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Search results 501 to 600 out of 633 for Lifr

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Type Details Score
Publication
17179859 | J:117040
First Author: Hatta T
Year: 2006
Journal: Neuroreport
Title: Quantitative analyses of leukemia inhibitory factor in the cerebrospinal fluid in mouse embryos.
Volume: 17
Issue: 18
Pages: 1863-6
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Publication
34350170 | J:314223
 
First Author: Wang H
Year: 2021
Journal: Front Cell Dev Biol
Title: Leukemia Inhibitory Factor Induces Proopiomelanocortin via CRH/CRHR Pathway in Mouse Trophoblast.
Volume: 9
Pages: 618947
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Publication
26066745 | J:230958
First Author: Royer DJ
Year: 2015
Journal: Invest Ophthalmol Vis Sci
Title: Granulocytes in Ocular HSV-1 Infection: Opposing Roles of Mast Cells and Neutrophils.
Volume: 56
Issue: 6
Pages: 3763-75
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Publication
15385618 | J:109773
First Author: Enwere E
Year: 2004
Journal: J Neurosci
Title: Aging results in reduced epidermal growth factor receptor signaling, diminished olfactory neurogenesis, and deficits in fine olfactory discrimination.
Volume: 24
Issue: 38
Pages: 8354-65
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Publication
21998580 | J:261895
First Author: Wuest T
Year: 2011
Journal: PLoS Pathog
Title: The herpes simplex virus-1 transactivator infected cell protein-4 drives VEGF-A dependent neovascularization.
Volume: 7
Issue: 10
Pages: e1002278
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Publication
10564261 | J:58439
First Author: Takagi M
Year: 1999
Journal: Mol Biol Cell
Title: Chimeric cytokine receptor can transduce expansion signals in interleukin 6 receptor alpha (IL-6Ralpha)-, IL-11Ralpha-, and gp130-low to -negative primitive hematopoietic progenitors.
Volume: 10
Issue: 11
Pages: 3633-42
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Publication
8843390 | J:34635
First Author: Nichols J
Year: 1996
Journal: Mech Dev
Title: Complementary tissue-specific expression of LIF and LIF-receptor mRNAs in early mouse embryogenesis.
Volume: 57
Issue: 2
Pages: 123-31
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Publication
10455174 | J:57062
First Author: Aubert J
Year: 1999
Journal: J Biol Chem
Title: Leukemia inhibitory factor and its receptor promote adipocyte differentiation via the mitogen-activated protein kinase cascade.
Volume: 274
Issue: 35
Pages: 24965-72
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Publication
17299136 | J:120902
First Author: Magni P
Year: 2007
Journal: Mol Endocrinol
Title: Leukemia inhibitory factor induces the chemomigration of immortalized gonadotropin-releasing hormone neurons through the independent activation of the Janus kinase/signal transducer and activator of transcription 3, mitogen-activated protein kinase/extracellularly regulated kinase 1/2, and phosphatidylinositol 3-kinase/Akt signaling pathways.
Volume: 21
Issue: 5
Pages: 1163-74
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Publication
18548006 | J:137646
First Author: Bozec A
Year: 2008
Journal: Nature
Title: Osteoclast size is controlled by Fra-2 through LIF/LIF-receptor signalling and hypoxia.
Volume: 454
Issue: 7201
Pages: 221-5
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Publication
35039652 | J:320026
First Author: Liu NQ
Year: 2022
Journal: Commun Biol
Title: gp130/STAT3 signaling is required for homeostatic proliferation and anabolism in postnatal growth plate and articular chondrocytes.
Volume: 5
Issue: 1
Pages: 64
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Publication
9500603 | J:46263
First Author: Robb L
Year: 1998
Journal: Nat Med
Title: Infertility in female mice lacking the receptor for interleukin 11 is due to a defective uterine response to implantation.
Volume: 4
Issue: 3
Pages: 303-8
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Publication
11160399 | J:77294
First Author: Oppenheim RW
Year: 2001
Journal: J Neurosci
Title: Cardiotrophin-1, a muscle-derived cytokine, is required for the survival of subpopulations of developing motoneurons.
Volume: 21
Issue: 4
Pages: 1283-91
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Publication
8001975 | J:19872
First Author: Kirschner MA
Year: 1994
Journal: Genomics
Title: The mouse and human excitatory amino acid transporter gene (EAAT1) maps to mouse chromosome 15 and a region of syntenic homology on human chromosome 5.
Volume: 22
Issue: 3
Pages: 631-3
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Publication
9454853 | J:45763
First Author: Arce V
Year: 1998
Journal: J Neurosci
Title: Synergistic effects of schwann- and muscle-derived factors on motoneuron survival involve GDNF and cardiotrophin-1 (CT-1).
