| Type |
Details |
Score |
| Strain |
| Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
| Allele |
| Name: |
HDGF like 1; endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Hdgfl2/Hdgfl2 |
| Background: |
involves: 129S5/SvEvBrd * C57BL/6J |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Hdgfl1/Hdgfl1 |
| Background: |
C57BL/6NCrl-Hdgfl1/Tcp |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Hdgfl2/Hdgfl2 |
| Background: |
C57BL/6N-Hdgfl2/Tcp |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Hdgfl3/Hdgfl3 |
| Background: |
C57BL/6NCrl-Hdgfl3/Tcp |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
endonuclease-mediated mutation, mutant stock |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Hdgfl1/Hdgfl1 |
| Background: |
involves: C57BL/6NJcl * DBA/2NJcl |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Hdgfl1/Hdgfl1<+> |
| Background: |
C57BL/6NCrl-Hdgfl1/Tcp |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhu X |
| Year: |
2020 |
| Journal: |
Nucleic Acids Res |
| Title: |
HRP2-DPF3a-BAF complex coordinates histone modification and chromatin remodeling to regulate myogenic gene transcription. |
| Volume: |
48 |
| Issue: |
12 |
| Pages: |
6563-6582 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sun J |
| Year: |
2020 |
| Journal: |
Biol Reprod |
| Title: |
CRISPR/Cas9-based genome editing in mice uncovers 13 testis- or epididymis-enriched genes individually dispensable for male reproduction†. |
| Volume: |
103 |
| Issue: |
2 |
| Pages: |
183-194 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yang J |
| Year: |
2007 |
| Journal: |
BMC Mol Biol |
| Title: |
Hepatoma-derived growth factor binds DNA through the N-terminal PWWP domain. |
| Volume: |
8 |
|
| Pages: |
101 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dietz F |
| Year: |
2002 |
| Journal: |
Biochem J |
| Title: |
The family of hepatoma-derived growth factor proteins: characterization of a new member HRP-4 and classification of its subfamilies. |
| Volume: |
366 |
| Issue: |
Pt 2 |
| Pages: |
491-500 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bao C |
| Year: |
2014 |
| Journal: |
Future Oncol |
| Title: |
HDGF: a novel jack-of-all-trades in cancer. |
| Volume: |
10 |
| Issue: |
16 |
| Pages: |
2675-85 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF [, , ]. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HRP1, HRP2, HRP3, HRP4, respectively) and lens epithelium-derived growth factor, LEDGF []. Members of the HDGF family have been linked to human diseases, and HDGF is a prognostic factor in several types of cancer [].The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins seem to be nuclear, often DNA-binding, proteins that function as transcription factors regulating a variety of developmental processes []. |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
202
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
283
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
327
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
260
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
178
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
90
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
283
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li Y |
| Year: |
2022 |
| Journal: |
ASN Neuro |
| Title: |
Hepatoma Derived Growth Factor Enhances Oligodendrocyte Genesis from Subventricular Zone Precursor Cells. |
| Volume: |
14 |
|
| Pages: |
17590914221086340 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Centre for Phenogenomics |
| Year: |
2022 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Direct Data Submission for The Centre for Phenogenomics Alleles. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang J |
| Year: |
2017 |
| Journal: |
Cell Death Dis |
| Title: |
MBD2 upregulates miR-301a-5p to induce kidney cell apoptosis during vancomycin-induced AKI. |
| Volume: |
8 |
| Issue: |
10 |
| Pages: |
e3120 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yoshida K |
| Year: |
2003 |
| Journal: |
J Gastroenterol Hepatol |
| Title: |
Expression of hepatoma-derived growth factor in hepatocarcinogenesis. |
| Volume: |
18 |
| Issue: |
11 |
| Pages: |
1293-301 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
669
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
528
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Stec I |
| Year: |
2000 |
| Journal: |
FEBS Lett |
| Title: |
The PWWP domain: a potential protein-protein interaction domain in nuclear proteins influencing differentiation? |
| Volume: |
473 |
| Issue: |
1 |
| Pages: |
1-5 |
|
•
•
•
•
•
|
| HT Experiment |
| Series Id: |
GSE25965 |
| Experiment Type: |
transcription profiling by array |
| Study Type: |
Baseline |
| Source: |
ArrayExpress |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Toronto Centre for Phenogenomics |
| Year: |
2013 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Strains and alleles submitted by Toronto Centre for Phenogenomics (NorCOMM2, funded by Genome Canada and Ontario Genomics Institute OGI-051). |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Georgas K |
| Year: |
2009 |
| Journal: |
Dev Biol |
| Title: |
Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment. |
| Volume: |
332 |
| Issue: |
2 |
| Pages: |
273-86 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mutant Mouse Regional Resource Centers |
| Year: |
2004 |
| Journal: |
Unpublished |
| Title: |
Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC) |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tang T |
| Year: |
2010 |
| Journal: |
Nat Biotechnol |
| Title: |
A mouse knockout library for secreted and transmembrane proteins. |
| Volume: |
28 |
| Issue: |
7 |
| Pages: |
749-55 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lexicon Genetics, Inc |
| Year: |
2011 |
| Journal: |
Database Download |
| Title: |
MGI download of Lexicon knockout data |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGI and IMPC |
| Year: |
2017 |
| Journal: |
MGI Direct Data Submission |
| Title: |
MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC) |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Blackshaw S |
| Year: |
2004 |
| Journal: |
PLoS Biol |
| Title: |
Genomic analysis of mouse retinal development. |
| Volume: |
2 |
| Issue: |
9 |
| Pages: |
E247 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
International Knockout Mouse Consortium |
| Year: |
2014 |
| Journal: |
Database Download |
| Title: |
MGI download of modified allele data from IKMC and creation of new knockout alleles |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yokoyama S |
| Year: |
2009 |
| Journal: |
Dev Cell |
| Title: |
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. |
| Volume: |
17 |
| Issue: |
6 |
| Pages: |
836-48 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
International Mouse Strain Resource |
| Year: |
2014 |
| Journal: |
Database Download |
| Title: |
MGI download of germline transmission data for alleles from IMSR strain data |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Stryke D |
| Year: |
2003 |
| Journal: |
Nucleic Acids Res |
| Title: |
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |
| Volume: |
31 |
| Issue: |
1 |
| Pages: |
278-81 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Mouse Synonym Curation |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wellcome Trust Sanger Institute |
| Year: |
2009 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
| Year: |
2014 |
| Journal: |
Database Release |
| Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Adams DJ |
| Year: |
2024 |
| Journal: |
Nature |
| Title: |
Genetic determinants of micronucleus formation in vivo. |
| Volume: |
627 |
| Issue: |
8002 |
| Pages: |
130-136 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Skarnes WC |
| Year: |
2011 |
| Journal: |
Nature |
| Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
| Volume: |
474 |
| Issue: |
7351 |
| Pages: |
337-42 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
GemPharmatech |
| Year: |
2020 |
|
| Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Magdaleno S |
| Year: |
2006 |
| Journal: |
PLoS Biol |
| Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
| Volume: |
4 |
| Issue: |
4 |
| Pages: |
e86 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
GOA curators |
| Year: |
2016 |
|
| Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGD Nomenclature Committee |
| Year: |
1995 |
|
| Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|