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Search results 501 to 572 out of 572 for Hira

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Strain
MGI:5004099 | STOCK Tg(Hira-EGFP)LC207Gsat/Mmucd
Attribute String: mutant stock, transgenic
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Strain
MGI:6354736 | C57BL/6JSmoc-Dgcr2<em1Smoc> Hira<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Genotype
Genotype
Symbol: Del(16T10-Hira)4Bld/+
Background: B6.Cg-Tyr Del(16T10-Hira)4Bld
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Del(16T10-Hira)4Bld/+
Background: involves: 129S7/SvEvBrd
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Del(16Cldn5-Hira)5Bld/Del(16Cldn5-Hira)5Bld
Background: involves: 129S7/SvEvBrd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Del(16Cldn5-Hira)5Bld/+
Background: B6.Cg-Tyr Del(16Cldn5-Hira)5Bld
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Del(16Cldn5-Hira)5Bld/+
Background: involves: 129S7/SvEvBrd * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Del(16Dgcr2-Hira)3Aam/+
Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Del(16Dgcr2-Hira)3Aam/+
Background: involves: 129S7/SvEvBrd * C57BL/6J
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Del(16Dgcr2-Hira)3Aam/+
Background: involves: 129S7/SvEvBrd
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Del(16Dgcr2-Hira)3Aam/+
Background: involves: 129S7/SvEvBrd * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Del(16Dgcr2-Hira)3Aam/+
Background: B6.129S7-Del(16Dgcr2-Hira)3Aam
Zygosity: ht
Has Mutant Allele: true
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Protein
F6UTU1
Organism: Mus musculus/domesticus
Length: 322  
Fragment?: true
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Publication
22401310 | -
First Author: Tang Y
Year: 2012
Journal: Biochemistry
Title: Identification of an ubinuclein 1 region required for stability and function of the human HIRA/UBN1/CABIN1/ASF1a histone H3.3 chaperone complex.
Volume: 51
Issue: 12
Pages: 2366-77
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Publication
10468587 | -
First Author: Schilke B
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Evidence for a conserved system for iron metabolism in the mitochondria of Saccharomyces cerevisiae.
Volume: 96
Issue: 18
Pages: 10206-11
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Protein Domain
IPR026943 | Ubinuclein-2
Type: Family
Description: This entry represents ubinuclein-2 (UBN2). It contains a conserved HIRA-binding domain, which directly interacts with the N-terminal WD repeats of HIRA []. UBN2 and UBN1 are believed to be the orthologs of Hpc2p, a subunit of the HIR complex (a nucleosome assembly complex involved in regulation of histone gene transcription) in budding yeast []. It is phosphorylated upon DNA damage, probably by ATM or ATR [].
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Protein Domain
IPR026936 | Ubinuclein-1
Type: Family
Description: Ubinuclein-1 (UBN1) is part of the histone chaperone complex HIRA/UBN1/CABIN1/ASF1a that preferentially deposits the histone variant H3.3 into chromatin and is implicated in diverse chromatin regulatory events from gene activation to heterochromatinisation [, ].Ubinuclein-1 interacts with HIRA and is involved in the formation of senescence-associated heterochromatin foci (SAHF). SAHF are domains of specialised chromatin found in senescent cells that repress expression of proliferation-promoting genes [].
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Protein Domain
IPR035433 | NFU1-like
Type: Family
Description: This entry includes NFU1-like proteins from eukaryotes and some uncharacterised proteins from prokaryotes.Nfu functions as a scaffold protein for assembly and delivery of rudimentary Fe-S clusters to target proteins [, ]. A human Nfu homologue, HIRA-interacting protein 5 (HIRIP5), was first identified in a two-hybrid screen for proteins that interact with the transcription regulator HIRA []. It seems that two human Nfu isoforms are generated by alternative explicing, which are subsequently targeted to different subcellular compartments [].
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HT Experiment
GSE79937 | Mesp1Cre;Hira-/fl and Mesp1Cre;Hira+/fl in heart at E11.5 and E12.5
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
25913858 | J:221568
First Author: Mukai J
Year: 2015
Journal: Neuron
Title: Molecular substrates of altered axonal growth and brain connectivity in a mouse model of schizophrenia.
Volume: 86
Issue: 3
Pages: 680-95
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Publication
18836441 | J:141432
First Author: Mukai J
Year: 2008
Journal: Nat Neurosci
Title: Palmitoylation-dependent neurodevelopmental deficits in a mouse model of 22q11 microdeletion.
Volume: 11
Issue: 11
Pages: 1302-10
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HT Experiment
E-GEOD-73381 | Single cell RNA-Seq of Hira-KO and control MII oocytes [Zp3-Cre]
Series Id: GSE73381
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-GEOD-66931 | Single cell RNA-Seq of Hira-KO and control MII oocytes [Gdf9-Cre+]
Series Id: GSE66931
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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Protein
Q8BLH7
Organism: Mus musculus/domesticus
Length: 601  
Fragment?: false
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Protein
A0A2R8VI01
Organism: Mus musculus/domesticus
Length: 231  
Fragment?: true
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Publication
19029251 | -
First Author: Banumathy G
Year: 2009
Journal: Mol Cell Biol
Title: Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells.
Volume: 29
Issue: 3
Pages: 758-70
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Publication
28696314 | J:243862
First Author: Diamantopoulou A
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Loss-of-function mutation in Mirta22/Emc10 rescues specific schizophrenia-related phenotypes in a mouse model of the 22q11.2 deletion.
Volume: 114
Issue: 30
Pages: E6127-E6136
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Publication
10819462 | -
First Author: Agar JN
Year: 2000
Journal: J Biol Inorg Chem
Title: Modular organization and identification of a mononuclear iron-binding site within the NifU protein.
Volume: 5
Issue: 2
Pages: 167-77
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Publication
19367708 | -
First Author: Zanivan S
Year: 2008
Journal: J Proteome Res
Title: Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry.
Volume: 7
Issue: 12
Pages: 5314-26
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Publication
21807893 | -
First Author: Rai TS
Year: 2011
Journal: Mol Cell Biol
Title: Human CABIN1 is a functional member of the human HIRA/UBN1/ASF1a histone H3.3 chaperone complex.
Volume: 31
Issue: 19
Pages: 4107-18
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Publication
11404324 | -
First Author: Sutton A
Year: 2001
Journal: Genetics
Title: Yeast ASF1 protein is required for cell cycle regulation of histone gene transcription.
Volume: 158
Issue: 2
Pages: 587-96
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Publication
8417331 | -
First Author: Sherwood PW
Year: 1993
Journal: Mol Cell Biol
Title: Characterization of HIR1 and HIR2, two genes required for regulation of histone gene transcription in Saccharomyces cerevisiae.
Volume: 13
Issue: 1
Pages: 28-38
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Protein Domain
IPR031120 | HIR1
Type: Family
Description: This entry includes HIR1/HIR2 from yeasts and HIRA from animals. They are WD-repeat containing proteins required for regulation of histone gene transcription. The budding yeast HIR complex is composed of Hir1, Hir2, Hir3 and Hpc2, and interacts with ASF1 [, ]. The HIR complex cooperates with ASF1 to promote replication-independent chromatin assembly. The HIR complex is also required for the periodic repression of three of the four histone gene loci during cell cycle as well as for autogenous regulation of the HTA1-HTB1 locus by H2A and H2B. DNA-binding by the HIR complex may repress transcription by inhibiting nucleosome remodeling by the SWI/SNF complex. The HIR complex may also be required for transcriptional silencing of centromeric, telomeric and mating-type loci in the absence of CAF-1 [].
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Publication
9524281 | J:46565
First Author: Llevadot R
Year: 1998
Journal: Gene
Title: Isolation and genomic characterization of the TUPLE1/HIRA gene of the pufferfish Fugu rubripes.
Volume: 208
Issue: 2
Pages: 279-83
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Publication
32169215 | J:351687
First Author: Gou LT
Year: 2020
Journal: Cell
Title: Initiation of Parental Genome Reprogramming in Fertilized Oocyte by Splicing Kinase SRPK1-Catalyzed Protamine Phosphorylation.
Volume: 180
Issue: 6
Pages: 1212-1227.e14
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Publication
26139371 | J:356262
First Author: Maze I
Year: 2015
Journal: Neuron
Title: Critical Role of Histone Turnover in Neuronal Transcription and Plasticity.
Volume: 87
Issue: 1
Pages: 77-94
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HT Experiment
E-GEOD-69807 | Critical role of histone turnover in neuronal transcription and plasticity [RNA-seq]
Series Id: GSE69807
Experiment Type: RNA-Seq
Study Type: Baseline
Source: ArrayExpress
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Publication
12858556 | J:110378
 
