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Search results 501 to 600 out of 2705 for Foxp3

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Type Details Score
Publication
First Author: Cortez JT
Year: 2020
Journal: Nature
Title: CRISPR screen in regulatory T cells reveals modulators of Foxp3.
Volume: 582
Issue: 7812
Pages: 416-420
Publication
First Author: Housley WJ
Year: 2011
Journal: J Immunol
Title: Natural but not inducible regulatory T cells require TNF-alpha signaling for in vivo function.
Volume: 186
Issue: 12
Pages: 6779-87
Publication
First Author: Sharma R
Year: 2007
Journal: J Autoimmun
Title: Large functional repertoire of regulatory T-cell suppressible autoimmune T cells in scurfy mice.
Volume: 29
Issue: 1
Pages: 10-9
Publication
First Author: Jang E
Year: 2011
Journal: J Immunol
Title: Foxp3+ regulatory T cells control humoral autoimmunity by suppressing the development of long-lived plasma cells.
Volume: 186
Issue: 3
Pages: 1546-53
Publication
First Author: Huter EN
Year: 2008
Journal: Eur J Immunol
Title: TGF-beta-induced Foxp3+ regulatory T cells rescue scurfy mice.
Volume: 38
Issue: 7
Pages: 1814-21
Publication
First Author: Khattri R
Year: 2001
Journal: J Immunol
Title: The amount of scurfin protein determines peripheral T cell number and responsiveness.
Volume: 167
Issue: 11
Pages: 6312-20
Publication
First Author: Gavin MA
Year: 2007
Journal: Nature
Title: Foxp3-dependent programme of regulatory T-cell differentiation.
Volume: 445
Issue: 7129
Pages: 771-5
Publication
First Author: Paiva RS
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Recent thymic emigrants are the preferential precursors of regulatory T cells differentiated in the periphery.
Volume: 110
Issue: 16
Pages: 6494-9
Publication
First Author: Lim DG
Year: 2011
Journal: Int Immunol
Title: Aurintricarboxylic acid promotes the conversion of naive CD4+CD25- T cells into Foxp3-expressing regulatory T cells.
Volume: 23
Issue: 9
Pages: 583-92
Publication
First Author: Alexander KL
Year: 2017
Journal: PLoS One
Title: CBirTox is a selective antigen-specific agonist of the Treg-IgA-microbiota homeostatic pathway.
Volume: 12
Issue: 7
Pages: e0181866
Publication
First Author: O'Connor RA
Year: 2010
Journal: J Immunol
Title: Myelin-reactive, TGF-β-induced regulatory T cells can be programmed to develop Th1-like effector function but remain less proinflammatory than myelin-reactive Th1 effectors and can suppress pathogenic T cell clonal expansion in vivo.
Volume: 185
Issue: 12
Pages: 7235-43
Publication
First Author: Ma J
Year: 2014
Journal: J Leukoc Biol
Title: Differential role of all-trans retinoic acid in promoting the development of CD4+ and CD8+ regulatory T cells.
Volume: 95
Issue: 2
Pages: 275-83
Publication
First Author: Nguyen P
Year: 2010
Journal: J Immunol
Title: Discrete TCR repertoires and CDR3 features distinguish effector and Foxp3+ regulatory T lymphocytes in myelin oligodendrocyte glycoprotein-induced experimental allergic encephalomyelitis.
Volume: 185
Issue: 7
Pages: 3895-904
Publication
First Author: Kanamori M
Year: 2018
Journal: Int Immunol
Title: Reprogramming of Th1 cells into regulatory T cells through rewiring of the metabolic status.
Volume: 30
Issue: 8
Pages: 357-373
Publication
First Author: Yamazaki S
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Effective expansion of alloantigen-specific Foxp3+ CD25+ CD4+ regulatory T cells by dendritic cells during the mixed leukocyte reaction.
Volume: 103
Issue: 8
Pages: 2758-63
Publication
First Author: Kasprowicz DJ
Year: 2003
Journal: J Immunol
Title: Scurfin (FoxP3) controls T-dependent immune responses in vivo through regulation of CD4+ T cell effector function.
