2*/EGFP)4Awb/?
Background: involves: 129S6/SvEvTac
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dvl1/Dvl1 Dvl2/Dvl2 Tg(Dvl2/EGFP)1Awb/?
Background: involves: 129S6/SvEvTac
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dvl2/Dvl2 Tg(Dvl2/EGFP)2Awb/? Vangl2/Vangl2<+>
Background: involves: 129S6/SvEvTac * LPT/LeJ
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dvl1/Dvl1 Dvl2/Dvl2 Tg(Dvl2*/EGFP)3Awb/?
Background: involves: 129S6/SvEvTac
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dvl1/Dvl1 Dvl2/Dvl2 Tg(Dvl2*K446M/EGFP)5Awb/?
Background: involves: 129S6/SvEvTac
Zygosity: cx
Has Mutant Allele: true
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Publication
24711502 | J:215806
First Author: Bentzinger CF
Year: 2014
Journal: J Cell Biol
Title: Wnt7a stimulates myogenic stem cell motility and engraftment resulting in improved muscle strength.
Volume: 205
Issue: 1
Pages: 97-111
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Publication
27477274 | J:238983
First Author: Jin X
Year: 2016
Journal: Cell Rep
Title: The ID1-CULLIN3 Axis Regulates Intracellular SHH and WNT Signaling in Glioblastoma Stem Cells.
Volume: 16
Issue: 6
Pages: 1629-1641
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Publication
28963394 | J:249243
First Author: Morgenstern Y
Year: 2017
Journal: EMBO J
Title: Casein kinase 1-epsilon or 1-delta required for Wnt-mediated intestinal stem cell maintenance.
Volume: 36
Issue: 20
Pages: 3046-3061
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Publication
37260921 | J:336154
   
First Author: Rim EY
Year: 2023
Journal: MicroPubl Biol
Title: APEX2-Mediated Proximity Labeling of Wnt Receptor Interactors Upon Pathway Activation.
Volume: 2023
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Publication
9407023 | J:45118
First Author: Cadigan KM
Year: 1997
Journal: Genes Dev
Title: Wnt signaling: a common theme in animal development.
Volume: 11
Issue: 24
Pages: 3286-305
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Publication
10318824 | J:54993
First Author: Sakanaka C
Year: 1999
Journal: J Biol Chem
Title: Functional domains of axin. Importance of the C terminus as an oligomerization domain.
Volume: 274
Issue: 20
Pages: 14090-3
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Publication
10330181 | -
First Author: Kishida S
Year: 1999
Journal: Mol Cell Biol
Title: DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability.
Volume: 19
Issue: 6
Pages: 4414-22
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Publication
11041490 | -
First Author: Fukui A
Year: 2000
Journal: Dev Growth Differ
Title: Effects of rat Axin domains on axis formation in Xenopus embryos.
Volume: 42
Issue: 5
Pages: 489-98
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Publication
11027605 | -
First Author: Julius MA
Year: 2000
Journal: Biochem Biophys Res Commun
Title: Domains of axin and disheveled required for interaction and function in wnt signaling.
Volume: 276
Issue: 3
Pages: 1162-9
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Publication
12384700 | -
First Author: Capelluto DG
Year: 2002
Journal: Nature
Title: The DIX domain targets dishevelled to actin stress fibres and vesicular membranes.
Volume: 419
Issue: 6908
Pages: 726-9
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Protein Domain
IPR038207 | DIX_dom_sf
Type: Homologous_superfamily
Description: Proteins of the dishevelled family (Dsh and Dvl) play a key role in thetransduction of the Wg/Wnt signal from the cell surface tothe nucleus: in response to Wnt signal, they block the degradation of beta-catenin by interacting with the scaffolding protein axin. The N terminus ofproteins of the dishevelled family and the C terminus of proteins of the axinfamily share a region of homology of about 85 amino acids, which has beencalled DIX for DIshevelled and aXin []. The DIX domain is found associated with PDZ and DEP domains in proteins of the dishevelled family and with an RGS domain in proteins of the axin family. DIX has been shown to be a protein-protein interaction domain that is important for homo- and hetero-oligomerization of proteins of the dishevelled and axin families [, , , ]. The DIX domain has also be shownto be a signalling module that can target proteins to actin stress fibres andcytoplasmic vesicles to control Wnt signalling [].The Dvl2 DIX domain has been shown to form a predominantly helical structure[].A third type of DIX domain-possessing protein, known as Coiled-coil-DIX1 (Ccd1) or Dixin, forms homomeric and heteromeric complexes with Dvl and Axin and is positive regulator of Wnt signaling [].
