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Search results 501 to 600 out of 2139 for Lck

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Type Details Score
Allele
Tg(Lck-Bmi1)P1Naka | MGI:7495822
Name: transgene insertion P1, Toshinori Nakayama
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Lck-Bhlhe40)1Homy | MGI:7514897
Name: transgene insertion 1, Hiroaki Honda
Allele Type: Transgenic
Attribute String: Epitope tag, Inserted expressed sequence
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Allele
Tg(Lck-MYBL2)1Sis | MGI:7610616
Name: transgene insertion 1, Shunsuke Ishii
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Publication
10636863 | -
First Author: Cho YS
Year: 2000
Journal: J Biol Chem
Title: Direct interaction of the CD38 cytoplasmic tail and the Lck SH2 domain. Cd38 transduces T cell activation signals through associated Lck.
Volume: 275
Issue: 3
Pages: 1685-90
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Publication
20074548 | -
First Author: Baumgart F
Year: 2010
Journal: Biochim Biophys Acta
Title: Palmitoylation of R-Ras by human DHHC19, a palmitoyl transferase with a CaaX box.
Volume: 1798
Issue: 3
Pages: 592-604
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Publication
17436253 | -
First Author: Raymond FL
Year: 2007
Journal: Am J Hum Genet
Title: Mutations in ZDHHC9, which encodes a palmitoyltransferase of NRAS and HRAS, cause X-linked mental retardation associated with a Marfanoid habitus.
Volume: 80
Issue: 5
Pages: 982-7
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Protein Domain
IPR030292 | ZDHHC9
Type: Family
Description: ZDHHC9 is a palmitoyl acyltransferase (PAT) whose substrates include small GTPases, such as H-Ras, N-Ras and R-Ras [, ], Lck kinase, and many transmembrane proteins and channels []. Mutations in ZDHHC9 cause mental retardation, X-linked, syndromic, ZDHHC9-related (MRXSZ) [].
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Publication
9442882 | -
 
First Author: Thomas SM
Year: 1997
Journal: Annu Rev Cell Dev Biol
Title: Cellular functions regulated by Src family kinases.
Volume: 13
Pages: 513-609
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Protein Domain
IPR035850 | Lck_SH2
Type: Domain
Description: Lck is a member of the Src non-receptor type tyrosine kinase family of proteins. CD4 and CD8 directly couple with Lck, and cross-linking of these receptors leads to Lck activation [, ]. The N-terminal tail of Lck is myristoylated and palmitoylated and it tethers the protein to the plasma membrane of the cell. Lck also contains an SH3 domain, an SH2 domain, and a C-terminal tyrosine kinase domain. Lck has 2 phosphorylation sites, the first an autophosphorylation site that is linked to activation of the protein and the second which is phosphorylated by Csk, which inhibits it. Lck is also inhibited by SHP-1 dephosphorylation and by Cbl ubiquitin ligase, which is part of the ubiquitin-mediated pathway []. This entry represents the SH2 domain of Lck.The Src non-receptor type tyrosine kinase (SFK) family members have an unique N-terminal domain, an SH3 domain, an SH2 domain, a kinase domain and a regulatory tail. The SH2 domain of SFKs is involved in kinase autoinhibition and T-cell receptor signaling. The binding SH2 domains to phosphotyrosine (pY) sites is critical for the autoinhibition and substrate recognition of the SFKs [].
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Publication
23166773 | J:195461
First Author: Collins S
Year: 2012
Journal: PLoS One
Title: Regulation of CD4⁺ and CD8⁺ effector responses by Sprouty-1.
Volume: 7
Issue: 11
Pages: e49801
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Publication
17118402 | -
First Author: Romir J
Year: 2007
Journal: J Mol Biol
Title: Crystal structure analysis and solution studies of human Lck-SH3; zinc-induced homodimerization competes with the binding of proline-rich motifs.
Volume: 365
Issue: 5
Pages: 1417-28
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Protein Domain
IPR035749 | Lck_SH3
Type: Domain
Description: Lck is a member of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Lck is expressed in T-cellsand natural killer cells. It plays a critical role in T-cell maturation, activation, and T-cell receptor (TCR) signaling [, ]. Lck phosphorylates ITAM (immunoreceptor tyr activation motif) sequences on several subunits of TCRs, leading to the activation of different second messenger cascades. Phosphorylated ITAMs serve as binding sites for other signaling factor such as Syk and ZAP-70, leading to their activation and propagation of downstream events []. In addition, Lck regulates drug-induced apoptosis by interfering with the mitochondrial death pathway. The apototic role of Lck is independent of its primary function in T-cell signaling []. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The SH3 domain of Src kinases contributes to substrate recruitment by binding adaptor proteins/substrates, and regulation of kinase activity through an intramolecular interaction [, ].