Volume: 171
Issue: 3
Pages: 1216-23
Publication
First Author: Hancock WW
Year: 2009
Journal: PLoS One
Title: Three distinct domains contribute to nuclear transport of murine Foxp3.
Volume: 4
Issue: 11
Pages: e7890
Publication
First Author: Feuerer M
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Genomic definition of multiple ex vivo regulatory T cell subphenotypes.
Volume: 107
Issue: 13
Pages: 5919-24
Publication
First Author: Guerin LR
Year: 2011
Journal: Biol Reprod
Title: Seminal fluid regulates accumulation of FOXP3+ regulatory T cells in the preimplantation mouse uterus through expanding the FOXP3+ cell pool and CCL19-mediated recruitment.
Volume: 85
Issue: 2
Pages: 397-408
Publication
First Author: Zeng WP
Year: 2011
Journal: Mol Immunol
Title: Domain requirements for the diverse immune regulatory functions of foxp3.
Volume: 48
Issue: 15-16
Pages: 1932-9
Publication
First Author: Dépis F
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Unstable FoxP3+ T regulatory cells in NZW mice.
Volume: 113
Issue: 5
Pages: 1345-50
Publication
First Author: Kasheta M
Year: 2017
Journal: J Exp Med
Title: Identification and characterization of T reg-like cells in zebrafish.
Volume: 214
Issue: 12
Pages: 3519-3530
Publication
First Author: Holohan DR
Year: 2019
Journal: PLoS One
Title: Thymically-derived Foxp3+ regulatory T cells are the primary regulators of type 1 diabetes in the non-obese diabetic mouse model.
Volume: 14
Issue: 10
Pages: e0217728
Publication  
First Author: Herzog RW
Year: 2019
Journal: Front Immunol
Title: Reprogrammed CD4+ T Cells That Express FoxP3+ Control Inhibitory Antibody Formation in Hemophilia A Mice.
Volume: 10
Pages: 274
Publication
First Author: Hu W
Year: 2021
Journal: Nat Immunol
Title: Regulatory T cells function in established systemic inflammation and reverse fatal autoimmunity.
Volume: 22
Issue: 9
Pages: 1163-1174
Publication
First Author: Xiao X
Year: 2008
Journal: J Immunol
Title: OX40/OX40L costimulation affects induction of Foxp3+ regulatory T cells in part by expanding memory T cells in vivo.
Volume: 181
Issue: 5
Pages: 3193-201
Publication
First Author: Liao G
Year: 2010
Journal: Int Immunol
Title: GITR engagement preferentially enhances proliferation of functionally competent CD4+CD25+FoxP3+ regulatory T cells.
Volume: 22
Issue: 4
Pages: 259-70
Publication
First Author: Saligrama PT
Year: 2014
Journal: Cell Death Differ
Title: IL-15 maintains T-cell survival via S-nitrosylation-mediated inhibition of caspase-3.
Volume: 21
Issue: 6
Pages: 904-14
Publication      
First Author: Krempski JW
Year: 2022
Journal: J Allergy Clin Immunol
Title: A mouse model of the LEAP study reveals a role for CTLA-4 in preventing peanut allergy induced by environmental peanut exposure.
Publication
First Author: Feng T
Year: 2010
Journal: J Immunol
Title: Generation of mucosal dendritic cells from bone marrow reveals a critical role of retinoic acid.
Volume: 185
Issue: 10
Pages: 5915-25
Publication
First Author: Gounaris E
Year: 2009
Journal: Cancer Res
Title: T-regulatory cells shift from a protective anti-inflammatory to a cancer-promoting proinflammatory phenotype in polyposis.
Volume: 69
Issue: 13
Pages: 5490-7
Publication
First Author: Arumugam V
Year: 2015
Journal: J Leukoc Biol
Title: TCR signaling intensity controls CD8+ T cell responsiveness to TGF-β.
