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Search results 501 to 600 out of 727 for Irf3

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Type Details Score
Publication
23650567 | J:203155
First Author: Kuo RL
Year: 2013
Journal: PLoS One
Title: MDA5 plays a crucial role in enterovirus 71 RNA-mediated IRF3 activation.
Volume: 8
Issue: 5
Pages: e63431
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Publication
21248248 | J:169149
First Author: Siednienko J
Year: 2011
Journal: J Immunol
Title: Absence of MyD88 results in enhanced TLR3-dependent phosphorylation of IRF3 and increased IFN-β and RANTES production.
Volume: 186
Issue: 4
Pages: 2514-22
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Publication
37871014 | J:342560
First Author: Li WW
Year: 2023
Journal: PLoS Pathog
Title: Tyrosine phosphorylation of IRF3 by BLK facilitates its sufficient activation and innate antiviral response.
Volume: 19
Issue: 10
Pages: e1011742
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Publication
33785602 | J:304755
 
First Author: Yum S
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections.
Volume: 118
Issue: 14
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Publication
36603579 | J:332899
First Author: Yang S
Year: 2023
Journal: Mol Cell
Title: Metabolic enzyme UAP1 mediates IRF3 pyrophosphorylation to facilitate innate immune response.
Volume: 83
Issue: 2
Pages: 298-313.e8
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Publication
21419663 | J:169862
First Author: Rajput A
Year: 2011
Journal: Immunity
Title: RIG-I RNA helicase activation of IRF3 transcription factor is negatively regulated by caspase-8-mediated cleavage of the RIP1 protein.
Volume: 34
Issue: 3
Pages: 340-51
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Publication
24726876 | J:209955
First Author: Long L
Year: 2014
Journal: Immunity
Title: Recruitment of phosphatase PP2A by RACK1 adaptor protein deactivates transcription factor IRF3 and limits type I interferon signaling.
Volume: 40
Issue: 4
Pages: 515-29
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Publication
22331441 | J:182746
First Author: Sugiyama Y
Year: 2012
Journal: Int Immunol
Title: Smad2 and Smad3 are redundantly essential for the suppression of iNOS synthesis in macrophages by regulating IRF3 and STAT1 pathways.
Volume: 24
Issue: 4
Pages: 253-65
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Publication
25772359 | J:228183
     
First Author: James SJ
Year: 2015
Journal: Cell Rep
Title: MAPK Phosphatase 5 Expression Induced by Influenza and Other RNA Virus Infection Negatively Regulates IRF3 Activation and Type I Interferon Response.
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Interaction Experiment
Liu S (2015)
Description: Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation.
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Publication
33372854 | J:304591
First Author: Moustaqil M
Year: 2021
Journal: Emerg Microbes Infect
Title: SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species.
Volume: 10
Issue: 1
Pages: 178-195
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Allele
Irf3<em2Smoc> | MGI:7290576
Name: interferon regulatory factor 3; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6475609 | C57BL/6JSmoc-Irf3<em2Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
11124948 | -
First Author: Smith EJ
Year: 2001
Journal: J Biol Chem
Title: IRF3 and IRF7 phosphorylation in virus-infected cells does not require double-stranded RNA-dependent protein kinase R or Ikappa B kinase but is blocked by Vaccinia virus E3L protein.
Volume: 276
Issue: 12
Pages: 8951-7
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Allele
Irf3<em1Smoc> | MGI:7290575
Name: interferon regulatory factor 3; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Publication
18818105 | -
First Author: Zhong B
Year: 2008
Journal: Immunity
Title: The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation.
Volume: 29
Issue: 4
Pages: 538-50
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Publication
25636800 | -
First Author: Liu S
Year: 2015
Journal: Science
Title: Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation.
Volume: 347
Issue: 6227
Pages: aaa2630
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Publication
23761407 | -
First Author: Ferguson BJ
Year: 2013
Journal: J Gen Virol
Title: Vaccinia virus protein N2 is a nuclear IRF3 inhibitor that promotes virulence.
Volume: 94
Issue: Pt 9
Pages: 2070-2081
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Publication
22394562 | -
First Author: Tanaka Y
Year: 2012
Journal: Sci Signal
Title: STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway.
