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Search results 501 to 600 out of 1209 for Itch

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Hits by Strain

Type Details Score
Interaction Experiment
Theivanthiran B (2015)
Description: The E3 ubiquitin ligase Itch inhibits p38 signaling and skin inflammation through the ubiquitylation of Tab1.
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Interaction Experiment
Noyes NC (2016)
Description: Regulation of Itch and Nedd4 E3 Ligase Activity and Degradation by LRAD3.
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Interaction Experiment
Gao Y (2022)
Description: TRPV1 SUMOylation suppresses itch by inhibiting TRPV1 interaction with H1 receptors.
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DO Term
DOID:11917 | tinea cruris
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Publication
25319702 | J:217158
First Author: Rogoz K
Year: 2014
Journal: J Neurosci
Title: Multimodal use of calcitonin gene-related peptide and substance P in itch and acute pain uncovered by the elimination of vesicular glutamate transporter 2 from transient receptor potential cation channel subfamily V member 1 neurons.
Volume: 34
Issue: 42
Pages: 14055-68
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Interaction Experiment
Shembade N (2008)
Description: The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20.
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Interaction Experiment
Oliver PM (2006)
Description: Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammation.
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Interaction Experiment
Zhang H (2013)
Description: Ubiquitin E3 ligase Itch negatively regulates osteoclast formation by promoting de-ubiquitination of TNF receptor-associated factor 6 (TRAF6).
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Interaction Experiment
ZeRuth GT (2015)
Description: HECT E3 Ubiquitin Ligase Itch Functions as a Novel Negative Regulator of Gli-Similar 3 (Glis3) Transcriptional Activity.
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Strain
MGI:6429007 | C57BL/6JSmoc-Itch<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Genotype
Genotype
Symbol: Itch/Itch
Background: involves: C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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DO Term
DOID:14374 | norwegian scabies
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Publication
16446428 | -
First Author: Gallagher E
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change.
Volume: 103
Issue: 6
Pages: 1717-22
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Publication
26555021 | -
First Author: Koshizuka T
Year: 2016
Journal: J Gen Virol
Title: Degradation of host ubiquitin E3 ligase Itch by human cytomegalovirus UL42.
Volume: 97
Issue: 1
Pages: 196-208
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Publication
16387660 | -
First Author: Yang C
Year: 2006
Journal: Mol Cell
Title: Negative regulation of the E3 ubiquitin ligase itch via Fyn-mediated tyrosine phosphorylation.
Volume: 21
Issue: 1
Pages: 135-41
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Publication
15971201 | -
First Author: Shaw AZ
Year: 2005
Journal: Proteins
Title: Phosphorylation of either Ser16 or Thr30 does not disrupt the structure of the Itch E3 ubiquitin ligase third WW domain.
Volume: 60
Issue: 3
Pages: 558-60
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Protein Coding Gene
MGI:1915289 | Nmb
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
21460831 | J:172290
First Author: Wilson SR
Year: 2011
Journal: Nat Neurosci
Title: TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch.
Volume: 14
Issue: 5
Pages: 595-602
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Allele
a<18H> | MGI:1856404
 
Name: nonagouti; 18 Harwell
Allele Type: Chemically and radiation induced
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Strain
MGI:2164225 | C57BL/6J-a<18H>
Attribute String: mutant strain, coisogenic
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Strain
MGI:3577196 | C3H101H-a<18H>/H
Attribute String: chemically induced mutation, mutant stock, radiation induced mutation
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Genotype
Genotype
Symbol: a<18H>/a<18H>
Background: involves: C3H/HeH * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Publication
20962770 | J:244459
First Author: Ramon HE
Year: 2011
Journal: Mucosal Immunol
Title: The ubiquitin ligase adaptor Ndfip1 regulates T cell-mediated gastrointestinal inflammation and inflammatory bowel disease susceptibility.
Volume: 4
Issue: 3
Pages: 314-24
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Publication
26559620 | J:228059
   
First Author: Martinez-Espinosa PL
Year: 2015
Journal: Elife
Title: Knockout of Slo2.2 enhances itch, abolishes KNa current, and increases action potential firing frequency in DRG neurons.
Volume: 4
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Publication
33876765 | J:304844
 
First Author: Steele HR
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: MrgprC11+ sensory neurons mediate glabrous skin itch.
Volume: 118
Issue: 15
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Allele
In(2a;Itch)18H | MGI:4822472
 
