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Search results 501 to 600 out of 687 for Gapdh

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Type Details Score
Publication
38418556 | J:346910
First Author: Ayyangar U
Year: 2024
Journal: EMBO J
Title: Metabolic rewiring of macrophages by epidermal-derived lactate promotes sterile inflammation in the murine skin.
Volume: 43
Issue: 7
Pages: 1113-1134
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Publication
9169087 | J:40384
First Author: Craig JC
Year: 1997
Journal: Biochem Mol Med
Title: Developmental expression of morphoregulatory genes in the mouse embryo: an analytical approach using a novel technology.
Volume: 60
Issue: 2
Pages: 81-91
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Publication
19075228 | J:142671
First Author: Kalsotra A
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart.
Volume: 105
Issue: 51
Pages: 20333-8
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Publication
32253237 | J:293624
 
First Author: Lee S
Year: 2020
Journal: Development
Title: Cleft lip and cleft palate in Esrp1 knockout mice is associated with alterations in epithelial-mesenchymal crosstalk.
Volume: 147
Issue: 21
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Publication
28893950 | J:245730
First Author: Bardot P
Year: 2017
Journal: Development
Title: The TAF10-containing TFIID and SAGA transcriptional complexes are dispensable for early somitogenesis in the mouse embryo.
Volume: 144
Issue: 20
Pages: 3808-3818
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Publication
17626619 | J:125993
 
First Author: Cankaya M
Year: 2007
Journal: BMC Genomics
Title: An analysis of expression patterns of genes encoding proteins with catalytic activities.
Volume: 8
Pages: 232
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Publication
11180952 | J:67747
First Author: Thut CJ
Year: 2001
Journal: Dev Biol
Title: A large-scale in situ screen provides molecular evidence for the induction of eye anterior segment structures by the developing lens.
Volume: 231
Issue: 1
Pages: 63-76
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Publication
16987237 | J:119559
First Author: Bouwman J
Year: 2006
Journal: J Neurochem
Title: Reduced expression of neuropeptide genes in a genome-wide screen of a secretion-deficient mouse.
Volume: 99
Issue: 1
Pages: 84-96
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Publication
28245920 | J:240028
First Author: Bulusu V
Year: 2017
Journal: Dev Cell
Title: Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development.
Volume: 40
Issue: 4
Pages: 331-341.e4
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Publication
- | J:342612
       
First Author: UniProt curators
Year: 2014
Title: Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
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Publication
17634366 | J:145263
First Author: Werner HB
Year: 2007
Journal: J Neurosci
Title: Proteolipid protein is required for transport of sirtuin 2 into CNS myelin.
Volume: 27
Issue: 29
Pages: 7717-30
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Publication
9811942 | J:50869
First Author: Ko MS
Year: 1998
Journal: Hum Mol Genet
Title: Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome.
Volume: 7
Issue: 12
Pages: 1967-78
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
16919269 | J:112701
First Author: Bailey PJ
Year: 2006
Journal: Exp Cell Res
Title: A global genomic transcriptional code associated with CNS-expressed genes.
Volume: 312
Issue: 16
Pages: 3108-19
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Publication
14651853 | J:86816
First Author: Mootha VK
Year: 2003
Journal: Cell
Title: Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.
Volume: 115
Issue: 5
Pages: 629-40
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Publication
21731673 | J:174767
First Author: Tang F
Year: 2011
Journal: PLoS One
Title: Deterministic and stochastic allele specific gene expression in single mouse blastomeres.
Volume: 6
Issue: 6
Pages: e21208
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Publication
- | J:342601
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniPathway vocabulary mapping
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Publication
- | J:342608
       
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
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Publication
- | J:72245
       
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
14681479 | J:122989
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
37133968 | J:352740
First Author: Jing X
Year: 2023
Journal: Mol Biol Cell
Title: Acetate regulates GAPDH acetylation and T helper 1 cell differentiation.
Volume: 34
Issue: 7
Pages: br10
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Publication
30659183 | J:270154
First Author: Galván-Peña S
Year: 2019
Journal: Nat Commun
Title: Malonylation of GAPDH is an inflammatory signal in macrophages.
Volume: 10
Issue: 1
Pages: 338
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Allele
Gapdh<m2Neu> | MGI:2183516
 
