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Search results 501 to 600 out of 893 for Lyn

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Hits by Pathway

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Hits by Strain

Type Details Score
UniProt Feature
UniProt Feature
Begin: 317
Description: Phosphotyrosine; by LYN
Type: modified residue
End: 317
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UniProt Feature
UniProt Feature
Begin: 72
Description: Phosphotyrosine; by LYN
Type: modified residue
End: 72
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UniProt Feature
UniProt Feature
Begin: 2
Description: Tyrosine-protein kinase Lyn
Type: chain
End: 512
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UniProt Feature
UniProt Feature
Begin: 107
Description: Phosphotyrosine; by LYN
Type: modified residue
End: 107
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UniProt Feature
UniProt Feature
Begin: 280
Description: Phosphotyrosine; by LYN
Type: modified residue
End: 280
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UniProt Feature
UniProt Feature
Begin: 96
Description: Phosphotyrosine; by LYN
Type: modified residue
End: 96
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UniProt Feature
UniProt Feature
Begin: 69
Description: Phosphotyrosine; by LYN
Type: modified residue
End: 69
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UniProt Feature
UniProt Feature
Begin: 96
Description: Phosphotyrosine; by LYN
Type: modified residue
End: 96
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UniProt Feature
UniProt Feature
Begin: 564
Description: Phosphotyrosine; by LYN
Type: modified residue
End: 564
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UniProt Feature
UniProt Feature
Begin: 253
Description: Phosphotyrosine; by LYN
Type: modified residue
End: 253
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Publication
27728800 | J:236716
First Author: Dong S
Year: 2016
Journal: Cancer Cell
Title: A New Role for Lyn in the CLL Microenvironment.
Volume: 30
Issue: 4
Pages: 511-512
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Gene
288077 | Hcls1
Type: gene
Organism: rat
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Gene
108695301 | lyn.S
Type: gene
Organism: frog, African clawed
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Gene
373649 | lyn.L
Type: gene
Organism: frog, African clawed
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Gene
398923 | hcls1.S
Type: gene
Organism: frog, African clawed
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Publication
8530369 | -
First Author: Sotirellis N
Year: 1995
Journal: J Biol Chem
Title: Autophosphorylation induces autoactivation and a decrease in the Src homology 2 domain accessibility of the Lyn protein kinase.
Volume: 270
Issue: 50
Pages: 29773-80
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GXD Expression
GXD Expression
 
Probe: MGI:6342543
Assay Type: RNA in situ
Annotation Date: 2019-08-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3590420
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:6342550
Age: embryonic day 12.5
Note: Similar as the Lyn expression, but stronger.
Specimen Label: 3I
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:6342543
Assay Type: RNA in situ
Annotation Date: 2019-08-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3518620
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:6342550
Age: embryonic day 12.5
Note: Similar as the Lyn expression, but stronger.
Specimen Label: 3I
Detected: true
Specimen Num: 1
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UniProt Feature
UniProt Feature
Begin: 551
Description: Phosphotyrosine; by LYN and SYK
Type: modified residue
End: 551
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UniProt Feature
UniProt Feature
Begin: 261
Description: Phosphotyrosine; by LYN or LCK
Type: modified residue
End: 261
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UniProt Feature
UniProt Feature
Begin: 242
Description: Phosphotyrosine; by LYN or LCK
Type: modified residue
End: 242
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Publication
17996076 | J:139930
 