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Publication
16249387 | J:129312
First Author: Ahn E
Year: 2006
Journal: Blood
Title: LIME acts as a transmembrane adapter mediating BCR-dependent B-cell activation.
Volume: 107
Issue: 4
Pages: 1521-7
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Allele
Tg(Lck-cre)I57Jxm | MGI:2177584
Name: transgene insertion I57, Jamey Marth
Allele Type: Transgenic
Attribute String: Recombinase
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Allele
Tg(Tox)1Kay | MGI:2181728
Name: transgene insertion 1, Jonathan Kaye
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Lck-cre)1Cwi | MGI:2448686
Name: transgene insertion 1, Christopher B Wilson
Allele Type: Transgenic
Attribute String: Recombinase
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Allele
Tg(Lck-cre)#Zhu | MGI:3054844
Name: transgene insertion, Yuan Zhuang
Allele Type: Transgenic
Attribute String: Recombinase
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Allele
Tg(LckNotch1)9Erob | MGI:3056811
Name: transgene insertion 9, Ellen Robey
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Lck-cre)1Thr | MGI:3584021
Name: transgene insertion 1, Terence H Rabbitts
Allele Type: Transgenic
Attribute String: Recombinase
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Allele
Tg(Lck-CrmA)1Hed | MGI:3588561
Name: transgene insertion 1, Stephen Hedrick
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:6145874 | B6.Cg-Tg(Lck-cre)1Jtak/JtakAyosRbrc
Attribute String: mutant strain, congenic, transgenic
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Publication
17406863 | J:121425
First Author: Huang F
Year: 2007
Journal: Immunogenetics
Title: TM1 and TM2: two mutant alleles that constitute a genetic trait controlling thymocyte development.
Volume: 59
Issue: 6
Pages: 473-7
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Allele
Tg(Lck-Sox13)#Jskg | MGI:3697895
Name: transgene insertion #, Joonsoo Kang
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Lck-ZAP70)824Saka | MGI:3698650
Name: transgene insertion 824, Shimon Sakaguchi
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Lck-CIITA)16Spark | MGI:6107219
Name: transgene insertion 16, Seong Park
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:6107224 | C57BL/6-Tg(Lck-CIITA)16Spark/J
Attribute String: coisogenic, transgenic
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Strain
MGI:6429100 | C57BL/6JSmoc-Lck<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Allele
Tg(Lck-Cdkn2a)1Mtkn | MGI:7507549
Name: transgene insertion 1, Masamoto Kanno
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Lck-Cdkn2a)2Mtkn | MGI:7507551
Name: transgene insertion 2, Masamoto Kanno
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Lck-Pcgf6)P3Naka | MGI:7494235
Name: transgene insertion P3, Toshinori Nakayama
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Lck-Pcgf6)P4Naka | MGI:7494237
Name: transgene insertion P4, Toshinori Nakayama
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:6144647 | C57BL/6-Tg(Lck-Bmi1)P1Naka/NakaRbrc
Attribute String: mutant strain, coisogenic, transgenic
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Strain
MGI:6145934 | C57BL/6N-Tg(Lck-Bhlhe40)1Homy/HomyRbrc
Attribute String: mutant strain, coisogenic, transgenic
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Strain
MGI:7610752 | C57BL/6-Tg(Lck-MYBL2)1Sis/Rbrc
Attribute String: coisogenic, mutant strain, transgenic
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Allele
Tg(Igh-Riox2)1Kubo | MGI:7709502
Name: transgene insertion 1, Masato Kubo
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Publication
9087424 | J:39450
First Author: Ceci JD
Year: 1997
Journal: Genes Dev
Title: Tpl-2 is an oncogenic kinase that is activated by carboxy-terminal truncation.
Volume: 11
Issue: 6
Pages: 688-700
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Publication
8265598 | J:107359
First Author: Lewis DB
Year: 1993
Journal: Proc Natl Acad Sci U S A
Title: Osteoporosis induced in mice by overproduction of interleukin 4.
