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Search results 501 to 600 out of 605 for Dyrk1a

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Type Details Score
HT Sample
GSM6057925
       
Organism Name: mouse, laboratory
Notes: extra copy of the Dyrk1A gene
Curation Status: Not curated (Transgenic sample)
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HT Sample
GSM6057926
       
Organism Name: mouse, laboratory
Notes: extra copy of the Dyrk1A gene
Curation Status: Not curated (Transgenic sample)
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HT Sample
GSM6057927
       
Organism Name: mouse, laboratory
Notes: extra copy of the Dyrk1A gene
Curation Status: Not curated (Transgenic sample)
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Publication
36927854 | J:338911
First Author: Stoler-Barak L
Year: 2023
Journal: Nat Commun
Title: B cell class switch recombination is regulated by DYRK1A through MSH6 phosphorylation.
Volume: 14
Issue: 1
Pages: 1462
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HT Experiment
GSE201290 | Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism and late-onset Alzheimer's disease
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
23969234 | J:201757
 
First Author: Pons-Espinal M
Year: 2013
Journal: Neurobiol Dis
Title: Environmental enrichment rescues DYRK1A activity and hippocampal adult neurogenesis in TgDyrk1A.
Volume: 60
Pages: 18-31
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Publication
27049307 | J:234953
First Author: Lu S
Year: 2016
Journal: Biochem Biophys Res Commun
Title: Overexpression of Dyrk1A regulates cardiac troponin T splicing in cells and mice.
Volume: 473
Issue: 4
Pages: 993-998
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Publication
29221819 | J:259317
 
First Author: GarcĂ­a-Cerro S
Year: 2018
Journal: Neurobiol Dis
Title: Cerebellar alterations in a model of Down syndrome: The role of the Dyrk1A gene.
Volume: 110
Pages: 206-217
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Publication
32896600 | J:348530
 
First Author: Lee HJ
Year: 2020
Journal: Free Radic Biol Med
Title: The novel DYRK1A inhibitor KVN93 regulates cognitive function, amyloid-beta pathology, and neuroinflammation.
Volume: 160
Pages: 575-595
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Publication
17229891 | J:245708
First Author: Alvarez M
Year: 2007
Journal: Mol Biol Cell
Title: DYRK1A autophosphorylation on serine residue 520 modulates its kinase activity via 14-3-3 binding.
Volume: 18
Issue: 4
Pages: 1167-78
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Publication
22250195 | J:197313
First Author: Park J
Year: 2012
Journal: J Cell Sci
Title: Dyrk1A negatively regulates the actin cytoskeleton through threonine phosphorylation of N-WASP.
Volume: 125
Issue: Pt 1
Pages: 67-80
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Publication
23124096 | J:196990
 
First Author: Hijazi M
Year: 2013
Journal: Exp Neurol
Title: Overexpression of DYRK1A inhibits choline acetyltransferase induction by oleic acid in cellular models of Down syndrome.
Volume: 239
Pages: 229-34
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Transgene
MGI:4867505 | Tg(DYRK1A)36Wjs
Type: transgene
Organism: mouse, laboratory
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GXD Expression
GXD Expression
 
Probe: MGI:6506451
Assay Type: RNA in situ
Annotation Date: 2021-02-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608916
Pattern: Regionally restricted
Stage: TS16
Assay Id: MGI:6506463
Age: embryonic day 10.0
Note: Expression pattern similar to that of Dyrk1a in proliferative regious surrounding ventricles
Specimen Label: 1A Dscr1 E10
Detected: true
Specimen Num: 1
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Interaction Experiment
Sitz JH (2004)
Description: Dyrk1A potentiates steroid hormone-induced transcription via the chromatin remodeling factor Arip4.
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Interaction Experiment
Guo X (2010)
Description: DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1.
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Interaction Experiment
Li Y (2021)
Description: DYRK1a mediates BAFF-induced noncanonical NF-?B activation to promote autoimmunity and B-cell leukemogenesis.
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Publication
15369779 | -
First Author: Kim D
Year: 2004
Journal: Biochem Biophys Res Commun
Title: Regulation of Dyrk1A kinase activity by 14-3-3.
Volume: 323
Issue: 2
Pages: 499-504
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HT Experiment
GSE196445 | Dyrk1a dosage effects on the transcriptome of embryonic hearts from the Dp1Tyb mouse model of Down syndrome using bulk RNAseq
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE196446 | Dyrk1a dosage effects on the transcriptome of embryonic hearts from the Dp1Tyb mouse model of Down syndrome using scRNAseq
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Protein
E0CXW9
Organism: Mus musculus/domesticus
Length: 41  
Fragment?: true
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Protein Domain
IPR042868 | PHYHIP/PHYHIPL
Type: Family
Description: This entry includes PHYHIP and PHYHIPL from humans. PHYHIP interacts with DYRK1A and may contribute to new cellular functions of DYRK1A [].
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Publication
24465139 | -
First Author: Park J
Year: 2013
Journal: Exp Neurobiol
Title: New Perspectives of Dyrk1A Role in Neurogenesis and Neuropathologic Features of Down Syndrome.
Volume: 22
Issue: 4
Pages: 244-8
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Allele
Dyrk1a<tm1Smoc> | MGI:7289422
Name: dual-specificity tyrosine phosphorylation regulated kinase 1a; targeted mutation 1, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Dyrk1a<em1Kzy> | MGI:6149776
Name: dual-specificity tyrosine phosphorylation regulated kinase 1a; endonuclease-mediated mutation 1, Kazuhiro Yamakawa
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Publication
24021800 | J:201827
 