Name: inversion, Chr 2, 18 Harwell
Allele Type: Chemically and radiation induced
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HT Experiment
E-MTAB-4150 | Transcription profiling by array of the frontal cortices of embryonic UspX knock out mice
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Protein Coding Gene
MGI:1345149 | Scn11a
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
12397184 | J:87341
First Author: Han SK
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide-related peptides through the Galpha q/11 pathway.
Volume: 99
Issue: 23
Pages: 14740-5
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Publication
33727332 | J:311626
First Author: Grundy L
Year: 2021
Journal: J Neurosci
Title: Activation of MrgprA3 and MrgprC11 on Bladder-Innervating Afferents Induces Peripheral and Central Hypersensitivity to Bladder Distension.
Volume: 41
Issue: 17
Pages: 3900-3916
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Publication
21037581 | J:166905
First Author: Liu T
Year: 2010
Journal: Nat Neurosci
Title: Toll-like receptor 7 mediates pruritus.
Volume: 13
Issue: 12
Pages: 1460-2
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Strain
MGI:6314319 | B6.C3H(101)-In(2a;Itch)18H/LmatMmjax
Attribute String: congenic, chemically induced mutation, mutant strain
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Genotype
Genotype
Symbol: In(2a;Itch)18H/In(2a;Itch)18H
Background: involves: 101/H * C3H/HeH
Zygosity: hm
Has Mutant Allele: true
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Protein
Q3UG30
Organism: Mus musculus/domesticus
Length: 109  
Fragment?: false
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Protein
A0A087WR15
Organism: Mus musculus/domesticus
Length: 122  
Fragment?: false
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Protein
E0CX70
Organism: Mus musculus/domesticus
Length: 76  
Fragment?: true
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Protein
A0A087WR17
Organism: Mus musculus/domesticus
Length: 57  
Fragment?: false
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Protein
E0CYD1
Organism: Mus musculus/domesticus
Length: 72  
Fragment?: true
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Protein Domain
IPR026234 | MRGPCRFAMILY
Type: Family
Description: Members of the mas-related receptor family (also known as oncogene-like MAS and mas-related G-protein coupled receptor MRG) have been implicated in the development, regulation and function of nociceptive neurons, specifically in the modulation of pain. Most members are orphaned, with no endogeneous ligand identified. Of the human mas-related GPCRs, four (MRGPRD, MRGPRE, MRGPRF and MRGPRG) are also found in rodents, whereas MRGPRX1, MRGPRX2, MRGPRX3 and MRGPRX4 are found exclusively in primates. Certain rodent MRGs have been reported to respond to adenine []and to RF-amide peptides, including neuropeptide FF [, ], but the relevance of these findings to man is unclear. MRGs are expressed predominantly in small diameter sensory neurons of the dorsal root ganglia, where there is emerging evidence that they may be mediators of histamine-independent itch [, ].This entry represents the mas-related G protein-coupled receptor family.
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Protein Domain
IPR027344 | MRGPCRX4
Type: Family
Description: Members of the mas-related receptor family (also known as oncogene-like MAS and mas-related G-protein coupled receptor MRG) have been implicated in the development, regulation and function of nociceptive neurons, specifically in the modulation of pain. Most members are orphaned, with no endogeneous ligand identified. Of the human mas-related GPCRs, four (MRGPRD, MRGPRE, MRGPRF and MRGPRG) are also found in rodents, whereas MRGPRX1, MRGPRX2, MRGPRX3 and MRGPRX4 are found exclusively in primates. Certain rodent MRGs have been reported to respond to adenine []and to RF-amide peptides, including neuropeptide FF [, ], but the relevance of these findings to man is unclear. MRGs are expressed predominantly in small diameter sensory neurons of the dorsal root ganglia, where there is emerging evidence that they may be mediators of histamine-independent itch [, ].This entry represents mas-related G protein-coupled receptor X4. X4 may regulate nociceptor function and/or development, including the sensation or modulation of pain. This receptor is currently orphaned, no specific endogenous ligand having been identified.
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Publication
24473265 | J:208441
First Author: Bautista DM
Year: 2014
Journal: Nat Neurosci
Title: Why we scratch an itch: the molecules, cells and circuits of itch.
Volume: 17
Issue: 2
Pages: 175-82
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Protein Coding Gene
MGI:3033139 | Mrgprx1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CAROLIEiJ_G0029779 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0032286 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0032265 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0032201 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0032277 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0031990 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_3033139 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0032770 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0031318 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0031955 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0032112 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0032066 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0032193 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0032103 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0032787 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0031040 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0031438 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_SPRETEiJ_G0030880 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
27215903 | J:344764
First Author: Chang AY
Year: 2016
Journal: Respir Res
Title: Investigating the role of MRGPRC11 and capsaicin-sensitive afferent nerves in the anti-influenza effects exerted by SLIGRL-amide in murine airways.
Volume: 17
Issue: 1
Pages: 62
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Publication
26022362 | J:319185
 
First Author: Li Z
Year: 2015
Journal: Neuroscience
Title: The inhibition of high-voltage-activated calcium current by activation of MrgC11 involves phospholipase C-dependent mechanisms.
Volume: 300
Pages: 393-403
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Publication
12084918 | J:77352
First Author: Bender E
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Characterization of an orphan G protein-coupled receptor localized in the dorsal root ganglia reveals adenine as a signaling molecule.
Volume: 99
Issue: 13
Pages: 8573-8
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Publication
18250432 | -
First Author: Lee MG
Year: 2008
Journal: J Immunol
Title: Agonists of the MAS-related gene (Mrgs) orphan receptors as novel mediators of mast cell-sensory nerve interactions.
Volume: 180
Issue: 4
Pages: 2251-5
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Publication
35875660 | J:326957
 
First Author: Cao Z
Year: 2022
Journal: Front Mol Neurosci
Title: Meis1 Regulates Nociceptor Development and Behavioral Response to Tactile Stimuli.
Volume: 15
Pages: 901466
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Protein Coding Gene
MGI:3036273 | Kcnt2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CAROLIEiJ_G0014672 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGI:2157521 | Hpcal4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CAROLIEiJ_G0026432 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGI:1321386 | Entpd3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CAROLIEiJ_G0032818 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0016559 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_129S1SvImJ_G0028736 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_129S1SvImJ_G0035436 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0016542 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0028695 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0035417 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0016507 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0028648 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0035350 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0016502 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0028717 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0035413 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0016327 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0028433 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0035121 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_3036273 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2157521 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1321386 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0016963 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0029159 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0035936 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0015906 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0027864 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0034425 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0016301 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0028398 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0035088 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0016407 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0028547 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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