First Author: Thomas SG
Year: 2007
Journal: BMC Cell Biol
Title: Studies on the actin-binding protein HS1 in platelets.
Volume: 8
Pages: 46
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Publication
22031761 | J:179761
First Author: Huang Y
Year: 2011
Journal: J Immunol
Title: The actin regulatory protein HS1 is required for antigen uptake and presentation by dendritic cells.
Volume: 187
Issue: 11
Pages: 5952-63
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Publication
16782030 | J:113367
First Author: Gomez TS
Year: 2006
Journal: Immunity
Title: HS1 functions as an essential actin-regulatory adaptor protein at the immune synapse.
Volume: 24
Issue: 6
Pages: 741-52
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Publication
17579181 | J:147018
First Author: Kahner BN
Year: 2007
Journal: Blood
Title: Hematopoietic lineage cell specific protein 1 (HS1) is a functionally important signaling molecule in platelet activation.
Volume: 110
Issue: 7
Pages: 2449-56
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Publication
12077122 | -
First Author: Hong JJ
Year: 2002
Journal: J Biol Chem
Title: Regulation of signaling in B cells through the phosphorylation of Syk on linker region tyrosines. A mechanism for negative signaling by the Lyn tyrosine kinase.
Volume: 277
Issue: 35
Pages: 31703-14
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Publication
7641686 | J:28146
First Author: Taniuchi I
Year: 1995
Journal: EMBO J
Title: Antigen-receptor induced clonal expansion and deletion of lymphocytes are impaired in mice lacking HS1 protein, a substrate of the antigen-receptor-coupled tyrosine kinases.
Volume: 14
Issue: 15
Pages: 3664-78
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Publication
30590041 | J:270746
First Author: Tornillo G
Year: 2018
Journal: Cell Rep
Title: Dual Mechanisms of LYN Kinase Dysregulation Drive Aggressive Behavior in Breast Cancer Cells.
Volume: 25
Issue: 13
Pages: 3674-3692.e10
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Publication
35857476 | J:327552
First Author: Tawaratsumida K
Year: 2022
Journal: Sci Adv
Title: A phospho-tyrosine-based signaling module using SPOP, CSK, and LYN controls TLR-induced IRF activity.
Volume: 8
Issue: 27
Pages: eabq0084
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Publication
11784333 | J:73856
First Author: Omura T
Year: 2002
Journal: Eur J Biochem
Title: Acceleration of granulocyte colony-stimulating factor-induced neutrophilic nuclear lobulation by overexpression of Lyn tyrosine kinase.
Volume: 269
Issue: 1
Pages: 381-9
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Publication
27751872 | J:328484
 
First Author: Plani-Lam JH
Year: 2017
Journal: Exp Hematol
Title: Csk-binding protein controls red blood cell development via regulation of Lyn tyrosine kinase activity.
Volume: 46
Pages: 70-82.e10
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Publication
11584010 | J:72917
First Author: Fujimoto M
Year: 2001
Journal: J Biol Chem
Title: CD19 amplification of B lymphocyte Ca2+ responses: a role for Lyn sequestration in extinguishing negative regulation.
Volume: 276
Issue: 48
Pages: 44820-7
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Allele
Lyn<tm1Smoc> | MGI:7290913
Name: LYN proto-oncogene, Src family tyrosine kinase; targeted mutation 1, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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UniProt Feature
UniProt Feature
Begin: 518
Description: Phosphotyrosine; by autocatalysis, LYN and JAK2
Type: modified residue
End: 518
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Publication
9573010 | -
First Author: Chin H
Year: 1998
Journal: Blood
Title: Lyn physically associates with the erythropoietin receptor and may play a role in activation of the Stat5 pathway.
Volume: 91
Issue: 10
Pages: 3734-45
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Publication
39378329 | J:357745
 