First Author: Song WJ
Year: 2013
Journal: Neurosci Lett
Title: Dyrk1A-mediated phosphorylation of RCAN1 promotes the formation of insoluble RCAN1 aggregates.
Volume: 554
Pages: 135-40
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Genotype
Genotype
Symbol: Dyrk1a/Dyrk1a<+>
Background: C57BL/6J-Dyrk1a
Zygosity: ht
Has Mutant Allele: true
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Publication
15694837 | -
First Author: Bescond M
Year: 2005
Journal: Int J Biochem Cell Biol
Title: Dual-specificity tyrosine-phosphorylated and regulated kinase 1A (DYRK1A) interacts with the phytanoyl-CoA alpha-hydroxylase associated protein 1 (PAHX-AP1), a brain specific protein.
Volume: 37
Issue: 4
Pages: 775-83
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Publication
30850713 | J:276650
First Author: Souchet B
Year: 2019
Journal: Sci Rep
Title: Prenatal treatment with EGCG enriched green tea extract rescues GAD67 related developmental and cognitive defects in Down syndrome mouse models.
Volume: 9
Issue: 1
Pages: 3914
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Allele
Tg(Dyrk1a-EGFP)JF4Gsat | MGI:4847010
Name: transgene insertion JF4, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
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Strain
MGI:6475171 | C57BL/6JSmoc-Dyrk1a<em1Smoc>/Smoc
Attribute String: coisogenic, targeted mutation, mutant strain
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Protein Domain
IPR044131 | PKc_DYR1A/1B
Type: Domain
Description: Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) () phosphorylates serine, threonine and tyrosine residues in proteins such as CRY2, FOXO1 and SIRT1 [, , , ]. It can be activated by tyrosine autophosphorylation [, ]. DYRK1A play a role in a signaling pathway regulating nuclear functions of cell proliferation. DYRK1A is a neurogenesis regulator and plays an important role in altered brain development in Down syndrome [, ]. Dual specificity tyrosine-phosphorylation-regulated kinase 1B (DYRK1B also known as Mirk) also phosphorylates serine, threonine and tyrosine residues, and has been shown to enhance the transcriptional activity of HNF1A and FOXO1 []. Mirk is reported to be an inhibitor of epithelial cell migration [], and appears to mediate carcinoma cell survival in specific environments [].This entry also includes mnb from Drosophila melanogaster. It plays a role in the specific control of proper proliferation of optic lobe neuronal progeny [].This entry represents the catalytic domain found in DYRK1A and DYRK1B.
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Publication
8769099 | -
First Author: Shindoh N
Year: 1996
Journal: Biochem Biophys Res Commun
Title: Cloning of a human homolog of the Drosophila minibrain/rat Dyrk gene from "the Down syndrome critical region" of chromosome 21.
Volume: 225
Issue: 1
Pages: 92-9
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Publication
21156027 | -
First Author: Tejedor FJ
Year: 2011
Journal: FEBS J
Title: MNB/DYRK1A as a multiple regulator of neuronal development.
Volume: 278
Issue: 2
Pages: 223-35
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Publication
19685005 | -
First Author: Park J
Year: 2009
Journal: Cell Mol Life Sci
Title: Function and regulation of Dyrk1A: towards understanding Down syndrome.
Volume: 66
Issue: 20
Pages: 3235-40
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Publication
23809146 | -
First Author: Walte A
Year: 2013
Journal: FEBS J
Title: Mechanism of dual specificity kinase activity of DYRK1A.
Volume: 280
Issue: 18
Pages: 4495-511
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Publication
8631952 | -
First Author: Kentrup H
Year: 1996
Journal: J Biol Chem
Title: Dyrk, a dual specificity protein kinase with unique structural features whose activity is dependent on tyrosine residues between subdomains VII and VIII.
Volume: 271
Issue: 7
Pages: 3488-95
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Publication
22876196 | -
First Author: Hong SH
Year: 2012
Journal: PLoS Genet
Title: Minibrain/Dyrk1a regulates food intake through the Sir2-FOXO-sNPF/NPY pathway in Drosophila and mammals.
Volume: 8
Issue: 8
Pages: e1002857
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Publication
11980910 | -
First Author: Lim S
Year: 2002
Journal: J Biol Chem
Title: Mirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alpha.
Volume: 277
Issue: 28
Pages: 25040-6
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Publication
14500717 | -
First Author: Zou Y
Year: 2003
Journal: J Biol Chem
Title: Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M.
Volume: 278
Issue: 49
Pages: 49573-81
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Publication
10910078 | -
First Author: Lee K
Year: 2000
Journal: Cancer Res
Title: Mirk protein kinase is a mitogen-activated protein kinase substrate that mediates survival of colon cancer cells.
Volume: 60
Issue: 13
Pages: 3631-7
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Strain
MGI:5004084 | STOCK Tg(Dyrk1a-EGFP)JF4Gsat/Mmucd
Attribute String: mutant stock, transgenic
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Allele
Tg(Dyrk1a)189N3Yah | MGI:5430362
Name: transgene insertion 189N3, Yann Herault
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Protein
A9C477
Organism: Mus musculus/domesticus
Length: 110  
Fragment?: true
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Protein Domain
IPR028318 | DYRK1A/B_MNB
Type: Family
Description: Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) () phosphorylates serine, threonine and tyrosine residues in proteins such as CRY2, FOXO1 and SIRT1 [, , , ]. It can be activated by tyrosine autophosphorylation [, ]. DYRK1A play a role in a signaling pathway regulating nuclear functions of cell proliferation. DYRK1A is a neurogenesis regulator and plays an important role in altered brain development in Down syndrome [, ]. Dual specificity tyrosine-phosphorylation-regulated kinase 1B (DYRK1B also known as Mirk) also phosphorylates serine, threonine and tyrosine residues, and has been shown to enhance the transcriptional activity of HNF1A and FOXO1 []. Mirk is reported to be an inhibitor of epithelial cell migration [], and appears to mediate carcinoma cell survival in specific environments [].This entry also includes mnb from Drosophila melanogaster. It plays a role in the specific control of proper proliferation of optic lobe neuronal progeny [].
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Publication
30115750 | J:278768
 
