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Search results 501 to 564 out of 564 for Map3k12

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Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:1379184
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1672823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826116
Age: embryonic day 14.5
Image: euxassay_005376_08
Specimen Label: euxassay_005376_08
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
 
Probe: MGI:1379184
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1672823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826116
Age: embryonic day 14.5
Image: euxassay_005376_09
Specimen Label: euxassay_005376_09
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
 
Probe: MGI:1379184
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1672823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826116
Age: embryonic day 14.5
Image: euxassay_005376_10
Specimen Label: euxassay_005376_10
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
 
Probe: MGI:1379184
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1672823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826116
Age: embryonic day 14.5
Image: euxassay_005376_11
Specimen Label: euxassay_005376_11
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
 
Probe: MGI:1379184
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1672823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826116
Age: embryonic day 14.5
Image: euxassay_005376_12
Specimen Label: euxassay_005376_12
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
 
Probe: MGI:1379184
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1672823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826116
Age: embryonic day 14.5
Image: euxassay_005376_13
Specimen Label: euxassay_005376_13
Detected: true
Specimen Num: 13
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GXD Expression
GXD Expression
 
Probe: MGI:1379184
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1672823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826116
Age: embryonic day 14.5
Image: euxassay_005376_14
Specimen Label: euxassay_005376_14
Detected: true
Specimen Num: 14
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GXD Expression
GXD Expression
 
Probe: MGI:1379184
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1672823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826116
Age: embryonic day 14.5
Image: euxassay_005376_15
Specimen Label: euxassay_005376_15
Detected: true
Specimen Num: 15
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GXD Expression
GXD Expression
 
Probe: MGI:1379184
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1672823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826116
Age: embryonic day 14.5
Image: euxassay_005376_16
Specimen Label: euxassay_005376_16
Detected: true
Specimen Num: 16
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GXD Expression
GXD Expression
 
Probe: MGI:1379184
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1672823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826116
Age: embryonic day 14.5
Image: euxassay_005376_17
Specimen Label: euxassay_005376_17
Detected: true
Specimen Num: 17
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GXD Expression
GXD Expression
 
Probe: MGI:1379184
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1672823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826116
Age: embryonic day 14.5
Image: euxassay_005376_18
Specimen Label: euxassay_005376_18
Detected: true
Specimen Num: 18
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GXD Expression
GXD Expression
 