Name: glyceraldehyde-3-phosphate dehydrogenase; mutation 2, Neuherberg
Allele Type: Radiation induced
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Allele
Gapdh<m4Neu> | MGI:2183518
 
Name: glyceraldehyde-3-phosphate dehydrogenase; mutation 4, Neuherberg
Allele Type: Radiation induced
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Publication
752540 | J:6167
First Author: Bruns GA
Year: 1978
Journal: Cytogenet Cell Genet
Title: Expression of GAPDH and TPI in dog-rodent hybrids.
Volume: 22
Issue: 1-6
Pages: 547-51
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Publication
31704924 | J:281743
First Author: Liao ST
Year: 2019
Journal: Nat Commun
Title: 4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects.
Volume: 10
Issue: 1
Pages: 5091
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Publication
31447347 | J:279380
First Author: Mondragón L
Year: 2019
Journal: Cancer Cell
Title: GAPDH Overexpression in the T Cell Lineage Promotes Angioimmunoblastic T Cell Lymphoma through an NF-κB-Dependent Mechanism.
Volume: 36
Issue: 3
Pages: 268-287.e10
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Publication
25394713 | J:220619
First Author: Chiche J
Year: 2015
Journal: Leukemia
Title: GAPDH enhances the aggressiveness and the vascularization of non-Hodgkin's B lymphomas via NF-κB-dependent induction of HIF-1α.
Volume: 29
Issue: 5
Pages: 1163-76
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Publication
36351405 | J:348610
First Author: Yoo HJ
Year: 2022
Journal: Cell Rep
Title: MsrB1-regulated GAPDH oxidation plays programmatic roles in shaping metabolic and inflammatory signatures during macrophage activation.
Volume: 41
Issue: 6
Pages: 111598
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Publication
37450367 | J:338534
First Author: Lin XT
Year: 2023
Journal: Cell Rep
Title: Elevated FBXW10 drives hepatocellular carcinoma tumorigenesis via AR-VRK2 phosphorylation-dependent GAPDH ubiquitination in male transgenic mice.
Volume: 42
Issue: 7
Pages: 112812
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Allele
Gapdh<m1Neu> | MGI:2183515
 
Name: glyceraldehyde-3-phosphate dehydrogenase; mutation 1, Neuherberg
Allele Type: Chemically induced (ENU)
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Allele
Gapdh<m3Neu> | MGI:2183517
 
Name: glyceraldehyde-3-phosphate dehydrogenase; mutation 3, Neuherberg
Allele Type: Chemically induced (ENU)
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Publication
30827861 | J:276002
First Author: Chiche J
Year: 2019
Journal: Cell Metab
Title: GAPDH Expression Predicts the Response to R-CHOP, the Tumor Metabolic Status, and the Response of DLBCL Patients to Metabolic Inhibitors.
Volume: 29
Issue: 6
Pages: 1243-1257.e10
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Publication
27551151 | J:237037
First Author: Cha SJ
Year: 2016
Journal: J Exp Med
Title: Identification of GAPDH on the surface of Plasmodium sporozoites as a new candidate for targeting malaria liver invasion.
Volume: 213
Issue: 10
Pages: 2099-112
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Publication
38215888 | J:347904
 