First Author: Nguyen TL
Year: 2018
Journal: Dis Model Mech
Title: Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A.
Volume: 11
Issue: 9
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Strain
MGI:5439977 | C57BL/6-Tg(DYRK1A)36Wjs/J
Attribute String: coisogenic, mutant strain, transgenic
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Allele
Tg(CEPHY152F7)12Hgc | MGI:5293446
Name: transgene insertion 12, Edward M Rubin
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:5424161 | B6.129P2-Tg(Dyrk1a)189N3Yah/JmdOrl
Attribute String: transgenic, congenic, mutant strain
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Strain
MGI:5430655 | B6.129P2-Tg(Dyrk1a)189N3Yah/Yah
Attribute String: transgenic, mutant strain, congenic
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Genotype
Genotype
Symbol: Tg(DYRK1A)36Wjs/?
Background: involves: C57BL/6NCrjBgi
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Dyrk1a)189N3Yah/?
Background: B6.129P2-Tg(Dyrk1a)189N3Yah/Yah
Zygosity: ot
Has Mutant Allele: true
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Strain
MGI:5320338 | FVB-Tg(CEPHY152F7)12Hgc
Attribute String: coisogenic, mutant strain, transgenic
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Strain
MGI:5293449 | FVB-Tg(CEPHY152F7)12Hgc/Orl
Attribute String: coisogenic, mutant strain, transgenic
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Strain
MGI:5424162 | B6.FVB-Tg(CEPHY152F7)12Hgc/Orl
Attribute String: transgenic, mutant strain, congenic
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Allele
Del(16Dyrk1a-Kcnj6)14Yey | MGI:5689441
Name: deletion, Chr 16, Y Eugene Yu 14
Allele Type: Targeted
Attribute String: Null/knockout
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Genotype
Genotype
Symbol: Tg(CEPHY152F7)12Hgc/?
Background: (C57BL/6 x FVB/N)F1
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(CEPHY152F7)12Hgc/?
Background: FVB-Tg(CEPHY152F7)12Hgc
Zygosity: ot
Has Mutant Allele: true
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Protein
A9C478
Organism: Mus musculus/domesticus
Length: 181  
Fragment?: true
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Protein
Q80ZK5
Organism: Mus musculus/domesticus
Length: 329  
Fragment?: true
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Strain
MGI:5690046 | B6.129S7-Del(16Dyrk1a-Kcnj6)14Yey
Attribute String: mutant strain, congenic, chromosome aberration
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Genotype
Genotype
Symbol: Del(16Dyrk1a-Kcnj6)14Yey/+
Background: B6.129S7-Del(16Dyrk1a-Kcnj6)14Yey
Zygosity: ht
Has Mutant Allele: true
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Publication
9918863 | J:52193
First Author: Leder S
Year: 1999
Journal: Biochem Biophys Res Commun
Title: Cloning and characterization of DYRK1B, a novel member of the DYRK family of protein kinases.
Volume: 254
Issue: 2
Pages: 474-9
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Publication
26310823 | J:224975
 