Volume: 18
Issue: 4
Pages: 1440-8
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Publication
12831858 | J:84736
First Author: Tamura S
Year: 2003
Journal: Neuroscience
Title: Localization of oncostatin M receptor beta in adult and developing CNS.
Volume: 119
Issue: 4
Pages: 991-7
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Publication
27539849 | J:237300
First Author: Walker EC
Year: 2016
Journal: J Biol Chem
Title: Murine Oncostatin M Acts via Leukemia Inhibitory Factor Receptor to Phosphorylate Signal Transducer and Activator of Transcription 3 (STAT3) but Not STAT1, an Effect That Protects Bone Mass.
Volume: 291
Issue: 41
Pages: 21703-21716
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Publication
24594094 | J:356300
First Author: Finn EH
Year: 2014
Journal: Dev Biol
Title: Maternal bias and escape from X chromosome imprinting in the midgestation mouse placenta.
Volume: 390
Issue: 1
Pages: 80-92
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Publication
15051883 | J:89246
First Author: Derouet D
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor.
Volume: 101
Issue: 14
Pages: 4827-32
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Allele
Lifr<tm1Imx> | MGI:1857213
Name: LIF receptor alpha; targeted mutation 1, Immunex
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Publication
16467531 | J:105646
First Author: Oberle S
Year: 2006
Journal: J Neurosci
Title: Loss of leukemia inhibitory factor receptor beta or cardiotrophin-1 causes similar deficits in preganglionic sympathetic neurons and adrenal medulla.
Volume: 26
Issue: 6
Pages: 1823-32
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Publication
18521186 | J:137720
First Author: Kubota Y
Year: 2008
Journal: J Clin Invest
Title: Leukemia inhibitory factor regulates microvessel density by modulating oxygen-dependent VEGF expression in mice.
Volume: 118
Issue: 7
Pages: 2393-403
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Publication
34034544 | J:317814
First Author: Fan L
Year: 2022
Journal: J Dent Res
Title: Lif Deficiency Leads to Iron Transportation Dysfunction in Ameloblasts.
Volume: 101
Issue: 1
Pages: 63-72
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Publication
30658714 | J:272505
First Author: Catela C
Year: 2019
Journal: Neural Dev
Title: An ancient role for collier/Olf/Ebf (COE)-type transcription factors in axial motor neuron development.
Volume: 14
Issue: 1
Pages: 2
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Publication
7743917 | J:24333
First Author: Harvey MB
Year: 1995
Journal: Development
Title: Proteinase expression in early mouse embryos is regulated by leukaemia inhibitory factor and epidermal growth factor.
Volume: 121
Issue: 4
Pages: 1005-14
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Publication
15634701 | J:95357
First Author: Gregg C
Year: 2005
Journal: Development
Title: CNTF/LIF/gp130 receptor complex signaling maintains a VZ precursor differentiation gradient in the developing ventral forebrain.
Volume: 132
Issue: 3
Pages: 565-78
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Publication
9175833 | J:40624
First Author: Beebe AM
Year: 1997
Journal: Immunity
Title: Serial backcross mapping of multiple loci associated with resistance to Leishmania major in mice.
Volume: 6
Issue: 5
Pages: 551-7
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Publication
25127137 | J:314320
First Author: Wang H
Year: 2014
Journal: Cell Rep
Title: Gli3 repressor controls cell fates and cell adhesion for proper establishment of neurogenic niche.
Volume: 8
Issue: 4
Pages: 1093-104
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Publication
19228596 | J:152946
First Author: Sferruzzi-Perri AN
Year: 2009
Journal: Biol Reprod
Title: Csf2 null mutation alters placental gene expression and trophoblast glycogen cell and giant cell abundance in mice.
Volume: 81
Issue: 1
Pages: 207-21
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Publication
29379870 | J:262472
 
First Author: Edmond M
Year: 2017
Journal: eNeuro
Title: Topoisomerase IIβ Selectively Regulates Motor Neuron Identity and Peripheral Connectivity through Hox/Pbx-Dependent Transcriptional Programs.
Volume: 4
Issue: 6
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Publication
37528140 | J:338821
First Author: Li R
Year: 2023
Journal: Nat Commun
Title: TRIM28 modulates nuclear receptor signaling to regulate uterine function.
Volume: 14
Issue: 1
Pages: 4605
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Publication
27568519 | J:253351
First Author: Hanley O
Year: 2016
Journal: Neuron
Title: Parallel Pbx-Dependent Pathways Govern the Coalescence and Fate of Motor Columns.
Volume: 91
Issue: 5
Pages: 1005-1020
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Publication
9507200 | J:46507
First Author: Takenaka M
Year: 1998
Journal: Kidney Int
Title: Isolation of genes identified in mouse renal proximal tubule by comparing different gene expression profiles.
