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Search results 501 to 600 out of 652 for Fus

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
120100562 | Fus-ps4
Type: gene
Organism: rat
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Gene
380075 | fus.S
Type: gene
Organism: frog, African clawed
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Gene
444722 | fus.L
Type: gene
Organism: frog, African clawed
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Allele
Fus<Gt(U3NeoSV1)HO14Ggh> | MGI:2177561
Name: fused in sarcoma; gene trap HO14, Geoffrey G Hicks
Allele Type: Gene trapped
Attribute String: Null/knockout, Reporter
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HT Experiment
GSE147288 | RNA-sequencing from mouse embryonic spinal cord in the presence of FUS knockout or FUS NLS mutation delta14
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Protein
Q8BNR3
Organism: Mus musculus/domesticus
Length: 122  
Fragment?: false
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Allele
Tg(Thy1-FUS*)1Dit | MGI:6476958
Name: transgene insertion 1, Daisuke Ito
Allele Type: Transgenic
Attribute String: Epitope tag, Humanized sequence, Inserted expressed sequence
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HT Experiment
E-MTAB-1229 | Transcription profiling by array of brain from FUS knockout and wild type mouse embryos
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
11896599 | J:75210
First Author: PĂ©rez-Mancera PA
Year: 2002
Journal: Oncogene
Title: Expression of the FUS domain restores liposarcoma development in CHOP transgenic mice.
Volume: 21
Issue: 11
Pages: 1679-84
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Publication
25792726 | J:221604
First Author: Finelli MJ
Year: 2015
Journal: Hum Mol Genet
Title: Oxr1 improves pathogenic cellular features of ALS-associated FUS and TDP-43 mutations.
Volume: 24
Issue: 12
Pages: 3529-44
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HT Experiment
E-GEOD-78730 | Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss
Series Id: GSE78730
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
32950644 | J:304400
 
First Author: Johnson MA
Year: 2020
Journal: Neurobiol Dis
Title: Divergent FUS phosphorylation in primate and mouse cells following double-strand DNA damage.
Volume: 146
Pages: 105085
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Allele
Tg(Thy1-FUS*)19Vlb | MGI:5577178
Name: transgene insertion 19, Vladimir L Buchman
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(CAG-lacZ,-FUS,-EGFP)629Gyu | MGI:5644690
Name: transgene insertion 629, Gang Yu
Allele Type: Transgenic
Attribute String: Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter
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Allele
Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu | MGI:5644691
Name: transgene insertion 682, Gang Yu
Allele Type: Transgenic
Attribute String: Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter
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Publication
22459602 | J:191373
First Author: Farg MA
Year: 2012
Journal: Neurobiol Aging
Title: Mutant FUS induces endoplasmic reticulum stress in amyotrophic lateral sclerosis and interacts with protein disulfide-isomerase.
Volume: 33
Issue: 12
Pages: 2855-68
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Publication
28515487 | J:287440
First Author: Mirra A
Year: 2017
Journal: Sci Rep
Title: Functional interaction between FUS and SMN underlies SMA-like splicing changes in wild-type hFUS mice.
Volume: 7
Issue: 1
Pages: 2033
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Publication
22961620 | J:189360
First Author: Mitchell JC
Year: 2013
Journal: Acta Neuropathol
Title: Overexpression of human wild-type FUS causes progressive motor neuron degeneration in an age- and dose-dependent fashion.
Volume: 125
Issue: 2
Pages: 273-88
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Publication
29380416 | J:259193
First Author: Kia A
Year: 2018
Journal: Glia
Title: Astrocytes expressing ALS-linked mutant FUS induce motor neuron death through release of tumor necrosis factor-alpha.
Volume: 66
Issue: 5
Pages: 1016-1033
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Publication
37756636 | J:344467
First Author: Wang Y
Year: 2023
Journal: Hum Mol Genet
Title: Disrupted phase behavior of FUS underlies poly-PR-induced DNA damage in amyotrophic lateral sclerosis.
Volume: 33
Issue: 1
Pages: 64-77
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Publication
22493728 | J:355717
First Author: Pokrishevsky E
Year: 2012
Journal: PLoS One
Title: Aberrant localization of FUS and TDP43 is associated with misfolding of SOD1 in amyotrophic lateral sclerosis.
