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Search results 501 to 532 out of 532 for Kmt2a

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0.018s

Type

Details

Score

Strain

MGI:3847934 | STOCK Kmt2a<tm2(MLLT3)Thr>/KsyJ

Attribute String:

mutant stock, targeted mutation

•

Allele

Hprt1<tm1(tetO-KMT2A/MLLT3)Sguo> | MGI:6385058

Name:	hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, Shangqin Guo
Allele Type:	Targeted
Attribute String:	Humanized sequence, Inserted expressed sequence

•

Genotype

Symbol:	Kmt2a/Kmt2a
Background:	involves: 129P2/OlaHsd * C57BL/6 * FVB
Zygosity:	hm
Has Mutant Allele:	true

•

Genotype

Symbol:	Kmt2a/Kmt2a<+>
Background:	involves: 129P2/OlaHsd
Zygosity:	ht
Has Mutant Allele:	true

•

Genotype

Symbol:	Kmt2a/Kmt2a
Background:	involves: 129P2/OlaHsd
Zygosity:	hm
Has Mutant Allele:	true

•

Publication

16990798 | -

First Author:	Allen MD
Year:	2006
Journal:	EMBO J
Title:	Solution structure of the nonmethyl-CpG-binding CXXC domain of the leukaemia-associated MLL histone methyltransferase.
Volume:	25
Issue:	19
Pages:	4503-12

•

Protein Domain

IPR041958 | KMT2A_ePHD

Type:

Domain

Description:

The extended plant homeodomain (ePHD) zinc finger is characterised as Cys2HisCys5HisCys2His. This entry represents the ePHD finger of Histone-lysine N-methyltransferase 2A (KMT2A), which is a histone methyltransferase that belongs to the MLL subfamily of H3K4-specific histone lysine methyltransferases (KMT2). It regulates chromatin-mediated transcription through the catalysis of methylation of histone 3 lysine 4 (H3K4), and is frequently rearranged in acute leukaemia []. KMT2A functions as the catalytic subunit in the MLL1 complex, which also contains WDR5, RbBP5, ASH2L and DPY30 as integral core subunits required for the efficient methylation activity of the complex [, ]. The MLL1 complex is highly active and specific for H3K4 methylation. KMT2A contains a CxxC (x for any residue) zinc finger domain, three PHD fingers, a Bromodomain domain, this extended PHD finger, two FY (phenylalanine tyrosine)-rich domains, and a SET (Suppressor of variegation, Enhancer of zeste, Trithorax) domain [].

•

Publication

12453419 | -

First Author:	Nakamura T
Year:	2002
Journal:	Mol Cell
Title:	ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation.
Volume:	10
Issue:	5
Pages:	1119-28

•

Publication

26886794 | -

First Author:	Li Y
Year:	2016
Journal:	Nature
Title:	Structural basis for activity regulation of MLL family methyltransferases.
Volume:	530
Issue:	7591
Pages:	447-52

•

Publication

25998713 | J:223408

First Author:	Rao RC
Year:	2015
Journal:	Nat Rev Cancer
Title:	Hijacked in cancer: the KMT2 (MLL) family of methyltransferases.
Volume:	15
Issue:	6
Pages:	334-46

•

HT Experiment

GSE185182 | Postnatal SETD1B is essential for learning and the regulation of neuronal plasticity genes [WT scRNA-seq]


Experiment Type:	RNA-Seq
Study Type:	Baseline
Source:	GEO

•

Publication

41192422 | J:376439

First Author:	Datar GK
Year:	2025
Journal:	Cell
Title:	Disparate leukemia mutations converge on nuclear phase-separated condensates.
Volume:	188
Issue:	25
Pages:	7118-7136.e21

•

Publication

35534777 | J:392434

First Author:	Aubrey BJ
Year:	2022
Journal:	Nat Cancer
Title:	IKAROS and MENIN coordinate therapeutically actionable leukemogenic gene expression in MLL-r acute myeloid leukemia.
Volume:	3
Issue:	5
Pages:	595-613