Volume: 53
Issue: 3
Pages: 562-72
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Publication
26764350 | J:232444
First Author: Li S
Year: 2016
Journal: Biol Reprod
Title: Ggnbp2 Is Essential for Pregnancy Success via Regulation of Mouse Trophoblast Stem Cell Proliferation and Differentiation.
Volume: 94
Issue: 2
Pages: 41
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Publication
24859004 | J:219394
First Author: Boroviak T
Year: 2014
Journal: Nat Cell Biol
Title: The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification.
Volume: 16
Issue: 6
Pages: 516-28
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Publication
22967998 | J:190524
First Author: Shalom-Barak T
Year: 2012
Journal: Dev Biol
Title: Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network.
Volume: 372
Issue: 1
Pages: 143-55
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Publication
24006456 | J:221550
First Author: Abonnenc M
Year: 2013
Journal: Circ Res
Title: Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.
Volume: 113
Issue: 10
Pages: 1138-47
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Publication
- | J:77000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
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Publication
27626380 | J:236599
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
11943154 | -
First Author: He W
Year: 2002
Journal: FEBS Lett
Title: Membrane distal cytokine binding domain of LIFR interacts with soluble CNTFR in vitro.
Volume: 514
Issue: 2-3
Pages: 214-8
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Protein Domain
IPR040901 | LIFR_N
Type: Domain
Description: This domain can be found in leukemia inhibitory factor receptor (LIFR). LIFR is a cell surface receptor that mediates the actions of LIF and other interleukin-6 type cytokines through the formation of signalling complexes with gp130. This is the N-terminal domain, referred to as domain 1, which contains conserved disulfide bonds between Cys-10 to Cys-20 and Cys-37 to Cys-45 [].
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Publication
18775332 | -
First Author: Skiniotis G
Year: 2008
Journal: Mol Cell
Title: Structural organization of a full-length gp130/LIF-R cytokine receptor transmembrane complex.
Volume: 31
Issue: 5
Pages: 737-48
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Publication
22325776 | -
First Author: Dagil R
Year: 2012
Journal: Structure
Title: The WSXWS motif in cytokine receptors is a molecular switch involved in receptor activation: insight from structures of the prolactin receptor.
Volume: 20
Issue: 2
Pages: 270-82
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Protein Domain
IPR040817 | LIFR_D2
Type: Domain
Description: This is the D2 domain in cytokine-binding module 1 (CBM1) found in Leukemia inhibitory factor receptor (LIFR) and OSM receptors (OSMR). LIFR has an extracellular region with a modular structure containing two cytokine-binding modules (CBM) separated by an Ig-like domain and followed by three membrane-proximal fibronectin type-III (FNIII) domains. The D2 domain in CBM1 shows structural similarity to the corresponding CBM domains of both gp130 and IL-6Ralpha because it contains conserved structural features like the WSXWS motif [, ]. The WSXWS motif in cytokine receptors is a molecular switch involved in receptor activation [].
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HT Experiment
GSE231827 | Blastocyst derived signal facilitate the embryo implantation via protein degradation via activating lysosome in the uterine epithelia [RNA-Seq: Epithelium_Igf1r_WT_KO]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
32795400 | J:338519
First Author: Skelly DA
Year: 2020
Journal: Cell Stem Cell
Title: Mapping the Effects of Genetic Variation on Chromatin State and Gene Expression Reveals Loci That Control Ground State Pluripotency.
Volume: 27
Issue: 3
Pages: 459-469.e8
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Publication
8943050 | J:37050
First Author: Presky DH
Year: 1996
Journal: Proc Natl Acad Sci U S A
Title: A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits.
Volume: 93
Issue: 24
Pages: 14002-7
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Publication
7796798 | -
First Author: McDonald NQ
Year: 1995
Journal: EMBO J
Title: Crystal structure of dimeric human ciliary neurotrophic factor determined by MAD phasing.
Volume: 14
Issue: 12
Pages: 2689-99
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Publication
12417647 | -
First Author: Stankoff B
Year: 2002
Journal: J Neurosci
Title: Ciliary neurotrophic factor (CNTF) enhances myelin formation: a novel role for CNTF and CNTF-related molecules.
Volume: 22
Issue: 21
Pages: 9221-7
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Publication
8999038 | -
First Author: Mosley B
Year: 1996
Journal: J Biol Chem
Title: Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation.