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Protein Domain
IPR001158 | DIX
Type: Domain
Description: Proteins of the dishevelled family (Dsh and Dvl) play a key role in thetransduction of the Wg/Wnt signal from the cell surface tothe nucleus: in response to Wnt signal, they block the degradation of beta-catenin by interacting with the scaffolding protein axin. The N terminus ofproteins of the dishevelled family and the C terminus of proteins of the axinfamily share a region of homology of about 85 amino acids, which has beencalled DIX for DIshevelled and aXin []. The DIX domain is found associated with PDZ and DEP domains in proteins of the dishevelled family and with an RGS domain in proteins of the axin family. DIX has been shown to be a protein-protein interaction domain that is important for homo- and hetero-oligomerization of proteins of the dishevelled and axin families [, , , ]. The DIX domain has also be shownto be a signalling module that can target proteins to actinstress fibres andcytoplasmic vesicles to control Wnt signalling [].The Dvl2 DIX domain has been shown to form a predominantly helical structure[].A third type of DIX domain-possessing protein, known as Coiled-coil-DIX1 (Ccd1) or Dixin, forms homomeric and heteromeric complexes with Dvl and Axin and is positive regulator of Wnt signaling [].
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Publication
19001364 | J:219089
First Author: Andersson T
Year: 2009
Journal: J Biol Chem
Title: CXXC5 is a novel BMP4-regulated modulator of Wnt signaling in neural stem cells.
Volume: 284
Issue: 6
Pages: 3672-81
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Publication
21317929 | J:173694
First Author: Li Y
Year: 2011
Journal: Oncogene
Title: HEF1, a novel target of Wnt signaling, promotes colonic cell migration and cancer progression.
Volume: 30
Issue: 23
Pages: 2633-43
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Publication
10769039 | J:61768
First Author: Charpentier E
Year: 2000
Journal: J Cell Biol
Title: Plakoglobin suppresses epithelial proliferation and hair growth in vivo.
Volume: 149
Issue: 2
Pages: 503-20
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Publication
22128168 | J:179664
First Author: Yamagata K
Year: 2012
Journal: J Biol Chem
Title: Dissection of Wnt5a-Ror2 signaling leading to matrix metalloproteinase (MMP-13) expression.
Volume: 287
Issue: 2
Pages: 1588-99
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Publication
35144597 | J:322488
First Author: Kim Y
Year: 2022
Journal: BMC Biol
Title: DIX domain containing 1 (DIXDC1) modulates VEGFR2 level in vasculatures to regulate embryonic and postnatal retina angiogenesis.
Volume: 20
Issue: 1
Pages: 41
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Publication
20837657 | J:164680
First Author: Singh J
Year: 2010
Journal: Genes Dev
Title: Abelson family kinases regulate Frizzled planar cell polarity signaling via Dsh phosphorylation.
Volume: 24
Issue: 19
Pages: 2157-68
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Publication
16446366 | J:111564
First Author: Zhang L
Year: 2006
Journal: J Biol Chem
Title: Dapper 1 antagonizes Wnt signaling by promoting dishevelled degradation.
Volume: 281
Issue: 13
Pages: 8607-12
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Publication
21697359 | J:173523
First Author: Wilkinson MB
Year: 2011
Journal: J Neurosci
Title: A novel role of the WNT-dishevelled-GSK3β signaling cascade in the mouse nucleus accumbens in a social defeat model of depression.
Volume: 31
Issue: 25
Pages: 9084-92
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Publication
22328498 | J:197303
First Author: Endo M
Year: 2012
Journal: J Cell Sci
Title: Ror family receptor tyrosine kinases regulate the maintenance of neural progenitor cells in the developing neocortex.
Volume: 125
Issue: Pt 8
Pages: 2017-29
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Publication
29659741 | J:298070
First Author: Lian G
Year: 2019
Journal: Cereb Cortex
Title: Formin 2 Regulates Lysosomal Degradation of Wnt-Associated β-Catenin in Neural Progenitors.
Volume: 29
Issue: 5
Pages: 1938-1952
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Publication
31867777 | J:300618
First Author: Novellasdemunt L
Year: 2020
Journal: EMBO J
Title: NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor.
Volume: 39
Issue: 3
Pages: e102771
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Publication
12948650 | -
First Author: Copp AJ
Year: 2003
Journal: Trends Neurosci
Title: Dishevelled: linking convergent extension with neural tube closure.