First Author: Schneider P
Year: 2015
Journal: Nat Commun
Title: Identification of a novel actin-dependent signal transducing module allows for the targeted degradation of GLI1.
Volume: 6
Pages: 8023
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Publication
21843906 | J:188193
First Author: Sheppard O
Year: 2012
Journal: Neurobiol Aging
Title: Altered regulation of tau phosphorylation in a mouse model of down syndrome aging.
Volume: 33
Issue: 4
Pages: 828.e31-44
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Publication
27285583 | J:234838
First Author: Lee P
Year: 2016
Journal: Leukemia
Title: The biology, pathogenesis and clinical aspects of acute lymphoblastic leukemia in children with Down syndrome.
Volume: 30
Issue: 9
Pages: 1816-23
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Protein
Q9Z188
Organism: Mus musculus/domesticus
Length: 629  
Fragment?: false
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Protein
Q61214
Organism: Mus musculus/domesticus
Length: 763  
Fragment?: false
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Protein
F6U6X3
Organism: Mus musculus/domesticus
Length: 725  
Fragment?: false
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Protein
Q8K006
Organism: Mus musculus/domesticus
Length: 593  
Fragment?: true
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Protein
A9C475
Organism: Mus musculus/domesticus
Length: 763  
Fragment?: false
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Protein
Q8C774
Organism: Mus musculus/domesticus
Length: 523  
Fragment?: false
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Protein
A1L341
Organism: Mus musculus/domesticus
Length: 754  
Fragment?: false
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Strain
MGI:5690043 | B6.129S7-Del(16Dyrk1a-Kcnj6)14Yey/Dp(16Lipi-Zbtb21)1Yey
Attribute String: chromosome aberration, congenic, deletion, duplication, mutant strain
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Strain
MGI:5689553 | B6.129S7-Del(16Dyrk1a-Kcnj6)14Yey/Dp(16Lipi-Zbtb21)1Yey/J
Attribute String: deletion, congenic, mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Del(16Dyrk1a-Kcnj6)14Yey/? Dp(16Lipi-Zbtb21)1Yey/?
Background: B6.129S7-Del(16Dyrk1a-Kcnj6)14Yey/Dp(16Lipi-Zbtb21)1Yey
Zygosity: cx
Has Mutant Allele: true
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Publication
24710275 | J:217445
First Author: Forristal C
Year: 2014
Journal: Mol Cell Biol
Title: Loss of the mammalian DREAM complex deregulates chondrocyte proliferation.
Volume: 34
Issue: 12
Pages: 2221-34
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Publication
21926299 | J:178735
First Author: Deitz SL
Year: 2011
Journal: Genetics
Title: Trisomic and allelic differences influence phenotypic variability during development of Down syndrome mice.
Volume: 189
Issue: 4
Pages: 1487-95
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Publication
27569213 | J:236858
First Author: Kim J
Year: 2016
Journal: Cancer Res
Title: Ablation of miR-10b Suppresses Oncogene-Induced Mammary Tumorigenesis and Metastasis and Reactivates Tumor-Suppressive Pathways.
Volume: 76
Issue: 21
Pages: 6424-6435
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Publication
35196359 | J:322527
First Author: Jamal R
Year: 2022
Journal: PLoS One
Title: Increased dosage and treatment time of Epigallocatechin-3-gallate (EGCG) negatively affects skeletal parameters in normal mice and Down syndrome mouse models.
Volume: 17
Issue: 2
Pages: e0264254
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Publication
30685352 | J:277908
 
