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Search results 501 to 538 out of 538 for Map1b

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0.025s

Type

Details

Score

Protein Domain

IPR009603 | MAP_Futsch

Type:

Repeat

Description:

The Drosophila protein Futsch has homology to MAP1B and controls synaptic growth at the Drosophila neuromuscular junction through the regulation of the synaptic microtubule cytoskeleton. Futsch protein colocalises with microtubules and identifies cytoskeletal loops that traverse the lateral margin of select synaptic boutons. Futsch mutations disrupt synaptic microtubule organisation, reduce bouton number, and increase bouton size. These deficits can be partially rescued by neuronal overexpression of a Futsch MAP1B homology domain []. The translation of Futsch is repressed by fragile X messenger ribonucleoprotein 1 (FMR1/FMRP), an RNA binding protein that acts as a negative translational regulator []. The N- and C-terminal domains of Futsch are homologous to the vertebrate MAP1B microtubule-associated protein. The central domain of Futsch is highly repetitive []. This entry represents the Futsch repeats.

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Protein

Q9QYR6

Organism:	Mus musculus/domesticus
Length:	2776
Fragment?:	false

•

Protein

A2ARP8

Organism:	Mus musculus/domesticus
Length:	3014
Fragment?:	false

•

Protein

A0A1D5RML0

Organism:	Mus musculus/domesticus
Length:	79
Fragment?:	false

•

Protein

A0A1D5RMF1

Organism:	Mus musculus/domesticus
Length:	133
Fragment?:	true

•

Protein

A0A1D5RMG7

Organism:	Mus musculus/domesticus
Length:	239
Fragment?:	true

•

Publication

17234756 | -

First Author:	Dallol A
Year:	2007
Journal:	Cancer Res
Title:	Depletion of the Ras association domain family 1, isoform A-associated novel microtubule-associated protein, C19ORF5/MAP1S, causes mitotic abnormalities.
Volume:	67
Issue:	2
Pages:	492-500

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Publication

15899810 | -

First Author:	Liu L
Year:	2005
Journal:	Cancer Res
Title:	Distinct structural domains within C19ORF5 support association with stabilized microtubules and mitochondrial aggregation and genome destruction.
Volume:	65
Issue:	10
Pages:	4191-201

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Publication

14627543 | -

First Author:	Wong EY
Year:	2004
Journal:	Biol Reprod
Title:	Identification and characterization of human VCY2-interacting protein: VCY2IP-1, a microtubule-associated protein-like protein.
Volume:	70
Issue:	3
Pages:	775-84

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Publication

21262964 | J:170757

First Author:	Xie R
Year:	2011
Journal:	J Biol Chem
Title:	Microtubule-associated protein 1S (MAP1S) bridges autophagic components with microtubules and mitochondria to affect autophagosomal biogenesis and degradation.
Volume:	286
Issue:	12
Pages:	10367-77

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Publication

19759419 | -

First Author:	Liu L
Year:	2009
Journal:	Cell Oncol
Title:	Dual function microtubule- and mitochondria-associated proteins mediate mitotic cell death.
Volume:	31
Issue:	5
Pages:	393-405

•

Protein Domain

IPR026074 | MAP1

Type:

Family

Description:

MAP1-family proteins are microtubule-associated proteins (MAPs) that bind along the microtubule lattice. Mammalian genomes usually contain three family members, MAP1A, MAP1B and MAP1S. Only one family member, Futsch, is found in Drosophila.Human MAP1A and MAP1B, are predominantly expressed in neurons, where they are thought to be important in the formation and development of axons and dendrites []. Human MAP1A and MAP1B stabilise microtubules and interact with other cellular components, including filamentous actin and signaling proteins. The activity of MAP1A and MAP1B is controlled by upstream signaling mechanisms, including the MAP kinase and glycogen synthase kinase-3 beta pathways []. Human MAP1S is a heterodimer with a heavy and a light chain. Both MAP1S heavy and light chains interact with microtubules, while MAP1S light chain interacts with actin []. MAP1S is involved in the formation of microtubule bundles []. It mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD) []. It bridges autophagic components with microtubules and mitochondria plays a role in apoptosis [, , ].