Volume: 98
Issue: 5
Pages: 703-12
Publication
First Author: Zandian M
Year: 2011
Journal: PLoS One
Title: IL-2 suppression of IL-12p70 by a recombinant HSV-1 expressing IL-2 induces T-cell auto-reactivity and CNS demyelination.
Volume: 6
Issue: 2
Pages: e16820
Publication
First Author: Ramanan D
Year: 2020
Journal: Cell
Title: An Immunologic Mode of Multigenerational Transmission Governs a Gut Treg Setpoint.
Volume: 181
Issue: 6
Pages: 1276-1290.e13
Publication
First Author: Allam A
Year: 2014
Journal: J Immunol
Title: Dual function of CD70 in viral infection: modulator of early cytokine responses and activator of adaptive responses.
Volume: 193
Issue: 2
Pages: 871-8
Publication
First Author: Delacher M
Year: 2020
Journal: Immunity
Title: Precursors for Nonlymphoid-Tissue Treg Cells Reside in Secondary Lymphoid Organs and Are Programmed by the Transcription Factor BATF.
Volume: 52
Issue: 2
Pages: 295-312.e11
Publication
First Author: Ouyang W
Year: 2012
Journal: Nature
Title: Novel Foxo1-dependent transcriptional programs control T(reg) cell function.
Volume: 491
Issue: 7425
Pages: 554-9
Publication
First Author: Kuhn C
Year: 2017
Journal: J Immunol
Title: IL-6 Inhibits Upregulation of Membrane-Bound TGF-β 1 on CD4+ T Cells and Blocking IL-6 Enhances Oral Tolerance.
Volume: 198
Issue: 3
Pages: 1202-1209
Publication
First Author: Pan F
Year: 2009
Journal: Science
Title: Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells.
Volume: 325
Issue: 5944
Pages: 1142-6
Publication
First Author: Oliveira VG
Year: 2011
Journal: Eur J Immunol
Title: Sub-optimal CD4+ T-cell activation triggers autonomous TGF-β-dependent conversion to Foxp3+ regulatory T cells.
Volume: 41
Issue: 5
Pages: 1249-55
Publication
First Author: Gondek DC
Year: 2008
Journal: J Immunol
Title: Transplantation survival is maintained by granzyme B+ regulatory cells and adaptive regulatory T cells.
Volume: 181
Issue: 7
Pages: 4752-60
Publication
First Author: Zelenay S
Year: 2010
Journal: J Immunol
Title: Cutting edge: Intrathymic differentiation of adaptive Foxp3+ regulatory T cells upon peripheral proinflammatory immunization.
Volume: 185
Issue: 7
Pages: 3829-33
Publication
First Author: Khattri R
Year: 2003
Journal: Nat Immunol
Title: An essential role for Scurfin in CD4+CD25+ T regulatory cells.
Volume: 4
Issue: 4
Pages: 337-42
Publication
First Author: Leung MW
Year: 2009
Journal: J Exp Med
Title: TCR-dependent differentiation of thymic Foxp3+ cells is limited to small clonal sizes.
Volume: 206
Issue: 10
Pages: 2121-30
Publication
First Author: Maynard CL
Year: 2007
Journal: Nat Immunol
Title: Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10.
Volume: 8
Issue: 9
Pages: 931-41
Publication
First Author: Zhang P
Year: 2013
Journal: PLoS One
Title: PARP-1 controls immunosuppressive function of regulatory T cells by destabilizing Foxp3.
Volume: 8
Issue: 8
Pages: e71590
Publication
First Author: Tanaka S
Year: 2018
Journal: Cell Rep
Title: KAP1 Regulates Regulatory T Cell Function and Proliferation in Both Foxp3-Dependent and -Independent Manners.
Volume: 23
Issue: 3
Pages: 796-807
Publication
First Author: Ding X
Year: 2016
Journal: Cell Rep
Title: Protein SUMOylation Is Required for Regulatory T Cell Expansion and Function.
Volume: 16
Issue: 4
Pages: 1055-1066
Publication
First Author: Drashansky TT
Year: 2019
Journal: Sci Adv
Title: Bcl11b prevents fatal autoimmunity by promoting Treg cell program and constraining innate lineages in Treg cells.