First Author: Chhabra Y
Year: 2024
Journal: Endocrinology
Title: Roles of Growth Hormone-Dependent JAK-STAT5 and Lyn Kinase Signaling in Determining Lifespan and Cancer Incidence.
Volume: 165
Issue: 11
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Publication
11517336 | -
First Author: Grishin AV
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Interaction between growth arrest-DNA damage protein 34 and Src kinase Lyn negatively regulates genotoxic apoptosis.
Volume: 98
Issue: 18
Pages: 10172-7
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Publication
21636860 | J:174862
First Author: Futami M
Year: 2011
Journal: Blood
Title: G-CSF receptor activation of the Src kinase Lyn is mediated by Gab2 recruitment of the Shp2 phosphatase.
Volume: 118
Issue: 4
Pages: 1077-86
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Publication
15304502 | J:119327
First Author: Shao Y
Year: 2004
Journal: J Biol Chem
Title: Differential regulation of the B cell receptor-mediated signaling by the E3 ubiquitin ligase Cbl.
Volume: 279
Issue: 42
Pages: 43646-53
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Publication
20944008 | J:165625
First Author: Samayawardhena LA
Year: 2010
Journal: J Immunol
Title: PTPalpha activates Lyn and Fyn and suppresses Hck to negatively regulate FcepsilonRI-dependent mast cell activation and allergic responses.
Volume: 185
Issue: 10
Pages: 5993-6002
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Publication
10672044 | -
First Author: Dahl ME
Year: 2000
Journal: Genes Cells
Title: Association of Lyn tyrosine kinase to the GM-CSF and IL-3 receptor common betac subunit and role of Src tyrosine kinases in DNA synthesis and anti-apoptosis.
Volume: 5
Issue: 2
Pages: 143-53
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Publication
15335855 | -
First Author: Law DA
Year: 1993
Journal: Curr Biol
Title: B-cell antigen receptor motifs have redundant signalling capabilities and bind the tyrosine kinases PTK72, Lyn and Fyn.
Volume: 3
Issue: 10
Pages: 645-57
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Publication
10415030 | -
First Author: Katagiri T
Year: 1999
Journal: J Immunol
Title: CD45 negatively regulates lyn activity by dephosphorylating both positive and negative regulatory tyrosine residues in immature B cells.
Volume: 163
Issue: 3
Pages: 1321-6
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Protein
P49710
Organism: Mus musculus/domesticus
Length: 486  
Fragment?: false
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Publication
8621063 | -
First Author: Mano H
Year: 1996
Journal: FASEB J
Title: Tec protein-tyrosine kinase is an effector molecule of Lyn protein-tyrosine kinase.
Volume: 10
Issue: 5
Pages: 637-42
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Allele
Lyn<m4Btlr> | MGI:6285919
Name: LYN proto-oncogene, Src family tyrosine kinase; mutation 4, Bruce Beutler
Allele Type: Chemically induced (ENU)
Attribute String: Not Specified
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Publication
23001182 | J:190337
First Author: Skokowa J
Year: 2012
Journal: Nat Med
Title: Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesis.
Volume: 18
Issue: 10
Pages: 1550-9
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Publication
2166951 | J:20074
First Author: Giguère V
Year: 1990
Journal: Proc Natl Acad Sci U S A
Title: Molecular cloning of cDNA encoding a second cellular retinoic acid-binding protein.
Volume: 87
Issue: 16
Pages: 6233-7
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Allele
Lyn<tm1Ard> | MGI:2157129
Name: LYN proto-oncogene, Src family tyrosine kinase; targeted mutation 1, Ashley R Dunn
Allele Type: Targeted
Attribute String: Null/knockout
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Publication
19001085 | J:144768
First Author: McPherson VA
Year: 2009
Journal: Mol Cell Biol
Title: Contributions of F-BAR and SH2 domains of Fes protein tyrosine kinase for coupling to the FcepsilonRI pathway in mast cells.
Volume: 29
Issue: 2
Pages: 389-401
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Interaction Experiment
Ingley E (2006)
Description: Csk-binding protein mediates sequential enzymatic down-regulation and degradation of Lyn in erythropoietin-stimulated cells.
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Publication
8753773 | J:125631
First Author: Zarn JA
Year: 1996
Journal: Biochem Biophys Res Commun
Title: Association of CD24 with the kinase c-fgr in a small cell lung cancer cell line and with the kinase lyn in an erythroleukemia cell line.
Volume: 225
Issue: 2
Pages: 384-91
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Allele
Lyn<M1Btlr> | MGI:5603319
Name: LYN proto-oncogene, Src family tyrosine kinase; mutation 1, Bruce Beutler
Allele Type: Chemically induced (ENU)
Attribute String: Hypomorph
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Publication
35196496 | J:331828
First Author: Tanishita Y
Year: 2022
Journal: Cell Rep
Title: Listeria toxin promotes phosphorylation of the inflammasome adaptor ASC through Lyn and Syk to exacerbate pathogen expansion.
Volume: 38
Issue: 8
Pages: 110414
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Publication
1702903 | -
First Author: Yamanashi Y
Year: 1991
Journal: Science
Title: Association of B cell antigen receptor with protein tyrosine kinase Lyn.
Volume: 251
Issue: 4990
Pages: 192-4
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Publication
8183901 | -
First Author: Pleiman CM
Year: 1994
Journal: Proc Natl Acad Sci U S A
Title: Distinct p53/56lyn and p59fyn domains associate with nonphosphorylated and phosphorylated Ig-alpha.
Volume: 91
Issue: 10
Pages: 4268-72
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Publication
15489917 | -
First Author: Gauld SB
Year: 2004
Journal: Oncogene
Title: Src-family kinases in B-cell development and signaling.
Volume: 23
Issue: 48
Pages: 8001-6
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Publication
15220000 | -
First Author: Lowell CA
Year: 2004
Journal: Mol Immunol
Title: Src-family kinases: rheostats of immune cell signaling.
Volume: 41
Issue: 6-7
Pages: 631-43
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Publication
8978766 | J:31445
First Author: Egashira M
Year: 1996
Journal: Cytogenet Cell Genet
Title: The human HCLS1 gene maps to chromosome 3q13 by fluorescence in situ hybridization.
Volume: 72
Issue: 2-3
Pages: 175-6
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Strain
MGI:6285920 | C57BL/6J-Lyn<m4Btlr>
Attribute String: coisogenic, chemically induced mutation, mutant strain
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Genotype
Genotype
Symbol: Lyn/Lyn
Background: C57BL/6J-Lyn
Zygosity: hm
Has Mutant Allele: true
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Strain
MGI:7623423 | C57BL/6JSmoc-Lyn<tm1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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GO Term
GO:0070332 | CD20-Lck-Lyn-Fyn complex
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Interaction Experiment
Whiting RJ (2012)
Description: Targeting Lyn tyrosine kinase through protein fusions encompassing motifs of Cbp (Csk-binding protein) and the SOCS box of SOCS1.
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Protein Coding Gene
MGP_CAROLIEiJ_G0020723 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0022796 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0022761 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0022733 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0022762 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0022526 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_104568 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0023209 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0022052 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0022497 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0022629 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0022604 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0022697 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0022623 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0023224 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0021792 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0022096 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0016424 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0021623 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
7535527 | J:24179
First Author: Kitamura D
Year: 1995
Journal: Biochem Biophys Res Commun
Title: Molecular cloning and characterization of mouse HS1.
Volume: 208
Issue: 3
Pages: 1137-46
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GXD Expression
GXD Expression
 