Volume: 90
Issue: 24
Pages: 11618-22
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Publication
20939892 | J:164872
First Author: Chung SH
Year: 2010
Journal: Arthritis Res Ther
Title: CXC chemokine receptor 4 expressed in T cells plays an important role in the development of collagen-induced arthritis.
Volume: 12
Issue: 5
Pages: R188
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Publication
8890164 | J:169817
First Author: Cloutier JF
Year: 1996
Journal: EMBO J
Title: Association of inhibitory tyrosine protein kinase p50csk with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells.
Volume: 15
Issue: 18
Pages: 4909-18
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Publication
15273934 | -
First Author: Kyogoku C
Year: 2004
Journal: Am J Hum Genet
Title: Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE.
Volume: 75
Issue: 3
Pages: 504-7
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Publication
16839418 | -
 
First Author: Granum S
Year: 2006
Journal: BMC Immunol
Title: Structure function analysis of SH2D2A isoforms expressed in T cells reveals a crucial role for the proline rich region encoded by SH2D2A exon 7.
Volume: 7
Pages: 15
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Protein Domain
IPR016276 | PTPN22
Type: Family
Description: Tyrosine-protein phosphatase non-receptor type 22 (PTPN22) acts as negative regulator of T-cell receptor (TCR) signalling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signalling molecules [].Variations of the PTPN22 gene affects the susceptibility of systemic lupus erythematosus (SLE) [].
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Protein Domain
IPR035884 | SH2D2A_SH2
Type: Domain
Description: This entry includes the single SH2 domain of SH2D2A. SH2D2A interacts with and modulates Lck activity [].In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites [, , ].
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Protein Domain
IPR021963 | Tcell_CD4_Cterm
Type: Domain
Description: This domain is the C-terminal domain of the CD4 T cell receptor. The C-terminal domain is the cytoplasmic domain which relays the signal for T cell activation. This process involves co-receptor internalisation. This domain is involved in binding to the N-terminal of Lck co-receptor in a Zn2+ clasp structure.
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Publication
11850626 | J:74993
First Author: Wilkinson B
Year: 2002
Journal: Nat Immunol
Title: TOX: an HMG box protein implicated in the regulation of thymocyte selection.
Volume: 3
Issue: 3
Pages: 272-80
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Publication
15078895 | J:91035
First Author: Aliahmad P
Year: 2004
Journal: J Exp Med
Title: TOX provides a link between calcineurin activation and CD8 lineage commitment.
Volume: 199
Issue: 8
Pages: 1089-99
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Publication
1495975 | J:75414
First Author: Orban PC
Year: 1992
Journal: Proc Natl Acad Sci U S A
Title: Tissue- and site-specific DNA recombination in transgenic mice.
Volume: 89
Issue: 15
Pages: 6861-5
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Strain
MGI:5604774 | B6NTac.Cg-Tg(Lck-cre)1Cwi/Mmnc
Attribute String: congenic, transgenic, mutant strain
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Strain
MGI:6438683 | B6.Cg-Tg(Lck-cre)1Cwi/Tac
Attribute String: mutant strain, congenic, transgenic
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Publication
35536646 | J:326847
 
First Author: Canté-Barrett K
Year: 2022
Journal: JCI Insight
Title: MEF2C opposes Notch in lymphoid lineage decision and drives leukemia in the thymus.
Volume: 7
Issue: 13
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Publication
21469121 | J:176485
First Author: Mele DA
Year: 2011
Journal: Eur J Immunol
Title: Th17 differentiation is the default program for DPP2-deficient T-cell differentiation.