Volume: 5
Issue: 214
Pages: ra20
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Protein
Q3TBT3
Organism: Mus musculus/domesticus
Length: 378  
Fragment?: false
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Protein
Q3TBT3-2
Organism: Mus musculus/domesticus
Length: 427  
Fragment?: false
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Protein
Q3TBT3-3
Organism: Mus musculus/domesticus
Length: 337  
Fragment?: false
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Ontology Term
- | Inhibition of host IKBKE by virus
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Ontology Term
- | Inhibition of host TBK1 by virus
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Allele
Sting1<em1Zjc> | MGI:7490020
Name: stimulator of interferon response cGAMP interactor 1; endonuclease-mediated mutation 1, Zhijian Chen
Allele Type: Endonuclease-mediated
Attribute String: Not Specified
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Allele
Gt(ROSA)26Sor<tm4(CAG-Irf3*S388D*S390D)Evdr> | MGI:6695703
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 4, Evan Rosen
Allele Type: Targeted
Attribute String: Conditional ready, Epitope tag, Inserted expressed sequence
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Strain
MGI:7490021 | C57BL/6N-Sting1<em1Zjc>/J
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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HT Experiment
E-GEOD-17344 | Analysis of spatial mRNA expression differences in the skin of Casp-8F/-K5-Cre or Casp-8F/+K5-Cre mice
Series Id: GSE17344
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Strain
MGI:6695704 | C57BL/6-Gt(ROSA)26Sor<tm4(CAG-Irf3*S388D*S390D)Evdr>/J
Attribute String: coisogenic, mutant strain, targeted mutation
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Ontology Term
- | Inhibition of host RLR pathway by virus
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Ontology Term
- | Inhibition of host TLR pathway by virus
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Protein
P70671
Organism: Mus musculus/domesticus
Length: 419  
Fragment?: false
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Publication
16125763 | -
First Author: Seth RB
Year: 2005
Journal: Cell
Title: Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3.
Volume: 122
Issue: 5
Pages: 669-82
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Publication
16153868 | -
First Author: Xu LG
Year: 2005
Journal: Mol Cell
Title: VISA is an adapter protein required for virus-triggered IFN-beta signaling.
Volume: 19
Issue: 6
Pages: 727-40
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Publication
16177806 | -
First Author: Meylan E
Year: 2005
Journal: Nature
Title: Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus.
Volume: 437
Issue: 7062
Pages: 1167-72
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Protein
Q9D3J9
Organism: Mus musculus/domesticus
Length: 298  
Fragment?: false
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Protein
Q8BHV4
Organism: Mus musculus/domesticus
Length: 303  
Fragment?: false
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Protein
A2ALN9
Organism: Mus musculus/domesticus
Length: 83  
Fragment?: true
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Protein
Q08EG0
Organism: Mus musculus/domesticus
Length: 298  
Fragment?: false
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Protein
Q3U5B1
Organism: Mus musculus/domesticus
Length: 333  
Fragment?: false
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Publication
18845156 | -
First Author: Kalverda AP
Year: 2009
Journal: J Mol Biol
Title: Poxvirus K7 protein adopts a Bcl-2 fold: biochemical mapping of its interactions with human DEAD box RNA helicase DDX3.
Volume: 385
Issue: 3
Pages: 843-53
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Publication
18636090 | -
First Author: Schröder M
Year: 2008
Journal: EMBO J
Title: Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKepsilon-mediated IRF activation.
Volume: 27
Issue: 15
Pages: 2147-57
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Publication
28257484 | -
First Author: Teferi WM
Year: 2017
Journal: PLoS One
Title: The vaccinia virus K7 protein promotes histone methylation associated with heterochromatin formation.
Volume: 12
Issue: 3
Pages: e0173056
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Publication
23580427 | -
First Author: Benfield CTO
Year: 2013
Journal: J Gen Virol
Title: Vaccinia virus protein K7 is a virulence factor that alters the acute immune response to infection.
Volume: 94
Issue: Pt 7
Pages: 1647-1657
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Publication
31001245 | -
 
First Author: Harris VM
Year: 2019
Journal: Front Immunol
Title: Lysosomal pH Is Regulated in a Sex Dependent Manner in Immune Cells Expressing CXorf21.
Volume: 10
Pages: 578
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Publication
32433612 | -
First Author: Heinz LX
Year: 2020
Journal: Nature
Title: TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7-9.
Volume: 581
Issue: 7808
Pages: 316-322
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Protein Domain
IPR026148 | Mt_antiviral_sig_pro_met
Type: Family
Description: Human mitochondrial antiviral-signalling protein is required for innate immune defence against viruses. It acts downstream of DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). It may activate the same pathways following detection of extracellular dsRNA by TLR3. It also may protect cells from apoptosis [, , , , ].