First Author: Yang S
Year: 2024
Journal: Brain Behav Immun
Title: Multi-omics analysis reveals GAPDH posttranscriptional regulation of IFN-γ and PHGDH as a metabolic checkpoint of microglia polarization.
Volume: 117
Pages: 155-166
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UniProt Feature
UniProt Feature
Begin: 2
Description: Necessary for association with microtubule and interaction with GAPDH
Type: short sequence motif
End: 6
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Allele
Gapdh<em1Smoc> | MGI:7289821
Name: glyceraldehyde-3-phosphate dehydrogenase; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Reporter
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Interaction Experiment
Hara MR (2006)
Description: Neuroprotection by pharmacologic blockade of the GAPDH death cascade.
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Interaction Experiment
Makhina T (2009)
Description: Extracellular GAPDH binds to L1 and enhances neurite outgrowth.
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Protein
P16858
Organism: Mus musculus/domesticus
Length: 333  
Fragment?: false
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Strain
MGI:6428704 | C57BL/6JSmoc-Gapdh<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Interaction Experiment
Iqbal IK (2021)
Description: Hydrogen sulfide-induced GAPDH sulfhydration disrupts the CCAR2-SIRT1 interaction to initiate autophagy.
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Publication
16505364 | -
First Author: Hara MR
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Neuroprotection by pharmacologic blockade of the GAPDH death cascade.
Volume: 103
Issue: 10
Pages: 3887-9
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Publication
19285135 | -
First Author: Makhina T
Year: 2009
Journal: Mol Cell Neurosci
Title: Extracellular GAPDH binds to L1 and enhances neurite outgrowth.
Volume: 41
Issue: 2
Pages: 206-18
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Publication
33459133 | -
   
