Type |
Details |
Score |
Publication |
First Author: |
Libert S |
Year: |
2011 |
Journal: |
Cell |
Title: |
SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive. |
Volume: |
147 |
Issue: |
7 |
Pages: |
1459-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Laval SH |
Year: |
1991 |
Journal: |
Genomics |
Title: |
The properdin structural locus (Pfc) lies close to the locus for tissue inhibitor of metallothionine proteases (Timp) on the mouse X chromosome. |
Volume: |
10 |
Issue: |
4 |
Pages: |
1030-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Laval SH |
Year: |
1993 |
Journal: |
Mamm Genome |
Title: |
Partial inversion of gene order within a homologous segment on the X chromosome. |
Volume: |
4 |
Issue: |
2 |
Pages: |
119-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Edelhoff S |
Year: |
1992 |
Journal: |
Am J Hum Genet |
Title: |
Mapping of the glutamic acid decarboxylase (GAD) gene family |
Volume: |
51 |
Issue: |
4 |
Pages: |
A395 (Abstr.) |
|
•
•
•
•
•
|
Publication |
First Author: |
Charles CH |
Year: |
1992 |
Journal: |
Oncogene |
Title: |
cDNA sequence of a growth factor-inducible immediate early gene and characterization of its encoded protein. |
Volume: |
7 |
Issue: |
1 |
Pages: |
187-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bonnin A |
Year: |
2011 |
Journal: |
Nature |
Title: |
A transient placental source of serotonin for the fetal forebrain. |
Volume: |
472 |
Issue: |
7343 |
Pages: |
347-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cheng A |
Year: |
2010 |
Journal: |
J Neurosci |
Title: |
Monoamine oxidases regulate telencephalic neural progenitors in late embryonic and early postnatal development. |
Volume: |
30 |
Issue: |
32 |
Pages: |
10752-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Derry JM |
Year: |
1989 |
Journal: |
Nucleic Acids Res |
Title: |
Localization of monoamine oxidase A and B genes on the mouse X chromosome. |
Volume: |
17 |
Issue: |
20 |
Pages: |
8403 |
|
•
•
•
•
•
|
Publication |
First Author: |
Laval SH |
Year: |
1993 |
Journal: |
Genomics |
Title: |
Novel sequences conserved on the human and mouse X chromosomes. |
Volume: |
15 |
Issue: |
3 |
Pages: |
483-91 |
|
•
•
•
•
•
|
Publication |
First Author: |
Herman GE |
Year: |
1991 |
Journal: |
Genomics |
Title: |
The construction of human somatic cell hybrids containing portions of the mouse X chromosome and their use to generate DNA probes via interspersed repetitive sequence polymerase chain reaction. |
Volume: |
10 |
Issue: |
4 |
Pages: |
961-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kiebish MA |
Year: |
2008 |
Journal: |
J Neurochem |
Title: |
Lipidomic analysis and electron transport chain activities in C57BL/6J mouse brain mitochondria. |
Volume: |
106 |
Issue: |
1 |
Pages: |
299-312 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shi M |
Year: |
2008 |
Journal: |
Mol Cell Neurosci |
Title: |
DCC is required for the tangential migration of noradrenergic neurons in locus coeruleus of mouse brain. |
Volume: |
39 |
Issue: |
4 |
Pages: |
529-38 |
|
•
•
•
•
•
|
Publication |
First Author: |
Song NN |
Year: |
2020 |
Journal: |
Development |
Title: |
Rnf220/Zc4h2-mediated monoubiquitylation of Phox2 is required for noradrenergic neuron development. |
Volume: |
147 |
Issue: |
6 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Shetty AS |
Year: |
2013 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Lhx2 regulates a cortex-specific mechanism for barrel formation. |
Volume: |
110 |
Issue: |
50 |
Pages: |
E4913-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang YB |
Year: |
2022 |
Journal: |
Front Cell Dev Biol |
Title: |
Rnf220 is Implicated in the Dorsoventral Patterning of the Hindbrain Neural Tube in Mice. |
Volume: |
10 |
|
Pages: |
831365 |
|
•
•
•
•
•
|
Publication |
First Author: |
Blair HJ |
Year: |
2000 |
Journal: |
Mamm Genome |
Title: |
Positioning of five genes (CASK, ARX, SAT, IMAGE cDNAs 248928 and 253949) from the human X chromosome short arm with respect to evolutionary breakpoints on the mouse X chromosome. |
Volume: |
11 |
Issue: |
8 |
Pages: |
710-2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kuroiwa A |
Year: |
1998 |
Journal: |
Cytogenet Cell Genet |
Title: |
Comparative FISH mapping of mouse and rat homologues of twenty-five human X-linked genes. |
Volume: |
81 |
Issue: |
3-4 |
Pages: |
208-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
He Y |
Year: |
2021 |
Journal: |
Aging Cell |
Title: |
Single-cell RNA-Seq reveals a highly coordinated transcriptional program in mouse germ cells during primordial follicle formation. |
Volume: |
20 |
Issue: |
7 |
Pages: |
e13424 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shi M |
Year: |
2012 |
Journal: |
J Cell Sci |
Title: |
Notch-Rbpj signaling is required for the development of noradrenergic neurons in the mouse locus coeruleus. |
Volume: |
125 |
Issue: |
Pt 18 |
Pages: |
4320-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Manti M |
Year: |
2020 |
Journal: |
FASEB J |
Title: |
