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Search results 501 to 600 out of 3463 for Grasp

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Categories

Hits by Pathway

Hits by Category

Type Details Score
Genotype
Genotype
Symbol: Slc17a1/Slc17a1
Background: C57BL/6NJ-Slc17a1/Mmjax
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Slc25a42/Slc25a42<+>
Background: C57BL/6NJ-Slc25a42/Mmjax
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Socs2/Socs2
Background: C57BL/6NTac-Socs2/H
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Stimate/Stimate
Background: C57BL/6N-Stimate/Wtsi
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Taf5/Taf5<+>
Background: C57BL/6NJ-Taf5/Mmjax
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tent5c/Tent5c<+>
Background: C57BL/6N-Tent5c/Wtsi
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tecrl/Tecrl
Background: C57BL/6NJ-Tecrl/Mmjax
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tfpi2/Tfpi2
Background: C57BL/6NTac-Tfpi2/Kmpc
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tm2d3/Tm2d3<+>
Background: C57BL/6NJ-Tm2d3/Mmjax
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tubb2a/Tubb2a
Background: C57BL/6NJ-Tubb2a/J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Vps51/Vps51<+>
Background: C57BL/6N-Vps51/Wtsi
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Wdr24/Wdr24<+>
Background: C57BL/6N-Wdr24/J
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Zfp146/Zfp146
Background: C57BL/6NJ-Zfp146/Mmjax
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Zfp711/Zfp711
Background: C57BL/6NJ-Zfp711/J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Zftraf1/Zftraf1
Background: C57BL/6NTac-Zftraf1/H
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Znfx1/Znfx1
Background: C57BL/6NJ-Znfx1/Mmjax
Zygosity: hm
Has Mutant Allele: true
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Allele
Dnaja1<tm1.1(KOMP)Vlcg> | MGI:5445777
Name: DnaJ heat shock protein family (Hsp40) member A1; targeted mutation 1.1, Velocigene
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Genotype
Genotype
Symbol: Limd1/Limd1
Background: C57BL/6NTac-Limd1/H
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tm4sf5/Tm4sf5
Background: C57BL/6NTac-Tm4sf5/Kmpc
Zygosity: hm
Has Mutant Allele: true
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Publication
7862655 | -
First Author: Fan C
Year: 1995
Journal: Proc Natl Acad Sci U S A
Title: A common fold for peptide synthetases cleaving ATP to ADP: glutathione synthetase and D-alanine:d-alanine ligase of Escherichia coli.
Volume: 92
Issue: 4
Pages: 1172-6
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Protein Domain
IPR041290 | Tli4_C
Type: Domain
Description: T6SS bacteria employ toxic effectors to inhibit rival cells and concurrently use effector cognate immunity proteins to protect their sibling cells. The effector and immunity pairs (E-I pairs) endow the bacteria with a great advantage in niche competition. This is the C-terminal domain of Tli4. The Tle cognate immunity proteins (Tlis) can directly disable the transported Tle protein and thereby mediate the self-protection process. The Tle-Tli effector-immunity (E-I) pairs confer substantial advantage to the donor cell during interbacterial competition. Tli4 displays a two-domain structure, in which a large lobe and a small lobe form a crab claw-like conformation. Tli4 uses this crab claw to grasp the cap domain of Tle4, especially the lid2 region, which prevents the interfacial activation of Tle4 and thus causes enzymatic dysfunction of Tle4. Structural comparison indicates similarity between this C-terminal domain of Tli4 and Tsi3, which is the cognate immunity protein of the effector protein Tse3 in P. aeruginosa PDB:4n7s [].
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Protein Domain
IPR011761 | ATP-grasp
Type: Domain
Description: The ATP-grasp superfamily currently includes 17 groups of enzymes, catalyzing ATP-dependent ligation of a carboxylate containing molecule to an amino or thiol group-containing molecule []. They contribute predominantly to macromolecular synthesis. ATP-hydrolysis is used to activate a substrate. For example, DD-ligase transfers phosphate from ATP to D-alanine on the first step of catalysis. On the second step the resulting acylphosphate is attacked by a second D-alanine to produce a DD dipeptide following phosphate elimination [].The ATP-grasp domain contains three conserved motifs, corresponding to the phosphate binding loop and the Mg(2+) binding site []. The fold is characterised by two α-β subdomains that grasp the ATP molecule between them. Each subdomain provides a variable loop that formspart of the active site, with regions from other domains also contributing to the active site, even though these other domains are not conserved between the various ATP-grasp enzymes [].
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Protein Domain