Probe: MGI:1407984
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1752323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825334
Age: embryonic day 14.5
Image: euxassay_006086_07
Specimen Label: euxassay_006086_07
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:1407984
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1752323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825334
Age: embryonic day 14.5
Image: euxassay_006086_08
Specimen Label: euxassay_006086_08
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:1407984
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1752323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825334
Age: embryonic day 14.5
Image: euxassay_006086_09
Specimen Label: euxassay_006086_09
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:1407984
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1752323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825334
Age: embryonic day 14.5
Image: euxassay_006086_10
Specimen Label: euxassay_006086_10
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:1407984
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1752323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825334
Age: embryonic day 14.5
Image: euxassay_006086_11
Specimen Label: euxassay_006086_11
Detected: true
Specimen Num: 5
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Allele
Lyn<weeb> | MGI:3837125
 
Name: LYN proto-oncogene, Src family tyrosine kinase; WeeB
Allele Type: Chemically induced (ENU)
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Pseudogene
MGI:104858 | Lyn-ps1
Type: pseudogene
Organism: mouse, laboratory
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Strain
MGI:5603322 | C57BL/6J-Lyn<M1Btlr>
Attribute String: chemically induced mutation, coisogenic, mutant strain
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Strain
MGI:5616420 | C57BL/6J-Lyn<M1Btlr>/Mmmh
Attribute String: mutant strain, coisogenic, chemically induced mutation
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Genotype
Genotype
Symbol: Lyn/Lyn
Background: C57BL/6J-Lyn
Zygosity: hm
Has Mutant Allele: true
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Publication
10594682 | J:59099
First Author: Igietseme JU
Year: 1999
Journal: Immunology
Title: The intercellular adhesion molecule type-1 is required for rapid activation of T helper type 1 lymphocytes that control early acute phase of genital chlamydial infection in mice.
Volume: 98
Issue: 4
Pages: 510-9
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Strain
MGI:3832856 | B6.129P2-Lyn<tm1Ard>
Attribute String: targeted mutation, congenic
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Genotype
Genotype
Symbol: Lyn/Lyn
Background: involves: 129P2/OlaHsd
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lyn/Lyn
Background: B6.129P2-Lyn
Zygosity: hm
Has Mutant Allele: true
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Publication
7782294 | -
First Author: Tanaka S
Year: 1995
Journal: J Biol Chem
Title: Tyrosine phosphorylation and translocation of the c-cbl protein after activation of tyrosine kinase signaling pathways.
Volume: 270
Issue: 24
Pages: 14347-51
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Publication
7513017 | -
First Author: Kurosaki T
Year: 1994
Journal: J Exp Med
Title: Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling.
Volume: 179
Issue: 5
Pages: 1725-9
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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