Excess of ovarian nerve growth factor impairs embryonic development and causes reproductive and metabolic dysfunction in adult female mice. |
Volume: |
34 |
Issue: |
11 |
Pages: |
14440-14457 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang Q |
Year: |
2018 |
Journal: |
Cell Death Dis |
Title: |
Temporal requirements for ISL1 in sympathetic neuron proliferation, differentiation, and diversification. |
Volume: |
9 |
Issue: |
2 |
Pages: |
247 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shalom-Barak T |
Year: |
2012 |
Journal: |
Dev Biol |
Title: |
Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network. |
Volume: |
372 |
Issue: |
1 |
Pages: |
143-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Quina LA |
Year: |
2009 |
Journal: |
J Neurosci |
Title: |
Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development. |
Volume: |
29 |
Issue: |
45 |
Pages: |
14309-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sansom SN |
Year: |
2009 |
Journal: |
PLoS Genet |
Title: |
The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. |
Volume: |
5 |
Issue: |
6 |
Pages: |
e1000511 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mootha VK |
Year: |
2003 |
Journal: |
Cell |
Title: |
Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. |
Volume: |
115 |
Issue: |
5 |
Pages: |
629-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pagliarini DJ |
Year: |
2008 |
Journal: |
Cell |
Title: |
A mitochondrial protein compendium elucidates complex I disease biology. |
Volume: |
134 |
Issue: |
1 |
Pages: |
112-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
MGC Data curation in Mouse Genome Informatics |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
FANTOM2 Data Curation in Mouse Genome Informatics |
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|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Thompson CL |
Year: |
2014 |
Journal: |
Neuron |
Title: |
A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. |
Volume: |
83 |
Issue: |
2 |
Pages: |
309-323 |
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•
•
•
•
•
|
Publication |
First Author: |
Visel A |
Year: |
2004 |
Journal: |
Nucleic Acids Res |
Title: |
GenePaint.org: an atlas of gene expression patterns in the mouse embryo. |
Volume: |
32 |
Issue: |
Database issue |
Pages: |
D552-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
International Mouse Strain Resource |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of germline transmission data for alleles from IMSR strain data |
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|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2009 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Magdaleno S |
Year: |
2006 |
Journal: |
PLoS Biol |
Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
Volume: |
4 |
Issue: |
4 |
Pages: |
e86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
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•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
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|
|
•
•
•
•
•
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Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
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Title: |
GemPharmatech Website. |
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•
•
•
•
•
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Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
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•
•
•
•
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Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
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Title: |
Cyagen Biosciences Website. |
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•
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•
•
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Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
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|
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•
•
•
•
•
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Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
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•
•
•
•
•
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Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
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•
•
•
•
•
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Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
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•
•
•
•
•
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Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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|
•
•
•
•
•
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Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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•
•
•
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•
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
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|
•
•
•
•
•
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
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|