IPR013650 | ATP-grasp_succ-CoA_synth-type
Type: Domain
Description: The ATP-grasp superfamily currently includes 17 groups of enzymes, catalysing ATP-dependent ligation of a carboxylate containing molecule to an amino or thiol group-containing molecule []. They contribute predominantly to macromolecular synthesis. ATP-hydrolysis is used to activate a substrate. For example, DD-ligase transfers phosphate from ATP to D-alanine on the first step of catalysis. On the second step the resulting acylphosphate is attacked by a second D-alanine to produce a DD dipeptide following phosphate elimination [].The ATP-grasp domain contains three conserved motifs, corresponding to the phosphate binding loop and the Mg(2+) binding site []. The fold is characterised by two α-β subdomains that grasp the ATP molecule between them. Each subdomain provides a variable loop that forms a part of the active site, completed by region of other domains not conserved between the various ATP-grasp enzymes [].The ATP-grasp domain represented by this entry is found primarily in succinyl-CoA synthetases ().
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Publication
7939684 | -
First Author: Fan C
Year: 1994
Journal: Science
Title: Vancomycin resistance: structure of D-alanine:D-alanine ligase at 2.3 A resolution.
Volume: 266
Issue: 5184
Pages: 439-43
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Protein Domain
IPR005875 | PurK
Type: Domain
Description: Phosphoribosylaminoimidazole carboxylase is a fusion protein in plants and fungi, but consists of two non-interacting proteins in bacteria, PurK and PurE. This family represents PurK, N5-carboxyaminoimidazole ribonucleotide (N5_CAIR) synthetase, which catalyzes the conversion of 5-aminoimidazole ribonucleotide (AIR), ATP, and bicarbonate to N5-CAIR, ADP, and Pi. PurE converts N5-CAIR to CAIR. In the presence of high concentrations of bicarbonate, PurE is reported able to convert AIR to CAIR directly and without ATP. PurK belongs to the ATP grasp superfamily of C-N ligase enzymes. Each subunit of PurK is composed of three domains (A, B, and C). The B domain contains a flexible, glycine-rich loop (B loop, T123-G130) that is disordered in the sulphate-PurK structure and becomes ordered in the MgADP-PurK structure. MgADP is wedged between the B and C domains, as with all members of the ATP grasp superfamily. Other enzymes in this superfamily contain a conserved Omega loop proposed to interact with the B loop, define the specificity of their nonnucleotide substrate, and protect the acyl phosphate intermediate formed from this substrate. PurK contains a minimal Omega loopwithout conserved residues. In the reaction catalyzed by PurK, carboxyphosphate is the putative acyl phosphate intermediate. The sulphate of the sulphate ion-liganded PurK interacts electrostatically with Arg 242 and the backbone amide group of Asn 245, components of the J loop of the C domain. This sulphate may reveal the location of the carboxyphosphate binding site. Conserved residues within the C terminus of the C domain define a pocket that is proposed to bind AIR in collaboration with an N-terminal strand loop helix motif in the A domain (P loop, G8-L1). The P loop is proposed to bind the phosphate of AIR on the basis of similar binding sites observed in PurN and PurE and proposed in PurD and PurT, four other enzymes in the purine pathway [].
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Publication
12884264 | J:104862
First Author: Takeda Y
Year: 2003
Journal: J Neurobiol
Title: Impaired motor coordination in mice lacking neural recognition molecule NB-3 of the contactin/F3 subgroup.
Volume: 56
Issue: 3
Pages: 252-65
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Publication
15537875 | J:96567
First Author: Goldshmit Y
Year: 2004
Journal: J Neurosci
Title: Axonal regeneration and lack of astrocytic gliosis in EphA4-deficient mice.
Volume: 24
Issue: 45
Pages: 10064-73
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Publication
10828067 | J:62592
First Author: Nevrivy DJ
Year: 2000
Journal: J Biol Chem
Title: Interaction of GRASP, a protein encoded by a novel retinoic acid-induced gene, with members of the cytohesin family of guanine nucleotide exchange factors.
Volume: 275
Issue: 22
Pages: 16827-36
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Publication
23489835 | J:214898
First Author: Kleven GA
Year: 2013
Journal: Eur J Neurosci
Title: Prenatal ontogeny of the dopamine-dependent neurobehavioral phenotype in Pitx3-deficient mice.
Volume: 37
Issue: 10
Pages: 1564-72
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Publication
34162999 | J:314282
First Author: Chevalier NR
Year: 2021
Journal: Commun Biol
Title: A neural crest cell isotropic-to-nematic phase transition in the developing mammalian gut.
Volume: 4
Issue: 1
Pages: 770
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Publication
23711927 | J:199110
 