Volume: 26
Issue: 9
Pages: 453-5
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Protein Domain
IPR015506 | Dsh/Dvl-rel
Type: Family
Description: This entry includes the dishevelled (Dsh) proteins and dixin (also known as coiled-coil-DIX1, Ccd1).The transduction mechanism requires dishevelled protein (Dsh), a cytoplasmic phosphoprotein that acts directly downstream of frizzled []. In addition to its role in Wnt signalling, Dsh is also involved in generating planar polarity in Drosophila and has been implicated in the Notch signal transduction cascade. Furthermore, Dsh plays a vital molecular role in neural tube closure. Disruption of dishevelled signalling in Xenopus and inactivation of the genes encoding dishevelled 1 and dishevelled 2 (Dvl1 and Dvl2) in the mouse yield similar phenotypes, in which the neural tube fails to close []. Three human and mouse homologues of Dsh have been cloned (DVL-1 to 3); it is believed that these proteins, like their Drosophila counterpart, are involved in signal transduction. Human and murine orthologues share more than 95% sequence identity and are each 40-50% identical to Drosophila Dsh.Sequence similarity amongst Dsh proteins is concentrated around three conserved domains: at the N terminus lies a DIX domain (mutations mapping to this region reduce or completely disrupt Wg signalling); a PDZ (or DHR) domain, often found in proteins involved in protein-protein interactions, lies within the central portion of the protein (point mutations within this module have been shown to have little effect on Wg-mediated signal transduction); and a DEP domain is located towards the C terminus and is conserved among a set of proteins that regulate various GTPases. Whilst genetic and molecular assays have shown this module to be dispensable for Wg signalling, it is thought to be important in planar polarity signalling in flies [].Ccd1 is another DIX domain-possessing protein that forms complexes with the Dishevelled homologue Dvl and Axin. Ccd1 is a positive regulator of Wnt signalling []. It regulates JNK activation by AXIN1 and DVL2 [].
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Publication
15857680 | J:97956
First Author: Shiomi K
Year: 2005
Journal: Brain Res Mol Brain Res
Title: Identification and differential expression of multiple isoforms of mouse Coiled-coil-DIX1 (Ccd1), a positive regulator of Wnt signaling.
Volume: 135
Issue: 1-2
Pages: 169-80
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Publication
34733849 | J:312854
 
First Author: Zhong G
Year: 2021
Journal: Front Cell Dev Biol
Title: WWP1 Deficiency Alleviates Cardiac Remodeling Induced by Simulated Microgravity.
Volume: 9
Pages: 739944
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Publication
15262978 | -
First Author: Wong CK
Year: 2004
Journal: J Biol Chem
Title: The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms.
Volume: 279
Issue: 38
Pages: 39366-73
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Protein
Q7TMI9
Organism: Mus musculus/domesticus
Length: 435  
Fragment?: true
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Protein
Q6IS36
Organism: Mus musculus/domesticus
Length: 169  
Fragment?: true
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Protein
Q80Y83
Organism: Mus musculus/domesticus
Length: 711  
Fragment?: false
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Protein
Q61062
Organism: Mus musculus/domesticus
Length: 716  
Fragment?: false
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Protein
P51141
Organism: Mus musculus/domesticus
Length: 695  
Fragment?: false
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Protein
E9Q150
Organism: Mus musculus/domesticus
Length: 699  
Fragment?: false
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Protein
E9Q967
Organism: Mus musculus/domesticus
Length: 718  
Fragment?: false
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Protein
O88566
Organism: Mus musculus/domesticus
Length: 840  
Fragment?: false
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Protein
O35625
Organism: Mus musculus/domesticus
Length: 863  
Fragment?: false
•
•
•
•
•
Protein
E9QMJ8
Organism: Mus musculus/domesticus
Length: 868  
Fragment?: false
•
•
•
•
•
Protein
Q3UQK5
Organism: Mus musculus/domesticus
Length: 793  
Fragment?: true
•
•
•
•
•
Protein
A2ABR0
Organism: Mus musculus/domesticus
Length: 775  
Fragment?: false
•
•
•
•
•
Protein
Q14DJ8
Organism: Mus musculus/domesticus
Length: 832  
Fragment?: false
•
•
•
•
•
Protein
F2Z453
Organism: Mus musculus/domesticus
Length: 117  
Fragment?: false
•
•
•
•
•
Publication
12072470 | -
First Author: Penton A
Year: 2002
Journal: Genetics
Title: A mutational analysis of dishevelled in Drosophila defines novel domains in the dishevelled protein as well as novel suppressing alleles of axin.
Volume: 161
Issue: 2
Pages: 747-62
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•
•
•
•
Protein
Q571M1
Organism: Mus musculus/domesticus
Length: 406  
Fragment?: true
•
•
•
•
•
Protein
Q3TRW4
Organism: Mus musculus/domesticus
Length: 412  
Fragment?: false
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•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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