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Protein Domain
IPR009174 | Orthopox_K7
Type: Family
Description: This family represents Protein K7 from Orthopoxvirus. K7 is Bcl-2-like protein which, through its interaction with the DEAD box RNA helicase DDX3X/DDX3, prevents TBK1/IKKepsilon-mediated IRF3 activation []. It contributes to virulence by binding to the host TRAF6 and IRAK2 and preventing host NF-kappa-B activation and affects the acute immune response to infection [, , ]. In vaccinia virus, this protein has been related to the increase in cellular histone methylation during infection [].
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Protein Domain
IPR027869 | TASL
Type: Family
Description: In humans, TASL (TLR adaptor interacting with SLC15A4 on the lysosome) is encoded by CXorf21 that is associated with systemic lupus erythematosus []. It is an immune adaptor that is required for recruitment and activation of IRF5 by TLR7, TLR8 and TLR9, in mechanistic analogy to IRF3 and its three adaptors STING, MAVS and TRIF. TASL interacts with the endolysosomal transporter SLC15A4; the SLC15A4-TASL complex is required for endolysosomal TLR signalling. TASL contains a pLxIS motif that is important for its function [].
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Publication
15207627 | -
First Author: Langland JO
Year: 2004
Journal: Virology
Title: Inhibition of PKR by vaccinia virus: role of the N- and C-terminal domains of E3L.
Volume: 324
Issue: 2
Pages: 419-29
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Publication
1681618 | -
First Author: Watson JC
Year: 1991
Journal: Virology
Title: Characterization of a vaccinia virus-encoded double-stranded RNA-binding protein that may be involved in inhibition of the double-stranded RNA-dependent protein kinase.
Volume: 185
Issue: 1
Pages: 206-16
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Protein Domain
IPR009179 | E3L
Type: Family
Description: RNA-binding protein E3 from Vaccinia virus (E3L) is a dsRNA-binding protein capable of inhibiting protein kinase R and is an effective IRF3 and -7 phosphorylation inhibitor []. The C terminus of E3L binds to double-stranded RNA (dsRNA), while the N terminus of E3L is required for the additional regulation of eIF2alpha phosphorylation [].Protein E3 from Variola virus is also included in this family. It plays a role in the inhibition of multiple cellular antiviral responses activated by dsRNA, such as inhibition of PKR activation, apoptosis, and IFN-mediated antiviral activities [].
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Publication
16127453 | -
First Author: Kawai T
Year: 2005
Journal: Nat Immunol
Title: IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction.
Volume: 6
Issue: 10
Pages: 981-8
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Publication
24755855 | -
First Author: Yan J
Year: 2014
Journal: J Mol Cell Biol
Title: TRIM4 modulates type I interferon induction and cellular antiviral response by targeting RIG-I for K63-linked ubiquitination.
Volume: 6
Issue: 2
Pages: 154-63
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Publication
22678061 | -
First Author: Feyeux M
Year: 2012
Journal: Hum Mol Genet
Title: Early transcriptional changes linked to naturally occurring Huntington's disease mutations in neural derivatives of human embryonic stem cells.
Volume: 21
Issue: 17
Pages: 3883-95
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Publication
25254379 | -
First Author: Qin Y
Year: 2014
Journal: PLoS Pathog
Title: RNF26 temporally regulates virus-triggered type I interferon induction by two distinct mechanisms.
Volume: 10
Issue: 9
Pages: e1004358
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Publication
11352657 | -
First Author: Katoh M
Year: 2001
Journal: Biochem Biophys Res Commun
Title: Molecular cloning and characterization of RNF26 on human chromosome 11q23 region, encoding a novel RING finger protein with leucine zipper.
Volume: 282
Issue: 4
Pages: 1038-44
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Protein Domain
IPR040089 | RNF26_mRING-HC-C3HC5
Type: Domain
Description: RNF26 is an E3 ubiquitin ligase that temporally regulates virus-triggered type I interferon induction by increasing the stability of Mediator of IRF3 activation, MITA, also known as STING, through K11-linked polyubiquitination of MITA after viral infection and promoting degradation of IRF3, another important component required for virus-triggered interferon induction []. Although RNF26 substrates of ubiquitination remain unclear at present, RNF26 upregulation in gastric cancer might be implicated in carcinogenesis through dysregulation of growth regulators [].RNF26 contains an N-terminal leucine zipper domain and a C-terminal modified C3HC5-type RING-HC finger, which is distinguished from typical C3HC4 RING-HC finger due to the existence of the additional cysteine residue in the middle portion of the RING finger domain [].