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
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|
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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•
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•
|
Allele |
Name: |
monoamine oxidase A; transgene insertion 8, Isabelle Seif |
Allele Type: |
Transgenic |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Pathway |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Maoa/? |
Background: |
involves: C3H/HeJ |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Allele |
Name: |
monoamine oxidase A; K284stop |
Allele Type: |
Spontaneous |
|
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
520
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Maoa/? |
Background: |
129S6/SvEvTac-Maoa |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
526
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Maoa/? |
Background: |
involves: C3H/HeJ |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Sugino H |
Year: |
1992 |
Journal: |
J Bacteriol |
Title: |
A monoamine-regulated Klebsiella aerogenes operon containing the monoamine oxidase structural gene (maoA) and the maoC gene. |
Volume: |
174 |
Issue: |
8 |
Pages: |
2485-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hiltunen JK |
Year: |
1992 |
Journal: |
J Biol Chem |
Title: |
Peroxisomal multifunctional beta-oxidation protein of Saccharomyces cerevisiae. Molecular analysis of the fox2 gene and gene product. |
Volume: |
267 |
Issue: |
10 |
Pages: |
6646-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fukui T |
Year: |
1998 |
Journal: |
J Bacteriol |
Title: |
Expression and characterization of (R)-specific enoyl coenzyme A hydratase involved in polyhydroxyalkanoate biosynthesis by Aeromonas caviae. |
Volume: |
180 |
Issue: |
3 |
Pages: |
667-73 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
The maoC gene is part of an operon with maoA which is involved in the synthesis of monoamine oxidase []. The MaoC protein shares similarity with a region found in a wide variety of enzymes, such as peroxisomal hydratase-dehydrogenase-epimerase and fatty acid synthase beta subunit. A deletion mutant of the C-terminal 271 amino acids in peroxisomal hydratase-dehydrogenase-epimerase (), corresponding to the MaoC domain, abolished its 2-enoyl-CoA hydratase activity, suggesting that this region may be a hydratase enzyme []. Several bacterial proteins that are composed solely of this domain have (R)-specific enoyl-CoA hydratase activity []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Cell division cycle-associated 7-like protein (CDCA7L/JPO2/R1) is closely related to CDCA7/JPO1; and like CDCA7, it plays a role in transcriptional regulation and interacts with c-Myc []. JPO2 overexpression induces metastasis in medulloblastoma []. JPO2 can interact directly and dynamically with chromatin, the dynamics of JPO2 chromatin binding being decelerated upon interaction with LEDGF/p75, which binds and tethers JPO2 to chromatin [, ].JPO2 inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter []. JPO2 and MAOA act upstream of cyclin D1 and E2F1, and are involved in apoptotic signalling pathways []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Ikemoto K |
Year: |
1999 |
Journal: |
Neurosci Lett |
Title: |
Cholinergic neurons with monoamine oxidase type B (MAOB)-activity in the laterodorsal tegmental nucleus of the mouse. |
Volume: |
271 |
Issue: |
1 |
Pages: |
53-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huang A |
Year: |
2005 |
Journal: |
Cancer Res |
Title: |
Identification of a novel c-Myc protein interactor, JPO2, with transforming activity in medulloblastoma cells. |
Volume: |
65 |
Issue: |
13 |
Pages: |
5607-19 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
438
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
226
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
308
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen K |
Year: |
2005 |
Journal: |
J Biol Chem |
Title: |
R1, a novel repressor of the human monoamine oxidase A. |
Volume: |
280 |
Issue: |
12 |
Pages: |
11552-9 |
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Publication |
First Author: |
Chan TS |
Year: |
2016 |
Journal: |
Cancer Res |
Title: |
JPO2/CDCA7L and LEDGF/p75 Are Novel Mediators of PI3K/AKT Signaling and Aggressive Phenotypes in Medulloblastoma. |
Volume: |
76 |
Issue: |
9 |
Pages: |
2802-12 |
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Publication |
First Author: |
Hendrix J |
Year: |
2014 |
Journal: |
J Biol Chem |
Title: |
Dynamics of the ternary complex formed by c-Myc interactor JPO2, transcriptional co-activator LEDGF/p75, and chromatin. |
Volume: |
289 |
Issue: |
18 |
Pages: |
12494-506 |
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Publication |
First Author: |
Maertens GN |
Year: |
2006 |
Journal: |
J Cell Sci |
Title: |
Transcriptional co-activator p75 binds and tethers the Myc-interacting protein JPO2 to chromatin. |
Volume: |
119 |
Issue: |
Pt 12 |
Pages: |