First Author: Blaney CE
Year: 2013
Journal: Behav Brain Res
Title: Maternal genotype influences behavioral development of 3×Tg-AD mouse pups.
Volume: 252
Pages: 40-8
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Publication
25340339 | J:232540
First Author: Traboulsi H
Year: 2014
Journal: PLoS Genet
Title: Dynamic partnership between TFIIH, PGC-1α and SIRT1 is impaired in trichothiodystrophy.
Volume: 10
Issue: 10
Pages: e1004732
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Publication
28549651 | J:249886
 
First Author: Stamenkovic V
Year: 2017
Journal: Behav Brain Res
Title: Enriched environment alters the behavioral profile of tenascin-C deficient mice.
Volume: 331
Pages: 241-253
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Publication
20086247 | J:160795
First Author: Cordell PA
Year: 2010
Journal: Blood
Title: Association of coagulation factor XIII-A with Golgi proteins within monocyte-macrophages: implications for subcellular trafficking and secretion.
Volume: 115
Issue: 13
Pages: 2674-81
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Publication
15496679 | J:96533
First Author: Fleming SM
Year: 2004
Journal: J Neurosci
Title: Early and progressive sensorimotor anomalies in mice overexpressing wild-type human alpha-synuclein.
Volume: 24
Issue: 42
Pages: 9434-40
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Protein Coding Gene
MGI:1922854 | Tm4sf5
Type: protein_coding_gene
Organism: mouse, laboratory
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Allele
Lats1<em1(IMPC)H> | MGI:6153801
Name: large tumor suppressor; endonuclease-mediated mutation 1, Harwell
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Slc30a4<em1(IMPC)Tcp> | MGI:6156460
Name: solute carrier family 30 (zinc transporter), member 4; endonuclease-mediated mutation 1, The Centre for Phenogenomics
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Genotype
Genotype
Symbol: Acox1/Acox1
Background: C57BL/6N-Acox1/Bay
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dnaja1/Dnaja1<+>
Background: C57BL/6N-Dnaja1/J
Zygosity: ht
Has Mutant Allele: true
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Protein
Q99JX3
Organism: Mus musculus/domesticus
Length: 451  
Fragment?: false
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Protein
Q91X51
Organism: Mus musculus/domesticus
Length: 446  
Fragment?: false
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Protein
Q3TX06
Organism: Mus musculus/domesticus
Length: 451  
Fragment?: false
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Protein
A2ATI8
Organism: Mus musculus/domesticus
Length: 317  
Fragment?: false
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Protein
Q3TIK1
Organism: Mus musculus/domesticus
Length: 451  
Fragment?: false
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Protein
A2ATI6
Organism: Mus musculus/domesticus
Length: 351  
Fragment?: false
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Protein
A2ATI9
Organism: Mus musculus/domesticus
Length: 431  
Fragment?: false
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Protein
Q3TG07
Organism: Mus musculus/domesticus
Length: 431  
Fragment?: false
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Protein
Q3V458
Organism: Mus musculus/domesticus
Length: 283  
Fragment?: false
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Protein
Q3TCN5
Organism: Mus musculus/domesticus
Length: 446  
Fragment?: false
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Publication
8804825 | -
First Author: Murzin AG
Year: 1996
Journal: Curr Opin Struct Biol
Title: Structural classification of proteins: new superfamilies.
Volume: 6
Issue: 3
Pages: 386-94
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Publication
37290534 | J:337576
 
First Author: Alonso C
Year: 2023
Journal: Neuropharmacology
Title: Disease-modifying effects of cannabidiol, β-caryophyllene and their combination in Syn1-Cre/Scn1a(WT/A1783V) mice, a preclinical model of Dravet syndrome.
Volume: 237
Pages: 109602
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Publication
32997569 | J:353136
First Author: Becker MI
Year: 2020
Journal: J Neurophysiol
Title: Online control of reach accuracy in mice.
Volume: 124
Issue: 6
Pages: 1637-1655
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Publication
25523027 | J:223978
 
First Author: Fenrich KK
Year: 2015
Journal: Behav Brain Res
Title: Improved single pellet grasping using automated ad libitum full-time training robot.
Volume: 281
Pages: 137-48
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Protein Coding Gene
MGI:1928333 | Creg2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:104849 | Cd55b
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1916185 | Trmt1l
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1921331 | Cep350
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1918990 | Nectin4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1918110 | Septin10
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1914727 | Abhd15
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2159605 | Acot2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2685108 | Zdhhc22
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1277180 | Ifi27
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2442264 | Idi1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2443098 | Slc17a2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2137677 | Sfxn1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1921379 | Dmgdh
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1916971 | Nkiras1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1914669 | Armh4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:103206 | Acod1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1919822 | Spats2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:101825 | Tango2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1925225 | Tmem50b
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1347059 | Decr2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1915755 | Vps51
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1931071 | Sec61a2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1924971 | Mrps5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1917315 | Ankrd60
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:106660 | Sprr1a
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2148896 | Palmd
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1917184 | Trmt10b
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1915325 | Lurap1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2384297 | Map7d1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1095396 | Col16a1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96276 | Htr1d
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1916157 | Gpr153
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:3045263 | Dnajc5g
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1916941 | Sel1l3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:3605543 | Fam222a
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1890386 | Fscn3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1890359 | Igf2bp3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1098586 | Rab11fip5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2179720 | Oscar
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:94907 | Dmwd
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1916797 | Nkpd1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1352748 | Dpf1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1915223 | Mphosph10
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1917511 | Chp2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1859867 | Syt8
Type: protein_coding_gene
Organism: mouse, laboratory
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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Cambridge CB2 3EH, United Kingdom