•

Publication

30232013 | J:271715

First Author:	Bouchard C
Year:	2018
Journal:	Cell Rep
Title:	Genomic Location of PRMT6-Dependent H3R2 Methylation Is Linked to the Transcriptional Outcome of Associated Genes.
Volume:	24
Issue:	12
Pages:	3339-3352

•

Strain

MGI:6385061 | STOCK Gt(ROSA)26Sor<tm1(rtTA*M2)Jae> Hprt1<tm1(tetO-KMT2A/MLLT3)Sguo>/J

Attribute String:

targeted mutation, mutant stock

•

Publication

31852898 | J:282726

First Author:	Chen X
Year:	2019
Journal:	Nat Commun
Title:	MLL-AF9 initiates transformation from fast-proliferating myeloid progenitors.
Volume:	10
Issue:	1
Pages:	5767

•

Publication

37509285 | J:338812

First Author:	Barone C
Year:	2023
Journal:	Cancers (Basel)
Title:	Hematopoietic Stem Cell (HSC)-Independent Progenitors Are Susceptible to Mll-Af9-Induced Leukemic Transformation.
Volume:	15
Issue:	14

•

Publication

12482972 | -

First Author:	Hsieh JJ
Year:	2003
Journal:	Mol Cell Biol
Title:	Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization.
Volume:	23
Issue:	1
Pages:	186-94

•

Publication

15960975 | J:156231

First Author:	Dou Y
Year:	2005
Journal:	Cell
Title:	Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.
Volume:	121
Issue:	6
Pages:	873-85

•

Publication

39380002 | J:357666

First Author:	Sheridan M
Year:	2024
Journal:	J Hematol Oncol
Title:	The small inhibitor WM-1119 effectively targets KAT6A-rearranged AML, but not KMT2A-rearranged AML, despite shared KAT6 genetic dependency.
Volume:	17
Issue:	1
Pages:	91

•

Publication

19556245 | -

First Author:	Patel A
Year:	2009
Journal:	J Biol Chem
Title:	On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex.
Volume:	284
Issue:	36
Pages:	24242-56

•

Publication

17707229 | J:387817

First Author:	Demers C
Year:	2007
Journal:	Mol Cell
Title:	Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus.
Volume:	27
Issue:	4
Pages:	573-84

•

Publication

10637508 | -

First Author:	Huntsman DG
Year:	1999
Journal:	Oncogene
Title:	MLL2, the second human homolog of the Drosophila trithorax gene, maps to 19q13.1 and is amplified in solid tumor cell lines.
Volume:	18
Issue:	56
Pages:	7975-84

•

Publication

10409430 | -

First Author:	FitzGerald KT
Year:	1999
Journal:	Genomics
Title:	MLL2: A new mammalian member of the trx/MLL family of genes.
Volume:	59
Issue:	2
Pages:	187-92

•

Protein

Q5DTR3

Organism:	Mus musculus/domesticus
Length:	762
Fragment?:	true

•

Protein

Q80XM0

Organism:	Mus musculus/domesticus
Length:	142
Fragment?:	true

•

Protein

Q9CT28

Organism:	Mus musculus/domesticus
Length:	209
Fragment?:	true

•

Protein

Q6P6H8

Organism:	Mus musculus/domesticus
Length:	442
Fragment?:	true

•

Protein

O08550

Organism:	Mus musculus/domesticus
Length:	2713
Fragment?:	false

•

Protein

F6W623

Organism:	Mus musculus/domesticus
Length:	2014
Fragment?:	true

•

Protein

F8WJ40

Organism:	Mus musculus/domesticus
Length:	2721
Fragment?:	false

•

Protein

Q6PHU4

Organism:	Mus musculus/domesticus
Length:	2013
Fragment?:	true

•

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