Volume: 7
Issue: 4
Pages: e35050
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Genotype
Genotype
Symbol: Tg(Thy1-FUS*)1Dit/?
Background: B6.Cg-Tg(Thy1-FUS*)1Dit
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Thy1-FUS*)19Vlb/?
Background: B6.Cg-Tg(Thy1-FUS*)19Vlb
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Meox2/Meox2<+> Tg(CAG-lacZ,-FUS,-EGFP)629Gyu/?
Background: involves: 129S4/SvJaeSor * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Meox2/Meox2<+> Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu/?
Background: involves: 129S4/SvJaeSor * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Publication
26573619 | -
 
First Author: Luo Y
Year: 2015
Journal: BMC Genomics
Title: EWS and FUS bind a subset of transcribed genes encoding proteins enriched in RNA regulatory functions.
Volume: 16
Pages: 929
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Allele
Tg(Prnp-FUS)WT3Cshw | MGI:5445385
Name: transgene insertion WT3, Christopher Shaw
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(Prnp-FUS*R521C)3313Ejh | MGI:5618414
Name: transgene insertion 3313, Eric J Huang
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence, Modified isoform(s)
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Publication
21438137 | -
First Author: Ticozzi N
Year: 2011
Journal: Am J Med Genet B Neuropsychiatr Genet
Title: Mutational analysis reveals the FUS homolog TAF15 as a candidate gene for familial amyotrophic lateral sclerosis.
Volume: 156B
Issue: 3
Pages: 285-90
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Publication
11929860 | J:77258
First Author: Shuttleworth TL
Year: 2002
Journal: J Biol Chem
Title: Characterization of the murine hyaluronidase gene region reveals complex organization and cotranscription of Hyal1 with downstream genes, Fus2 and Hyal3.
Volume: 277
Issue: 25
Pages: 23008-18
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Transgene
MGI:5445409 | Tg(Prnp-FUS)WT3Cshw
Type: transgene
Organism: mouse, laboratory
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Transgene
MGI:5577177 | Tg(Thy1-FUS*)19Vlb
Type: transgene
Organism: mouse, laboratory
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Transgene
MGI:5618416 | Tg(Prnp-FUS*R521C)3313Ejh
Type: transgene
Organism: mouse, laboratory
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Transgene
MGI:5644688 | Tg(CAG-lacZ,-FUS,-EGFP)629Gyu
Type: transgene
Organism: mouse, laboratory
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Transgene
MGI:5644689 | Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu
Type: transgene
Organism: mouse, laboratory
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Transgene
MGI:6476960 | Tg(Thy1-FUS*)1Dit
Type: transgene
Organism: mouse, laboratory
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Genotype
Genotype
Symbol: Tg(Prnp-FUS)WT3Cshw/Tg(Prnp-FUS)WT3Cshw
Background: involves: C57BL/6 * Crl:CD-1(ICR)
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Prnp-FUS*R521C)3313Ejh/?
Background: involves: C57BL/6 * SJL
Zygosity: ot
Has Mutant Allele: true
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DO Term
DOID:0060198 | amyotrophic lateral sclerosis type 6
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Genotype
Genotype
Symbol: Fus/Fus<+>
Background: involves: C3H * C57BL/6J * C57BL/6N
Zygosity: ht
Has Mutant Allele: true
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DO Term
DOID:0111431 | essential tremor 4
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Publication
28928015 | J:277077
 
First Author: Shiihashi G
Year: 2017
Journal: EBioMedicine
Title: Dendritic Homeostasis Disruption in a Novel Frontotemporal Dementia Mouse Model Expressing Cytoplasmic Fused in Sarcoma.
Volume: 24
Pages: 102-115
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Allele
Fus<em2(FUS*Q519I)Emcf> | MGI:6403272
Name: fused in sarcoma; endonuclease-mediated mutation 2, Elizabeth MC Fisher
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence, Inserted expressed sequence
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Publication
32184412 | J:286857
First Author: Ito D
Year: 2020
Journal: Sci Rep
Title: Extensive splicing changes in an ALS/FTD transgenic mouse model overexpressing cytoplasmic fused in sarcoma.