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Publication

19781524 | J:155134

First Author:	Moritz A
Year:	2009
Journal:	Biochem Biophys Res Commun
Title:	Metabotropic glutamate receptor 4 interacts with microtubule-associated protein 1B.
Volume:	390
Issue:	1
Pages:	82-6

•

Protein

Q8C052

Organism:	Mus musculus/domesticus
Length:	973
Fragment?:	false

•

Protein

A0A1D5RLY6

Organism:	Mus musculus/domesticus
Length:	864
Fragment?:	false

•

Protein

B2RWW1

Organism:	Mus musculus/domesticus
Length:	973
Fragment?:	false

•

Publication

2555150 | -

First Author:	Rienitz A
Year:	1989
Journal:	EMBO J
Title:	Neuraxin, a novel putative structural protein of the rat central nervous system that is immunologically related to microtubule-associated protein 5.
Volume:	8
Issue:	10
Pages:	2879-88

•

Protein Domain

IPR000102 | MAP1B_neuraxin

Type:

Repeat

Description:

In microtubule-associated protein 1B (MAP1B) the basic region containing the KKEE and KKEVI motifs is responsible for the interaction between MAP1B and microtubules in vivo. This region bears no sequence relationship to the microtubule binding domains of kinesin, MAP2, or tau [].Neuraxin is a putative structural protein of the rat central nervous system that is immunologically related to microtubule-associated protein 5 (MAP5). Neuraxin may be implicated in neuronal membrane-microtubule interactions [].Both proteins contain a region that consists of 12 tandemrepeats of a 17 residues motif.

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Publication

22301994 | J:244655

First Author:	Liu L
Year:	2012
Journal:	Autophagy
Title:	MAP1S enhances autophagy to suppress tumorigenesis.
Volume:	8
Issue:	2
Pages:	278-80

•

Protein Domain

IPR027322 | MAP1S

Type:

Family

Description:

MAP1-family proteins are microtubule-associated proteins (MAPs) that bind along the microtubule lattice. Mammalian genomes usually contain three family members, MAP1A, MAP1B and MAP1S. Only one family member, Futsch, is found in Drosophila.Human MAP1S is a heterodimer with a heavy and a light chain. Both MAP1S heavy and light chains interact with microtubules, while MAP1S light chain interacts with actin []. Unlike MAP1A and MAP1B, MAP1S is expressed in a wide range of tissues in addition to neurons []. MAP1S serves as a linker to connect mitochondria with microtubules for trafficking, and to bridge the autophagy machinery with microtubules and mitochondria to affect autophagosomal biogenesis and degradation [, , , ]. In mice, MAP1S may enhance autophagy to suppress genomic instability and tumorigenesis [].

•

Publication

12689591 | J:109559

First Author:	Chang L
Year:	2003
Journal:	Dev Cell
Title:	JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins.
Volume:	4
Issue:	4
Pages:	521-33

•

Publication

25078444 | J:225212

First Author:	Gobrecht P
Year:	2014
Journal:	Nat Commun
Title:	Sustained GSK3 activity markedly facilitates nerve regeneration.
Volume:	5

Pages:	4561

•

Publication

22737234 | J:225103

First Author:	El Fatimy R
Year:	2012
Journal:	PLoS One
Title:	Fragile X mental retardation protein interacts with the RNA-binding protein Caprin1 in neuronal RiboNucleoProtein complexes [corrected].
Volume:	7
Issue:	6
Pages:	e39338

•

Publication

29259219 | J:256006

First Author:	Ma XX
Year:	2017
Journal:	Sci Rep
Title:	PiT2 regulates neuronal outgrowth through interaction with microtubule-associated protein 1B.
Volume:	7
Issue:	1
Pages:	17850

•

Publication

31408169 | J:283232

First Author:	Wu Y
Year:	2019
Journal:	J Mol Cell Biol
Title:	The molecular chaperone Hsp90α deficiency causes retinal degeneration by disrupting Golgi organization and vesicle transportation in photoreceptors.