Volume: 5
Issue: 8
Pages: eaaw0480
Publication
First Author: O'Hagan KL
Year: 2017
Journal: Sci Rep
Title: Pak2 is essential for the function of Foxp3+ regulatory T cells through maintaining a suppressive Treg phenotype.
Volume: 7
Issue: 1
Pages: 17097
Publication  
First Author: Li Y
Year: 2016
Journal: Nat Commun
Title: USP21 prevents the generation of T-helper-1-like Treg cells.
Volume: 7
Pages: 13559
Publication
First Author: Hasan SN
Year: 2019
Journal: Sci Adv
Title: Bcl11b prevents catastrophic autoimmunity by controlling multiple aspects of a regulatory T cell gene expression program.
Volume: 5
Issue: 8
Pages: eaaw0706
Publication
First Author: Smith PM
Year: 2013
Journal: Science
Title: The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis.
Volume: 341
Issue: 6145
Pages: 569-73
Publication
First Author: Cabarrocas J
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Foxp3+ CD25+ regulatory T cells specific for a neo-self-antigen develop at the double-positive thymic stage.
Volume: 103
Issue: 22
Pages: 8453-8
Publication
First Author: Haribhai D
Year: 2011
Journal: Immunity
Title: A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity.
Volume: 35
Issue: 1
Pages: 109-22
Publication  
First Author: Nickle RA
Year: 2023
Journal: Cell Immunol
Title: Soluble CD25 imposes a low-zone IL-2 signaling environment that favors competitive outgrowth of antigen-experienced CD25(high) regulatory and memory T cells.
Volume: 384
Pages: 104664
Publication
First Author: Wang Y
Year: 2014
Journal: Cancer Res
Title: Foxp3+ T cells inhibit antitumor immune memory modulated by mTOR inhibition.
Volume: 74
Issue: 8
Pages: 2217-28
Publication
First Author: Tatura R
Year: 2015
Journal: Immunology
Title: Relevance of Foxp3⁺ regulatory T cells for early and late phases of murine sepsis.
Volume: 146
Issue: 1
Pages: 144-56
Publication
First Author: Wojciech L
Year: 2018
Journal: Sci Rep
Title: Non-canonicaly recruited TCRαβCD8αα IELs recognize microbial antigens.
Volume: 8
Issue: 1
Pages: 10848
Publication
First Author: Cong Y
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota.
Volume: 106
Issue: 46
Pages: 19256-61
Publication
First Author: Johnson MC
Year: 2013
Journal: Diabetes
Title: β-cell-specific IL-2 therapy increases islet Foxp3+Treg and suppresses type 1 diabetes in NOD mice.
Volume: 62
Issue: 11
Pages: 3775-84
Publication
First Author: Zemmour D
Year: 2018
Journal: Nat Immunol
Title: Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR.
Volume: 19
Issue: 3
Pages: 291-301
Publication
First Author: Barrachina F
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: Regulatory T cells play a crucial role in maintaining sperm tolerance and male fertility.
Volume: 120
Issue: 37
Pages: e2306797120
Publication
First Author: Levine AG
Year: 2017
Journal: Nature
Title: Stability and function of regulatory T cells expressing the transcription factor T-bet.
Volume: 546
Issue: 7658
Pages: 421-425
Publication
First Author: Rivas MN
Year: 2012
Journal: J Clin Invest
Title: MyD88 is critically involved in immune tolerance breakdown at environmental interfaces of Foxp3-deficient mice.
Volume: 122
Issue: 5
Pages: 1933-47
Publication
First Author: Kälin S
Year: 2017
Journal: Cell Metab
Title: A Stat6/Pten Axis Links Regulatory T Cells with Adipose Tissue Function.
Volume: 26
Issue: 3
Pages: 475-492.e7
Publication
First Author: Corpuz TM
Year: 2017
Journal: J Immunol
Title: IL-2 Shapes the Survival and Plasticity of IL-17-Producing γδ T Cells.