Volume: 10
Issue: 1
Pages: 4857
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Publication
27731383 | -
 
First Author: Yamaguchi A
Year: 2016
Journal: Sci Rep
Title: FUS interacts with nuclear matrix-associated protein SAFB1 as well as Matrin3 to regulate splicing and ligand-mediated transcription.
Volume: 6
Pages: 35195
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Allele
Tg(FUS)2Kt | MGI:7564422
Name: transgene insertion 2, Kevin Talbot
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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DO Term
DOID:0081406 | round cell sarcoma with EWSR1-non-ETS fusion
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Protein Coding Gene
MGI:1333805 | Srsf10
Type: protein_coding_gene
Organism: mouse, laboratory
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Allele
Tg(Prrx1-FUS/DDIT3)1Mete | MGI:5428676
Name: transgene insertion 1, Melissa Terry
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Strain
MGI:7798817 | C3H.129(B6)-Fus<em2(FUS*Q519I)Emcf>/H
Attribute String: congenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:7278826 | B6.Cg-Tg(Thy1-FUS*)1Dit
Attribute String: congenic, mutant strain, transgenic
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Strain
MGI:6147282 | B6.Cg-Tg(Thy1-FUS*)1Dit/Rbrc
Attribute String: mutant strain, congenic, transgenic
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Genotype
Genotype
Symbol: Tg(Thy1-FUS*)1Dit/? Tg(Thy1-TARDBP)4Singh/?
Background: involves: C57BL/6J * DBA/2J * SJL/J
Zygosity: cx
Has Mutant Allele: true
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Publication
23867462 | J:203550
First Author: Shelkovnikova TA
Year: 2013
Journal: J Biol Chem
Title: Fused in sarcoma (FUS) protein lacking nuclear localization signal (NLS) and major RNA binding motifs triggers proteinopathy and severe motor phenotype in transgenic mice.
Volume: 288
Issue: 35
Pages: 25266-74
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Publication
24334610 | J:209072
First Author: Shelkovnikova TA
Year: 2014
Journal: Hum Mol Genet
Title: Compromised paraspeckle formation as a pathogenic factor in FUSopathies.
Volume: 23
Issue: 9
Pages: 2298-312
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HT Experiment
GSE245520 | FUS-NLS mutation causes neurodevelopmental and systemic metabolic alterations
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
30806671 | J:276436
First Author: Baron DM
Year: 2019
Journal: Hum Mol Genet
Title: Quantitative proteomics identifies proteins that resist translational repression and become dysregulated in ALS-FUS.
Volume: 28
Issue: 13
Pages: 2143-2160
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Allele
Fus<tm1(DDIT3)Dron> | MGI:2177655
Name: fused in sarcoma; targeted mutation 1, David Ron
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
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Strain
MGI:5430314 | B6;CBA-Tg(Prrx1-FUS/DDIT3)1Mete/J
Attribute String: mutant stock, transgenic
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Allele
Tg(Prnp-FUS)17Ljh | MGI:5621048
Name: transgene insertion 17, Lawrence Hayward
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(CAG-lacZ,-FUS*R521G,-EGFP)673Gyu | MGI:5662097
Name: transgene insertion 673, Gang Yu
Allele Type: Transgenic
Attribute String: Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter
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Strain
MGI:7570303 | B6JOlaHsd.Cg-Tg(FUS)2Kt/H
Attribute String: congenic, mutant strain, transgenic
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Allele
Tg(FUS*P525L)1Kt | MGI:6751616
Name: transgene insertion 1, Kevin Talbot
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(FUS*P525L)3Kt | MGI:6751619
Name: transgene insertion 3, Kevin Talbot
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Genotype
Genotype
Symbol: Tg(Prrx1-FUS/DDIT3)1Mete/?
Background: involves: C57BL/6 * CBA
Zygosity: ot
Has Mutant Allele: true
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Protein Domain
IPR034869 | EWS_RRM
Type: Domain
Description: This entry represents the RNA recognition motif (RRM) of EWS.RNA-binding protein EWS (also known as EWSR1) participates in transcriptional regulation and RNA processing. It is structurally and functionally related to FUS (TLS) protein []. EWSR1 gene rearrangements are often observed in myoepithelial tumours [, ].