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Protein Domain
IPR035829 | PRY/SPRY_TRIM4
Type: Domain
Description: This domain, consisting of the distinct N-terminal PRY subdomain followed by the SPRY subdomain, is found at the C terminus of TRIM4 which is also known as RING finger protein 87 (RNF87). TRIM proteins are defined by the presence of the tripartite motif RING/B-box/coiled-coil region and also known as RBCC proteins []. TRIM4 is a positive regulator of RIG-I-mediated interferon (IFN) induction. It regulates virus-induced IFN induction and cellular antiviral innate immunity by targeting RIG-I for K63-linked poly-ubiquitination []. Over-expression of TRIM4 enhances virus-triggered activation of transcription factors IRF3 and NF-kappaB, as well as IFN-beta induction []. Expression of TRIM4 differs significantly in Huntington's Disease (HD) neural cells when compared with wild-type controls, possibly impacting down-regulation of the Huntingtin (HTT) gene, which is involved in the regulation of diverse cellular activities that are impaired in Huntington's Disease (HD) cells [].
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Publication
32126128 | J:292408
First Author: Yang B
Year: 2020
Journal: PLoS Pathog
Title: RNF90 negatively regulates cellular antiviral responses by targeting MITA for degradation.
Volume: 16
Issue: 3
Pages: e1008387
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Publication
17468758 | J:122421
First Author: Zhao T
Year: 2007
Journal: Nat Immunol
Title: The NEMO adaptor bridges the nuclear factor-kappaB and interferon regulatory factor signaling pathways.
Volume: 8
Issue: 6
Pages: 592-600
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Publication
28132841 | J:253023
First Author: Willemsen J
Year: 2017
Journal: Mol Cell
Title: Phosphorylation-Dependent Feedback Inhibition of RIG-I by DAPK1 Identified by Kinome-wide siRNA Screening.
Volume: 65
Issue: 3
Pages: 403-415.e8
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Publication
19913487 | -
First Author: Oda S
Year: 2009
Journal: Structure
Title: Structural basis for targeting of human RNA helicase DDX3 by poxvirus protein K7.
Volume: 17
Issue: 11
Pages: 1528-37
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Publication
32346490 | -
First Author: Mirza MU
Year: 2020
Journal: J Pharm Anal
Title: Structural elucidation of SARS-CoV-2 vital proteins: Computational methods reveal potential drug candidates against main protease, Nsp12 polymerase and Nsp13 helicase.
Volume: 10
Issue: 4
Pages: 320-328
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Publication
32875166 | -
 
First Author: Gurung AB
Year: 2020
Journal: Gene Rep
Title: In silico structure modelling of SARS-CoV-2 Nsp13 helicase and Nsp14 and repurposing of FDA approved antiviral drugs as dual inhibitors.
Volume: 21
Pages: 100860
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Publication
32529952 | -
First Author: Yuen CK
Year: 2020
Journal: Emerg Microbes Infect
Title: SARS-CoV-2 nsp13, nsp14, nsp15 and orf6 function as potent interferon antagonists.
Volume: 9
Issue: 1
Pages: 1418-1428
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Protein Domain
IPR044343 | NSP13_1B_dom_CoV
Type: Domain
Description: Helicase nonstructural protein 13 (NSP13) is encoded by the replicase polyprotein 1a/ab of coronaviruses and released after a proteolytic process. It plays a vital role in catalysing the unwinding of duplex oligonucleotides into single strands in an NTP-dependent manner. It is a multidomain protein which includes an N-terminal Cys/His rich zinc-binding domain (ZBD), followed by a stalk and 1B domains, and a helicase core that belongs to the superfamily SF1 of helicases, containing two RecA1 and RecA2 domains [, ]. The stalk region connects the ZBD domain and 1B domain. Nsp13 adopts a triangular pyramid shape in which the two RecA1 and A2 and 1B domain form the triangular base, while N-terminal ZBD and stalk domains are arranged at the apex of the pyramid [, , ]. Recently, it has been reported that SARS-CoV-2 NSP13 as an interferon antagonist. It is involved in type I interferon (IFN-I) response as it binds and blocks TBK1 phosphorylation to inhibit interferon regulatory factor 3 (IRF3) which results in decreased IRF3 activation [, ].This entry represents the 1B domain, which has a regulatory role modulating the nucleic acid substrate binding. Based on the structures from the related Equine arteritis virus (EAV) NSP10, it is likely that 1B domain forms a channel together with 1A and 2A domains that accommodates the single stranded nucleic acids [, ].