First Author: Vitelli F
Year: 2002
Journal: Cold Spring Harb Symp Quant Biol
Title: Genetic dissection of the DiGeorge syndrome phenotype.
Volume: 67
Pages: 327-32
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Strain
MGI:3692531 | B6.Cg-Tyr<c-Brd> Del(16T10-Hira)4Bld
Attribute String: targeted mutation, mutant strain, deletion, congenic, chromosome aberration
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Publication
23332760 | J:193500
First Author: Xu B
Year: 2013
Journal: Cell
Title: Derepression of a neuronal inhibitor due to miRNA dysregulation in a schizophrenia-related microdeletion.
Volume: 152
Issue: 1-2
Pages: 262-75
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Publication
9790763 | J:50534
First Author: Funke B
Year: 1998
Journal: Genomics
Title: Isolation and characterization of a human gene containing a nuclear localization signal from the critical region for velo-cardio-facial syndrome on 22q11.
Volume: 53
Issue: 2
Pages: 146-54
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Protein
Q80WC1
Organism: Mus musculus/domesticus
Length: 1314  
Fragment?: false
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Protein
Q4G0F8
Organism: Mus musculus/domesticus
Length: 1135  
Fragment?: false
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Protein
F6TB64
Organism: Mus musculus/domesticus
Length: 1043  
Fragment?: true
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Publication
16264190 | -
First Author: Prochasson P
Year: 2005
Journal: Genes Dev
Title: The HIR corepressor complex binds to nucleosomes generating a distinct protein/DNA complex resistant to remodeling by SWI/SNF.
Volume: 19
Issue: 21
Pages: 2534-9
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Publication
35680927 | J:328657
First Author: Rabadan MA
Year: 2022
Journal: Nat Commun
Title: An in vitro model of neuronal ensembles.
Volume: 13
Issue: 1
Pages: 3340
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Publication
28384469 | J:253243
First Author: Hamm JP
Year: 2017
Journal: Neuron
Title: Altered Cortical Ensembles in Mouse Models of Schizophrenia.
Volume: 94
Issue: 1
Pages: 153-167.e8
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Publication
24904170 | J:211625
First Author: Chun S
Year: 2014
Journal: Science
Title: Specific disruption of thalamic inputs to the auditory cortex in schizophrenia models.
Volume: 344
Issue: 6188
Pages: 1178-82
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Publication
27507786 | J:235604
First Author: Nilsson SR
Year: 2016
Journal: Cereb Cortex
Title: Assessing the Cognitive Translational Potential of a Mouse Model of the 22q11.2 Microdeletion Syndrome.
Volume: 26
Issue: 10
Pages: 3991-4003
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Strain
MGI:3713859 | B6.Cg-Tyr<c-Brd> Del(16Cldn5-Hira)5Bld
Attribute String: chromosome aberration, congenic, deletion, mutant strain, spontaneous mutation, targeted mutation
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Publication
30675529 | J:278079
 