Volume: 199
Issue: 7
Pages: 2366-2376
Publication
First Author: Keller HR
Year: 2020
Journal: J Immunol
Title: The Abundance and Availability of Cytokine Receptor IL-2Rβ (CD122) Constrain the Lymphopenia-Induced Homeostatic Proliferation of Naive CD4 T Cells.
Volume: 204
Issue: 12
Pages: 3227-3235
Publication
First Author: Round JL
Year: 2011
Journal: Science
Title: The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota.
Volume: 332
Issue: 6032
Pages: 974-7
Publication
First Author: Zhou Y
Year: 2019
Journal: Mol Med Rep
Title: MicroRNA‑30a controls the instability of inducible CD4+ Tregs through SOCS1.
Volume: 20
Issue: 5
Pages: 4303-4314
Publication
First Author: Yuan X
Year: 2015
Journal: J Immunol
Title: IL-2Rβ-dependent signaling and CD103 functionally cooperate to maintain tolerance in the gut mucosa.
Volume: 194
Issue: 3
Pages: 1334-46
Publication
First Author: Deaglio S
Year: 2007
Journal: J Exp Med
Title: Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression.
Volume: 204
Issue: 6
Pages: 1257-65
Publication
First Author: Agnihotri P
Year: 2017
Journal: Immunology
Title: Lack of Ikaros cripples expression of Foxo1 and its targets in naive T cells.
Volume: 152
Issue: 3
Pages: 494-506
Publication
First Author: Jun JC
Year: 2017
Journal: PLoS One
Title: T cell-intrinsic TLR2 stimulation promotes IL-10 expression and suppressive activity by CD45RbHi T cells.
Volume: 12
Issue: 7
Pages: e0180688
Publication
First Author: Elyaman W
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: IL-9 induces differentiation of TH17 cells and enhances function of FoxP3+ natural regulatory T cells.
Volume: 106
Issue: 31
Pages: 12885-90
Publication  
First Author: Yilmaz OK
Year: 2019
Journal: Front Immunol
Title: Scurfy Mice Develop Features of Connective Tissue Disease Overlap Syndrome and Mixed Connective Tissue Disease in the Absence of Regulatory T Cells.
Volume: 10
Pages: 881
Publication
First Author: Kuczma M
Year: 2010
Journal: PLoS One
Title: Intratumoral convergence of the TCR repertoires of effector and Foxp3+ CD4+ T cells.
Volume: 5
Issue: 10
Pages: e13623
Publication
First Author: Hu DY
Year: 2017
Journal: Cell Death Differ
Title: IL-2 prevents deletion of developing T-regulatory cells in the thymus.
Volume: 24
Issue: 6
Pages: 1007-1016
Publication
First Author: Tsuji M
Year: 2009
Journal: Science
Title: Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches.
Volume: 323
Issue: 5920
Pages: 1488-92
Publication
First Author: Ellis JS
Year: 2015
Journal: Immunology
Title: Regulatory T cells in B-cell-deficient and wild-type mice differ functionally and in expression of cell surface markers.
Volume: 144
Issue: 4
Pages: 598-610
Publication
First Author: Schreiber TH
Year: 2010
Journal: J Clin Invest
Title: Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation.
Volume: 120
Issue: 10
Pages: 3629-40
Publication
First Author: Wan X
Year: 2012
Journal: Diabetes
Title: Mechanisms underlying antigen-specific tolerance of stable and convertible Th17 cells during suppression of autoimmune diabetes.
Volume: 61
Issue: 8
Pages: 2054-65
Publication  
First Author: Wegorzewska MM
Year: 2019
Journal: Sci Immunol
Title: Diet modulates colonic T cell responses by regulating the expression of a Bacteroides thetaiotaomicron antigen.
Volume: 4
Issue: 32
Publication  
First Author: DePeaux K
Year: 2023
Journal: J Exp Med
Title: An oncolytic virus-delivered TGFβ inhibitor overcomes the immunosuppressive tumor microenvironment.