Volume: 41
Issue: 6
Pages: 1583-93
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Allele
Tg(Lck-Bcl6)83Tto | MGI:3056268
Name: transgene insertion 83, Takahashi Tokuhisa
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Lck-Akt1)1Pnt | MGI:3803799
Name: transgene insertion 1, Philip N Tsichlis
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(tetO/CMV-Lck)1Rza | MGI:3806710
Name: transgene insertion 1, Rose Zamoyska
Allele Type: Transgenic
Attribute String: Inducible, Inserted expressed sequence
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Allele
Tg(Lck-Smarce1*)1Grc | MGI:3837674
Name: transgene insertion 1, Gerald R Crabtree
Allele Type: Transgenic
Attribute String: Dominant negative, Inserted expressed sequence
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Allele
Tg(Lck-Smarce1*K112I)1Grc | MGI:3837675
Name: transgene insertion 1, Gerald R Crabtree
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Lck-Bcl2l1)1Cant | MGI:3840209
Name: transgene insertion 1, Harvey Cantor
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Lck/Emu-Eif4e)#Ppp | MGI:4438935
Name: transgene insertion #, Pier P Pandolfi
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(CD2-Lck)1Rza | MGI:4946120
Name: transgene insertion 1, Rose Zamoyska
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(CD2-Lck)2Rza | MGI:4946121
Name: transgene insertion 2, Rose Zamoyska
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Lck-Il7r)1676Trma | MGI:5140599
Name: transgene insertion 1676, Thomas Malek
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Lck-EZH2*Y641F)1Rkh | MGI:7491716
Name: transgene insertion 1, R Keith Humphries
Allele Type: Transgenic
Attribute String: Epitope tag, Inserted expressed sequence
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Strain
MGI:6144564 | B6.Cg-Tg(Lck-Pcgf6)P3Naka/NakaRbrc
Attribute String: mutant strain, congenic, transgenic
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Strain
MGI:6144566 | C.Cg-Tg(Lck-Pcgf6)P4Naka/NakaRbrc
Attribute String: mutant strain, congenic, transgenic
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Strain
MGI:6144565 | B6.Cg-Tg(Lck-Pcgf6)P4Naka/NakaRbrc
Attribute String: mutant strain, congenic, transgenic
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Strain
MGI:7715209 | C.B6-Tg(Lck-Riox2)1Kubo/Kubo
Attribute String: congenic, mutant strain, transgenic
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Genotype
Genotype
Symbol: Tg(Lck-Sox13)#Jskg/?
Background: involves: C57BL/6
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Lck-cre)1Cwi/?
Background: involves: C57BL/6 * DBA/2
Zygosity: ot
Has Mutant Allele: true
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Publication
18611169 | J:137580
First Author: Servert P
Year: 2008
Journal: Biotechniques
Title: In vivo site-specific recombination using the beta-rec/six system.
Volume: 45
Issue: 1
Pages: 69-78
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HT Experiment
GSE33306 | Alternative splicing controlled by heterogeneous nuclear ribonucleoprotein L (hnRNP L) regulates development, proliferation and migration of thymic pre-T cells
Series Id: E-GEOD-33306
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
15314041 | J:93656
First Author: Takamori M
Year: 2004
Journal: Int Immunol
Title: BAZF is required for activation of naive CD4 T cells by TCR triggering.
Volume: 16
Issue: 10
Pages: 1439-49
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Publication
16550188 | J:129531
First Author: Hasegawa H
Year: 2006
Journal: Nat Med
Title: Thymus-derived leukemia-lymphoma in mice transgenic for the Tax gene of human T-lymphotropic virus type I.
Volume: 12
Issue: 4
Pages: 466-72
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Publication
20206686 | -
First Author: Bradshaw JM
Year: 2010
Journal: Cell Signal
Title: The Src, Syk, and Tec family kinases: distinct types of molecular switches.
Volume: 22
Issue: 8
Pages: 1175-84
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Publication
11466625 | J:154583
First Author: Mende I
Year: 2001
Journal: Oncogene
Title: Oncogenic transformation induced by membrane-targeted Akt2 and Akt3.
Volume: 20
Issue: 32
Pages: 4419-23
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Publication
19414744 | J:150299
First Author: Saeki K
Year: 2009
Journal: J Immunol
Title: A major lipid raft protein raftlin modulates T cell receptor signaling and enhances th17-mediated autoimmune responses.
Volume: 182
Issue: 10
Pages: 5929-37
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Publication
10792495 | J:61801
First Author: Aono A
Year: 2000
Journal: Immunology
Title: Forced expression of terminal deoxynucleotidyl transferase in fetal thymus resulted in a decrease in gammadelta T cells and random dissemination of Vgamma3Vdelta1 T cells in skin of newborn but not adult mice.
Volume: 99
Issue: 4
Pages: 489-97
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Publication
19395373 | J:149570
First Author: Zhang H
Year: 2009
Journal: Int Immunol
Title: Mammalian nitrilase 1 homologue Nit1 is a negative regulator in T cells.