Probe: MGI:1379184
Assay Type: RNA in situ
Annotation Date: 2024-04-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672822
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7621975
Age: embryonic day 14.5
Image: S5Cg
Specimen Label: S5Cg
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:5009295
Assay Type: RNA in situ
Annotation Date: 2011-06-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3283722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:5009453
Age: embryonic day 14.5
Image: 4F
Specimen Label: 4F
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:5009295
Assay Type: RNA in situ
Annotation Date: 2011-06-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3266520
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:5009453
Age: embryonic day 12.5
Image: 4E
Note: Expression extends medially from the ganglionic eminence through the septum.
Specimen Label: 4E
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:5009295
Assay Type: RNA in situ
Annotation Date: 2011-06-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3747120
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:5009453
Age: embryonic day 12.5
Image: 4E
Note: Expression is in the medial ganglionic eminence subventricular zone and ventricular zone.
Specimen Label: 4E
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:5009295
Assay Type: RNA in situ
Annotation Date: 2011-06-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3747122
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5009453
Age: embryonic day 14.5
Image: 4F
Note: Expression is in the medial ganglionic eminence subventricular zone and ventricular zone.
Specimen Label: 4F
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:5009295
Assay Type: RNA in situ
Annotation Date: 2011-06-30
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3747122
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5009453
Age: embryonic day 14.5
Image: 7A
Note: Expression is expanded laterally in the mutant medial ganglionic eminence.
Specimen Label: 7A
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:5009295
Assay Type: RNA in situ
Annotation Date: 2011-06-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3747122
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5009453
Age: embryonic day 14.5
Image: S1C
Note: Expression is expanded laterally in the mutant medial ganglionic eminence.
Specimen Label: S1C
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
Probe: MGI:5009295
Assay Type: RNA in situ
Annotation Date: 2011-06-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3747122
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5009453
Age: embryonic day 14.5
Image: S1D
Note: Expression is expanded laterally in the mutant medial ganglionic eminence.
Specimen Label: S1D
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
Probe: MGI:7720172
Assay Type: RNA in situ
Annotation Date: 2024-09-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3747120
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:7720340
Age: embryonic day 12.5
Image: 6C LGE/MGE
Note: Expression was detected at the ventricular zone/subventricular zone border.
Specimen Label: 6C LGE/MGE
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7720172
Assay Type: RNA in situ
Annotation Date: 2024-09-26
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:3746920
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:7720340
Age: embryonic day 12.5
Image: 6C CGE
Specimen Label: 6C CGE
Specimen Num: 2
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Allele
Mbip<tm1e(EUCOMM)Wtsi> | MGI:4431635
Name: MAP3K12 binding inhibitory protein 1; targeted mutation 1e, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Mbip<tm1a(EUCOMM)Wtsi> | MGI:4434191
Name: MAP3K12 binding inhibitory protein 1; targeted mutation 1a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Allele
Mbip<tm3a(EUCOMM)Wtsi> | MGI:5511922
Name: MAP3K12 binding inhibitory protein 1; targeted mutation 3a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Strain
MGI:6317353 | C57BL/6NJ-Mbip<em1(IMPC)J>/Mmjax
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:7593533 | C57BL/6J-Mbip<em1Cya>/Cya
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:7589140 | C57BL/6J-Mbip<em2Cya>/Cya
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Mbip<em1(cre/ERT2)Smoc> | MGI:7766355
Name: MAP3K12 binding inhibitory protein 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Inducible, Recombinase, Reporter
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Genotype
Genotype
Symbol: Mbip/Mbip
Background: C57BL/6NJ-Mbip/Mmjax
Zygosity: hm
Has Mutant Allele: true
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Protein Domain
IPR027257 | MAPKKK12
Type: Family
Description: MAP3K12 (also known as leucine-zipper protein kinase (ZPK), dual leucine zipper-bearing kinase (DLK) or MAPK-upstream kinase (MUK)) is a MAPKKK class protein kinase that induces JNK/SAPK activation. MAP3K12 is known to interact with MUK-binding inhibitory protein (MBIP). MBIP contains two tandem leucine-zipper-like motifs; MBIP interacts with one of the two leucine-zipper-like motifs of MAP3K12 and inhibits the activity of MAP3K12 to induce JNK/SAPK activation [, ]. MAP3K12 is autophosphorylated on Ser/Thr in cytosol under basal conditions, and dephosphorylated when membrane-associated.
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Strain
MGI:7767548 | C57BL/6JSmoc-Mbip<em1(cre/ERT2)Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Mbip/Mbip<+>
Background: C57BL/6NJ-Mbip/Mmjax
Zygosity: ht
Has Mutant Allele: true
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Publication
14697235 | -
First Author: Itoh A
Year: 2004
Journal: Biochem Biophys Res Commun
Title: SP3 acts as a positive regulator on the core promoter of human ZPK gene.
Volume: 313
Issue: 3
Pages: 612-8
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Publication
10801814 | -
First Author: Fukuyama K
Year: 2000
Journal: J Biol Chem
Title: MAPK upstream kinase (MUK)-binding inhibitory protein, a negative regulator of MUK/dual leucine zipper-bearing kinase/leucine zipper protein kinase.
Volume: 275
Issue: 28
Pages: 21247-54
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Publication
14960307 | J:88977
First Author: Zhang X
Year: 2004
Journal: FEBS Lett
Title: The mouse FKBP23 binds to BiP in ER and the binding of C-terminal domain is interrelated with Ca2+ concentration.
Volume: 559
Issue: 1-3
Pages: 57-60
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Protein Domain
IPR017419 | MAP3K12_MAP3K13
Type: Family
Description: This entry represents mitogen-activated protein kinase kinase kinase, types 12/13 (MAP3K12 and MAP3K13), which form part of the mixed lineage kinase (MLK) family. MAP3K12 (also known as leucine-zipper protein kinase (ZPK), dual leucine zipper-bearing kinase (DLK) or MAPK-upstream kinase (MUK)) is a MAPKKK class protein kinase that induces JNK/SAPK activation. MAP3K12 is known to interact with MUK-binding inhibitory protein (MBIP). MBIP contains two tandem leucine-zipper-like motifs; MBIP interacts with one of the two leucine-zipper-like motifs of MAP3K12 and inhibits the activity of MAP3K12 to induce JNK/SAPK activation [, ]. MAP3K12 is autophosphorylated on Ser/Thr in cytosol under basal conditions, and dephosphorylated when membrane-associated.MAP3K13 (also known as leucine zipper-bearing kinase LZK) activates the c-Jun-NH2 terminal kinase (JNK) pathway through activation of the MAP kinase kinase MAP2K7 []. MAP3K13 acts synergistically with peroxiredoxin-3 (PRDX3) to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B [].
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Protein
Q99LQ1
Organism: Mus musculus/domesticus
Length: 341  
Fragment?: false
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Protein Domain
IPR026062 | MBIP
Type: Family
Description: MAP3K12-binding inhibitory protein 1 (MBIP1) inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway []. It is a component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 [].
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Publication
12492477 | -
First Author: Masaki M
Year: 2003
Journal: Eur J Biochem
Title: Mixed lineage kinase LZK and antioxidant protein-1 activate NF-kappaB synergistically.
Volume: 270
Issue: 1
Pages: 76-83
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Allele
Tg(hs1538-cre/ERT2,-GFP)1608Jlr | MGI:5705320
Name: transgene insertion 1608, John L R Rubenstein
Allele Type: Transgenic
Attribute String: Inducible, Recombinase, Reporter
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Publication
19936620 | J:314756
First Author: Nagy Z
Year: 2010
Journal: Cell Mol Life Sci
Title: The metazoan ATAC and SAGA coactivator HAT complexes regulate different sets of inducible target genes.
Volume: 67
Issue: 4
Pages: 611-28
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Strain
MGI:5705323 | STOCK Tg(hs1538-cre/ERT2,-GFP)1608Jlr/Mmucd
Attribute String: mutant stock, transgenic
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Publication
19103755 | J:145720
First Author: Guelman S
Year: 2009
Journal: Mol Cell Biol
Title: The double-histone-acetyltransferase complex ATAC is essential for mammalian development.
Volume: 29
Issue: 5
Pages: 1176-88
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Publication
18799682 | J:142755
First Author: Tucker ES
Year: 2008
Journal: J Neurosci
Title: Molecular specification and patterning of progenitor cells in the lateral and medial ganglionic eminences.
Volume: 28
Issue: 38
Pages: 9504-18
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Publication
20562830 | J:162081
First Author: Orpinell M
Year: 2010
Journal: EMBO J
Title: The ATAC acetyl transferase complex controls mitotic progression by targeting non-histone substrates.
Volume: 29
Issue: 14
Pages: 2381-94
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Protein
Q60700
Organism: Mus musculus/domesticus
Length: 888  
Fragment?: false
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Protein
Q1HKZ5
Organism: Mus musculus/domesticus
Length: 959  
Fragment?: false
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Publication
20508642 | J:162104
First Author: Krebs AR
Year: 2010
Journal: EMBO Rep
Title: ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes.
Volume: 11
Issue: 7
Pages: 541-7
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Publication
- | J:279207
     