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Publication
22293175 | J:184491
First Author: Charytonowicz E
Year: 2012
Journal: J Clin Invest
Title: PPARÎł agonists enhance ET-743-induced adipogenic differentiation in a transgenic mouse model of myxoid round cell liposarcoma.
Volume: 122
Issue: 3
Pages: 886-98
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Strain
MGI:5763765 | 129S6/SvEvTac-Fus<tm1(DDIT3)Dron>
Attribute String: targeted mutation, mutant strain, coisogenic
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Strain
MGI:5578013 | B6.Cg-Tg(Thy1-FUS*)19Vlb
Attribute String: congenic, mutant strain, transgenic
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Allele
Tg(Prnp-FUS*R495X)78Ljh | MGI:5621045
Name: transgene insertion 78, Lawrence Hayward
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Strain
MGI:5621050 | B6.Cg-Tg(Prnp-FUS)17Ljh/J
Attribute String: transgenic, mutant strain, congenic
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Strain
MGI:5662069 | C57BL/6J-Tg(CAG-lacZ,-FUS,-EGFP)629Gyu/J
Attribute String: coisogenic, mutant strain, transgenic
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Strain
MGI:5662102 | C57BL/6J-Tg(CAG-lacZ,-FUS*R521G,-EGFP)673Gyu/J
Attribute String: coisogenic, mutant strain, transgenic
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Strain
MGI:6751617 | B6JOlaHsd.Cg-Tg(FUS*P525L)1Kt/KtH
Attribute String: congenic, mutant strain, transgenic
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Strain
MGI:6751620 | B6JOlaHsd.Cg-Tg(FUS*P525L)3Kt/KtH
Attribute String: congenic, mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Fus/Fus
Background: involves: 129S6/SvEvTac * CD-1
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Fus/Fus
Background: 129S6/SvEvTac-Fus
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Trp53/Trp53 Tg(Prrx1-FUS/DDIT3)1Mete/?
Background: involves: 129S2/SvPas * C57BL/6 * CBA
Zygosity: cx
Has Mutant Allele: true
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Publication
37974279 | J:342849
First Author: Pelaez MC
Year: 2023
Journal: Acta Neuropathol Commun
Title: Neuronal dysfunction caused by FUSR521G promotes ALS-associated phenotypes that are attenuated by NF-ÎşB inhibition.
Volume: 11
Issue: 1
Pages: 182
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Protein Domain
IPR033109 | EWSR1
Type: Family
Description: RNA-binding protein EWS (also known as EWSR1) participates in transcriptional regulation and RNA processing. It is structurally and functionally related to FUS (TLS) protein []. EWSR1 gene rearrangements are often observed in myoepithelial tumours [, ].TAF15/EWS/TLS family members include human FUS (Fused in liposarcoma), EWS (Ewing Sarcoma) and TAF15 (TATA binding associated factor 15), and the Drosophila orthologue Cabeza. They are RNA binding proteins that contain a transcriptional-activation domain (EAD), 3 glycine-arginine (RGG) rich regions, an RNA-binding domain (RBD), and a zinc finger domain [, ]. They are involved in transcription and alternative splicing. They are subjected to different environmental signals that induce post-translational modifications in their RBD and in the RGG domains, thus modulating their activity []. TAF15/EWS/TLS play important roles in oncogenesis and neuronal disease [].
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Protein
Q3UGI7
Organism: Mus musculus/domesticus
Length: 325  
Fragment?: false
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Protein
Q5SUS8
Organism: Mus musculus/domesticus
Length: 354  
Fragment?: false
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Publication
25706482 | -
First Author: Huang SC
Year: 2015
Journal: Genes Chromosomes Cancer
Title: Novel FUS-KLF17 and EWSR1-KLF17 fusions in myoepithelial tumors.
Volume: 54
Issue: 5
Pages: 267-75
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Publication
25231231 | -
First Author: Agaram NP
Year: 2015
Journal: Genes Chromosomes Cancer
Title: EWSR1-PBX3: a novel gene fusion in myoepithelial tumors.