2563-71 |
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Publication |
First Author: |
Chinnasamy P |
Year: |
2023 |
Journal: |
Nat Commun |
Title: |
Increased adipose catecholamine levels and protection from obesity with loss of Allograft Inflammatory Factor-1. |
Volume: |
14 |
Issue: |
1 |
Pages: |
38 |
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Publication |
First Author: |
Goto Y |
Year: |
2006 |
Journal: |
Biochim Biophys Acta |
Title: |
JPO1/CDCA7, a novel transcription factor E2F1-induced protein, possesses intrinsic transcriptional regulator activity. |
Volume: |
1759 |
Issue: |
1-2 |
Pages: |
60-8 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
192
 |
Fragment?: |
true |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
158
 |
Fragment?: |
false |
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Publication |
First Author: |
Gill RM |
Year: |
2013 |
Journal: |
Mol Cell Biol |
Title: |
The MYC-associated protein CDCA7 is phosphorylated by AKT to regulate MYC-dependent apoptosis and transformation. |
Volume: |
33 |
Issue: |
3 |
Pages: |
498-513 |
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Publication |
First Author: |
Prescott JE |
Year: |
2001 |
Journal: |
J Biol Chem |
Title: |
A novel c-Myc-responsive gene, JPO1, participates in neoplastic transformation. |
Volume: |
276 |
Issue: |
51 |
Pages: |
48276-84 |
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Publication |
First Author: |
Guiu J |
Year: |
2014 |
Journal: |
J Exp Med |
Title: |
Identification of Cdca7 as a novel Notch transcriptional target involved in hematopoietic stem cell emergence. |
Volume: |
211 |
Issue: |
12 |
Pages: |
2411-23 |
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Protein Domain |
Type: |
Family |
Description: |
This entry includes CDCA7 and CDA7L.Cell division cycle-associated protein 7 (CDCA7/JPO1) is a transcription regulator whose expression is activated by c-Myc and by E2F1 []. CDCA7 can associate with Myc in a phosphorylation-dependent manner. CDCA7 phosphorylation by AKT leads to loss of its association with Myc []. This interaction affects Myc-dependent apoptosis and transformation [, , ]. CDCA7 has also been identified as a Notch target involved in hematopoietic stem cell emergence [].Cell division cycle-associated 7-like protein (CDCA7L/JPO2/R1) is closely related to CDCA7/JPO1; and like CDCA7, it plays a role in transcriptional regulation and interacts with c-Myc []. JPO2 overexpression induces metastasis in medulloblastoma []. JPO2 can interact directly and dynamically with chromatin, the dynamics of JPO2 chromatin binding being decelerated upon interaction with LEDGF/p75, which binds and tethers JPO2 to chromatin [, ].JPO2 inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter []. JPO2 and MAOA act upstream of cyclin D1 and E2F1, and are involved in apoptotic signalling pathways []. |
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Publication |
First Author: |
Jahng JW |
Year: |
1998 |
Journal: |
Brain Res Dev Brain Res |
Title: |
Differential expression of monoamine oxidase A, serotonin transporter, tyrosine hydroxylase and norepinephrine transporter mRNA by anorexia mutation and food deprivation. |
Volume: |
107 |
Issue: |
2 |
Pages: |
241-6 |
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Publication |
First Author: |
Camell CD |
Year: |
2017 |
Journal: |
Nature |
Title: |
Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing. |
Volume: |
550 |
Issue: |
7674 |
Pages: |
119-123 |
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Publication |
First Author: |
Schmouth JF |
Year: |
2013 |
Journal: |
BMC Biol |
Title: |
Non-coding-regulatory regions of human brain genes delineated by bacterial artificial chromosome knock-in mice. |
Volume: |
11 |
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Pages: |
106 |
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Publication |
First Author: |
Grimsby J |
Year: |
1997 |
Journal: |
Nat Genet |
Title: |
Increased stress response and beta-phenylethylamine in MAOB-deficient mice. |
Volume: |
17 |
Issue: |
2 |
Pages: |
206-10 |
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Publication |
First Author: |
Tajeddinn W |
Year: |
2015 |
Journal: |
Neurosci Lett |
Title: |
5-HT1B and other related serotonergic proteins are altered in APPswe mutation. |
Volume: |
594 |
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Pages: |
137-43 |
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Publication |
First Author: |
Gumusoglu SB |
Year: |
2024 |
Journal: |
Neuropsychopharmacology |
Title: |
Anti-angiogenic mechanisms and serotonergic dysfunction in the Rgs2 knockout model for the study of psycho-obstetric risk. |
Volume: |
49 |
Issue: |
5 |
Pages: |
864-875 |
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Publication |
First Author: |
Sims KB |
Year: |
1992 |
Journal: |
Hum Mol Genet |
Title: |
The Norrie disease gene maps to a 150 kb region on chromosome Xp11.3. |
Volume: |
1 |
Issue: |
2 |
Pages: |
83-9 |
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