First Author: Mager J
Year: 2019
Journal: MGI Direct Data Submission
Title: A Catalog of Early Lethal KOMP Phenotypes
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Publication
35377797 | J:325356
First Author: Su-Feher L
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: Single cell enhancer activity distinguishes GABAergic and cholinergic lineages in embryonic mouse basal ganglia.
Volume: 119
Issue: 15
Pages: e2108760119
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Publication
35175194 | J:321499
   
First Author: Lee DR
Year: 2022
Journal: Elife
Title: Transcriptional heterogeneity of ventricular zone cells in the ganglionic eminences of the mouse forebrain.
Volume: 11
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Publication
27710791 | J:250401
First Author: Silberberg SN
Year: 2016
Journal: Neuron
Title: Subpallial Enhancer Transgenic Lines: a Data and Tool Resource to Study Transcriptional Regulation of GABAergic Cell Fate.
Volume: 92
Issue: 1
Pages: 59-74
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Publication
30728831 | J:304253
 
First Author: Jones MR
Year: 2018
Journal: Front Genet
Title: A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b Signaling on Epithelial Tip Progenitor Cells During Early Mouse Lung Branching Morphogenesis.
Volume: 9
Pages: 746
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Publication
- | J:188991
     
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
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Publication
- | J:342607
       
First Author: Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom
Year: 2023
Title: Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
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Publication
- | J:77000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:94077
     
First Author: Mutant Mouse Regional Resource Centers
Year: 2004
Journal: Unpublished
Title: Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC)
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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