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Publication

7806212 | J:19669

First Author:	Lien LL
Year:	1994
Journal:	Genomics
Title:	Cloning of human microtubule-associated protein 1B and the identification of a related gene on chromosome 15.
Volume:	22
Issue:	2
Pages:	273-80

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Publication

12147674 | J:78266

First Author:	Ding J
Year:	2002
Journal:	J Cell Biol
Title:	Microtubule-associated protein 1B: a neuronal binding partner for gigaxonin.
Volume:	158
Issue:	3
Pages:	427-33

•

Publication

16631377 | J:111946

First Author:	Antar LN
Year:	2006
Journal:	Mol Cell Neurosci
Title:	Local functions for FMRP in axon growth cone motility and activity-dependent regulation of filopodia and spine synapses.
Volume:	32
Issue:	1-2
Pages:	37-48

•

Publication

15525354 | J:131693

First Author:	Maurer MH
Year:	2004
Journal:	J Neurochem
Title:	Cloning of a novel neuronally expressed orphan G-protein-coupled receptor which is up-regulated by erythropoietin, interacts with microtubule-associated protein 1b and colocalizes with the 5-hydroxytryptamine 2a receptor.
Volume:	91
Issue:	4
Pages:	1007-17

•

Publication

12434312 | J:80806

First Author:	Dgany O
Year:	2002
Journal:	Am J Hum Genet
Title:	Congenital dyserythropoietic anemia type I is caused by mutations in codanin-1.
Volume:	71
Issue:	6
Pages:	1467-74

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Publication

17687394 | J:323451

First Author:	Wei ZX
Year:	2007
Journal:	Neurosci Bull
Title:	Expression changes of microtubule associated protein 1B in the brain of Fmr1 knockout mice.
Volume:	23
Issue:	4
Pages:	203-8

•

Publication

37108467 | J:335265

First Author:	Gąssowska-Dobrowolska M
Year:	2023
Journal:	Int J Mol Sci
Title:	Microtubule Cytoskeletal Network Alterations in a Transgenic Model of Tuberous Sclerosis Complex: Relevance to Autism Spectrum Disorders.
Volume:	24
Issue:	8

•

Publication

25151457 | J:217765

First Author:	Chan JL
Year:	2014
Journal:	Exp Neurol
Title:	Osteopontin expression in acute immune response mediates hippocampal synaptogenesis and adaptive outcome following cortical brain injury.
Volume:	261

Pages:	757-71

•

Publication

24849348 | J:211349

First Author:	Ma QL
Year:	2014
Journal:	J Neurosci
Title:	Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.
Volume:	34
Issue:	21
Pages:	7124-36

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Publication

28630333 | J:243841

First Author:	Leibinger M
Year:	2017
Journal:	Proc Natl Acad Sci U S A
Title:	Boosting CNS axon regeneration by harnessing antagonistic effects of GSK3 activity.
Volume:	114
Issue:	27
Pages:	E5454-E5463

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Publication

15572359 | J:96953

First Author:	Collins MO
Year:	2005
Journal:	J Biol Chem
Title:	Proteomic analysis of in vivo phosphorylated synaptic proteins.
Volume:	280
Issue:	7
Pages:	5972-82

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Publication

12411430 | J:81252

First Author:	Nakayama A
Year:	2003
Journal:	J Biol Chem
Title:	Role for RFX transcription factors in non-neuronal cell-specific inactivation of the microtubule-associated protein MAP1A promoter.
Volume:	278
Issue:	1
Pages:	233-40

•

Publication

19607922 | J:154231

First Author:	Wood-Kaczmar A
Year:	2009
Journal:	Mol Cell Neurosci
Title:	An alternatively spliced form of glycogen synthase kinase-3beta is targeted to growing neurites and growth cones.
Volume:	42
Issue:	3
Pages:	184-94

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