Volume: 271
Issue: 51
Pages: 32635-43
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Protein Domain
IPR000151 | Ciliary_neurotrophic_fac_CNTF
Type: Family
Description: Ciliary neurotrophic factor (CNTF) is a member of the gp130 family of cytokines. CNTF is a survival factor for various neuronal cell types and seems to prevent the degeneration of motor axons after axotomy suggesting it may be a potential therapeutic for treating neurodegeneration and nerve injury. CNTF acts on oligodendrocytes by favoring their final maturation, and this effect is mediated through the 130kDa glycoprotein receptor common to the CNTF family and transduced through the Janus kinase pathway. The functional receptor complex of CNTF is composed of the CNTF receptor alpha (CNTFR), gp130 and the leukemia inhibitory factor receptor (LIFR). The structure of CNTF is a four helical bundle []. CNTF acts as a homodimer. Three regions on CNTF have been identified as binding sites for its receptors. The ligand-receptor interactions are mediated through the cytokine binding domains (CBDs) and/or the immunoglobulin-like domains of the receptors. However, in the case of CNTF, the precise nature of the protein-protein contacts in the signalling complex has not yet been resolved, but there is evidence that the membrane distal CBD (CBD1) of LIFR associates in vitro with soluble CNTFR in the absence of CNTF [, ].
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Protein Domain
IPR003529 | Hematopoietin_rcpt_Gp130_CS
Type: Conserved_site
Description: A number of receptors for lymphokines, hematopoietic growth factors and growth hormone-related molecules have been found to share a common binding domain. These receptors are designated as hematopoietin receptors []and the corresponding ligands as hematopoietins. Further, hematopoietins have been subdivided into two major structural groups: Large/long and small/short hematopoietins.One subset of individual receptor chains that are part of receptor complexes for large hematopoietins contain common structural elements in their extracellular parts: an immunoglobulin-like domain, an hematopoietin-receptor domain, and 3 fibronectin type-III domains (2 in the leptin receptor). This subgroup was designated as "Gp130 family of receptors"[]and contains the following chains: Leptin receptor (LPTR), Granulocyte colony stimulating factor receptor (GCSFR), Interleukin-6/-11/LIF/OSM/CNTF common beta chain (Gp130), Leukemia inhibiting factor receptor (LIFR), Oncostatin-M receptor beta chain (OSMR), Interleukin-12 receptor beta-1 chain (IL12RB1), Interleukin-12 receptor beta-2 chain (IL12RB2). A schematic representation of the structure of these receptors is shown below: +-------+-------------------------+-----------------xxxxxxx-----------------+|Ig-like| C C C C Extracellular | FnIII (x3) XXXXXXX Cytoplasmic |+-------+-|-|--|--|---------------+-----------------xxxxxxx-----------------+| | | | Transmembrane+-+ +--+These receptor chains homodimerize (GCSFR, Gp130, LPTR) or heterodimerize (Gp130 with LIFR or OSMR, IL12RB1 with IL12RB2) upon binding of the cognate cytokine: G-CSF, LIF, OSM, LPT, or the cytokine/alpha chain complex: IL-6/IL6RA, IL-11/IL11RA, CNTF/CNTFRA, IL-12 (p35/p40) [, ].
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Publication
23885093 | J:211227
First Author: Sun X
Year: 2013
Journal: Mol Endocrinol
Title: Uterine deletion of Gp130 or Stat3 shows implantation failure with increased estrogenic responses.
Volume: 27
Issue: 9
Pages: 1492-501
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Publication
37782452 | J:346600
First Author: Guo D
Year: 2024
Journal: Inflammation
Title: LIF Aggravates Pulpitis by Promoting Inflammatory Response in Macrophages.
Volume: 47
Issue: 1
Pages: 307-322
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Publication
18451094 | J:136972
First Author: Takahashi Y
Year: 2008
Journal: Mol Endocrinol
Title: Leukemia inhibitory factor regulates trophoblast giant cell differentiation via Janus kinase 1-signal transducer and activator of transcription 3-suppressor of cytokine signaling 3 pathway.
Volume: 22
Issue: 7
Pages: 1673-81
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Publication
20051625 | J:156688
First Author: Walker EC
Year: 2010
Journal: J Clin Invest
Title: Oncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in mice.
Volume: 120
Issue: 2
Pages: 582-92
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Publication
37120549 | J:336118
First Author: Feng Y
Year: 2023
Journal: J Transl Med
Title: OSMR deficiency aggravates pressure overload-induced cardiac hypertrophy by modulating macrophages and OSM/LIFR/STAT3 signalling.
Volume: 21
Issue: 1
Pages: 290
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Publication
30651602 | J:339015
First Author: Noh K
Year: 2019
Journal: Mol Psychiatry
Title: Negr1 controls adult hippocampal neurogenesis and affective behaviors.
Volume: 24
Issue: 8
Pages: 1189-1205
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Publication
25418539 | J:271816
First Author: Jiang MH
Year: 2014
Journal: Cell Res
Title: Characterization of Nestin-positive stem Leydig cells as a potential source for the treatment of testicular Leydig cell dysfunction.
Volume: 24
Issue: 12
Pages: 1466-85
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