Volume: 220
Issue: 10
Publication
First Author: Saxena A
Year: 2012
Journal: PLoS One
Title: Mobilization of regulatory T cells in response to carotid injury does not influence subsequent neointima formation.
Volume: 7
Issue: 12
Pages: e51556
Publication
First Author: Tian D
Year: 2023
Journal: Theranostics
Title: TCRαβ(+)NK1.1(-)CD4(-)CD8(-) double-negative T cells inhibit central and peripheral inflammation and ameliorate ischemic stroke in mice.
Volume: 13
Issue: 3
Pages: 896-909
Publication
First Author: Kim JH
Year: 2016
Journal: J Neuroinflammation
Title: CCR5 ameliorates Japanese encephalitis via dictating the equilibrium of regulatory CD4(+)Foxp3(+) T and IL-17(+)CD4(+) Th17 cells.
Volume: 13
Issue: 1
Pages: 223
Publication
First Author: Zhu B
Year: 2013
Journal: J Immunol
Title: IL-4 and retinoic acid synergistically induce regulatory dendritic cells expressing Aldh1a2.
Volume: 191
Issue: 6
Pages: 3139-51
Publication
First Author: Dial CF
Year: 2017
Journal: Am J Respir Cell Mol Biol
Title: Foxp3(+) Regulatory T Cell Expression of Keratinocyte Growth Factor Enhances Lung Epithelial Proliferation.
Volume: 57
Issue: 2
Pages: 162-173
Publication
First Author: Ghosh D
Year: 2016
Journal: J Leukoc Biol
Title: Depletion of CD4+ CD25+ regulatory T cells confers susceptibility to experimental autoimmune encephalomyelitis (EAE) in GM-CSF-deficient Csf2-/- mice.
Volume: 100
Issue: 4
Pages: 747-760
Publication
First Author: Korn T
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells.
Volume: 105
Issue: 47
Pages: 18460-5
Publication
First Author: Korn LL
Year: 2014
Journal: Cell Rep
Title: Regulatory T cells occupy an isolated niche in the intestine that is antigen independent.
Volume: 9
Issue: 5
Pages: 1567-73
Publication  
First Author: Serr I
Year: 2016
Journal: Nat Commun
Title: Type 1 diabetes vaccine candidates promote human Foxp3(+)Treg induction in humanized mice.
Volume: 7
Pages: 10991
Publication
First Author: Gomez-Rodriguez J
Year: 2014
Journal: J Exp Med
Title: Itk-mediated integration of T cell receptor and cytokine signaling regulates the balance between Th17 and regulatory T cells.
Volume: 211
Issue: 3
Pages: 529-43
Publication  
First Author: Di Giovangiulio M
Year: 2019
Journal: Front Immunol
Title: Tbet Expression in Regulatory T Cells Is Required to Initiate Th1-Mediated Colitis.
Volume: 10
Pages: 2158
Publication
First Author: Price JD
Year: 2015
Journal: Diabetes
Title: DCIR2+ cDC2 DCs and Zbtb32 Restore CD4+ T-Cell Tolerance and Inhibit Diabetes.
Volume: 64
Issue: 10
Pages: 3521-31
Publication
First Author: Wing K
Year: 2008
Journal: Science
Title: CTLA-4 control over Foxp3+ regulatory T cell function.
Volume: 322
Issue: 5899
Pages: 271-5
Publication
First Author: Bertelli R
Year: 2014
Journal: PLoS One
Title: LPS nephropathy in mice is ameliorated by IL-2 independently of regulatory T cells activity.
Volume: 9
Issue: 10
Pages: e111285
Publication
First Author: Hosokawa T
Year: 2017
Journal: J Immunol
Title: Lamtor1 Is Critically Required for CD4+ T Cell Proliferation and Regulatory T Cell Suppressive Function.
Volume: 199
Issue: 6
Pages: 2008-2019
Publication  
First Author: Mittelsteadt KL
Year: 2021
Journal: J Exp Med
Title: ICOS signaling limits regulatory T cell accumulation and function in visceral adipose tissue.
Volume: 218
Issue: 6