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Publication
26829768 | J:231311
First Author: Xia P
Year: 2016
Journal: Nat Immunol
Title: Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity.
Volume: 17
Issue: 4
Pages: 369-78
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Publication
22588174 | J:184896
First Author: Kondo T
Year: 2012
Journal: Biochem Biophys Res Commun
Title: TRIM59 interacts with ECSIT and negatively regulates NF-κB and IRF-3/7-mediated signal pathways.
Volume: 422
Issue: 3
Pages: 501-7
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Publication
16039576 | J:100539
First Author: Kato H
Year: 2005
Journal: Immunity
Title: Cell type-specific involvement of RIG-I in antiviral response.
Volume: 23
Issue: 1
Pages: 19-28
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Publication
23258413 | J:196208
First Author: Sun L
Year: 2013
Journal: Science
Title: Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway.
Volume: 339
Issue: 6121
Pages: 786-91
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Publication
30332431 | J:266821
First Author: Dong D
Year: 2018
Journal: PLoS One
Title: GPR108, an NF-κB activator suppressed by TIRAP, negatively regulates TLR-triggered immune responses.
Volume: 13
Issue: 10
Pages: e0205303
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Publication
22945920 | J:219064
First Author: Zhang M
Year: 2012
Journal: J Exp Med
Title: TRAF-interacting protein (TRIP) negatively regulates IFN-β production and antiviral response by promoting proteasomal degradation of TANK-binding kinase 1.
Volume: 209
Issue: 10
Pages: 1703-11
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Publication
23258412 | J:196209
First Author: Wu J
Year: 2013
Journal: Science
Title: Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA.
Volume: 339
Issue: 6121
Pages: 826-30
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Publication
21167755 | J:167719
First Author: Yu Y
Year: 2010
Journal: Immunity
Title: The ubiquitin E3 ligase RAUL negatively regulates type i interferon through ubiquitination of the transcription factors IRF7 and IRF3.
Volume: 33
Issue: 6
Pages: 863-77
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Publication
21102435 | J:167454
First Author: Hayakawa S
Year: 2011
Journal: Nat Immunol
Title: ZAPS is a potent stimulator of signaling mediated by the RNA helicase RIG-I during antiviral responses.
Volume: 12
Issue: 1
Pages: 37-44
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Publication
23951545 | J:207797
 
First Author: Liu S
Year: 2013
Journal: Elife
Title: MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades.
Volume: 2
Pages: e00785
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Publication
19668221 | J:151757
First Author: Kawagoe T
Year: 2009
Journal: Nat Immunol
Title: TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis.
Volume: 10
Issue: 9
Pages: 965-72
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Publication
27026194 | J:336834
 
First Author: Zhao K
Year: 2016
Journal: Sci Rep
Title: Intracellular osteopontin stabilizes TRAF3 to positively regulate innate antiviral response.
Volume: 6
Pages: 23771
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Publication
32205422 | J:289674
First Author: Karki R
Year: 2020
Journal: J Immunol
Title: IRF8 Regulates Gram-Negative Bacteria-Mediated NLRP3 Inflammasome Activation and Cell Death.
Volume: 204
Issue: 9
Pages: 2514-2522
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Publication
31461653 | J:284075
First Author: Song N
Year: 2019
Journal: Cell Rep
Title: MAVS O-GlcNAcylation Is Essential for Host Antiviral Immunity against Lethal RNA Viruses.
Volume: 28
Issue: 9
Pages: 2386-2396.e5
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Publication
36085336 | J:329012
First Author: Yu Z
Year: 2022
Journal: Commun Biol
Title: TOB1 attenuates IRF3-directed antiviral responses by recruiting HDAC8 to specifically suppress IFN-β expression.
Volume: 5
Issue: 1
Pages: 943
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Publication
20453844 | J:160697
First Author: Yang P
Year: 2010
Journal: Nat Immunol
Title: The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway.
Volume: 11
Issue: 6
Pages: 487-94
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Publication
32926474 | J:299498
First Author: Wang C
Year: 2020
Journal: EMBO J
Title: EGFR-mediated tyrosine phosphorylation of STING determines its trafficking route and cellular innate immunity functions.
Volume: 39
Issue: 22
Pages: e104106
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