First Author: Iqbal IK
Year: 2021
Journal: Autophagy
Title: Hydrogen sulfide-induced GAPDH sulfhydration disrupts the CCAR2-SIRT1 interaction to initiate autophagy.
Pages: 1-19
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GO Term
GO:0004365 | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
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MP Term
MP:0011609 | decreased glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
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MP Term
MP:0011607 | abnormal glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
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MP Term
MP:0011608 | increased glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
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Protein Domain
IPR020828 | GlycerAld_3-P_DH_NAD(P)-bd
Type: Domain
Description: Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) plays an important role in glycolysis and gluconeogenesis []by reversibly catalysing the oxidation and phosphorylation of D-glyceraldehyde-3-phosphate to 1,3-diphospho-glycerate. The enzyme exists as a tetramer of identical subunits, each containing 2 conserved functional domains: an NAD-binding domain, and a highly conserved catalytic domain []. The enzyme has been found to bind to actin and tropomyosin, and may thus have a role in cytoskeleton assembly. Alternatively, the cytoskeleton may provide a framework for precise positioning of the glycolytic enzymes, thus permitting efficient passage of metabolites from enzyme to enzyme [].GAPDH displays diverse non-glycolytic functions as well, its role depending upon its subcellular location. For instance, the translocation of GAPDH to the nucleus acts as a signalling mechanism for programmed cell death, or apoptosis []. The accumulation of GAPDH within the nucleus is involved in the induction of apoptosis, where GAPDH functions in the activation of transcription. The presence of GAPDH is associated with the synthesis of pro-apoptotic proteins like BAX, c-JUN and GAPDH itself.GAPDH has been implicated in certain neurological diseases: GAPDH is able to bind to the gene products from neurodegenerative disorders such as Huntington's disease, Alzheimer's disease, Parkinson's disease and Machado-Joseph disease through stretches encoded by their CAG repeats. Abnormal neuronal apoptosis is associated with these diseases. Propargylamines such as deprenyl increase neuronal survival by interfering with apoptosis signalling pathways via their binding to GAPDH, which decreases the synthesis of pro-apoptotic proteins [].This entry represents the N-terminal domain which is a Rossmann NAD(P) binding fold.
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Protein Domain
IPR020829 | GlycerAld_3-P_DH_cat
Type: Domain
Description: Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) plays an important role in glycolysis and gluconeogenesis []by reversibly catalysing the oxidation and phosphorylation of D-glyceraldehyde-3-phosphate to 1,3-diphospho-glycerate. The enzyme exists as a tetramer of identical subunits, each containing 2 conserved functional domains: an NAD-binding domain, and a highly conserved catalytic domain []. The enzyme has been found to bind to actin and tropomyosin, and may thus have a role in cytoskeleton assembly. Alternatively, the cytoskeleton may provide a framework for precise positioning of the glycolytic enzymes, thus permitting efficient passage of metabolites from enzyme to enzyme [].GAPDH displays diverse non-glycolytic functions as well, its role depending upon its subcellular location. For instance, the translocation of GAPDH to the nucleus acts as a signalling mechanism for programmed cell death, or apoptosis []. The accumulation of GAPDH within the nucleus is involved in the induction of apoptosis, where GAPDH functions in the activation of transcription. The presence of GAPDH is associated with the synthesis of pro-apoptotic proteins like BAX, c-JUN and GAPDH itself.GAPDH has been implicated in certain neurological diseases: GAPDH is able to bind to the gene products from neurodegenerative disorders such as Huntington's disease, Alzheimer's disease, Parkinson's disease and Machado-Joseph disease through stretches encoded by their CAG repeats. Abnormal neuronal apoptosis is associated with these diseases. Propargylamines such as deprenyl increase neuronal survival by interfering with apoptosis signalling pathways via their binding to GAPDH, which decreases the synthesis of pro-apoptotic proteins [].This entry represents the C-terminal domain which is a mixed alpha/antiparallel beta fold.
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Protein
S4R2L8
Organism: Mus musculus/domesticus
Length: 67  
Fragment?: true
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Publication
2492940 | -
First Author: Fabry S
Year: 1989
Journal: Eur J Biochem
Title: Nucleotide sequence of the glyceraldehyde-3-phosphate dehydrogenase gene from the mesophilic methanogenic archaebacteria Methanobacterium bryantii and Methanobacterium formicicum. Comparison with the respective gene structure of the closely related extreme thermophile Methanothermus fervidus.
Volume: 179
Issue: 2
Pages: 405-13
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Protein Domain
IPR020831 | GlycerAld/Erythrose_P_DH
Type: Family
Description: Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) plays an important role in glycolysis and gluconeogenesis []by reversibly catalysing the oxidation and phosphorylation of D-glyceraldehyde-3-phosphate to 1,3-diphospho-glycerate. The enzyme exists as a tetramer of identical subunits, each containing 2 conserved functional domains: an NAD-binding domain, and a highly conserved catalytic domain []. The enzyme has been found to bind to actin and tropomyosin, and may thus have a role in cytoskeleton assembly. Alternatively, the cytoskeleton may provide a framework for precise positioning of the glycolytic enzymes, thus permitting efficient passage of metabolites from enzyme to enzyme [].GAPDH displays diverse non-glycolytic functions as well, its role depending upon its subcellular location. For instance, the translocation of GAPDH to the nucleus acts as a signalling mechanism for programmed cell death, or apoptosis []. The