First Author: Murano T
Year: 2019
Journal: Commun Biol
Title: Transcriptomic immaturity inducible by neural hyperexcitation is shared by multiple neuropsychiatric disorders.
Volume: 2
Pages: 32
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Publication
28869582 | J:258045
First Author: Zaremba JD
Year: 2017
Journal: Nat Neurosci
Title: Impaired hippocampal place cell dynamics in a mouse model of the 22q11.2 deletion.
Volume: 20
Issue: 11
Pages: 1612-1623
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Publication
37590138 | J:340024
First Author: Brockway DF
Year: 2023
Journal: Cell Rep
Title: Somatostatin peptide signaling dampens cortical circuits and promotes exploratory behavior.
Volume: 42
Issue: 8
Pages: 112976
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Publication
11242049 | J:67409
First Author: Lindsay EA
Year: 2001
Journal: Nature
Title: Tbx1 haploinsufficieny in the DiGeorge syndrome region causes aortic arch defects in mice.
Volume: 410
Issue: 6824
Pages: 97-101
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Publication
22900207 | J:196805
 
First Author: Nomura J
Year: 2012
Journal: Neural Plast
Title: Animal models of psychiatric disorders that reflect human copy number variation.
Volume: 2012
Pages: 589524
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Publication
12886008 | -
First Author: Tong WH
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Subcellular compartmentalization of human Nfu, an iron-sulfur cluster scaffold protein, and its ability to assemble a [4Fe-4S] cluster.
Volume: 100
Issue: 17
Pages: 9762-7
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Publication
39638997 | J:359574
First Author: Eom TY
Year: 2024
Journal: Nat Commun
Title: Tbx1 haploinsufficiency leads to local skull deformity, paraflocculus and flocculus dysplasia, and motor-learning deficit in 22q11.2 deletion syndrome.
Volume: 15
Issue: 1
Pages: 10510
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Publication
28532839 | J:336825
 
First Author: Raspa M
Year: 2017
Journal: Theriogenology
Title: Dry ice is a reliable substrate for the distribution of frozen mouse spermatozoa: A multi-centric study.
Volume: 96
Pages: 49-57
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Publication
21821099 | J:184660
 
First Author: Kvajo M
Year: 2012
Journal: Neuroscience
Title: Avoiding mouse traps in schizophrenia genetics: lessons and promises from current and emerging mouse models.
Volume: 211
Pages: 136-64
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Publication
- | J:157064
     
First Author: University of California, Davis
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the University of California, Davis
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Publication
27626380 | J:236599
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
- | J:73796
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Function or Process or Component Unknown following Literature Review
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
- | J:100256
     
First Author: The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year: 2005
Journal: Database Download
Title: MGI download of GENSAT transgene data
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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