First Author: Navarro-Romero A
Year: 2019
Journal: Neurobiol Dis
Title: Cannabinoid type-1 receptor blockade restores neurological phenotypes in two models for Down syndrome.
Volume: 125
Pages: 92-106
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Publication
19125866 | J:151137
First Author: Siddiqui A
Year: 2008
Journal: Genes Brain Behav
Title: Molecular responses of the Ts65Dn and Ts1Cje mouse models of Down syndrome to MK-801.
Volume: 7
Issue: 7
Pages: 810-20
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Publication
37841687 | J:342143
 
First Author: Thomazeau A
Year: 2023
Journal: Front Neurosci
Title: Glutamatergic synaptic deficits in the prefrontal cortex of the Ts65Dn mouse model for Down syndrome.
Volume: 17
Pages: 1171797
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Publication
33712740 | J:348197
First Author: Illouz T
Year: 2021
Journal: Commun Biol
Title: Maternal antibodies facilitate Amyloid-β clearance by activating Fc-receptor-Syk-mediated phagocytosis.
Volume: 4
Issue: 1
Pages: 329
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Publication
36907286 | J:351751
 
First Author: Lee HJ
Year: 2023
Journal: Pharmacol Res
Title: Inhibition of CDK4/6 regulates AD pathology, neuroinflammation and cognitive function through DYRK1A/STAT3 signaling.
Volume: 190
Pages: 106725
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Publication
36341365 | J:355371
 
First Author: Kim J
Year: 2022
Journal: Front Immunol
Title: Inhibiting EGFR/HER-2 ameliorates neuroinflammatory responses and the early stage of tau pathology through DYRK1A.
Volume: 13
Pages: 903309
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Publication
36590914 | J:353486
 
First Author: Ortega M
Year: 2022
Journal: Front Mol Neurosci
Title: Proteomic profiling reveals mitochondrial dysfunction in the cerebellum of transgenic mice overexpressing DYRK1A, a Down syndrome candidate gene.
Volume: 15
Pages: 1015220
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Publication
32032735 | J:297589
 
First Author: Trovò L
Year: 2020
Journal: Neurobiol Dis
Title: The green tea polyphenol epigallocatechin-3-gallate (EGCG) restores CDKL5-dependent synaptic defects in vitro and in vivo.
Volume: 138
Pages: 104791
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Publication
37926156 | J:342883
First Author: SengĂĽl GF
Year: 2024
Journal: Biochim Biophys Acta Mol Cell Res
Title: Hsc70 phosphorylation patterns and calmodulin regulate AP2 Clathrin-Coated-Vesicle life span for cell adhesion protein transport.
Volume: 1871
Issue: 1
Pages: 119611
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Publication
17963726 | J:128417
First Author: Rachidi M
Year: 2007
Journal: Biochem Biophys Res Commun
Title: New cerebellar phenotypes in YAC transgenic mouse in vivo library of human Down syndrome critical region-1.
Volume: 364
Issue: 3
Pages: 488-94
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Publication
21504804 | J:177005
First Author: Egusa H
Year: 2011
Journal: Bone
Title: The small molecule harmine regulates NFATc1 and Id2 expression in osteoclast progenitor cells.
Volume: 49
Issue: 2
Pages: 264-74
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Publication
24023715 | J:206403
First Author: Weiss CS
Year: 2013
Journal: PLoS One
Title: DYRK2 negatively regulates cardiomyocyte growth by mediating repressor function of GSK-3β on eIF2Bε.
Volume: 8
Issue: 9
Pages: e70848
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Protein
Q8K0S0
Organism: Mus musculus/domesticus
Length: 330  
Fragment?: false
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Protein
Q8BGT8
Organism: Mus musculus/domesticus
Length: 375  
Fragment?: false
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Protein
E0CXJ1
Organism: Mus musculus/domesticus
Length: 88  
Fragment?: true
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Protein
F7D3N3
Organism: Mus musculus/domesticus
Length: 330  
Fragment?: false
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Protein
B9EIC7
Organism: Mus musculus/domesticus
Length: 330  
Fragment?: false
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Protein
F6U6Z2
Organism: Mus musculus/domesticus
Length: 212  
Fragment?: true
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Publication
27538963 | J:242664
First Author: Gupta M
Year: 2016
Journal: Mamm Genome
Title: Mouse models of Down syndrome: gene content and consequences.
Volume: 27
Issue: 11-12
Pages: 538-555
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Publication
7558023 | J:128897
First Author: Smith DJ
Year: 1995
Journal: Genomics
Title: Construction of a panel of transgenic mice containing a contiguous 2-Mb set of YAC/P1 clones from human chromosome 21q22.2.
Volume: 27
Issue: 3
Pages: 425-34
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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