Volume: 54
Issue: 2
Pages: 63-71
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Strain
MGI:5621047 | B6.Cg-Tg(Prnp-FUS*R495X)78Ljh/J
Attribute String: congenic, mutant strain, transgenic
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Protein
Q8BQU4
Organism: Mus musculus/domesticus
Length: 113  
Fragment?: false
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Protein Domain
IPR034870 | TET_fam
Type: Family
Description: This entry represents the multi-functional TET (TAF15/EWS/TLS) or FET (FUS/EWS/TLS) protein family.TAF15/EWS/TLS family members include human FUS (Fused in liposarcoma), EWS (Ewing Sarcoma) and TAF15 (TATA binding associated factor 15), and the Drosophila orthologue Cabeza. They are RNA binding proteins that contain a transcriptional-activation domain (EAD), 3 glycine-arginine (RGG) rich regions, an RNA-binding domain (RBD), and a zinc finger domain [, ]. They are involved in transcription and alternative splicing. They are subjected to different environmental signals that induce post-translational modifications in their RBD and in the RGG domains, thus modulating their activity []. TAF15/EWS/TLS play important roles in oncogenesis and neuronal disease [].
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HT Experiment
E-GEOD-34896 | Muscle specific proteasome deficient mice
Series Id: GSE34896
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Protein
Q3V452
Organism: Mus musculus/domesticus
Length: 200  
Fragment?: false
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Protein
Q3V2Z2
Organism: Mus musculus/domesticus
Length: 200  
Fragment?: false
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Publication
35775484 | J:326871
 
First Author: Du S
Year: 2022
Journal: J Clin Invest
Title: A nerve injury-specific long noncoding RNA promotes neuropathic pain by increasing Ccl2 expression.
Volume: 132
Issue: 13
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Publication
38829885 | J:349920
First Author: Edelman BJ
Year: 2024
Journal: PLoS Biol
Title: The COMBO window: A chronic cranial implant for multiscale circuit interrogation in mice.
Volume: 22
Issue: 6
Pages: e3002664
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Publication
27796305 | J:242632
 
First Author: Tian F
Year: 2016
Journal: Nat Commun
Title: Monitoring peripheral nerve degeneration in ALS by label-free stimulated Raman scattering imaging.
Volume: 7
Pages: 13283
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Publication
23524377 | J:202416
First Author: McGoldrick P
Year: 2013
Journal: Biochim Biophys Acta
Title: Rodent models of amyotrophic lateral sclerosis.
Volume: 1832
Issue: 9
Pages: 1421-36
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Publication
21867700 | J:178390
First Author: Necchi D
Year: 2011
Journal: Exp Neurol
Title: Dysfunction of the ubiquitin-proteasome system in the cerebellum of aging Ts65Dn mice.
Volume: 232
Issue: 2
Pages: 114-8
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Publication
36343238 | J:358741
First Author: Murphy KR
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: A tool for monitoring cell type-specific focused ultrasound neuromodulation and control of chronic epilepsy.
Volume: 119
Issue: 46
Pages: e2206828119
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Publication
30022074 | J:266401
First Author: Chitiprolu M
Year: 2018
Journal: Nat Commun
Title: A complex of C9ORF72 and p62 uses arginine methylation to eliminate stress granules by autophagy.
Volume: 9
Issue: 1
Pages: 2794
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Publication
32528069 | J:292240
First Author: Aydin AK
Year: 2020
Journal: Nat Commun
Title: Transfer functions linking neural calcium to single voxel functional ultrasound signal.
Volume: 11
Issue: 1
Pages: 2954
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Publication
33378683 | J:306500
First Author: van den Berk P
Year: 2020
Journal: Cell Rep
Title: USP15 Deubiquitinase Safeguards Hematopoiesis and Genome Integrity in Hematopoietic Stem Cells and Leukemia Cells.
Volume: 33
Issue: 13
Pages: 108533
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Publication
29425503 | J:272750
First Author: Tanikawa C
Year: 2018
Journal: Cell Rep
Title: Citrullination of RGG Motifs in FET Proteins by PAD4 Regulates Protein Aggregation and ALS Susceptibility.
Volume: 22
Issue: 6
Pages: 1473-1483
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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