accumulation of GAPDH within the nucleus is involved in the induction of apoptosis, where GAPDH functions in the activation of transcription. The presence of GAPDH is associated with the synthesis of pro-apoptotic proteins like BAX, c-JUN and GAPDH itself.GAPDH has been implicated in certain neurological diseases: GAPDH is able to bind to the gene products from neurodegenerative disorders such as Huntington's disease, Alzheimer's disease, Parkinson's disease and Machado-Joseph disease through stretches encoded by their CAG repeats. Abnormal neuronal apoptosis is associated with these diseases. Propargylamines such as deprenyl increase neuronal survival by interfering with apoptosis signalling pathways via their binding to GAPDH, which decreases the synthesis of pro-apoptotic proteins [].This entry contains a small clade of dehydrogenases in gamma-proteobacteria which utilise NAD+ to oxidize erythrose-4-phosphate (E4P) to 4-phospho-erythronate, a precursor for the de novo synthesis of pyridoxine via 4-hydroxythreonine and D-1-deoxyxylulose []. This enzyme activity appears to have evolved from glyceraldehyde-3-phosphate dehydrogenase, whose substrate differs only in the lack of one carbon relative to E4P. It is possible that some of the GAPDH enzymes may prove to be bifunctional in certain species.
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Protein Domain
IPR020830 | GlycerAld_3-P_DH_AS
Type: Active_site
Description: Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) plays an important role in glycolysis and gluconeogenesis []by reversibly catalysing the oxidation and phosphorylation of D-glyceraldehyde-3-phosphate to 1,3-diphospho-glycerate. The enzyme exists as a tetramer of identical subunits, each containing 2 conserved functional domains: an NAD-binding domain, and a highly conserved catalytic domain []. The enzyme has been found to bind to actin and tropomyosin, and may thus have a role in cytoskeleton assembly. Alternatively, the cytoskeleton may provide a framework for precise positioning of the glycolytic enzymes, thus permitting efficient passage of metabolites from enzyme to enzyme [].GAPDH displays diverse non-glycolytic functions as well, its role depending upon its subcellular location. For instance, the translocation of GAPDH to the nucleus acts as a signalling mechanism for programmed cell death, or apoptosis []. The accumulation of GAPDH within the nucleus is involved in the induction of apoptosis, where GAPDH functions in the activation of transcription. The presence of GAPDH is associated with the synthesis of pro-apoptotic proteins like BAX, c-JUN and GAPDH itself.GAPDH has been implicated in certain neurological diseases: GAPDH is able to bind to the gene products from neurodegenerative disorders such as Huntington's disease, Alzheimer's disease, Parkinson's disease and Machado-Joseph disease through stretches encoded by their CAG repeats. Abnormal neuronal apoptosis is associated with these diseases. Propargylamines such as deprenyl increase neuronal survival by interfering with apoptosis signalling pathways via their binding to GAPDH, which decreases the synthesis of pro-apoptotic proteins [].A cysteine in the middle of the molecule is involved in forming a covalent phosphoglycerol thioester intermediate. The sequence around this cysteine is totally conserved in eubacterial and eukaryotic GAPDHs and is also present, albeit in a variant form, in the otherwise highly divergent archaebacterial GAPDH []. The pattern in this entry represents the active site.
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Protein
Q8CEV2
Organism: Mus musculus/domesticus
Length: 156  
Fragment?: false
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Protein
W8QM43
Organism: Mus musculus/domesticus
Length: 77  
Fragment?: true
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Protein
Q6IWE3
Organism: Mus musculus/domesticus
Length: 96  
Fragment?: true
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Protein
Q8BJ40
Organism: Mus musculus/domesticus
Length: 209  
Fragment?: false
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Protein
Q3V2I5
Organism: Mus musculus/domesticus
Length: 236  
Fragment?: true
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Publication
6303388 | -
First Author: Dugaiczyk A
Year: 1983
Journal: Biochemistry
Title: Cloning and sequencing of a deoxyribonucleic acid copy of glyceraldehyde-3-phosphate dehydrogenase messenger ribonucleic acid isolated from chicken muscle.
Volume: 22
Issue: 7
Pages: 1605-13
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Publication
2716055 | -
First Author: Huang XY
Year: 1989
Journal: J Mol Biol
Title: Genomic organization of the glyceraldehyde-3-phosphate dehydrogenase gene family of Caenorhabditis elegans.
Volume: 206
Issue: 3
Pages: 411-24
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Publication
12721812 | -
First Author: Tatton W
Year: 2003
Journal: J Neural Transm (Vienna)
Title: Neuroprotection by deprenyl and other propargylamines: glyceraldehyde-3-phosphate dehydrogenase rather than monoamine oxidase B.
Volume: 110
Issue: 5
Pages: 509-15
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Publication
10740219 | -
First Author: Berry MD
Year: 2000
Journal: J Neurosci Res
Title: Glyceraldehyde-3-phosphate dehydrogenase and apoptosis.
Volume: 60
Issue: 2
Pages: 150-4
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Publication
2078593 | J:11071
First Author: Galland F
Year: 1990
Journal: Biochimie
Title: Characterization of a murine glyceraldehyde-3-phosphate dehydrogenase pseudogene.
Volume: 72
Issue: 10
Pages: 759-62
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Publication
7751290 | -
First Author: Zhao G
Year: 1995
Journal: J Bacteriol
Title: Biochemical characterization of gapB-encoded erythrose 4-phosphate dehydrogenase of Escherichia coli K-12 and its possible role in pyridoxal 5'-phosphate biosynthesis.
Volume: 177
Issue: 10
Pages: 2804-12
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Protein
Q64467
Organism: Mus musculus/domesticus
Length: 440  
Fragment?: false
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Protein
S4R257
Organism: Mus musculus/domesticus
Length: 280  
Fragment?: true
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