Volume: 21
Issue: 6
Pages: 691-703
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Allele
Tg(Lck-cre)548Jxm | MGI:2176199
Name: transgene insertion 548, Jamey Marth
Allele Type: Transgenic
Attribute String: Recombinase
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Allele
Tg(Lck-Tnfsf4)1Nish | MGI:2388725
Name: transgene insertion 1, Naoto Ishii
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Lck-Hhex)1Hro | MGI:2448671
Name: transgene insertion 1, Robert Hromas
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Publication
15499020 | J:93221
First Author: Kong M
Year: 2004
Journal: Science
Title: The PP2A-associated protein alpha4 is an essential inhibitor of apoptosis.
Volume: 306
Issue: 5696
Pages: 695-8
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Allele
Tg(Lck-cre)3785Nik | MGI:2655481
Name: transgene insertion 3785, Nigel Killeen
Allele Type: Transgenic
Attribute String: Recombinase
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Strain
MGI:2164711 | C57BL/6-Tg(LckNotch1)9Erob/J
Attribute String: mutant strain, transgenic
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Publication
25585350 | J:219269
First Author: Ahrenhoerster LS
Year: 2015
Journal: Toxicol Appl Pharmacol
Title: Developmental exposure to 2,3,7,8 tetrachlorodibenzo-p-dioxin attenuates later-life Notch1-mediated T cell development and leukemogenesis.
Volume: 283
Issue: 2
Pages: 99-108
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Publication
15905513 | J:99008
First Author: Manilay JO
Year: 2005
Journal: J Immunol
Title: Impairment of thymocyte development by dominant-negative Kuzbanian (ADAM-10) is rescued by the Notch ligand, delta-1.
Volume: 174
Issue: 11
Pages: 6732-41
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Publication
21642990 | J:176182
First Author: Mavrakis KJ
Year: 2011
Journal: Nat Genet
Title: A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL).
Volume: 43
Issue: 7
Pages: 673-8
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Publication
12842084 | J:85026
First Author: Beverly LJ
Year: 2003
Journal: Cancer Cell
Title: Perturbation of Ikaros isoform selection by MLV integration is a cooperative event in Notch(IC)-induced T cell leukemogenesis.
Volume: 3
Issue: 6
Pages: 551-64
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Allele
Tg(Lck-FADD)1Hed | MGI:3588560
Name: transgene insertion 1, Stephen Hedrick
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Lck-Cd1d1)1Aben | MGI:3589763
Name: transgene insertion 1, Albert Bendelac
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Publication
19155474 | J:144334
First Author: Bai Z
Year: 2009
Journal: J Immunol
Title: CXC chemokine ligand 12 promotes CCR7-dependent naive T cell trafficking to lymph nodes and Peyer's patches.
Volume: 182
Issue: 3
Pages: 1287-95
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Allele
Tg(Lck-Jak3)2Ljb | MGI:3769343
Name: transgene insertion 2, Leslie J Berg
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Lck-Jak3)1Ljb | MGI:3769344
Name: transgene insertion 1, Leslie J Berg
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:3840343 | B6.Cg-Tg(Lck-Bcl2l1)1Cant
Attribute String: transgenic, congenic
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Allele
Tg(Lck-tTA)1Doi | MGI:4418667
Name: transgene insertion 1, Christophe Benoist and Diane Mathis
Allele Type: Transgenic
Attribute String: Transactivator
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Allele
Tg(Emu-FGFR3)A5Wmk | MGI:4818998
Name: transgene insertion A5, W Michael Kuehl
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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•
•
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Allele
Tg(Emu-FGFR3)D3Wmk | MGI:4819001
Name: transgene insertion D3, W Michael Kuehl
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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•
•
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Allele
Tg(Lck-Tnfsf15,-EGFP)#Targ | MGI:4943308
Name: transgene insertion, Stephan R Targan
Allele Type: Transgenic
Attribute String: Inserted expressed sequence, Reporter
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•
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Allele
Tg(Lck-Akt2*)#Test | MGI:5500790
Name: transgene insertion, Joseph R Testa
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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•
•
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Allele
Tg(Lck-cre)#Jxm | MGI:5538658
Name: transgene insertion, Jamey Marth
Allele Type: Transgenic
Attribute String: Recombinase
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•
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Strain
MGI:6145092 | C57BL/6-Tg(Lck-Cdkn2a)1Mtkn/MtknRbrc
Attribute String: mutant strain, coisogenic, transgenic
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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